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1. 发明申请

US20070219436A1 BIOLOGICAL COMPONENT MEASURING APPARATUS AND METHOD 失效
标题翻译：生物组分测量装置和方法
公开(公告)号：US20070219436A1
公开(公告)日：2007-09-20
申请号：US11538230
申请日：2006-10-03
申请人： Tomohiro Takase , Isao Nawata , Ikuo Uematsu , Kayoko Oomiya
发明人： Tomohiro Takase , Isao Nawata , Ikuo Uematsu , Kayoko Oomiya
IPC分类号： A61B5/00
CPC分类号： A61B5/14532
摘要： It is an object to provide a measuring apparatus and method which can easily measure an amount of a biological component such as glucose without requiring an ordinary person who is to be measured to have special knowledge and techniques. A measuring apparatus according to an embodiment of the present invention uses a biological component sensor including a plate-shaped sensor chip 112 having a biological component sensing function and a sensor chip holding frame 111 for surrounding and holding the sensor chip 112, and the biological component sensor is disposed in a measuring apparatus main body housing 110. A fixed click-shaped engaging member 118 and a movable click-shaped engaging member 119 are disposed on a sensor chip support table 124 fixed to the measuring apparatus main body housing 110, and they fix and support the sensor chip holding frame 111 and the sensor chip can be thus replaced. The biological component sensor of the measuring apparatus is caused to come in contact with a forearm portion 100 of a human body and a biological component exuded from a contact part of the forearm portion is caused to come in contact with the sensor chip to change the physical or chemical surface property of the sensor chip, thereby measuring the change through an irradiation of an inspection light. Thus, a concentration of the biological component is calculated.
摘要翻译：本发明的目的是提供一种可以容易地测量诸如葡萄糖等生物成分的量的测量装置和方法，而不需要测量的普通人具有特殊的知识和技术。根据本发明的实施例的测量装置使用包括具有生物部件感测功能的板状传感器芯片112和用于围绕和保持传感器芯片112的传感器芯片保持框架111的生物部件传感器和生物部件传感器设置在测量装置主体外壳110中。在固定在测量装置本体壳体110上的传感器芯片支撑台124上设置有固定的点击状的卡合部件118和活动卡爪部件119，并且固定并支撑传感器芯片固定框架111和传感器芯片可以这样替换。使测量装置的生物部件传感器与人体的前臂部分100接触，并且使从前臂部分的接触部分渗出的生物成分与传感器芯片接触以改变物理或化学表面性质，从而通过检查光的照射来测量变化。因此，计算生物成分的浓度。

2. 发明授权

US07738934B2 Biological component measuring apparatus and method 失效
标题翻译：生物成分测量装置及方法
公开(公告)号：US07738934B2
公开(公告)日：2010-06-15
申请号：US11538230
申请日：2006-10-03
申请人： Tomohiro Takase , Isao Nawata , Ikuo Uematsu , Kayoko Oomiya
发明人： Tomohiro Takase , Isao Nawata , Ikuo Uematsu , Kayoko Oomiya
IPC分类号： A61B5/145
CPC分类号： A61B5/14532
摘要： A measuring apparatus uses a biological component sensor including a plate-shaped sensor chip having a biological component sensing function and a sensor chip holding frame surrounding and holding the sensor chip. The biological component sensor is disposed in a measuring apparatus main body housing. A fixed engaging member and movable engaging member disposed on a sensor chip support table fixed to the measuring apparatus main body housing fix and support the sensor chip holding frame, and the sensor chip can be thus replaced. The biological component sensor contacts a forearm portion of a human body, and a biological component exuded from a contact part of the forearm portion is caused to contact the sensor chip to change a physical or chemical surface property of the sensor chip, thereby measuring the change through an irradiation of an inspection light to calculate concentration of the biological component.
摘要翻译：测量装置使用包括具有生物成分感测功能的板状传感器芯片和围绕并保持传感器芯片的传感器芯片保持框架的生物体成分传感器。生物体传感器配置在测量装置主体壳体内。设置在传感器芯片支撑台上的固定接合构件和可移动接合构件，固定到测量装置主体外壳固定并支撑传感器芯片保持框架，并且可以更换传感器芯片。生物成分传感器接触人体的前臂部分，并且从前臂部分的接触部分渗出的生物成分与传感器芯片接触以改变传感器芯片的物理或化学表面性质，从而测量变化通过照射检查光来计算生物成分的浓度。

3. 发明申请

US20090124024A1 OPTICAL-WAVEGUIDE SENSOR CHIP, METHOD OF MANUFACTURING THE SAME, METHOD OF MEASURING SUBSTANCE, SUBSTANCE-MEASURING KIT AND OPTICAL-WAVEGUIDE SENSOR 审中-公开
标题翻译：光波导传感器芯片，其制造方法，测量物质的方法，物质测量套件和光波导传感器
公开(公告)号：US20090124024A1
公开(公告)日：2009-05-14
申请号：US12266023
申请日：2008-11-06
申请人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
发明人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
IPC分类号： G01N33/543 , G01N21/00 , B05D5/06
CPC分类号： G01N21/75 , G01N21/552 , G01N21/7703 , G01N33/54313 , G01N33/54373 , G02B6/12007 , G02B6/124
摘要： An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.
摘要翻译：光波导传感器芯片包括具有固定在其表面上的第一物质的光波导，第一物质与分析物质特异性反应，以及分散在光波导上并且固定在其表面上的第二物质的细颗粒，第二物质与分析物质特异性反应。

4. 发明授权

US08642319B2 Optical-waveguide sensor chip, method of manufacturing the same, method of measuring substance, substance-measuring kit and optical-waveguide sensor 有权
标题翻译：光波导传感器芯片，其制造方法，测量物质的方法，物质测量套件和光波导传感器
公开(公告)号：US08642319B2
公开(公告)日：2014-02-04
申请号：US13462196
申请日：2012-05-02
申请人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
发明人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
IPC分类号： C12M1/34
CPC分类号： G01N21/75 , G01N21/552 , G01N21/7703 , G01N33/54313 , G01N33/54373 , G02B6/12007 , G02B6/124
摘要： An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.
摘要翻译：光波导传感器芯片包括具有固定在其表面上的第一物质的光波导，第一物质与分析物质特异性反应，以及分散在光波导上并且固定在其表面上的第二物质的细颗粒，第二物质与分析物质特异性反应。

5. 发明申请

US20120213669A1 OPTICAL-WAVEGUIDE SENSOR CHIP, METHOD OF MANUFACTURING THE SAME, METHOD OF MEASURING SUBSTANCE, SUBSTANCE-MEASURING KIT AND OPTICAL-WAVEGUIDE SENSOR 有权
标题翻译：光波导传感器芯片，其制造方法，测量物质的方法，物质测量套件和光波导传感器
公开(公告)号：US20120213669A1
公开(公告)日：2012-08-23
申请号：US13462196
申请日：2012-05-02
申请人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
发明人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
IPC分类号： G01N33/53 , B05D5/06
CPC分类号： G01N21/75 , G01N21/552 , G01N21/7703 , G01N33/54313 , G01N33/54373 , G02B6/12007 , G02B6/124
摘要： An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.
摘要翻译：光波导传感器芯片包括具有固定在其表面上的第一物质的光波导，第一物质与分析物质特异性反应，以及分散在光波导上并且固定在其表面上的第二物质的细颗粒，第二物质与分析物质特异性反应。

6. 发明授权

US09274104B2 Measuring system using optical waveguide, measuring device, measuring method, optical waveguide type sensor chip, and magnetic fine particle 有权
标题翻译：使用光波导的测量系统，测量装置，测量方法，光波导型传感器芯片和磁性细颗粒
公开(公告)号：US09274104B2
公开(公告)日：2016-03-01
申请号：US13436115
申请日：2012-03-30
申请人： Ichiro Tono , Shingo Kasai , Takaaki Wada , Isao Nawata , Masaaki Hirakawa , Tomohiro Takase , Kayoko Oomiya , Takeshi Yamauchi , Tadahiro Nakayama , Isamu Nitta
发明人： Ichiro Tono , Shingo Kasai , Takaaki Wada , Isao Nawata , Masaaki Hirakawa , Tomohiro Takase , Kayoko Oomiya , Takeshi Yamauchi , Tadahiro Nakayama , Isamu Nitta
IPC分类号： G01N15/06 , G01N27/00 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54326 , G01N15/0656 , G01N33/5434 , G01N33/54373 , G01N33/585
摘要： According to one embodiment, a measuring system using an optical waveguide is provided. The measuring system has an optical waveguide, magnetic fine particles, a magnetic field applying unit, a light source and a light receiving element. The optical waveguide has a sensing area to which first substances having a property of specifically bonding to subject substances to be measured are fixed. Second substances having a property of specifically bonding to the subject substances are fixed to the magnetic fine particle. The magnetic field applying unit generates a magnetic field for moving the magnetic fine particles. The light source inputs a light into the optical waveguide. The light receiving element receives the light output from the optical waveguide.
摘要翻译：根据一个实施例，提供了使用光波导的测量系统。测量系统具有光波导，磁性微粒，磁场施加单元，光源和光接收元件。光波导具有感测区域，第一物质具有特异性地结合待测物质的特性固定。具有特异性地结合到被摄体物质的特性的第二物质被固定在磁性细颗粒上。磁场施加单元产生用于移动磁性细颗粒的磁场。光源将光输入到光波导中。光接收元件接收从光波导输出的光。

7. 发明申请

US20120252111A1 MEASURING SYSTEM USING OPTICAL WAVEGUIDE, MEASURING DEVICE, MEASURING METHOD, OPTICAL WAVEGUIDE TYPE SENSOR CHIP, AND MAGNETIC FINE PARTICLE 有权
标题翻译：使用光波导的测量系统，测量装置，测量方法，光波导型传感器芯片和磁性微粒
公开(公告)号：US20120252111A1
公开(公告)日：2012-10-04
申请号：US13436115
申请日：2012-03-30
申请人： Ichiro Tono , Shingo Kasai , Takaaki Wada , Isao Nawata , Masaaki Hirakawa , Tomohiro Takase , Kayoko Oomiya , Takeshi Yamauchi , Tadahiro Nakayama , Isamu Nitta
发明人： Ichiro Tono , Shingo Kasai , Takaaki Wada , Isao Nawata , Masaaki Hirakawa , Tomohiro Takase , Kayoko Oomiya , Takeshi Yamauchi , Tadahiro Nakayama , Isamu Nitta
IPC分类号： C12M1/34 , G01N21/00
CPC分类号： G01N33/54326 , G01N15/0656 , G01N33/5434 , G01N33/54373 , G01N33/585
摘要： According to one embodiment, a measuring system using an optical waveguide is provided. The measuring system has an optical waveguide, magnetic fine particles, a magnetic field applying unit, a light source and a light receiving element. The optical waveguide has a sensing area to which first substances having a property of specifically bonding to subject substances to be measured are fixed. Second substances having a property of specifically bonding to the subject substances are fixed to the magnetic fine particle. The magnetic field applying unit generates a magnetic field for moving the magnetic fine particles. The light source inputs a light into the optical waveguide. The light receiving element receives the light output from the optical waveguide.
摘要翻译：根据一个实施例，提供了使用光波导的测量系统。测量系统具有光波导，磁性微粒，磁场施加单元，光源和光接收元件。光波导具有感测区域，第一物质具有特异性地结合待测物质的特性固定。具有特异性地结合到被摄体物质的特性的第二物质被固定在磁性细颗粒上。磁场施加单元产生用于移动磁性细颗粒的磁场。光源将光输入到光波导中。光接收元件接收从光波导输出的光。

8. 发明申请

US20070146718A1 OPTICAL INSPECTION METHOD AND OPTICAL INSPECTION APPARATUS USED FOR THE SAME 审中-公开
标题翻译：光学检测方法和光学检测装置
公开(公告)号：US20070146718A1
公开(公告)日：2007-06-28
申请号：US11565897
申请日：2006-12-01
申请人： Tomohiro TAKASE , Ikuo Uematsu , Isao Nawata
发明人： Tomohiro TAKASE , Ikuo Uematsu , Isao Nawata
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/553 , G01N21/648
摘要： An inspection method using a portable optical inspection apparatus adapted to be driven by a battery and capable of producing an accurate sensing result without being adversely affected by the environmental temperature conditions is disclosed. The light is radiated on a sensor chip for a predetermined length of time and the amount of a substance contained in a specimen placed on a sensing thin film is measured by an optical signal obtained from the sensing chip, using an optical inspection apparatus comprising the sensor chip including a substrate 5, an optical waveguide layer 6 arranged on the substrate and the sensing thin film 7 attached on the surface of the optical waveguide layer, a light source 8 for radiating the light on the sensor chip and a photodetector 9 for receiving and converting the light output from the sensor chip into an electrical signal The light source is turned on and off a plurality of times for a predetermined length of time during which the inspection light is radiated. The amount of light with the light source on is measured by the photodetector thereby to determine the amount of the substance. In the process, the light amount with the light source off can also be measured so that the amount of the substance is determined from the difference between the light amount with the light source on and off.
摘要翻译：公开了一种使用便携式光学检查装置的检查方法，该便携式光学检查装置适于由电池驱动并且能够产生精确的感测结果而不受环境温度条件的不利影响。将光照射在传感器芯片上预定的时间长度，并且通过使用包括传感器的光学检查装置的感测芯片获得的光学信号来测量放置在感测薄膜上的样本中所含有的物质的量芯片，其包括基板5，布置在基板上的光波导层6和安装在光波导层的表面上的感测薄膜7，用于在传感器芯片上照射光的光源8和用于接收和将来自传感器芯片的光输出转换为电信号。在其中辐射检查光的预定长度的时间内，光源被多次打开和关闭。通过光电检测器测量光源的光量，从而确定物质的量。在该过程中，也可以测量光源关闭的光量，使得物质的量由光源的光量的开启和关闭之间的差确定。

9. 发明申请

US20110020852A1 METHOD OF ANALYZING BIOLOGICAL COMPONENT, BIOLOGICAL COMPONENT ANALYZER AND EXTRACTION CARTRIDGE 审中-公开
标题翻译：分析生物成分，生物成分分析仪和提取物盒的方法
公开(公告)号：US20110020852A1
公开(公告)日：2011-01-27
申请号：US12935434
申请日：2009-03-27
申请人： Junko Kojima , Yasunori Maekawa , Tomohiro Takase , Ikuo Uematsu , Masaaki Hirakawa , Isao Nawata , Ichiro Tono , Shingo Kasai
发明人： Junko Kojima , Yasunori Maekawa , Tomohiro Takase , Ikuo Uematsu , Masaaki Hirakawa , Isao Nawata , Ichiro Tono , Shingo Kasai
IPC分类号： C12Q1/54 , C12M1/40
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150091 , A61B5/150229 , A61B5/150251 , A61B5/150343 , A61B5/150358 , A61B5/150748 , A61B5/150984 , A61B5/15113 , A61B5/15186 , A61B5/1519 , A61B5/157 , A61B5/6824 , A61B5/685 , C12Q1/006
摘要： This method of analyzing a biological component includes steps of arranging an extraction medium holding part configured to be capable of holding a prescribed quantity of extraction medium for holding an extract extracted from a subject on the skin of the subject, transferring the extraction medium stored in a liquid storing part storing substantially the same quantity of the extraction medium as the prescribed quantity to the extraction medium holding part, transferring at least part of the extraction medium holding the extracted extract to a reaction part, and analyzing a result of detecting the extract.
摘要翻译：这种分析生物成分的方法包括以下步骤：将提取介质保持部件配置为能够保持规定量的提取介质，用于保持从被检体提取的提取物在被检体的皮肤上，将存储在对象物中的提取介质将与所述规定量大致相同量的所述提取介质的液体储存部分提取到所述提取介质保持部，将保持所述萃取液的所述萃取介质的至少一部分转移到反应部，并且对所述提取物的检测结果进行分析。

10. 发明申请

US20080131315A1 COLOR REACTION DETECTING DEVICE AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：颜色反应检测装置及其制造方法
公开(公告)号：US20080131315A1
公开(公告)日：2008-06-05
申请号：US11771533
申请日：2007-06-29
申请人： Tomohiro Takase , Isao Nawata , Ikuo Uematsu , Masaaki Hirakawa
发明人： Tomohiro Takase , Isao Nawata , Ikuo Uematsu , Masaaki Hirakawa
IPC分类号： G01N21/76 , G11B7/00 , G11B20/18
CPC分类号： G01N21/78 , G01N21/7703
摘要： A color reaction detecting device includes: a support configured to support a sensor chip, the sensor chip including a thin film which causes a color reaction by a substance released from an object under inspection; a light source configured to introduce light into the sensor chip supported by the support; a photodetector configured to sense light emitted from the sensor chip; a temperature sensor configured to measure temperature; and a control unit. The control unit computes an amount of color reaction in the sensor chip using a result of the sensing by the photodetector and a result of the measurement by the temperature sensor.
摘要翻译：一种颜色反应检测装置，包括：支撑体，其被配置为支撑传感器芯片，所述传感器芯片包括由检查对象物质释放的物质引起着色反应的薄膜; 光源，被配置为将光引入由所述支撑件支撑的所述传感器芯片中; 光检测器，被配置为感测从所述传感器芯片发射的光; 配置成测量温度的温度传感器; 和控制单元。控制单元使用光检测器的感测结果和温度传感器的测量结果来计算传感器芯片中的颜色反应量。

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