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1. 发明申请

US20050065140A1 Serotonine reuptake inhibitor 审中-公开
标题翻译： 5-羟色胺再摄取抑制剂
公开(公告)号：US20050065140A1
公开(公告)日：2005-03-24
申请号：US10498482
申请日：2002-12-12
申请人： Toru Kodo , Hideki Yagi , Akihito Dan , Shuji Masumoto , Naoya Kinomura , Koji Koyama
发明人： Toru Kodo , Hideki Yagi , Akihito Dan , Shuji Masumoto , Naoya Kinomura , Koji Koyama
IPC分类号： A61K31/445 , A61K31/4545 , A61K31/4709 , A61K31/5355 , A61P1/00 , A61P3/04 , A61P5/00 , A61P9/12 , A61P15/00 , A61P25/06 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P43/00 , C07D211/18 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/34 , C07D401/06 , C07D413/06 , C07D417/06 , A61K31/454 , A61K31/40 , A61K31/4025
CPC分类号： C07D401/06 , A61K31/445 , A61K31/4545 , A61K31/4709 , A61K31/5355 , C07D211/18 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/34 , C07D413/06 , C07D417/06
摘要： There is provided a selective serotonin reuptake inhibitor having affinity for serotonin 1A receptors which comprises a cyclic amine represented by the formula: wherein G represents a formula (2): a prodrug of said cyclic amine, or a pharmaceutically acceptable salt of said cyclic amine or prodrug, as an active ingredient.
摘要翻译：提供了对5-羟色胺1A受体具有亲和力的选择性5-羟色胺再摄取抑制剂，其包含由下式表示的环胺：其中G表示式（2）：所述环胺的前药或所述环胺的药学上可接受的盐或前药，作为活性成分。

2. 发明授权

US06787560B2 Serotonin reuptake inhibitor 失效
标题翻译： 5-羟色胺再摄取抑制剂
公开(公告)号：US06787560B2
公开(公告)日：2004-09-07
申请号：US10346062
申请日：2003-01-17
申请人： Toru Kodo , Shuji Masumoto , Koji Koyama , Naoya Kinomura
发明人： Toru Kodo , Shuji Masumoto , Koji Koyama , Naoya Kinomura
IPC分类号： A61K31445
CPC分类号： C07D401/06 , C07D211/18 , C07D211/22 , C07D401/10 , C07D405/06
摘要： A serotonin reuptake inhibitor containing a cyclic amine represented by the following formula, a prodrug thereof, or a pharmaceutically acceptable salt of said cyclic amine or prodrug as an active ingredient: wherein R0 is a hydrogen atom, a halogen atom, an alkyl group, a substituted alkyl group, a hydroxyl group, an alkoxy group or the like, R3 is a hydrogen atom or the like, Y is an alkylene group or the like, Z is a hydrogen atom, a cycloalkyl group, an aryl group or the like, n is 1, 2 or 3, and m is 2, 3, 4, 5 or 6.
摘要翻译：含有由下式表示的环状胺的5-羟色胺再摄取抑制剂，其前药或所述环状胺或前药的药学上可接受的盐作为活性成分：其中R 0为氢原子，卤素原子，烷基基团，取代烷基，羟基，烷氧基等，R 3为氢原子等，Y为亚烷基等，Z为氢原子，环烷基，芳基等，n为1,2或3，m为2,3,4,5或6。

3. 发明申请

US20070191447A1 Novel heterocyclic compound 审中-公开
标题翻译：新型杂环化合物
公开(公告)号：US20070191447A1
公开(公告)日：2007-08-16
申请号：US10590157
申请日：2005-02-18
申请人： Toru Kodo , Takayuki Fukaya , Koji Koyama , Shuji Masumoto , Nao Fujibayashi
发明人： Toru Kodo , Takayuki Fukaya , Koji Koyama , Shuji Masumoto , Nao Fujibayashi
IPC分类号： A01N43/52 , C07D209/32 , C07D235/24
CPC分类号： C07D413/04 , A61K31/40 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4745 , A61K31/536 , A61K31/551 , C07D235/26 , C07D263/58 , C07D277/68 , C07D401/04 , C07D401/12 , C07D471/06 , C07D487/06 , C07D491/06
摘要： A drug having a high affinity for benzodiazepine ω3 receptors and showing curative and preventive effects for anxiety and depression, which comprises as the active ingredient, for example, a compound of the formula (1): wherein R1 and R2 are independently a hydrogen atom, an optionally substituted alkyl group, an optionally substituted aryl group, etc., R3 and R4 are independently a hydrogen atom, an optionally substituted alkyl group, etc., R5, R6, R7 and R8 are independently a hydrogen atom, an optionally substituted alkyl group, an optionally substituted aryl group, etc., X is an oxygen atom, a sulfur atom, NR10, etc. (in which R10 is a hydrogen atom, an optionally substituted alkyl group, etc.)
摘要翻译：一种对苯并二氮ω3 N受体具有高亲和力并对焦虑和抑郁有疗效和预防作用的药物，其包括作为活性成分的例如式（1）的化合物：其中R R 1和R 2各自独立地为氢原子，任选取代的烷基，任选取代的芳基等，R 3和R R 4独立地是氢原子，任选取代的烷基等，R 5，R 6，R 7， O 2和R 8独立地是氢原子，任选取代的烷基，任选取代的芳基等，X是氧原子，硫原子，NR 10， SUP>等（其中R 10是氢原子，任选取代的烷基等）

4. 发明申请

US20120095256A1 PROCESS FOR PRODUCING THREO-3-(3,4-DIHYDROXYPHENYL)-L-SERINE 有权
标题翻译：生产3-（3,4-二羟基苯基）-L-丝氨酸的方法
公开(公告)号：US20120095256A1
公开(公告)日：2012-04-19
申请号：US13380205
申请日：2010-06-29
申请人： Toshikazu Yagi , Koji Koyama , Masanori Itoh
发明人： Toshikazu Yagi , Koji Koyama , Masanori Itoh
IPC分类号： C07C227/18 , C07C229/36 , C07C227/40
CPC分类号： C07D209/48 , C07C227/18 , C07C227/30 , C07C229/36
摘要： The present invention provides a process for producing Droxidopa or a pharmaceutically acceptable salt thereof comprising a step of reacting threo-N-phthaloyl-3-(3,4-dihydroxyphenyl)-L-serine represented by the formula (1) with methylamine, whereby a process for producing threo-3-(3,4-dihydroxyphenyl)-L-serine (common name: Droxidopa), which is useful as an agent for treatment of peripheral orthostatic hypotension or an agent for treatment of Parkinson's disease, with high production efficiency and without requiring troublesome operations.
摘要翻译：本发明提供了一种制备Droxidopa或其药学上可接受的盐的方法，其包括使由式（1）表示的N-邻苯二甲酰基-3-（3,4-二羟基苯基）-L-丝氨酸与甲胺反应的步骤，由此制备可用作治疗周围直立性低血压药物或治疗帕金森病药物的3-（3,4-二羟基苯基）-L-丝氨酸（通用名：Droxidopa）的方法，产量高效率并且不需要麻烦的操作。

5. 发明申请

US20120013045A1 MATTE LAMINATE FILM 审中-公开
标题翻译： MATTE层压膜
公开(公告)号：US20120013045A1
公开(公告)日：2012-01-19
申请号：US13240974
申请日：2011-09-22
申请人： Norio SUGIMURA , Koji Koyama , Shinsuke Ochiai
发明人： Norio SUGIMURA , Koji Koyama , Shinsuke Ochiai
IPC分类号： B29C59/16 , B29C59/00
CPC分类号： B32B27/365 , B32B27/08 , B32B27/18 , B32B27/20 , B32B27/302 , B32B27/308 , B32B2250/24 , B32B2255/10 , B32B2255/26 , B32B2264/0207 , B32B2264/025 , B32B2307/408 , B32B2307/412 , B32B2307/50 , B32B2307/712 , B32B2307/714 , B32B2307/75 , B32B2451/00 , B32B2509/00 , B32B2605/00 , Y10T428/24802 , Y10T428/2495 , Y10T428/265 , Y10T428/31507
摘要： A matte laminate film comprising a transparent resin film substrate and a matte layer formed on at least one surface of the transparent resin film substrate, in which the transparent resin film substrate is a laminate film comprising a layer (A) formed of a polycarbonate resin and a layer (B) formed of a methacrylic resin which is laminated on at least one surface of the layer (A). The matte laminate film is preferably used as a decorative film having good resistance to whitening and high mechanical properties and surface hardness.
摘要翻译：一种无光泽层压膜，其包括透明树脂膜基材和形成在所述透明树脂膜基材的至少一个表面上的无光泽层，其中所述透明树脂膜基材为包含由聚碳酸酯树脂形成的层（A）和由层压在层（A）的至少一个表面上的甲基丙烯酸树脂形成的层（B）。无光泽层压膜优选用作具有良好的抗白化和高机械性能和表面硬度的装饰膜。

6. 发明申请

US20080199675A1 LAMINATE FILM 审中-公开
标题翻译：层压膜
公开(公告)号：US20080199675A1
公开(公告)日：2008-08-21
申请号：US12021360
申请日：2008-01-29
申请人： Koji Koyama , Tomohiro Maekawa , Shinsuke Ochiai
发明人： Koji Koyama , Tomohiro Maekawa , Shinsuke Ochiai
IPC分类号： B32B27/00
CPC分类号： B32B25/00 , B32B27/08
摘要： A laminate film having a base layer which contains a thermoplastic resin, and a surface layer which is laminated on at least one surface of the base layer and contains a polycarbonate resin, in which a total thickness of the laminate film is from 20 to 500 μm and a thickness of the base layer constitutes at least 50% of the total thickness of the laminate film.
摘要翻译：具有含有热塑性树脂的基层的层压膜和层叠在基材层的至少一个表面上并含有聚碳酸酯树脂的表层，其中层压膜的总厚度为20〜500μm 并且基底层的厚度构成层压膜的总厚度的至少50％。

7. 发明授权

US06844053B2 Acrylic resin film and injection molded article using the same 失效
标题翻译：丙烯酸树脂膜和使用其的注射成型制品
公开(公告)号：US06844053B2
公开(公告)日：2005-01-18
申请号：US10315104
申请日：2002-12-10
申请人： Koji Koyama , Kazuhiro Yokoo
发明人： Koji Koyama , Kazuhiro Yokoo
IPC分类号： C08J5/18 , B29C45/14 , B29L9/00 , B32B27/08 , B32B27/30 , C08L23/08 , C08L33/10 , C08L33/12
CPC分类号： B32B27/30 , B32B27/08 , C08L23/0815 , C08L2205/02 , Y10T428/254 , Y10T428/26 , Y10T428/31917 , Y10T428/31928 , Y10T428/31931 , Y10T428/31935 , C08L2666/04
摘要： An acrylic resin film, a laminate film comprising the acrylic resin film and a thermoplastic resin layer placed on one surface of the acrylic resin film, and an injection molded article using the acrylic resin film are provided. The acrylic resin film laminate film have little white turbidity even if being heated in molding and maintains excellent design properties, and the injection molded article having the acrylic resin film on its surface is excellent in design properties such as color depth.
摘要翻译：提供丙烯酸树脂膜，包含丙烯酸树脂膜和位于丙烯酸树脂膜的一个表面上的热塑性树脂层的层压膜和使用丙烯酸树脂膜的注塑制品。丙烯酸树脂膜层叠膜即使在成型时被加热也具有很小的白浊度，并且保持优异的设计性能，并且其表面上具有丙烯酸树脂膜的注射成型制品具有优异的设计性质如颜色深度。

8. 发明授权

US09498912B2 Extruded resin film and method for producing the same 有权
标题翻译：挤出树脂膜及其制造方法
公开(公告)号：US09498912B2
公开(公告)日：2016-11-22
申请号：US12323166
申请日：2008-11-25
申请人： Tomohiro Maekawa , Koji Koyama
发明人： Tomohiro Maekawa , Koji Koyama
IPC分类号： B32B27/00 , B29C47/00 , B29C47/88 , B32B27/08 , B32B27/30 , B32B27/36 , B32B27/32
CPC分类号： B29C47/8845 , B29C47/0021 , B29C47/886 , B32B27/08 , B32B27/302 , B32B27/308 , B32B27/325 , B32B27/365 , B32B2250/00 , B32B2250/24 , B32B2270/00 , B32B2274/00 , B32B2307/40 , B32B2307/734 , B32B2457/00 , B32B2509/00 , B32B2605/00 , B32B2605/003 , B32B2605/08
摘要： An object of the present invention is to provide an extruded resin film which thermally shrinks little and a method for producing the same. The present invention provides an extruded resin film, formed by an extrusion forming method, made of a thermoplastic resin, having a thickness of from 0.03 to 0.5 mm, wherein the extruded resin film has a shrinkage ratio in the extrusion direction, S1 (%), which satisfies the following formula (1) and has a shrinkage ratio in the cross-extrusion direction, S2 (%), of from 0 to 5% when being left at rest for 0.5 hours under a hot atmosphere at the temperature of 20° C. above heat distortion temperature (Th) of the thermoplastic resin: 0.1/X≦S1≦1.7/X (1) wherein X is thickness of the extruded resin film (mm).

9. 发明授权

US07614610B2 Hoisting and pulling device 有权
标题翻译：起重牵引装置
公开(公告)号：US07614610B2
公开(公告)日：2009-11-10
申请号：US11920539
申请日：2006-06-05
申请人： Desheng Xia , Koji Koyama
发明人： Desheng Xia , Koji Koyama
IPC分类号： B66D1/30
CPC分类号： B66D3/16
摘要： A hoisting and pulling device including a main body frame 2 for forming a load sheave containing space by constituting an inner face by a guide face 25a for guiding a load chain 5 wound around a load sheave, a bearing plate 21b fixedly provided to an inner side of the main body frame 2 for bearing the load sheave and a speed reducing gear on a side of speed reducing means, and a bearing plate 21a for bearing the load sheave 11 on a side of driving means for partitioning the load sheave containing space, the driving means, and the speed reducing means by the bearing plates.According to a hoist of a background art, portability and operability and durability are not compatible with each other and the hoist is not provided with a function of preventing dust of a mechanical brake. Further, a problem is posed also in the operability of the hand chain.
摘要翻译：一种提升牵引装置，包括：主体框架2，用于通过用于引导缠绕在负载滑轮上的负载链5的引导面25a构成内表面来形成负载滑轮容纳空间;固定地设置在内侧的支承板21b 用于承载负载滑轮的主体框架2和减速装置一侧的减速齿轮;以及用于在用于分隔负载滑轮容纳空间的驱动装置的一侧承载负载滑轮11的支承板21a，驱动装置和减速装置。根据背景技术的起重机，便携性和可操作性和耐久性彼此不兼容，并且提升器不具有防止机械制动器的灰尘的功能。此外，在手链的可操作性方面也存在问题。

10. 发明申请

US20080173851A1 Overload Preventing Apparatus in Hoist 有权
标题翻译：起重机过载防护装置
公开(公告)号：US20080173851A1
公开(公告)日：2008-07-24
申请号：US11886313
申请日：2006-03-02
申请人： Desheng Xia , Koji Koyama
发明人： Desheng Xia , Koji Koyama
IPC分类号： B66D3/16 , B66D1/58
CPC分类号： B66D1/58 , B66D3/16 , B66D3/26
摘要： An overload preventing apparatus of a hoist characterized in including a drive shaft 2 for driving a load sheave 1, a pressure receiving member 4 outwardly fitted to the drive shaft 2, a drive member 10 for transmitting a drive force from operating means 14 to the drive shaft 2 by way of the pressure receiving member 4, a rotation drive member 12 including means of transmitting the drive force from the operating means 14 to the drive member 10 and releasing an engagement with the drive portion 10 when the operating means 14 is applied with a torque equal to or larger than a predetermined torque value and an elastic member 13 mounted along an axial direction of the drive member between a back face of the rotation drive member 12 and an inner side end face of the operating means 14 to pose a problem that a belleville spring is obliged to be used as urging means, and therefore, a stroke in the axial direction of the urging means is small, also a height of an engaging claw becomes small in accordance with the stroke of the belleville spring and a variation in a load relative to a height of the claw becomes large.
摘要翻译：一种起重机的过载防止装置，其特征在于包括用于驱动负载滑轮1的驱动轴2，向外装配到驱动轴2的压力接收构件4，用于将来自操作装置14的驱动力传递到驱动装置的驱动构件10 轴2通过压力接收构件4;旋转驱动构件12，包括将操作装置14的驱动力传递到驱动构件10的装置，并且当操作装置14被施加时释放与驱动部分10的接合扭矩等于或大于预定扭矩值的扭矩和沿着驱动构件的轴向方向安装在旋转驱动构件12的背面和操作装置14的内侧端面之间的问题的弹性构件13，以产生问题必须将贝氏弹簧用作推动装置，因此，推动装置的轴向行程小，接合爪的高度变小根据贝尔维尔弹簧的行程，并且相对于爪的高度的负载的变化变大。

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