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1. 发明授权

US07048944B2 Method for preparing closed vesicles 失效
公开(公告)号：US07048944B2
公开(公告)日：2006-05-23
申请号：US10253641
申请日：2002-09-25
申请人： Toshiaki Tagawa , Saiko Hosokawa , Kazuhiro Nagaike
发明人： Toshiaki Tagawa , Saiko Hosokawa , Kazuhiro Nagaike
IPC分类号： A61K9/127
CPC分类号： A61K9/1277 , A61K9/1278
摘要： A method for preparing a closed vesicle by a rehydration of a closed vesicle using a rehydration solution, wherein said closed vesicle comprises a dehydrated micelle particle or dehydrated amphipathic micelle bilayers, preferably a liposome loading a pharmaceutically active substance, and the method is characterized in that the rehydration is carried out at a low temperature such as in the range of from 0° C. to 10° C. The method can provides a rehydrated stable vesicle without a leak of the loaded substance.

2. 发明授权

US5837845A Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane 失效
公开(公告)号：US5837845A
公开(公告)日：1998-11-17
申请号：US450578
申请日：1995-05-25
申请人： Saiko Hosokawa , Toshiaki Tagawa , Yoko Hirakawa , Norihiko Ito , Kazuhiro Nagaike
发明人： Saiko Hosokawa , Toshiaki Tagawa , Yoko Hirakawa , Norihiko Ito , Kazuhiro Nagaike
IPC分类号： A61K9/127 , A61K38/00 , A61K47/48 , C07K16/30 , C12N5/28 , C12P21/08 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： B82Y5/00 , A61K47/48615 , A61K47/48823 , A61K9/1271 , C07K16/3046 , A61K2039/505 , A61K38/00 , C07K2317/21 , C07K2317/50 , Y10S424/812 , Y10S530/808 , Y10S530/809 , Y10S530/865 , Y10S530/866 , Y10S530/867
摘要： A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surface of a liposome enclosing an anti-cancer agent or toxin is also provided.

3. 发明申请

US20080014255A1 Liposome bonded with antibody and polyalkylene glycol 审中-公开
标题翻译：与抗体和聚亚烷基二醇结合的脂质体
公开(公告)号：US20080014255A1
公开(公告)日：2008-01-17
申请号：US11812804
申请日：2007-06-21
申请人： Toshiaki Tagawa , Saiko Hosokawa
发明人： Toshiaki Tagawa , Saiko Hosokawa
IPC分类号： A61K9/127 , A61K31/704 , A61P35/00
CPC分类号： A61K31/704 , A61K9/1271 , A61K9/1272 , A61K47/6911 , A61K47/6913
摘要： A liposome wherein a compound containing a polyalkylene glycol moiety is bonded through a thioether group and an antibody is bonded through a thioether group to a liposome comprising lipids whose partial component has maleimidated terminal, wherein an amount of the bonded compound and an amount of bonded antibody is 15 to 50 mole % and 0.1 to 2 mole %, respectively, based on one mole of the maleimidated lipid contained in the liposome. The liposome achieves both excellent blood retention and therapeutic effect.
摘要翻译：一种脂质体，其中含有聚亚烷基二醇部分的化合物通过硫醚基团键合，并且抗体通过硫醚基团键合到包含其部分成分具有马来酰亚胺化末端的脂质的脂质体，其中键合化合物的量和结合抗体的量基于1摩尔脂质体中所含的马来酰亚胺化脂质，分别为15〜50摩尔％，0.1〜2摩尔％。脂质体具有优异的保血性和治疗效果。

4. 发明授权

US06787153B1 Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane 失效
标题翻译：特异性结合癌细胞膜表面抗原的人单克隆抗体
公开(公告)号：US06787153B1
公开(公告)日：2004-09-07
申请号：US09467903
申请日：1999-12-21
申请人： Saiko Hosokawa , Toshiaki Tagawa , Yoko Hirakawa , Norihiko Ito , Kazuhiro Nagaike
发明人： Saiko Hosokawa , Toshiaki Tagawa , Yoko Hirakawa , Norihiko Ito , Kazuhiro Nagaike
IPC分类号： A61K9127
CPC分类号： C07K16/3046 , A61K9/1271 , A61K38/00 , A61K47/6913 , A61K2039/505 , C07K2317/21 , C07K2317/50 , Y10S530/865 , Y10S530/866 , Y10S530/867
摘要： A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surface of a liposome enclosing an anti-cancer agent or toxin is also provided.
摘要翻译：特异性结合癌细胞膜的表面抗原的人单克隆抗体，编码抗体的分离的DNA和产生抗体的杂交瘤。还提供了包含结合到包围抗癌剂或毒素的脂质体表面的单克隆抗体的抗癌制剂。

5. 发明授权

US5767246A Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane 失效
公开(公告)号：US5767246A
公开(公告)日：1998-06-16
申请号：US360125
申请日：1994-12-20
申请人： Saiko Hosokawa , Toshiaki Tagawa , Yoko Hirakawa , Norihiko Ito , Kazuhiro Nagaike
发明人： Saiko Hosokawa , Toshiaki Tagawa , Yoko Hirakawa , Norihiko Ito , Kazuhiro Nagaike
IPC分类号： A61K9/127 , A61K38/00 , A61K47/48 , C07K16/30 , C12N5/28 , C12P21/08 , C07K16/00 , A61K39/395 , C12N5/24
CPC分类号： B82Y5/00 , A61K47/48615 , A61K47/48823 , A61K9/1271 , C07K16/3046 , A61K2039/505 , A61K38/00 , C07K2317/21 , C07K2317/50 , Y10S424/812 , Y10S530/808 , Y10S530/809 , Y10S530/865 , Y10S530/866 , Y10S530/867
摘要： A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surface of a liposome enclosing an anti-cancer agent or toxin is also provided.

6. 发明申请

US20050032132A1 Cancer diagnostics 审中-公开
标题翻译：癌症诊断
公开(公告)号：US20050032132A1
公开(公告)日：2005-02-10
申请号：US10483994
申请日：2002-07-25
申请人： Hisae Niki , Toshiaki Tagawa , Saiko Hosokawa
发明人： Hisae Niki , Toshiaki Tagawa , Saiko Hosokawa
IPC分类号： C07K16/30 , G01N33/533 , G01N33/574 , G01N33/577 , G01N33/58 , C07K16/46
CPC分类号： G01N33/582 , C07K16/3015 , C07K16/3046 , C07K2317/21 , C07K2317/54 , G01N33/533 , G01N33/574 , G01N33/577
摘要： Provided is a diagnostic comprising a peptide or protein capable of recognizing at least a portion of a tissue section and a fluorescent substance having the below-described characteristics: i) having, in a predetermined excitation wavelength, an emission wavelength not adjacent to a wavelength region of nonspecific autofluorescence which the tissue section has; and ii) permitting simultaneous observation of the image of the peptide or protein and the image of the tissue section. A diagnostic method and diagnostic kit each of which uses the peptide or protein, and the fluorescent substance is provided. A therapeutic agent administered to a disease after selection of the appropriate agent for the disease by using the above-described method. Also, a tissue section stained by the peptide or protein and the fluorescent substance is provided. In addition, a method of analyzing expression and/or behavior of a protein by using the fluorescent substance is provided.
摘要翻译：本发明提供一种包括能识别组织切片的至少一部分的肽或蛋白质的诊断装置和具有以下特征的荧光物质：i）在预定的激发波长中具有不与波长区域相邻的发射波长组织部分具有的非特异性自体荧光; 和ii）允许同时观察肽或蛋白质的图像和组织切片的图像。提供了各自使用肽或蛋白质和荧光物质的诊断方法和诊断试剂盒。通过使用上述方法选择适当的疾病剂后，给予该疾病的治疗剂。此外，提供了由肽或蛋白质和荧光物质染色的组织切片。此外，提供了通过使用荧光物质分析蛋白质的表达和/或行为的方法。

7. 发明授权

US5990297A Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane 失效
公开(公告)号：US5990297A
公开(公告)日：1999-11-23
申请号：US14880
申请日：1998-01-28
申请人： Saiko Hosokawa , Toshiaki Tagawa , Yoko Hirakawa , Norihiko Ito , Kazuhiro Nagaike
发明人： Saiko Hosokawa , Toshiaki Tagawa , Yoko Hirakawa , Norihiko Ito , Kazuhiro Nagaike
IPC分类号： A61K9/127 , A61K38/00 , A61K47/48 , C07K16/30 , C12N5/28 , C12P21/08 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： B82Y5/00 , A61K47/48615 , A61K47/48823 , A61K9/1271 , C07K16/3046 , A61K2039/505 , A61K38/00 , C07K2317/21 , C07K2317/50 , Y10S424/812 , Y10S530/808 , Y10S530/809 , Y10S530/865 , Y10S530/866 , Y10S530/867
摘要： A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surface of a liposome enclosing an anti-cancer agent or toxin is also provided.

8. 发明授权

US5264221A Drug-containing protein-bonded liposome 失效
标题翻译：含药物的蛋白质键合脂质体
公开(公告)号：US5264221A
公开(公告)日：1993-11-23
申请号：US886846
申请日：1992-05-22
申请人： Toshiaki Tagawa , Saiko Hosokawa , Kazuhiro Nagaike
发明人： Toshiaki Tagawa , Saiko Hosokawa , Kazuhiro Nagaike
IPC分类号： A61K9/127 , A61K39/395 , A61K45/00 , A61K47/48 , A61P35/00
CPC分类号： A61K9/1271 , A61K47/48823 , Y10S436/829 , Y10S530/812 , Y10T428/2984
摘要： A drug-containing protein-bonded liposome comprising a liposome containing a drug and having maleimide residues on its surface, and a protein and residues of a compound having a polyalkylene glycol moiety, bonded via respective thiol groups to the maleimide residues.

9. 发明申请

US20060057147A1 Antibody recognizing antibody 审中-公开
标题翻译：抗体识别抗体
公开(公告)号：US20060057147A1
公开(公告)日：2006-03-16
申请号：US10530171
申请日：2003-10-03
申请人： Hirakawa Youko , Hisae Niki , Shinsuke Oike , Toshiaki Tagawa , Saiko Hosokawa , Yoshiko Yoshiyama
发明人： Hirakawa Youko , Hisae Niki , Shinsuke Oike , Toshiaki Tagawa , Saiko Hosokawa , Yoshiko Yoshiyama
IPC分类号： A61K48/00 , C07H21/04 , A61K39/395
CPC分类号： A61K49/0002 , A61K9/127 , A61K39/39558 , A61K47/6913 , A61K51/1045 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3046
摘要： An antigen having a part which is exposed on the surface of a cell at the formation of a tumor mass, and a pharmaceutical composition and a labeling agent comprising a ligand which recognizes the antigen.
摘要翻译：具有在肿瘤块形成时暴露于细胞表面的部分的抗原，以及包含识别抗原的配体的药物组合物和标记试剂。

10. 发明申请

US20050074499A1 Ligand-bonded complex 审中-公开
标题翻译：配体结合复合物
公开(公告)号：US20050074499A1
公开(公告)日：2005-04-07
申请号：US10997880
申请日：2004-11-29
申请人： Toshiaki Tagawa , Tsutomu Suzuki , Nobuhisa Yada , Kazuhiro Nagaike , Youko Hirakawa , Saiko Hosokawa
发明人： Toshiaki Tagawa , Tsutomu Suzuki , Nobuhisa Yada , Kazuhiro Nagaike , Youko Hirakawa , Saiko Hosokawa
IPC分类号： A61K47/48 , A61K39/395 , A61K9/14
CPC分类号： A61K47/6913 , A61K47/6849 , A61K47/6853
摘要： A ligand-bonded complex which does not react with a free target such as a soluble tumor antigen, but enables substantially specific reaction with a non-free target such as a tumor cell and a tumor antigen existing in the cell.
摘要翻译：与游离靶（例如可溶性肿瘤抗原）不反应但与细胞中存在的非游离靶例如肿瘤细胞和肿瘤抗原基本上特异性反应的配体键合复合物。

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