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1. 发明申请

US20130338574A1 ORAL MEDICINAL COMPOSITION FOR PATIENTS UNDERGOING PERITONEAL DIALYSIS AND METHOD FOR USING SAME 审中-公开
标题翻译：腹膜透析患者的口服药物组合物及其使用方法
公开(公告)号：US20130338574A1
公开(公告)日：2013-12-19
申请号：US13811763
申请日：2011-07-22
申请人： Takatoshi Kakuta , Toshio Miyata
发明人： Takatoshi Kakuta , Toshio Miyata
IPC分类号： A61K9/00 , A61K31/4412
CPC分类号： A61K9/0053 , A61K31/4412 , A61K31/4415 , C07D213/66
摘要： The present invention provides an oral medicinal composition for peritoneal dialysis patients to suppress an increase of carbonyl compounds and/or advanced glycation/lipoxidation end products (AGEs) in the peritoneal cavity and peritoneal tissue after intraperitoneal administration of a glucose-containing peritoneal dialysis fluid, the oral medicinal composition comprising a pharmaceutically acceptable salt of pyridoxamine as an active ingredient.
摘要翻译：本发明提供一种腹膜透析患者的口服药物组合物，其用于抑制腹膜内给予含葡萄糖的腹膜透析液后腹膜腔和腹膜组织中羰基化合物和/或晚期糖化/脂氧化终产物（AGEs）的增加，所述口服药物组合物含有药学上可接受的吡哆胺盐作为活性成分。

2. 发明申请

US20090030047A1 PERITONEUM PROTECTING AGENT 审中-公开
标题翻译：百香保护剂
公开(公告)号：US20090030047A1
公开(公告)日：2009-01-29
申请号：US11915347
申请日：2006-05-23
申请人： Toshio Miyata , Takatoshi Kakuta
发明人： Toshio Miyata , Takatoshi Kakuta
IPC分类号： A61K31/4415 , C07D213/67 , A61P13/00
CPC分类号： A61K31/44 , A61K31/4415 , A61K31/675 , A61M1/287
摘要： It is an objective of the present invention to provide a novel peritoneal membrane protecting agent which can effectively suppress deterioration of peritoneal functions in long-term peritoneal dialysis (PD) patients and the like. The present invention provides a peritoneal membrane protecting agent comprising a pyridoxine or a salt thereof, as an active ingredient.
摘要翻译：本发明的目的是提供一种可以有效抑制长期腹膜透析（PD）患者等腹膜功能恶化的新型腹膜保护剂等。本发明提供包含吡哆醇或其盐作为活性成分的腹膜保护剂。

3. 发明授权

US07645882B2 Inhibitor of protein modification products formation 失效
标题翻译：抑制蛋白质改性产物的形成
公开(公告)号：US07645882B2
公开(公告)日：2010-01-12
申请号：US10581255
申请日：2004-12-03
申请人： Toshio Miyata , Kiyoshi Kurokawa
发明人： Toshio Miyata , Kiyoshi Kurokawa
IPC分类号： C07D271/00 , C07D285/02 , C07D285/04
CPC分类号： C07D491/04 , C07D231/22 , C07D231/26 , C07D231/54
摘要： To provide a inhibitor of protein modification products formation capable of inhibiting of vitamin B6 deficiency disease as a side effect, especially a renal protective agent.There is provided a use, as an active ingredient, of any of free or salt-form compounds of either of the formulae: (I) (II) [wherein R1 is substituted or unsubstituted aromatic ring; and each of R2, R3 and R4 is a hydrogen atom or monovalent organic group, or alternatively R2 and R3 cooperate to form a condensed ring or R3 and R4 cooperate to represent a divalent organic group, provided that R3 and R4 are not simultaneously hydrogen atoms].
摘要翻译：提供能够抑制维生素B6缺乏症作为副作用的蛋白质修饰产物形成抑制剂，特别是肾保护剂。提供以下任一式的任何游离或盐形式的化合物作为活性成分的用途：（I）（II）[其中R 1是取代或未取代的芳环; R 2，R 3和R 4各自为氢原子或一价有机基团，或者R 2和R 3相互配位以形成稠合环，或者R 3和R 4相互配位以表示二价有机基团，条件是R 3和R 4不同时为氢原子 ]。

4. 发明授权

US5773720A Impact sensor and manufacturing method therefor 失效
标题翻译：冲击传感器及其制造方法
公开(公告)号：US5773720A
公开(公告)日：1998-06-30
申请号：US790283
申请日：1997-01-28
申请人： Toshio Miyata
发明人： Toshio Miyata
IPC分类号： G01P15/00 , G01P1/02 , G01P15/08 , H01H35/14 , H05K3/30 , G01L7/08
CPC分类号： H05K3/301 , G01P1/02 , G01P15/08 , H01H35/14 , H01H35/147
摘要： An impact sensor 10 has mounting pins which are strongly fixed to a housing body 11 without having to increase the outside dimensions of the housing body. The impact sensor includes the housing body 11, which has a hollow space 12 for accommodating a sensing mechanism, and a mounting arrangement 17 for fixing the housing body 11 to a wiring board 13. The mounting arrangement 17 includes a first pin portion 17a, a second pin portion 17b extending from the first pin portion at right angles with the longitudinal direction thereof, and a third pin portion 17c extending from the first pin portion 17a in the opposite direction from the extending direction of the second pin portion. On each side of the housing body 11, a press-fit recess 16 is formed into which the first and second pin portions 17a and 17b are press-fitted. The housing body 11 is fixed to the wiring board 13 by those portions of the third pin portions 17c of the mounting arrangement 17 which protrude from the housing body 11.
摘要翻译：撞击传感器10具有牢固地固定到壳体主体11的安装销，而不必增加壳体的外部尺寸。冲击传感器包括壳体11，其具有用于容纳感测机构的中空空间12，以及用于将壳体11固定到布线板13的安装装置17.安装装置17包括第一销部分17a，第二销部分17b从第一销部分与其纵向成直角延伸;以及第三销部分17c，其从第一销部分17a沿与第二销部分的延伸方向相反的方向延伸。在壳体11的每一侧上，形成有压配合凹部16，第一和第二销部分17a和17b被压入其中。壳体11通过从壳体11突出的安装装置17的第三销部17c的那些部分固定到布线板13。

5. 发明授权

US08785473B2 Plasminogen activator inhibitor-1 inhibitor 有权
标题翻译：纤溶酶原激活物抑制剂-1抑制剂
公开(公告)号：US08785473B2
公开(公告)日：2014-07-22
申请号：US13262259
申请日：2010-03-31
申请人： Toshio Miyata , Kenji Murano , Nagahisa Yamaoka , Akihisa Maeda
发明人： Toshio Miyata , Kenji Murano , Nagahisa Yamaoka , Akihisa Maeda
IPC分类号： A61K31/4709 , C07D217/26 , C07D217/16
CPC分类号： C07D409/12 , C07C233/81 , C07D213/56 , C07D215/14 , C07D217/16 , C07D295/192 , C07D307/42 , C07D307/54 , C07D307/66 , C07D333/24 , C07D333/36 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.
摘要翻译：本发明提供了具有纤溶酶原激活物抑制剂-1抑制活性的新化合物和包含该化合物作为活性成分的PAI-1抑制剂。本发明还提供了具有对PAI-1活性的抑制作用并且有效预防和治疗其起始与PAI-1活性相关的各种疾病的药物组合物。

6. 发明授权

US07951806B2 Plasminogen activator inhibitor-1 inhibitor 失效
标题翻译：纤溶酶原激活物抑制剂-1抑制剂
公开(公告)号：US07951806B2
公开(公告)日：2011-05-31
申请号：US12046547
申请日：2008-03-12
申请人： Toshio Miyata , Nagahisa Yamaoka , Hidehiko Kodama
发明人： Toshio Miyata , Nagahisa Yamaoka , Hidehiko Kodama
IPC分类号： A61K31/495 , A61K31/381 , C07D241/04 , C07D333/10
CPC分类号： C07D295/18 , C07C233/54 , C07C235/16 , C07C237/04 , C07C271/22 , C07C275/30 , C07C311/19 , C07D333/36 , C07D409/12
摘要： The present invention relates to an inhibitor of plasminogen activator inhibitor-1. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity. Furthermore, the present invention relates to a novel compound having PAI-1 inhibitory activity represented by the following general formula (I), and a salt thereof. Each symbol is defined as those in the specification.
摘要翻译：本发明涉及纤溶酶原激活物抑制剂-1抑制剂。本发明还涉及对PAI-1活性具有抑制作用的药物组合物，其可用于预防和治疗与PAI-1活性相关的各种疾病。此外，本发明涉及由以下通式（I）表示的具有PAI-1抑制活性的新型化合物及其盐。每个符号被定义为说明书中的符号。

7. 发明申请

US20070020341A1 METHOD FOR PREPARING PERITONEAL DIALYSATE 有权
标题翻译：制备皮质透析液的方法
公开(公告)号：US20070020341A1
公开(公告)日：2007-01-25
申请号：US11534375
申请日：2006-09-22
申请人： Toshio Miyata
发明人： Toshio Miyata
IPC分类号： A61K33/00 , A61K31/4965
CPC分类号： A61K31/203 , A61K31/155 , A61K31/4965 , A61K33/00 , A61M1/287 , Y10S514/832 , Y10S514/866 , A61K2300/00
摘要： Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated during sterilization and storage of the peritoneal dialysate can be eliminated by pre-contacting with the trapping agent. Further, it is possible to eliminate carbonyl compounds transferred from the blood to the peritoneal cavity of the patient during peritoneal dialysis treatment, by adding the trapping agent to the peritoneal dialysate or by circulating the fluid through a carbonyl compound-trapping cartridge. Intraperitoneal protein modification by carbonyl compounds is inhibited by the present invention, thereby sufficiently reducing peritoneal disorders associated with peritoneal dialysis treatment.
摘要翻译：产生并积累在腹膜透析液中的羰基化合物可以被羰基化合物捕获剂如氨基胍灭活或消除。消毒和储存腹膜透析液期间产生的羰基化合物可以通过与捕获剂预接触来消除。此外，通过将腹膜透析液中的捕获剂添加到通过羰基化合物捕获筒的循环中，可以消除腹膜透析治疗期间从血液转移到患者腹膜的羰基化合物。通过羰基化合物的腹膜内蛋白质修饰被本发明抑制，从而充分减少与腹膜透析治疗相关的腹膜障碍。

8. 发明申请

US20120022080A1 Plasminogen Activator Inhibitor-1 Inhibitor 有权
标题翻译：纤溶酶原激活物抑制剂-1抑制剂
公开(公告)号：US20120022080A1
公开(公告)日：2012-01-26
申请号：US13262259
申请日：2010-03-31
申请人： Toshio Miyata , Kenji Murano , Nagahisa Yamaoka , Akihisa Maeda
发明人： Toshio Miyata , Kenji Murano , Nagahisa Yamaoka , Akihisa Maeda
IPC分类号： A61K31/495 , C07C233/88 , C07D409/12 , C07D333/24 , C07D213/56 , C07D405/10 , C07D215/14 , C07D217/16 , C07D295/16 , A61K31/341 , A61K31/196 , A61K31/381 , A61K31/4418 , A61K31/4025 , A61K31/4525 , A61K31/47 , A61K31/472 , A61P7/02 , A61P9/10 , A61P35/00 , A61P27/06 , A61P3/10 , A61P25/28 , A61P3/04 , C07D307/54
CPC分类号： C07D409/12 , C07C233/81 , C07D213/56 , C07D215/14 , C07D217/16 , C07D295/192 , C07D307/42 , C07D307/54 , C07D307/66 , C07D333/24 , C07D333/36 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.
摘要翻译：本发明提供了具有纤溶酶原激活物抑制剂-1抑制活性的新化合物和包含该化合物作为活性成分的PAI-1抑制剂。本发明还提供了具有对PAI-1活性的抑制作用并且有效预防和治疗其起始与PAI-1活性相关的各种疾病的药物组合物。

9. 发明授权

US07368251B2 MEGSIN protein 失效
标题翻译： MEGSIN蛋白
公开(公告)号：US07368251B2
公开(公告)日：2008-05-06
申请号：US10927766
申请日：2004-08-26
申请人： Toshio Miyata
发明人： Toshio Miyata
IPC分类号： G01N33/53 , G01N33/537 , G01N33/566
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , G01N33/56966 , G01N33/6893
摘要： A gene expressed specifically in mesangial cells. A DNA expressed specifically in mesangial cells; a protein encoded by this DNA; an antibody binding to this protein, etc. These substances are indigenous to mesangial cells and, therefore, useful in, for example, identifying mesangial cells and detecting abnormalities in mesangial cells. Moreover, the above protein would be helpful for clarification of the functions of masangial cells and, in its turn, for clarification of the causes of diseases relating to masangial cells. This protein is expectedly applicable to the treatment and diagnosis of diseases relating to masangial cells.
摘要翻译：一种特异性表达于肾小球系膜细胞的基因。特异性在肾小球系膜细胞中表达的DNA; 由该DNA编码的蛋白质; 与该蛋白质结合的抗体等。这些物质属于肾小球系膜细胞，因此可用于例如鉴定肾小球系膜细胞和检测肾小球系膜细胞异常。此外，上述蛋白质将有助于澄清肌球蛋白细胞的功能，并且有助于澄清与血管神经细胞有关的疾病的原因。该蛋白质预期适用于与流血细胞有关的疾病的治疗和诊断。

10. 发明申请

US20070161691A1 Modified-protein formation inhibitor 审中-公开
标题翻译：修饰蛋白形成抑制剂
公开(公告)号：US20070161691A1
公开(公告)日：2007-07-12
申请号：US10580465
申请日：2004-11-19
申请人： Toshio Miyata , Kiyoshi Kurokawa
发明人： Toshio Miyata , Kiyoshi Kurokawa
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D257/04 , A61M1/287
摘要： [PROBLEMS] To provide a inhibitor of protein modification products formation that exibits intense and excellent protein modification products formation inhibiting effects without causing any blood pressure drop. [MEANS FOR SOLVING PROBLEMS] There is provided a inhibitor of protein modification products formation comprising as an active ingredient a compound consisting of a tetrazole ring having, via methylene, various substituents, especially compound (I) or (II) of the following formula: (wherein R1 and R2 represent monovalent organic groups identical with or different from each other). This inhibitor of protein modification products formation is useful in the prevention and treatment of diseases associated with AGEs and ALEs, for example, used as a renal tissue protectant alone or in mixture in a peritoneal dialyzing solution or hemodialysate.
摘要翻译： [问题]提供蛋白质修饰产物形成的抑制剂，其在不引起任何血压降低的情况下发挥强烈和优异的蛋白质改性产物形成抑制作用。提供了一种蛋白质修饰产物形成抑制剂，其包含具有通过亚甲基，各种取代基，特别是下式的化合物（I）或（II）的四唑环作为活性成分的化合物：（其中R1和R2表示彼此相同或不同的一价有机基团）。这种蛋白质修饰产物形成抑制剂可用于预防和治疗与AGEs和ALE相关的疾病，例如单独用作肾组织保护剂或在腹膜透析溶液或血液透析液中混合使用。

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