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1. 发明授权

US08092992B2 Transcriptional regulation of gene expression by small double-stranded modulatory RNA 有权
标题翻译：通过小双链调节RNA的基因表达的转录调控
公开(公告)号：US08092992B2
公开(公告)日：2012-01-10
申请号：US10857784
申请日：2004-05-28
申请人： Tomoko Kuwabara , Fred H. Gage
发明人： Tomoko Kuwabara , Fred H. Gage
IPC分类号： C12Q1/68 , C12N5/00 , C12N5/02 , A61K48/00 , C07H21/04 , C07H21/02
CPC分类号： C12N5/0619 , C12N2501/60 , C12N2799/027
摘要： The invention provides a method for modulating gene expression by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes, wherein the association results in altered expression of the one or more genes. The invention is further directed to method for directing the differentiation of neuronal stem cells into neurons by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes involved in neuronal differentiation and directing the transcription of the one or more genes. In related embodiments, the invention provides particular compositions of double-stranded ribonucleic acid molecules as well as therapeutic and screening applications of the invention.
摘要翻译：本发明提供了一种通过使细胞系统与能够与控制一种或多种基因转录的调节机制缔合的双链核糖核酸分子来调节基因表达的方法，其中所述缔合导致一个或多个基因。本发明还涉及通过使细胞系统与能够与控制一种或多种参与神经元分化的基因转录的调节机制相关联的双链核糖核酸分子的方式来指导神经元干细胞分化为神经元的方法并指导一个或多个基因的转录。在相关实施方案中，本发明提供了双链核糖核酸分子的特定组合物以及本发明的治疗和筛选应用。

2. 发明授权

US08287114B2 Aqueous ink composition and image forming method 有权
标题翻译：水性油墨组合物和成像方法
公开(公告)号：US08287114B2
公开(公告)日：2012-10-16
申请号：US12874240
申请日：2010-09-02
申请人： Tomoko Kuwabara , Takahiro Ishizuka , Yasufumi Ooishi
发明人： Tomoko Kuwabara , Takahiro Ishizuka , Yasufumi Ooishi
IPC分类号： G01D11/00
CPC分类号： C09D11/101 , C09D11/326
摘要： An aqueous ink composition including a colorant, a polymer including a hydrophobic structural unit (a) represented by the following formula (1), a polymerization initiator, a polymerizable compound including an ethylenically unsaturated bond, and water: wherein, in formula (1), R1 represents a hydrogen atom, a methyl group or a halogen atom; L1 represents —COO—, —OCO—, —CONR2—, —O—, or a substituted or unsubstituted phenylene group; R2 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms; L2 represents a single bond or a divalent linking group having 1 to 30 carbon atoms; and R3 represents a hydrogen atom, a hydroxy group, an alkyl group, an alkyloxy group, an aryl group, an arylalkyl group, an aryloxy group, an acyl group, a halogen atom, a cyano group, or a nitro group.
摘要翻译：一种含有着色剂的水性油墨组合物，包含下述式（1）表示的疏水性结构单元（a）的聚合物，聚合引发剂，包含烯键式不饱和键的聚合性化合物和水。式中，式（1） R1表示氢原子，甲基或卤原子; L 1表示-COO - ， - OCO - ， - CONR 2 - ， - O-或取代或未取代的亚苯基; R2表示氢原子或碳原子数1〜10的烷基。 L2表示单键或碳原子数为1〜30的二价连接基团; R 3表示氢原子，羟基，烷基，烷氧基，芳基，芳烷基，芳氧基，酰基，卤素原子，氰基或硝基。

3. 发明申请

US20120157457A1 COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION 有权
标题翻译：用于诱导神经元差异的组合物和方法
公开(公告)号：US20120157457A1
公开(公告)日：2012-06-21
申请号：US13356079
申请日：2012-01-23
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A61K31/426 , A61K31/5377 , A61K31/427 , C07D277/42 , C07D417/12
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

4. 发明授权

US08105581B2 Compositions and methods for inducing neuronal differentiation 有权
标题翻译：用于诱导神经元分化的组合物和方法
公开(公告)号：US08105581B2
公开(公告)日：2012-01-31
申请号：US12095723
申请日：2006-12-01
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter G. Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A01N65/00 , A61K35/12 , A61P25/00
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

5. 发明申请

US20090111981A1 CELLULOSE ACYLATE FILM AND ITS APPLICATIONS 有权
标题翻译：纤维素乙酸酯薄膜及其应用
公开(公告)号：US20090111981A1
公开(公告)日：2009-04-30
申请号：US12260171
申请日：2008-10-29
申请人： Tomoko Kuwabara , Kunihiro Atsumi
发明人： Tomoko Kuwabara , Kunihiro Atsumi
IPC分类号： C08B3/00
CPC分类号： C08L1/10 , C08B3/16 , C08J5/18 , C08J2301/10 , C08J2301/14 , C08L1/14 , G02B5/30
摘要： A cellulose acylate film, comprising a cellulose acylate having at least one substituent (Substituent A) comprising an aromatic group having at least one C4 or longer aliphatic group, is disclosed.
摘要翻译：公开了一种纤维素酰化物膜，其包含具有至少一个具有至少一个C 4或更长的脂族基团的芳族基团的至少一个取代基（取代基A）的酰化纤维素。

6. 发明授权

US08394798B2 Compositions and methods for inducing neuronal differentiation 有权
标题翻译：用于诱导神经元分化的组合物和方法
公开(公告)号：US08394798B2
公开(公告)日：2013-03-12
申请号：US13356079
申请日：2012-01-23
申请人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter Schultz , Sheng Ding , Tomoko Kuwabara
发明人： Masaki Warashina , Kyung Hoon Min , Fred Gage , Peter Schultz , Sheng Ding , Tomoko Kuwabara
IPC分类号： A01N65/00 , A61K35/12 , A61P25/00
CPC分类号： C07D277/18
摘要： The present invention provides compositions and methods for inducing neuronal cell differentiation.
摘要翻译：本发明提供用于诱导神经元细胞分化的组合物和方法。

7. 发明授权

US08026357B2 Cellulose acylate film and its applications 有权
标题翻译：纤维素酰化膜及其应用
公开(公告)号：US08026357B2
公开(公告)日：2011-09-27
申请号：US12260171
申请日：2008-10-29
申请人： Tomoko Kuwabara , Kunihiro Atsumi
发明人： Tomoko Kuwabara , Kunihiro Atsumi
IPC分类号： C08B3/00 , C08B3/16 , C08B13/00 , C08B3/06 , C08B3/08 , G02B5/30 , G02F1/1335
CPC分类号： C08L1/10 , C08B3/16 , C08J5/18 , C08J2301/10 , C08J2301/14 , C08L1/14 , G02B5/30
摘要： A cellulose acylate film, comprising a cellulose acylate having at least one substituent (Substituent A) comprising an aromatic group having at least one C4 or longer aliphatic group, is disclosed.
摘要翻译：公开了一种纤维素酰化物膜，其包含具有至少一个具有至少一个C 4或更长的脂族基团的芳族基团的至少一个取代基（取代基A）的酰化纤维素。

8. 发明申请

US20110065213A1 METHOD FOR IMMUNOASSAY USING LATEX PARTICLES 审中-公开
标题翻译：使用LATEX颗粒免疫的方法
公开(公告)号：US20110065213A1
公开(公告)日：2011-03-17
申请号：US12879524
申请日：2010-09-10
申请人： Noriyuki KASAGI , Tomoko Kuwabara , Yuya Watanabe
发明人： Noriyuki KASAGI , Tomoko Kuwabara , Yuya Watanabe
IPC分类号： G01N33/543 , C08F20/06 , C08F12/08 , C08F4/30
CPC分类号： G01N33/585 , G01N33/54313 , G01N33/54393
摘要： An object of the present invention is to provide latex particles with high production reproducibility, by which a sufficiently high value of signal ΔS (=value of signal−value of noise) can be realized in immunodiagnosis. The present invention provides a method for assay which comprises steps of (1) causing a substance to be detected to come into contact with or compete with binding substance-labeled fluorescent latex particles which are obtained by causing a binding substance to bind to fluorescent latex particles, and (2) measuring fluorescence from the binding substance-labeled fluorescent latex particles, wherein: (a) the fluorescent latex particles are obtained by adding a fluorescent substance to latex particles characterized in that the amount of COOH groups existing on the surfaces of the latex particles is from 40 μeq/g to 300 μeq/g, or (b) the fluorescent latex particles contain latex particles and a fluorescent substance, which are characterized in that the amount of COOH groups existing on the surfaces of the fluorescent latex particles is from 40 μeq/g to 300 μeq/g.
摘要翻译：本发明的目的是提供具有高生产重现性的胶乳颗粒，通过该乳胶颗粒可以在免疫诊断中实现足够高的信号值Dgr; S（=噪声信号值的值）。本发明提供了一种测定方法，其包括以下步骤：（1）使被检测物质与通过使结合物质结合荧光胶乳颗粒获得的结合物质标记的荧光胶乳颗粒接触或竞争，和（2）测量来自结合物质标记的荧光胶乳颗粒的荧光，其中：（a）通过将荧光物质添加到胶乳颗粒中获得荧光胶乳颗粒，其特征在于存在于表面上的COOH基团的量胶乳粒子为40μeq/ g〜300μeq/ g，或（b）荧光胶乳粒子含有胶乳粒子和荧光物质，其特征在于，存在于荧光胶乳粒子表面的COOH基团的量为从40μeq/ g到300μeq/ g。

9. 发明申请

US20090247739A1 CELLULOSIC SUBSTANCE COMPOSITION, CELLULOSIC SUBSTANCE FILM, OPTICALLY COMPENSATORY FILM, POLARIZING PLATE AND IMAGE DISPLAY DEVICE 审中-公开
标题翻译：细胞物质组合物，细胞物质膜，光学补偿膜，极化板和图像显示装置
公开(公告)号：US20090247739A1
公开(公告)日：2009-10-01
申请号：US12411583
申请日：2009-03-26
申请人： Yutaka Nozoe , Tomoko Kuwabara , Kunihiro Atsumi
发明人： Yutaka Nozoe , Tomoko Kuwabara , Kunihiro Atsumi
IPC分类号： C07H7/02
CPC分类号： C07H7/02 , C08B3/16 , C08L1/14
摘要： A cellulosic substance composition includes: a cellulosic substance having a branched structure or cyclic structure-containing aliphatic acyl group (A) having from 4 to 30 carbon atoms, the aliphatic acyl group (A) being represented by formula (1): wherein R11, R12 and R13 each independently represents a hydrogen atom or an alkyl group, provided that at least two of R11, R12 and R13 are an alkyl group; R11, R12 and R13 may each independently have a substituent; at least two of R11, R12 and R13 may be connected to each other to form a ring; and a portion of * represents a bond to a cellulose skeleton of the cellulosic substance.
摘要翻译：纤维素物质组合物包括：具有支化结构的纤维素物质或含有4-30个碳原子的含有脂环族酰基（A）的脂肪族酰基（A）由式（1）表示：其中R11， R 12和R 13各自独立地表示氢原子或烷基，条件是R 11，R 12和R 13中的至少两个为烷基; R 11，R 12和R 13可各自独立地具有取代基; R11，R12和R13中的至少两个可以彼此连接以形成环; 并且*的一部分表示与纤维素物质的纤维素骨架的键。

10. 发明申请

US20060234378A1 Molecular switch regulating neurogenesis 审中-公开
标题翻译：分子开关调节神经发生
公开(公告)号：US20060234378A1
公开(公告)日：2006-10-19
申请号：US11400473
申请日：2006-04-06
申请人： Tomoko Kuwabara , Fred Gage
发明人： Tomoko Kuwabara , Fred Gage
IPC分类号： C12N5/08 , C07H21/04 , C12N15/09
CPC分类号： C12N15/1086
摘要： The present disclosure relates to a novel transcription regulatory master switch involved in neural development. The disclosure provides compositions and methods for regulating neural lineage specific genes and modulating the differentiation of stem cells into neural lineage cells.
摘要翻译：本公开涉及涉及神经发育的新型转录调控主开关。本公开提供了用于调节神经谱系特异性基因并调节干细胞分化成神经谱系细胞的组合物和方法。

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