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1. 发明授权

US5057514A Compounds effective as cerebral schemia treating agents 失效
标题翻译：化合物作为脑组织治疗剂有效
公开(公告)号：US5057514A
公开(公告)日：1991-10-15
申请号：US286857
申请日：1988-12-20
申请人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
发明人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
IPC分类号： C07C59/86 , C07C59/90 , C07D311/58 , C07D311/66 , C07C62/38 , C07D491/00 , C07D513/00
CPC分类号： C07D311/58 , C07C59/86 , C07C59/90 , C07D311/66
摘要： 1. A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, --O--, or --S--; R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy of carboxy which may be optionally esterized or amidated; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable sale thereof.
摘要翻译： 1.具有式（I）的化合物：其中A是-CH 2 - ， - O-或-S-; R1是CH3或OCH3; R 2是羧基的羟基，其可任选被酯化或酰胺化; R3是H或低级烷基; n为0或1〜6的整数或其药学上可接受的销售。

2. 发明授权

US4774241A Derivative of benzoquinonylphenyl alkanoic acid amide 失效
标题翻译：苯醌基苯基链烷酰胺衍生物
公开(公告)号：US4774241A
公开(公告)日：1988-09-27
申请号：US030557
申请日：1987-03-27
申请人： Toshio Tatsuoka , Kenji Suzuki , Kayoko Imao , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
发明人： Toshio Tatsuoka , Kenji Suzuki , Kayoko Imao , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
IPC分类号： A61K31/495 , A61K31/535 , A61K31/54 , C07D295/18 , C07D295/185 , C07D295/00 , C07D295/10
CPC分类号： C07D295/185 , Y10S514/822 , Y10S514/824 , Y10S514/879 , Y10S514/929
摘要： A derivative of benzoquinonylphenyl alkanoic acid amide having the formula: ##STR1## wherein X represents an oxygen atom, sulfur atom, or methylated nitrogen atom, Me represents methyl, and n is 2 or 3. This derivative is effective as a cerebral insufficiency improver.

3. 发明授权

US5292768A Compound effective as cerebral insufficiency improver 失效
标题翻译：化合物作为脑功能不全改善剂有效
公开(公告)号：US5292768A
公开(公告)日：1994-03-08
申请号：US980207
申请日：1992-11-23
申请人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
发明人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
IPC分类号： C07C59/86 , C07C59/90 , C07D311/58 , C07D311/66 , A61K31/35 , A61K31/38 , C07D311/04 , C07D335/06
CPC分类号： C07C59/90 , C07C59/86 , C07D311/58 , C07D311/66
摘要： A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, --O--, or --S--; R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy or carboxy which may be optionally esterized or amidated; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable salt thereof.
摘要翻译：具有式（I）的化合物：其中A是-CH 2 - ， - O-或-S-; R1是CH3或OCH3; R2是羟基或羧基，其可任选被酯化或酰胺化; R3是H或低级烷基; n为0或1〜6的整数或其药学上可接受的盐。

4. 发明授权

US4889853A Hydroquinonlyphenyl butyric acid amide derivative 失效
标题翻译：氢醌苯基丁酸酰胺衍生物
公开(公告)号：US4889853A
公开(公告)日：1989-12-26
申请号：US216337
申请日：1988-07-08
申请人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
发明人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
IPC分类号： C07D295/18 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P25/00 , A61P25/18 , A61P25/28 , C07D213/79 , C07D213/80 , C07D295/185 , C07D313/08 , C07D405/12
CPC分类号： C07D213/79 , C07D213/80 , C07D295/185 , C07D313/08 , C07D405/12
摘要： A hydroquinonylphenyl butyric acid amide derivative having the formula (I): ##STR1## wherein R.sup.1 represents an aromatic or heterocyclic group which may be substituted, R.sup.2 represents a hydrogen atom, a lower alkylcarbonyl group, an aromatic carbonyl or heterocyclic carbonyl group which may be substituted, and X represents an oxygen atom or sulfur atom or a pharmaceutically acceptable salt thereof, which has a cerebral insufficiency improving activity.

5. 发明授权

US5288752A Compound effective as cerebral insufficiency improver 失效
标题翻译：化合物作为脑功能不全改善剂有效
公开(公告)号：US5288752A
公开(公告)日：1994-02-22
申请号：US980238
申请日：1992-11-23
申请人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
发明人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
IPC分类号： C07C59/86 , C07C59/90 , C07D311/58 , C07D311/66 , A61K31/21
CPC分类号： C07C59/90 , C07C59/86 , C07D311/58 , C07D311/66
摘要： A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy or carboxy, carboxylic acid or carboxylic acid ester group; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable salt thereof.
摘要翻译：具有式（I）的化合物：其中A是-CH 2 - ，R 1是CH 3或OCH 3; R2是羟基或羧基，羧酸或羧酸酯基; R3是H或低级烷基; n为0或1〜6的整数或其药学上可接受的盐。

6. 发明授权

US5179092A Compound effective as cerebral insufficiency improver 失效
标题翻译：化合物作为脑功能不全改善剂有效
公开(公告)号：US5179092A
公开(公告)日：1993-01-12
申请号：US737717
申请日：1991-07-30
申请人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
发明人： Toshio Tatsuoka , Kenji Suzuki , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
IPC分类号： C07C59/86 , C07C59/90 , C07D311/58 , C07D311/66
CPC分类号： C07D311/66 , C07C59/86 , C07C59/90 , C07D311/58
摘要： A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, --O--, or --S--; R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy or carboxy which may be optionally esterized or amidated; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable salt thereof.
摘要翻译：具有式（I）的化合物：其中A是-CH 2 - ， - O-或-S-; R1是CH3或OCH3; R2是羟基或羧基，其可任选被酯化或酰胺化; R3是H或低级烷基; n为0或1〜6的整数或其药学上可接受的盐。

7. 发明授权

US4713453A Oxabicycloheptane derivatives 失效
标题翻译：氧杂双环庚烷衍生物
公开(公告)号：US4713453A
公开(公告)日：1987-12-15
申请号：US19973
申请日：1987-02-27
申请人： Toshio Tatsuoka , Kenji Suzuki , Kayoko Imao , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
发明人： Toshio Tatsuoka , Kenji Suzuki , Kayoko Imao , Fumio Satoh , Seiji Miyano , Kunihiro Sumoto
IPC分类号： C07D333/00 , A61K31/00 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61P9/00 , A61P25/18 , A61P25/28 , C07D311/94 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/04 , C07D487/04 , C07D417/00 , C07D401/00 , C07D405/00 , C07D413/00
CPC分类号： C07D405/04 , C07D311/94 , C07D405/12 , C07D409/04 , C07D487/04
摘要： The present invention relates to a novel oxabicycloheptane derivative of the following formula and a pharmaceutically acceptable salt thereof: ##STR1## where D is a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group, an arylalkoxy group, an acyloxy group, a dialkylcarbamoyloxy group or an amidoalkyloxy group; B is a substituted or unsubstituted phenyl, thienyl or furyl group; A is the group ##STR2## (where l is 0 or 1; m and n are each 1 or more, provided that m+n is an interger of 2-8; R.sup.1 is an alkylamino group, a dialkylamino group, an arylalkylamino group, a morpholino group, a thiomorpholino group, a 1-pyrrolidinyl group, a piperidino group, an N-alkylpiperazinyl group, an N-hydroxyalkylpiperazinyl or a pyrrolizidinyl group; and R.sup.2 is a lower alkyl group or a hydroxl group), or the group ##STR3## (where l, m, n, R.sup.1 and R.sup.2 are each the same as defined above), or the group ##STR4## (where R.sup.3 and R.sup.4 which may be the same or different each represents a hydrogen atom, a lower alkyl group, an alkoxycarbonyl group or an acyl group), or the group ##STR5## (where m, l, n, R.sup.1 and R.sup.2 are each the same as defined above). The oxabicycloheptane derivative having the formula defined above and pharmaceutically acceptable salts thereof are effective in ameliorating or eliminating the symptoms that appear either as a result of organic disorders in the brain or on account of pathergasia. These compouds also have antidepressant effects and the useful as psychopharmaceuticals.
摘要翻译：本发明涉及下式的新型氧杂双环庚烷衍生物及其药学上可接受的盐：其中D是氢原子，卤素原子，羟基，烷氧基，芳基烷氧基，酰氧基，二烷基氨基甲酰氧基或酰氨基烷氧基; B是取代或未取代的苯基，噻吩基或呋喃基; A是组（其中l是0或1; m和n各自为1或更多，条件是m + n是2-8的整数; R1是烷基氨基，二烷基氨基，芳基烷基氨基吗啉基，硫代吗啉基，1-吡咯烷基，哌啶子基，N-烷基哌嗪基，N-羟基烷基哌嗪基或吡咯烷基; R2为低级烷基或羟基），或该基团＆lt; IMAGE＆gt;（其中l，m，n，R 1和R 2各自与上述相同）或基团（其中可以相同或不同的R 3和R 4各自表示氢原子，低级烷基基团，烷氧基羰基或酰基）或基团（其中m，l，n，R 1和R 2各自与上述定义相同）。具有上述定义的式的氧杂双环庚烷衍生物及其药学上可接受的盐在改善或消除由于脑中有机疾病或由于麻醉引起的症状而有效。这些药物也具有抗抑郁作用，作为心理药物有用。

8. 发明授权

US4845094A 2-phenylbenzoxepin derivative 失效
标题翻译： 2-苯基苯并氧杂环庚烯衍生物
公开(公告)号：US4845094A
公开(公告)日：1989-07-04
申请号：US63839
申请日：1987-06-19
申请人： Toshio Tatsuoka , Kayoko Nomura , Fumio Satoh , Takafumi Ishihara , Seiji Miyano , Kunihiro Sumoto
发明人： Toshio Tatsuoka , Kayoko Nomura , Fumio Satoh , Takafumi Ishihara , Seiji Miyano , Kunihiro Sumoto
IPC分类号： A61K31/445 , A61K31/335 , A61K31/44 , A61K31/443 , A61K31/495 , A61K31/535 , A61K31/54 , A61P3/08 , A61P7/02 , A61P9/12 , C07D313/08 , C07D405/12
CPC分类号： C07D405/12 , C07D313/08
摘要： 2-phenylbenzoxepin derivatives having a hypoglycemic activity, hypotensive activity, and platelet coagulation inhibiting activity, a process for production of the derivatives, and pharmaceutical compositions containing the derivatives.

9. 发明授权

US4605662A 1-substituted pyrrolizidine derivatives and antiarrhythmic use thereof 失效
标题翻译： 1-取代的吡咯烷啶衍生物及其抗心律不齐用途
公开(公告)号：US4605662A
公开(公告)日：1986-08-12
申请号：US529548
申请日：1983-09-06
申请人： Seiji Miyano , Kunihiro Sumoto , Fumio Satoh , Hidetsura Cho
发明人： Seiji Miyano , Kunihiro Sumoto , Fumio Satoh , Hidetsura Cho
IPC分类号： A61K31/40 , A61P9/06 , C07D487/04
CPC分类号： C07D487/04
摘要： A novel 1-substituted pyrrolizidine derivative having the formula: ##STR1## (wherein R.sup.1 is hydrogen or a lower alkyl group; R.sup.2 is hydrogen, a lower alkyl or lower alkoxy group, or a halogen; R.sup.3 is hydrogen, a lower alkyl, lower alkoxy or amino group, or a halogen),which can be produced by reacting 1-chlorocarbonyl (or alkoxycarbonyl)pyrrolizidine with a corresponding substituted aniline (or an alkali metal salt thereof). The pyrrolizidine derivative has antiarrhythmic activity.
摘要翻译：具有下式的新颖的1-取代的吡咯烷子衍生物：其中R 1是氢或低级烷基; R 2是氢，低级烷基或低级烷氧基或卤素; R 3是氢，低级烷基，低级烷氧基或氨基，或卤素），其可以通过使1-氯羰基（或烷氧基羰基）吡咯烷酮与相应的取代的苯胺（或其碱金属盐）反应来制备。吡咯烷啶衍生物具有抗心律不齐活性。

10. 发明授权

US4831049A Pyrrolizidine compounds, and their use as antiarrhythmic agents 失效
标题翻译：吡咯烷啶化合物及其作为抗心律不齐剂的用途
公开(公告)号：US4831049A
公开(公告)日：1989-05-16
申请号：US751797
申请日：1985-07-03
申请人： Seiji Miyano , Kunihiro Sumoto , Fumio Satoh
发明人： Seiji Miyano , Kunihiro Sumoto , Fumio Satoh
IPC分类号： A61K31/40 , A61P9/06 , C07D487/04
CPC分类号： C07D487/04
摘要： A novel pyrrolizidine compound of the formula ##STR1## wherein R.sup.1 is an alkyl group of 1 to 4 carbon atoms or a phenyl group; and R.sup.2 and R.sup.3 are such that at least one of them is an alkyl group of 1 to 4 carbon atoms and the other, if not alkyl, being a hydrogen atom is produced by reacting .DELTA..sup.4(8) -dehydropyrrolizidine with a substituted malonic acid and the thus formed 2-substituted-8-pyrrolizidineacetic acid with a substituted aniline. The products are subjected to optical resolution and are potentantiarrhythmic agents.
摘要翻译：式（Ⅰ）的新型吡咯烷酮化合物，其中R 1为1至4个碳原子的烷基或苯基; 并且R2和R3使得它们中的至少一个是具有1至4个碳原子的烷基，而另一个（如果不是烷基）是氢原子，则通过使DELTA 4（8） - 溴丙啶与取代的丙二酸反应和由此形成的2-取代-8-吡咯烷二酸乙酯与取代的苯胺。产品经受光学拆分，是有效的抗心律失常药。

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