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1. 发明授权

US4763720A Microwave process for the fabrication of cores for use in foundry casting 失效
标题翻译：用于铸造铸造的芯的制造的微波工艺
公开(公告)号：US4763720A
公开(公告)日：1988-08-16
申请号：US86192
申请日：1987-08-17
申请人： Toshio Sakamoto , Kanichi Sato , Yoshiyuki Takemura
发明人： Toshio Sakamoto , Kanichi Sato , Yoshiyuki Takemura
IPC分类号： B22C1/00 , B22C1/16 , B22C1/18 , B22C1/20
CPC分类号： B22C1/00 , B22C1/167
摘要： For the fabrication of a disintegratable sand core, refractory particles such as silica sand are mixed with two binders, one consisting of an inorganic substance such as a silicate and the other consisting of a starch, and, preferably, with water. The two binders function to cancel the disadvantages arising from the use of only either. The mixture is introduced into a core box molded essentially of materials pervious to microwave energy. Exposed to microwave energy through the core box, the mixture hardens in the shape of the core box cavity. For the production of cores having greater surface stability at room temperature, the starch and water are first mixed together into a paste, and this paste is added to the refractory particles together with the inorganic binder, thereby assuring uniform dispersion of the starch throughout the mixture.
摘要翻译：对于可分解的砂芯的制造，将诸如硅砂的耐火颗粒与两种粘合剂混合，一种由无机物质如硅酸盐组成，另一种由淀粉，优选与水组成。两个粘合剂起到消除仅使用两者的缺点。将混合物引入基本上由微波能量透过的材料成型的芯盒中。通过芯盒暴露于微波能量中，混合物硬化为芯盒腔的形状。为了在室温下生产具有更大表面稳定性的芯，首先将淀粉和水混合在一起成糊状，并将该糊与无机粘合剂一起加入耐火颗粒中，从而确保淀粉在整个混合物中均匀分散。

2. 发明申请

US20070208033A1 Amine compound and use thereof 有权
标题翻译：胺化合物及其用途
公开(公告)号：US20070208033A1
公开(公告)日：2007-09-06
申请号：US11704860
申请日：2007-02-09
申请人： Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
发明人： Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
IPC分类号： A61K31/497 , A61K31/4709 , A61K31/4439 , A61K31/433 , A61K31/4196 , A61K31/4184 , A61K31/4178 , C07D403/02
CPC分类号： C07D233/64 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14
摘要： It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1): In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(═O) or NR11; and D is a group represented by the following general formula (4) or (6). In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.
摘要翻译：旨在提供对HIV病毒感染，风湿病和癌症转移等疾病有效的新型胺化合物。即，由以下通式（1）表示的胺化合物：在典型情况下，A1和A2各自表示任选取代的单环或多环芳族杂环; W表示环状C 3-10亚烷基，任选取代的单环或多环芳族杂环，单环或多环芳环或部分饱和多环芳环; X表示O，CH 2，C（-O）或NR 11; D为由以下通式（4）或（6）表示的基团。在式（6）中，Q表示单键，S，O或NR 12; Y为由以下通式（7）表示的基团。 z表示任选取代的单环或多环芳环。式（6）中，B表示NR25R26。在上式中，R 1至R 26各自表示氢，烷基，烯基或炔基。

3. 发明授权

US07833991B2 Amine compound and use thereof 有权
标题翻译：胺化合物及其用途
公开(公告)号：US07833991B2
公开(公告)日：2010-11-16
申请号：US11704860
申请日：2007-02-09
申请人： Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
发明人： Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
IPC分类号： C07D403/02 , A01N43/50
CPC分类号： C07D233/64 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14
摘要： It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1): In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(═O) or NR11; and D is a group represented by the following general formula (4) or (6). In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.
摘要翻译：旨在提供对HIV病毒感染，风湿病和癌症转移等疾病有效的新型胺化合物。即，由以下通式（1）表示的胺化合物：在典型情况下，A1和A2各自表示任选取代的单环或多环芳族杂环; W表示环状C 3-10亚烷基，任选取代的单环或多环芳族杂环，单环或多环芳环或部分饱和多环芳环; X表示O，CH 2，C（= O）或NR 11; D为由以下通式（4）或（6）表示的基团。在式（6）中，Q表示单键，S，O或NR 12; Y为由以下通式（7）表示的基团。 z表示任选取代的单环或多环芳环。式（6）中，B表示NR25R26。在上式中，R 1至R 26各自表示氢，烷基，烯基或炔基。

4. 发明授权

US07176227B2 Amine compounds and use thereof 有权
标题翻译：胺化合物及其用途
公开(公告)号：US07176227B2
公开(公告)日：2007-02-13
申请号：US10516158
申请日：2003-09-05
申请人： Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
发明人： Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
IPC分类号： C07D403/12 , A61K314/178
CPC分类号： C07D233/64 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14
摘要： Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof: wherein each of n1, n2, and n3 is an integer of 1; each of R1, R2, R3, R4, R5, and R6 is independently a hydrogen atom; A1 is imidazole; A2 is imidazole or imidazole substituted with an alkyl group; W is a phenyl group or naphthyl group; X is CH2; D is a group represented by -Q-Y—B, wherein Q is NR12 and R12 is a hydrogen atom or an alkyl group; Y is (CH2)m3 and m3 is an integer of 2 to 4; and B is N(R25R26), wherein each of R25 and R26 are independently a hydrogen atom, a C1–C6 alkyl group or a C3–C6 cycloalkyl group.
摘要翻译：对HIV病毒感染，风湿病，癌症转移等有害的新型胺化合物，可以举出以下通式（1）表示的化合物，其药理学上可接受的盐或其前药：其中，n， 1 1，n 2和n 3是1的整数; R 1，R 2，R 3，R 4，R 5，和/或R 3中的每一个 >，并且R 6独立地是氢原子; A 1是咪唑; A 2是被烷基取代的咪唑或咪唑; W是苯基或萘基; X是CH 2 2; D是由-Q-Y-B表示的基团，其中Q是NR 12和R 12是氢原子或烷基; Y为（CH 2 2）m 3，m 3为2〜4的整数，和B是N（R 25 R 26），其中R 25和R 26各自独立地是氢原子，C 1 -C 6烷基或C 3 -C 6 -C 6环烷基。

5. 发明申请

US20050165063A1 Amine compounds and use thereof 有权
标题翻译：胺化合物及其用途
公开(公告)号：US20050165063A1
公开(公告)日：2005-07-28
申请号：US10516158
申请日：2003-09-05
申请人： Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
发明人： Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
IPC分类号： A61P19/06 , A61P31/12 , A61P35/04 , C07D233/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D43/02 , A61K31/4172 , A61K31/4439
CPC分类号： C07D233/64 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14
摘要： It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1): In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(═O) or NR11; and D is a group represented by the following general formula (4) or (6). In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.
摘要翻译：旨在提供对HIV病毒感染，风湿病和癌症转移等疾病有效的新型胺化合物。即，由以下通式（1）表示的胺化合物：在典型情况下，A1和A2各自表示任选取代的单环或多环芳族杂环; W表示环状C 3-10亚烷基，任选取代的单环或多环芳族杂环，单环或多环芳环或部分饱和多环芳环; X表示O，CH 2，C（-O）或NR 11; D为由以下通式（4）或（6）表示的基团。在式（6）中，Q表示单键，S，O或NR 12; Y为由以下通式（7）表示的基团。 z表示任选取代的单环或多环芳环。式（6）中，B表示NR25R26。在上式中，R 1至R 26各自表示氢，烷基，烯基或炔基。

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