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1. 发明授权

US08822694B2 Process for producing pyrrole compound 有权
标题翻译：制备吡咯化合物的方法
公开(公告)号：US08822694B2
公开(公告)日：2014-09-02
申请号：US13203441
申请日：2010-02-24
申请人： Tomomi Ikemoto , Misayo Sera , Naohiro Fukuda
发明人： Tomomi Ikemoto , Misayo Sera , Naohiro Fukuda
IPC分类号： C07D401/12
CPC分类号： C07D207/337 , C07D207/30 , C07D207/333 , C07D207/34 , C07D207/36 , C07D207/48 , C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
摘要翻译：本发明提供了可用作药物的磺酰基吡咯化合物的制备方法，用于该方法的中间体的制备方法和新的中间体。本发明涉及一种制备磺酰基吡咯化合物（Ⅷ）的方法，其包括还原化合物（III）并水解还原产物得到化合物（Ⅳ），使化合物（Ⅳ）进行磺酰化反应得到化合物（Ⅵ），并使化合物（VI）进行胺化反应。

2. 发明申请

US20110306769A1 PROCESS FOR PRODUCING PYRROLE COMPOUND 有权
标题翻译：生产吡咯化合物的方法
公开(公告)号：US20110306769A1
公开(公告)日：2011-12-15
申请号：US13203441
申请日：2010-02-24
申请人： Tomomi Ikemoto , Hideya Mizufune , Toshiaki Nagata , Misayo Sera , Naohiro Fukuda , Takeshi Yamasaki
发明人： Tomomi Ikemoto , Hideya Mizufune , Toshiaki Nagata , Misayo Sera , Naohiro Fukuda , Takeshi Yamasaki
IPC分类号： C07D401/12 , C07D207/36
CPC分类号： C07D207/337 , C07D207/30 , C07D207/333 , C07D207/34 , C07D207/36 , C07D207/48 , C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
摘要翻译：本发明提供了可用作药物的磺酰基吡咯化合物的制备方法，用于该方法的中间体的制备方法和新的中间体。本发明涉及一种制备磺酰基吡咯化合物（Ⅷ）的方法，其包括还原化合物（III）并水解还原产物得到化合物（Ⅳ），使化合物（Ⅳ）进行磺酰化反应得到化合物（Ⅵ），并使化合物（VI）进行胺化反应。

3. 发明申请

US20090054655A1 Process for the Production of Organic Oxides 审中-公开
标题翻译：有机氧化物生产工艺
公开(公告)号：US20090054655A1
公开(公告)日：2009-02-26
申请号：US12295779
申请日：2007-04-05
申请人： Tomomi Ikemoto , Naohiro Fukuda
发明人： Tomomi Ikemoto , Naohiro Fukuda
IPC分类号： C07C317/14 , C07C317/04 , C07D277/26 , C07D333/48 , C07D213/24 , C07D213/26 , C07D213/34
CPC分类号： C07C315/02 , C07D213/70 , C07D213/71 , C07D213/84 , C07D277/76 , C07D333/48
摘要： The present invention provides a method for producing an organic oxide, wherein a substrate is oxidized using hypohalous acid, hypohalous acid salt, chlorine, bromine or iodine in the presence of water and a catalytic amount of a compound represented by the following formula (I): R1—X1—NY—R2, wherein: X1 represents —CO— or —SO2—; Y represents a hydrogen atom, a potassium atom, a sodium atom, a chlorine atom, a bromine atom or an iodine atom; R1 represents a substituted or unsubstituted hydrocarbon group, —NYR3 group or —OR3 group (in the formulae, R3 represents a substituted or unsubstituted hydrocarbon group, and Y represents the same meaning as defined above); and R2 represents a hydrogen atom or —CO—R4 group (in the formula, R4 represents a substituted or unsubstituted hydrocarbon group, —NYR5 group or —OR5 group (in the formulae, R5 represents a substituted or unsubstituted hydrocarbon group, and Y represents the same meaning as defined above)); or R1 and R4 may bind to each other to form a further substituted or unsubstituted nitrogen-containing heterocyclic ring.
摘要翻译：本发明提供一种有机氧化物的制造方法，其中在水和催化量的下式（I）表示的化合物的存在下，使用次卤酸，次卤酸，氯，溴或碘氧化底物，：R1-X1-NY-R2，其中：X1表示-CO-或-SO2-; Y表示氢原子，钾原子，钠原子，氯原子，溴原子或碘原子; R 1表示取代或未取代的烃基，-NYR 3基或-OR 3基（式中，R 3表示取代或未取代的烃基，Y表示与上述相同的含义）。 R2表示氢原子或-CO-R4基团（式中，R4表示取代或未取代的烃基，-NYR5基或-OR5基）（式中，R5表示取代或未取代的烃基，Y表示与上述定义相同））; 或者R 1和R 4可以彼此结合形成另外的取代或未取代的含氮杂环。

4. 发明申请

US20080009539A1 Azo Compounds and Process for Production Thereof 失效
标题翻译：偶氮化合物及其制备方法
公开(公告)号：US20080009539A1
公开(公告)日：2008-01-10
申请号：US11661183
申请日：2005-08-25
申请人： Tomomi Ikemoto , Takeshi Yamasaki
发明人： Tomomi Ikemoto , Takeshi Yamasaki
IPC分类号： A61K31/40 , A61K31/34 , A61P25/00 , C07D209/04 , C07D307/00
CPC分类号： C07D307/79 , C07D307/81 , C07D405/04
摘要： A process for the production of an aromatic azo compound having a 2,3-dihydrobenzofuran ring bearing a diazo group at the 5-position of the ring by conducting the diazo coupling of a 2,3-dihydrobenzofuran derivative represented by the general formula (II): [wherein R1 and R2 are each independently C1-6 alkyl; R3 is optionally substituted aryl; and R4, R5 and R6 are each independently hydrogen, C1-6 alkyl, halogeno, C1-6 alkoxy, or C1-6 alkylthio] with a benzenediazonium salt having an electron-withdrawing group at the p- and/or o-position in a mixed solvent composed of water and a polar organic solvent.
摘要翻译：通过进行由通式（II）表示的2,3-二氢苯并呋喃衍生物的重氮偶联，制备具有环的5-位上具有重氮基的2,3-二氢苯并呋喃环的芳族偶氮化合物的方法）：[其中R 1和R 2各自独立地为C 1-6烷基; R 3是任选取代的芳基; 和R 4，R 5和R 6各自独立地为氢，C 1-6烷基，卤代， C 1-6烷氧基或C 1-6烷基硫基]与在混合的p-和/或o位上具有吸电子基团的苯二氮鎓盐溶剂由水和极性有机溶剂组成。

5. 发明授权

US06566535B1 Processes for the preparation of 2,3-dihydrothiepine derivatives 失效
标题翻译： 2,3-二氢硫嘌呤衍生物的制备方法
公开(公告)号：US06566535B1
公开(公告)日：2003-05-20
申请号：US10019987
申请日：2001-11-07
申请人： Tatsuya Ito , Tomomi Ikemoto , Kiminori Tomimatsu
发明人： Tatsuya Ito , Tomomi Ikemoto , Kiminori Tomimatsu
IPC分类号： C07D33712
CPC分类号： C07D337/08 , C07D337/04
摘要： A process for preparing a compound represented by the following formula: wherein each symbol is as defined below, or a salt thereof, characterized by subjecting a compound represented by the following formula: wherein R1 is an electron-attracting group; R2, R3, R4, R5, R6 and R7 are each a hydrogen atom, a halogen atom, an optionally substituted amino group, an optionally substituted hydroxyl group, an optionally substituted thiol group, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group, provided that R6 and R7 may be united to form a ring; and R8 is a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof, to a ring-closing reaction.
摘要翻译：一种制备由下式表示的化合物的方法：其中每个符号如下所定义，或其盐，其特征在于使下式表示的化合物：其中R1是吸电子基团; R2，R3，R4，R5，R6和R7各自为氢原子，卤素原子，任选取代的氨基，任选取代的羟基，任选取代的硫醇基，任选取代的烃基或任选取代的杂环组合，条件是R 6和R 7可以结合形成环; 并且R8是氢原子或任选取代的烃基或其盐进行闭环反应。

6. 发明授权

US5623069A Method for producing 5'-nucleotide 失效
标题翻译：生产5'-核苷酸的方法
公开(公告)号：US5623069A
公开(公告)日：1997-04-22
申请号：US437984
申请日：1995-05-10
申请人： Akira Haze , Hiroyuki Hatano , Tomomi Ikemoto , Yoshifumi Kitamoto
发明人： Akira Haze , Hiroyuki Hatano , Tomomi Ikemoto , Yoshifumi Kitamoto
IPC分类号： C07D20060101 , C07H1/02 , C07H19/04 , C07H19/10 , C07H19/20 , C07H19/207 , C07H1/00 , C07H19/06 , C07H19/16
CPC分类号： C07H19/04
摘要： A method of producing 5'-nucleotide, which comprises maintaining a nucleoside suspension in an organic solvent at a temperature not lower than about 20.degree. C., and then subjecting the resultant suspension to a phosphorylatipon of the nucleoside(s).According to the present invention, 5'-nucleotide can be produced from a nucleoside at high purity and high yield in a shortened reaction time, and impurity removal in the nucleotide purification process is easily accomplished.
摘要翻译：一种生产5'-核苷酸的方法，其包括在不低于约20℃的温度下将核苷悬浮液保持在有机溶剂中，然后使所得悬浮液经受核苷的磷酸化。根据本发明，在缩短的反应时间内可以以高纯度和高产率从核苷生产5'-核苷酸，并且容易实现核苷酸纯化过程中的杂质去除。

7. 发明授权

US07521545B2 Azo compounds and process for production thereof 失效
标题翻译：偶氮化合物及其制备方法
公开(公告)号：US07521545B2
公开(公告)日：2009-04-21
申请号：US11661183
申请日：2005-08-25
申请人： Tomomi Ikemoto , Takeshi Yamasaki
发明人： Tomomi Ikemoto , Takeshi Yamasaki
IPC分类号： C07D307/79 , C07D405/04
CPC分类号： C07D307/79 , C07D307/81 , C07D405/04
摘要： A process for the production of an aromatic azo compound having a 2,3-dihydrobenzofuran ring bearing a diazo group at the 5-position of the ring by conducting the diazo coupling of a 2,3-dihydrobenzofuran derivative represented by the general formula (II): [wherein R1 and R2 are each independently C1-6 alkyl; R3 is optionally substituted aryl; and R4, R5 and R6 are each independently hydrogen, C1-6 alkyl, halogeno, C1-6 alkoxy, or C1-6 alkylthio] with a benzenediazonium salt having an electron-withdrawing group at the p- and/or o-position in a mixed solvent composed of water and a polar organic solvent.
摘要翻译：通过进行由通式（II）表示的2,3-二氢苯并呋喃衍生物的重氮偶联，制备具有环的5-位上具有重氮基的2,3-二氢苯并呋喃环的芳族偶氮化合物的方法）：[其中R 1和R 2各自独立地为C 1-6烷基; R3是任选取代的芳基; 和R 4，R 5和R 6各自独立地为氢，C 1-6烷基，卤代，C 1-6烷氧基或C 1-6烷硫基]，其中在苯二氮基和/或位置上具有吸电子基团的苯二氮鎓盐由水和极性有机溶剂组成的混合溶剂。

8. 发明申请

US20070099986A1 Preventives/remedies for urinary disturbance 审中-公开
标题翻译：预防/治疗尿路障碍
公开(公告)号：US20070099986A1
公开(公告)日：2007-05-03
申请号：US11589903
申请日：2006-10-31
申请人： Yuji Ishichi , Koichi Iwanaga , Tomomi Ikemoto , Hiroaki Yamamoto , Shokyo Miki
发明人： Yuji Ishichi , Koichi Iwanaga , Tomomi Ikemoto , Hiroaki Yamamoto , Shokyo Miki
IPC分类号： A61K31/343 , A61K31/36 , C07D319/14 , A61K31/18 , C07C311/18
CPC分类号： C07C311/37 , C07C45/46 , C07C49/813 , C07C2602/08 , C07D307/79 , C07D319/18 , C07D405/04
摘要： A compound represented by the formula: wherein Ar represents a group represented by the formula: (wherein Y represents methylene or an oxygen atom, R1 represents aminosulfonyl, C1-6 alkylaminosulfonyl, C1-6 alkylcarbonylamino or C1-6 alkylsulfonylamino, R2 represents a hydrogen atom or C1-6 alkyl, R3 represents C1-6 alkyl, and R4 represents a hydrogen atom or C1-6 alkyl); X represents a carbonyl group, or a methylene group which may be substituted with a hydroxy group; and L represents an optionally substituted C4-5 alkylene group, or a salt thereof is provided.
摘要翻译：由下式表示的化合物：其中Ar表示由下式表示的基团：其中Y表示亚甲基或氧原子，R 1表示氨基磺酰基，C 1-6烷基，烷基氨基磺酰基，C 1-6烷基羰基氨基或C 1-6烷基磺酰基氨基，R 2表示氢原子或C 1-6 - / SUB烷基，R 3表示C 1-6烷基，R 4表示氢原子或C 1-6 烷基）; X表示羰基或可被羟基取代的亚甲基; L表示任意取代的C 4〜5亚烷基，或其盐。

9. 发明授权

US07038042B2 Process for producing cyclic compound 失效
标题翻译：环状化合物的制备方法
公开(公告)号：US07038042B2
公开(公告)日：2006-05-02
申请号：US11010215
申请日：2004-12-10
申请人： Tomomi Ikemoto , Tatsuya Ito , Kiminori Tomimatsu
发明人： Tomomi Ikemoto , Tatsuya Ito , Kiminori Tomimatsu
IPC分类号： C07D487/00 , C07C313/00
CPC分类号： C07D225/06 , C07D313/08 , C07D313/20
摘要： A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula: {wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; R3 represents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then —X—CH2-Z is not —X1—X2—CH2, -Z (wherein X1 represents sulfur or optionally substituted nitrogen and X2 represents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof: (wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.
摘要翻译：一种适用于通过短步安全批量生产用于药物，农药，食品，化妆品和化学产品的环状化合物或其中间体的方法。该方法用于制备由下式表示的化合物：其中Z表示吸电子基团; W表示任选取代的乙烯或任选取代的亚乙烯基; R 3表示氢或任选取代的烃基; 并且X表示二价基团[条件是当W表示任选取代的亚乙烯基时，则-X-CH 2 -Z不是-X 1 - 2 - -CH 2 - ，其中X 1表示硫或任选取代的氮，X 2表示任选取代的亚乙基）]} 或其盐的特征在于，在含有碳酸二酯的溶剂中使式（II）表示的化合物或其盐（其中符号具有与上述相同的含义）进行闭环反应。

10. 发明授权

US06982344B2 Process for preparation of optically active sulfonamides and intermediates for their synthesis 有权
标题翻译：制备光学活性磺酰胺及其合成中间体的方法
公开(公告)号：US06982344B2
公开(公告)日：2006-01-03
申请号：US10399165
申请日：2001-10-17
申请人： Tomomi Ikemoto , Atsuko Nishiguchi , Kiminori Tomimatsu
发明人： Tomomi Ikemoto , Atsuko Nishiguchi , Kiminori Tomimatsu
IPC分类号： C07C311/51 , C07C311/14 , C07C311/28 , C07C303/40 , C07B57/00
CPC分类号： C07C311/51 , C07B2200/07 , C07C303/40 , C07C303/44 , C07C311/14 , C07C2601/16
摘要： A method including resolution of a diastereomeric mixture represented by the formula wherein R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, only one of R1 and R2 contains one asymmetric carbon, and Ra is an optically active and optionally substituted hydrocarbon group or an optically active and optionally substituted heterocyclic group, or a salt thereof, to produce the diastereomer having a steric configuration of the asymmetric carbon for R1 or R2 of an R configuration or an S configuration, or a salt thereof.
摘要翻译：一种包括由下式表示的非对映异构体混合物的拆分方法，其中R 1和R 2相同或不同，并且各自为任选取代的烃基或任选取代的杂环基团中，R 1和R 2中只有一个含有一个不对称碳，R a是光学活性和任选取代的烃基或光学活性和任选取代的杂环基或其盐，以产生R构型的R 1或R 2的不对称碳的立体构型的非对映异构体或 S构型或其盐。

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