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1. 发明申请

US20150133552A1 POLYHYDROXYLATED PENTACYCLIC TRITERPENE ACIDS AS HMG-COA REDUCTASE INHIBITORS 审中-公开
标题翻译：作为HMG-COA还原酶抑制剂的聚羟基化的PENTACYCLIC TRITERPENE
公开(公告)号：US20150133552A1
公开(公告)日：2015-05-14
申请号：US14401699
申请日：2013-05-07
申请人： Torsten Grothe , Joachim HANS
发明人： Joachim Hans , Kathrin Reinhardt , Torsten Grothe , Ingo Wöhrle , Jana Moldenhauer , Bärbel Köpcke , Thomas Küper , Jens Bitzer
IPC分类号： C07C62/32 , A61K45/06 , A61K31/191
CPC分类号： C07C62/32 , A21D2/165 , A21D2/36 , A21D8/047 , A23C9/1315 , A23C9/1322 , A23C9/133 , A23C9/156 , A23C9/1565 , A23C11/02 , A23C15/16 , A23C2260/152 , A23D7/0056 , A23G9/32 , A23L2/39 , A23L2/40 , A23L2/52 , A23L7/126 , A23L27/10 , A23L27/60 , A23L33/105 , A61K9/0007 , A61K9/0095 , A61K9/2018 , A61K9/2027 , A61K9/485 , A61K9/4866 , A61K9/4891 , A61K31/01 , A61K31/015 , A61K31/191 , A61K31/192 , A61K31/352 , A61K31/7048 , A61K36/73 , A61K45/06 , A61K47/26 , A61K47/46 , A61K2300/00
摘要： The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.
摘要翻译：本发明涉及用于预防和/或治疗治疗对HMG-CoA还原酶活性降低的疾病，病症或病症的式（I）的某些多羟基化五环三萜酸，其用作HMG-CoA还原酶抑制剂在哺乳动物中，优选人。本发明进一步涉及某些混合物和植物提取物，其中含有苹果酸和折酮酸，其中欧托卡酸与折羟酸的量超过一定比例。此外，本发明还涉及包含一种或多种所述式（I）化合物，根据本发明的组合物或根据本发明的植物提取物的制剂，优选药物或营养制剂。此外，本发明涉及一种获得式（I）的某些多羟基化五环三萜酸，根据本发明的组合物或根据本发明的植物提取物的方法。

2. 发明授权

US10047034B2 Polyhydroxylated pentacyclic triterpene acids as HMG-COA reductase inhibitors 有权
公开(公告)号：US10047034B2
公开(公告)日：2018-08-14
申请号：US14401699
申请日：2013-05-07
申请人： Joachim Hans , Torsten Grothe
发明人： Joachim Hans , Kathrin Reinhardt , Torsten Grothe , Ingo Wöhrle , Jana Moldenhauer , Bärbel Köpcke , Thomas Küper , Jens Bitzer
IPC分类号： A01N37/00 , A61K31/19 , C07C62/32 , A61K45/06 , A61K31/01 , A61K31/015 , A61K31/191 , A61K31/192 , A61K31/352 , A61K31/7048 , A61K36/73 , A61K9/46 , A61K47/26 , A61K47/46 , A61K9/20 , A61K9/48 , A23C9/13 , A23C9/133 , A23C9/156 , A23C11/02 , A23C15/16 , A23L2/39 , A23L2/40 , A23L2/52 , A23G9/32 , A21D2/16 , A21D2/36 , A21D8/04 , A23D7/005 , A23L7/126 , A23L27/10 , A23L27/60 , A23L33/105 , A61K9/00
摘要： The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.

3. 发明申请

US20130338219A1 Terpenoid Spiro Ketal Compounds with LXR Agonists Activity, Their Use and Formulations with Them 有权
标题翻译：萜类螺旋酮化合物与LXR激动剂的活性，它们的用途和配方
公开(公告)号：US20130338219A1
公开(公告)日：2013-12-19
申请号：US13994447
申请日：2011-12-08
申请人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
发明人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
IPC分类号： C07D471/10
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.
摘要翻译：本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

4. 发明授权

US09453016B2 Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them 有权
标题翻译：具有LXR激动剂活性的萜类螺旋酮缩酮化合物，它们的用途和配方
公开(公告)号：US09453016B2
公开(公告)日：2016-09-27
申请号：US13994447
申请日：2011-12-08
申请人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
发明人： Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
IPC分类号： A61K31/35 , C07D493/00 , C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.
摘要翻译：本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

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