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1. 发明申请

US20120088765A1 PURINE DERIVATIVE AND ANTITUMOR AGENT USING SAME 有权
标题翻译：嘌呤衍生物和抗肿瘤剂
公开(公告)号：US20120088765A1
公开(公告)日：2012-04-12
申请号：US13266681
申请日：2010-04-28
申请人： Toshiaki Suzuki , Hideki Satoh , Toshiyuki Matsuno , Kenichi Saitoh , Soichi Ohta , Manami Masuda , Shinichi Yaguchi , Ichiro Koshimizu , Yuriko Watanabe , Yoshie Minowa , Masayuki Takahashi , Tomoyoshi Kayou
发明人： Toshiaki Suzuki , Hideki Satoh , Toshiyuki Matsuno , Kenichi Saitoh , Soichi Ohta , Manami Masuda , Shinichi Yaguchi , Ichiro Koshimizu , Yuriko Watanabe , Yoshie Minowa , Masayuki Takahashi , Tomoyoshi Kayou
IPC分类号： A61K31/5377 , A61P35/00 , C07D473/24 , C07D413/14 , A61K31/52
CPC分类号： A61K31/52 , A61K31/5377 , C07D473/24
摘要： Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed is a compound represented by formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, or a prodrug thereof.
摘要翻译：公开了一种新型嘌呤衍生物，其组合物，使用嘌呤衍生物治疗肿瘤的方法，以及使用嘌呤衍生物的抗肿瘤剂。具体公开的是由式（I）表示的化合物或其药学上可接受的盐，溶剂合物或水合物或其前药。

2. 发明授权

US09132130B2 Purine derivative and antitumor agent using same 有权
标题翻译：嘌呤衍生物和抗肿瘤剂
公开(公告)号：US09132130B2
公开(公告)日：2015-09-15
申请号：US13266681
申请日：2010-04-28
申请人： Toshiaki Suzuki , Hideki Satoh , Toshiyuki Matsuno , Kenichi Saitoh , Soichi Ohta , Manami Masuda , Shinichi Yaguchi , Ichiro Koshimizu , Yuriko Watanabe , Yoshie Minowa , Masayuki Takahashi , Tomoyoshi Kayou
发明人： Toshiaki Suzuki , Hideki Satoh , Toshiyuki Matsuno , Kenichi Saitoh , Soichi Ohta , Manami Masuda , Shinichi Yaguchi , Ichiro Koshimizu , Yuriko Watanabe , Yoshie Minowa , Masayuki Takahashi , Tomoyoshi Kayou
IPC分类号： A61K31/52 , C07D473/36 , C07D487/12 , C07D473/24 , A61K31/5377
CPC分类号： A61K31/52 , A61K31/5377 , C07D473/24
摘要： Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed is a compound represented by formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, or a prodrug thereof.
摘要翻译：公开了一种新型嘌呤衍生物，其组合物，使用嘌呤衍生物治疗肿瘤的方法，以及使用嘌呤衍生物的抗肿瘤剂。具体公开的是由式（I）表示的化合物或其药学上可接受的盐，溶剂合物或水合物或其前药。

3. 发明申请

US20110230472A1 RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY 审中-公开
标题翻译：具有PI3K抑制活性的环状亚型衍生物
公开(公告)号：US20110230472A1
公开(公告)日：2011-09-22
申请号：US13061328
申请日：2009-08-25
申请人： Yasunori Mitsuoka , Manami Masuda , Daisuke Taniyama
发明人： Yasunori Mitsuoka , Manami Masuda , Daisuke Taniyama
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/53 , A61K31/501 , A61K31/4965 , A61K31/506 , A61K31/437 , A61K31/4725 , A61P29/00 , C07D513/04 , C07D487/04
CPC分类号： C07D487/04 , C07D513/04 , C07D519/00
摘要： It is an object of the present invention to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused azole compound shown in the present specification, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明的目的是提供抑制PI3K活性以调节包括细胞的生长，分化，存活，增殖，迁移，代谢等许多生物学过程的活性的化合物或其药学上可接受的盐，并且是因此可用于预防/治疗包括炎性疾病，动脉硬化，血管/循环系统疾病，癌症/肿瘤，免疫系统疾病，细胞增殖性疾病，感染性疾病等疾病。通过提供本说明书中所示的环稠唑唑化合物或其药学上可接受的盐来解决上述问题。

4. 发明授权

US06783480B2 Control device for automatic transmission 有权
标题翻译：自动变速箱控制装置
公开(公告)号：US06783480B2
公开(公告)日：2004-08-31
申请号：US10183604
申请日：2002-06-28
申请人： Manami Masuda , Shingo Nakano
发明人： Manami Masuda , Shingo Nakano
IPC分类号： F16H5910
CPC分类号： F16H61/22 , F16H59/0204 , F16H59/10 , Y10T477/647 , Y10T477/656
摘要： An automatic transmission control device having a specific shift lock system for prohibiting a selective operation of a select lever rotataby supported on a first rotary shaft which is supported on a housing and extended in a widthwise direction of a vehicle body. The shift lock system has a lock pin extending substantially in parallel with the first rotary shaft, a second rotary shaft supported on the housing and extended substantially in parallel with the first rotary shaft, and a lock member having a lock part. The lock pin is movable in a lengthwise direction of the vehicle body with response to a rotation of the select lever. The lock member is supported on the second rotary shaft so as to rotate around the second rotary shaft to have one of a lock position and an unlock position. In the lock position, the lock member restricts the selective operation of the select lever by bringing the lock part into contact with a periphery of the lock pin.
摘要翻译：一种自动变速器控制装置，具有特定的变速锁定系统，用于禁止选择杆旋转体的选择性操作，所述选择杆旋转体被支撑在支撑在壳体上并在车身的宽度方向上延伸的第一旋转轴上。换挡锁定系统具有大致平行于第一旋转轴延伸的锁销，支撑在壳体上并基本与第一旋转轴平行延伸的第二旋转轴以及具有锁定部的锁定构件。响应于选择杆的旋转，锁定销可在车体的长度方向上移动。锁定构件被支撑在第二旋转轴上，以围绕第二旋转轴旋转以具有锁定位置和解锁位置中的一个。在锁定位置，锁定构件通过使锁定部件与锁定销的周边接触来限制选择杆的选择性操作。

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