专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5292923A Method of preparing .alpha.-l-aspartyl-l-phenylalanine methyl ester hydrochloride 失效
标题翻译：制备α1-天冬氨酰-1-苯丙氨酸甲酯盐酸盐的方法
公开(公告)号：US5292923A
公开(公告)日：1994-03-08
申请号：US886101
申请日：1992-05-21
申请人： Toshihisa Kato , Shinichi Kishimoto , Hideo Takeda , Mikiya Kano , Tadashi Takemoto
发明人： Toshihisa Kato , Shinichi Kishimoto , Hideo Takeda , Mikiya Kano , Tadashi Takemoto
IPC分类号： C07K1/02 , C07K1/14 , C07K5/075 , C07C229/00
CPC分类号： C07K5/0613
摘要： A method of preparing .varies.-L-aspartyl-L-phenylalanine methyl ester hydrochloride (.varies.-APM.HCL) from a reaction mixture of N-formyl-L-aspartic acid anhydride and L-phenylalanine methyl ester (PM), wherein .alpha.-APM.HCl is produced without isolating an intermediate by solid-liquid separation during the course of the reaction process.
摘要翻译：从N-甲酰基-L-天冬氨酸酐和L-苯丙氨酸甲酯（的反应混合物）中制备（变化为）-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐（（根据-APM.HCL变化））的方法 PM），其中（α）-APM.HCl是在反应过程中通过固液分离而不分离中间体的。

2. 发明授权

US5391810A Method of crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester 失效
标题翻译： α-L-天冬氨酰-L-苯丙氨酸甲酯的结晶方法
公开(公告)号：US5391810A
公开(公告)日：1995-02-21
申请号：US121569
申请日：1993-09-16
申请人： So Abe , Shinichi Kishimoto , Toshihisa Kato , Hideo Takeda
发明人： So Abe , Shinichi Kishimoto , Toshihisa Kato , Hideo Takeda
IPC分类号： C07K5/072 , C07K5/075 , C07C101/02
CPC分类号： C07K5/0613
摘要： In crystallizing .alpha.-APM from a water solution or a mixed solvent solution of water and a lower alcohol in a crystallizer, the pressure in the crystallizer is held at not higher than atmospheric pressure, a water or water/alcohol mixed solution of .alpha.-APM is fed into the crystallizer with stirring so that the solvent is vaporized, and the crystallization solution is cooled and crystallized by the latent heat of vaporization or is heated so as to prevent supercooling.
摘要翻译：在结晶器中从水溶液或水和低级醇的混合溶剂溶液中结晶α-APM时，将结晶器中的压力保持在不高于大气压的水溶液或水/乙醇混合的α-APM溶液在搅拌下进料到结晶器中，使溶剂蒸发，并将结晶溶液冷却并通过蒸发潜热结晶或加热，以防止过冷。

3. 发明授权

US5424476A Method for preparing amino acid esters 失效
标题翻译：制备氨基酸酯的方法
公开(公告)号：US5424476A
公开(公告)日：1995-06-13
申请号：US194635
申请日：1994-02-10
申请人： Tadashi Takemoto , Hideo Takeda
发明人： Tadashi Takemoto , Hideo Takeda
IPC分类号： B01J27/02 , C07B61/00 , C07C227/18 , C07C229/02 , C07C229/24 , C07C229/34 , C07C229/08
CPC分类号： C07C227/18
摘要： A method for preparing an amino acid ester with sulfuric acid as the catalyst in high yield, in which a mixture of amino acid, sulfuric acid and an alcohol is heated while adding the alcohol as a liquid or gas to the reaction mixture and alcohol from the reaction mixture is distilled off.
摘要翻译：以高产率制备硫酸作为催化剂的氨基酸酯的方法，其中将氨基酸，硫酸和醇的混合物加热，同时将醇作为液体或气体加入到反应混合物中，并将醇从蒸馏出反应混合物。

4. 发明授权

US5041607A Process for crystallizing L-alpha-aspartyl-L-phenyl-alanine methyl 失效
标题翻译：用于结晶L-α-天冬氨酰-L-苯基 - 丙氨酸甲基的方法
公开(公告)号：US5041607A
公开(公告)日：1991-08-20
申请号：US293565
申请日：1989-01-03
申请人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
发明人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
IPC分类号： A23L27/30 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/44 , A23G9/32 , A23G9/34 , C07C67/00 , C07C231/00 , C07C231/24 , C07K1/14 , C07K5/072 , C07K5/075
CPC分类号： A23G3/44 , A23G3/346 , A23G3/42 , A23G9/32 , A23G9/34 , A23L27/32 , C07K5/0613 , A23G2200/06 , A23G2200/10
摘要： A crystalline L-alpha-aspartyl-L-phenyl-alanine methyl ester product is disclosed. The product is obtained by crystallizing the ester from an aqueous solution, by cooling. The initial concentration of ester in the aqueous solution used provides at least 10 grams of precipitated solid phase per liter of solution. The solution is cooled through conductive heat transfer without effecting forced flow to form a sherbet-like pseudo solid phase.
摘要翻译：公开了一种结晶的L-α-天冬氨酰-L-苯基 - 丙氨酸甲酯产物。通过冷却从水溶液中使酯结晶获得产物。所用水溶液中酯的初始浓度每升溶液提供至少10克沉淀固相。溶液通过导电传热而冷却，而不会受到强制流动，形成果汁冻样假固体相。

5. 发明授权

US5859282A Method of dissolving crystals of L-.alpha.-aspartyl-L-phenyl alanine methyl ester 失效
标题翻译：溶解L-天冬氨酰-L-苯丙氨酸甲酯晶体的方法
公开(公告)号：US5859282A
公开(公告)日：1999-01-12
申请号：US655945
申请日：1996-05-31
申请人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
发明人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
IPC分类号： A23L27/30 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/44 , A23G9/32 , A23G9/34 , C07C67/00 , C07C231/00 , C07C231/24 , C07K1/14 , C07K5/072 , C07K5/075 , C07C229/00
CPC分类号： A23G3/44 , A23G3/346 , A23G3/42 , A23G9/32 , A23G9/34 , A23L27/32 , C07K5/0613 , A23G2200/06 , A23G2200/10
摘要： A method for dissolving crystalline L-alpha-aspartyl-L-phenyl alanine methyl ester product is disclosed. The product is obtained by crystallizing the ester from an aqueous solution, by cooling. The initial concentration of ester in the aqueous solution used provides at least 10 grams of precipitated solid phase per liter of solution. The solution is cooled through conductive heat transfer without effecting forced flow to form a sherbet-like pseudo solid phase
摘要翻译：公开了一种溶解结晶性L-α-天冬氨酰-L-苯丙氨酸甲酯产物的方法。通过冷却从水溶液中使酯结晶获得产物。所用水溶液中酯的初始浓度每升溶液提供至少10克沉淀固相。溶液通过导电传热而冷却，而不会受到强制流动，形成果汁冻样假固相

6. 发明授权

US5744632A Process for crystallizing L-.alpha.-aspartyl-L-phenylalanine methyl ester 失效
标题翻译： L-天冬氨酰-L-苯丙氨酸甲酯的结晶方法
公开(公告)号：US5744632A
公开(公告)日：1998-04-28
申请号：US455707
申请日：1995-05-31
申请人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
发明人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
IPC分类号： A23L27/30 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/44 , A23G9/32 , A23G9/34 , C07C67/00 , C07C231/00 , C07C231/24 , C07K1/14 , C07K5/072 , C07K5/075 , C07C224/00
CPC分类号： A23G3/44 , A23G3/346 , A23G3/42 , A23G9/32 , A23G9/34 , A23L27/32 , C07K5/0613 , A23G2200/06 , A23G2200/10
摘要： A crystalline L-.alpha.-aspartyl-L-phenylalanine methyl ester product and the process for obtaining the same are disclosed. This product is obtained by adjusting the initial concentration of L-.alpha.-aspartyl-L-phenylalanine methyl ester in an aqueous solution so that the amount of precipitated solid, formed after cooling said solution, is about 10 grams or more of precipitate per liter of solvent. The solution is then cooled through conductive heat transfer, without causing forced flow, to obtain a sherbet-like pseudo solid phase.
摘要翻译：公开了一种结晶的L-α-天门冬酰基-L-苯丙氨酸甲酯产物及其获得方法。该产物通过调节水溶液中的L-天冬氨酰-L-苯丙氨酸甲酯的初始浓度得到，使得在冷却所述溶液后形成的沉淀固体的量为每升约10克或更多的沉淀物溶剂。然后将溶液通过导电热传递而冷却，而不引起强制流动，以获得果子露露样的假固相。

7. 发明授权

US5874609A Process for crystallizing L-.alpha.-aspartyl-L-phenylanlanine methyl ester 失效
标题翻译：用于结晶L-α-天冬氨酰-L-苯丙氨酸甲酯的方法
公开(公告)号：US5874609A
公开(公告)日：1999-02-23
申请号：US917507
申请日：1997-08-26
申请人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
发明人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
IPC分类号： A23L27/30 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/44 , A23G9/32 , A23G9/34 , C07C67/00 , C07C231/00 , C07C231/24 , C07K1/14 , C07K5/072 , C07K5/075 , C07C224/00
CPC分类号： A23G3/44 , A23G3/346 , A23G3/42 , A23G9/32 , A23G9/34 , A23L27/32 , C07K5/0613 , A23G2200/06 , A23G2200/10
摘要： A crystalline L-alpha-aspartyl-L-phenyl-alanine methyl ester product is disclosed. The product is obtained by crystallizing the ester from an aqueous solution, by cooling. The initial concentration of ester in the aqueous solution used provides at least 10 grams of precipitated solid phase per liter of solution. The solution is cooled through conductive heat transfer without effecting forced flow to form a sherbet-like pseudo solid phase.
摘要翻译：公开了一种结晶的L-α-天冬氨酰-L-苯基 - 丙氨酸甲酯产物。通过冷却从水溶液中使酯结晶获得产物。所用水溶液中酯的初始浓度每升溶液提供至少10克沉淀固相。溶液通过导电传热而冷却，而不会受到强制流动，形成果汁冻样假固相。

8. 发明授权

US5621137A Method of dissolving crystals of L-.alpha.-aspartyl-L-phenylalanine methyl ester 失效
标题翻译：溶解L-天冬氨酰-L-苯丙氨酸甲酯晶体的方法
公开(公告)号：US5621137A
公开(公告)日：1997-04-15
申请号：US462551
申请日：1995-06-05
申请人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
发明人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
IPC分类号： A23L27/30 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/44 , A23G9/32 , A23G9/34 , C07C67/00 , C07C231/00 , C07C231/24 , C07K1/14 , C07K5/072 , C07K5/075 , C07C229/00
CPC分类号： A23G3/44 , A23G3/346 , A23G3/42 , A23G9/32 , A23G9/34 , A23L27/32 , C07K5/0613 , A23G2200/06 , A23G2200/10
摘要： A method for dissolving crystalline L-alpha-aspartyl-L-phenyl-alanine methyl ester product is disclosed. The product is obtained by crystallizing the ester from an aqueous solution, by cooling. The initial concentration of ester in the aqueous solution used provides at least 10 grams of precipitated solid phase per liter of solution. The solution is cooled through conductive heat transfer without effecting forced flow to form a sherbet-like pseudo solid phase.
摘要翻译：公开了一种溶解结晶L-α-天冬氨酰-L-苯基 - 丙氨酸甲酯产物的方法。通过冷却从水溶液中使酯结晶获得产物。所用水溶液中酯的初始浓度每升溶液提供至少10克沉淀固相。溶液通过导电传热而冷却，而不会受到强制流动，形成果汁冻样假固相。

9. 发明授权

US5097060A Process for crystallizing L-alpha-aspartyl-L-phenyl-alanine methyl ester 失效
标题翻译：用于结晶L-ALPHA-ASPARTYL-L-PHENYL-ALANINE METHYLESTER的方法
公开(公告)号：US5097060A
公开(公告)日：1992-03-17
申请号：US715711
申请日：1991-06-18
申请人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
发明人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
IPC分类号： A23L27/30 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/44 , A23G9/32 , A23G9/34 , C07C67/00 , C07C231/00 , C07C231/24 , C07K1/14 , C07K5/072 , C07K5/075
CPC分类号： A23G3/44 , A23G3/346 , A23G3/42 , A23G9/32 , A23G9/34 , A23L27/32 , C07K5/0613 , A23G2200/06 , A23G2200/10
摘要： A process for crystallizing L-alpha-aspartyl-L-phenylalanine methyl ester from its aqueous solution by cooling, which comprises adjusting the initial concentration of the ester so that the amount of a precipitated solid phase to be formed after cooling becomes about 10 grams or more per liter of the solvent, cooling the solution through conductive heat transfer through a cooled surface to form an apparently sherbet-like pseudosolid phase without causing forced flow by mechanical stirring or the like, and optionally further cooling the system after formation of the pseudosolid phase, is disclosed along with various apparatuses which may be used to carry out the invention.

10. 发明申请

US20110163571A1 VEHICLE SIDE SECTON STRUCTURE 有权
标题翻译：车辆侧面结构
公开(公告)号：US20110163571A1
公开(公告)日：2011-07-07
申请号：US12679460
申请日：2008-12-01
申请人： Seiji Furusako , Hideo Takeda
发明人： Seiji Furusako , Hideo Takeda
IPC分类号： B62D25/06 , B62D25/04
CPC分类号： B62D25/06
摘要： A vehicle side section structure that is capable of a required stiffness and enables a reduction in weight of a roof side section is provided. A roof side rail that structures a vehicle side section structure is provided with: a roof outer panel that has length in a vehicle front-rear direction and is opened inward of the vehicle, and has a pair of upper and lower flanges; and a roof side frame member that is joined to the pair of upper and lower flanges of the roof outer panel at a pair of upper and lower flanges. The roof side frame member has, between the upper and lower flanges, an outward protruding portion that is protruded in a vehicle outward direction and an inward protruding portion 46 that is protruded in a vehicle inward direction, and in a sectional view cut orthogonally to the length direction, a length of a top wall of the outward protruding portion is longer than a length of a top wall of the inward protruding portion.
摘要翻译：提供能够具有所需刚度并且能够减小屋顶侧部分的重量的车辆侧部结构。构成车辆侧部结构的车顶侧钢轨设置有：车顶外板，其在车辆前后方向上具有长度并向车辆内侧开口，并具有一对上下凸缘; 以及车顶侧框架构件，其在一对上下凸缘处连接到所述屋顶外板的所述一对上凸缘和下凸缘。车顶侧框架件在上凸缘和下凸缘之间具有在车辆向外方向上突出的向外突出部分和在车辆向内方向上突出的向内突出部分46，并且在垂直于向外突出部的顶壁的长度比向内突出部的顶壁的长度长。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式