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1. 发明授权

US06744153B2 Apparatus for and method of generating a pulse signal 失效
标题翻译：用于产生脉冲信号的装置和方法
公开(公告)号：US06744153B2
公开(公告)日：2004-06-01
申请号：US09995758
申请日：2001-11-29
申请人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki , Osamu Uchiyama
发明人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki , Osamu Uchiyama
IPC分类号： H02M510
CPC分类号： G01D5/2013 , H03K17/9515
摘要： A pulse signal generator comprising a magnetic element able (1) to cause a large Barkhausen jump; a detection member (2) for detecting a magnetic change in the magnetic element to generate a pulse signal; and a pair of magnetic field sources (3, 4, 6, and 7) provided in parallel to each other on both sides of the magnetic element such that their poles (3A, 4A) are opposed to each other so that when an object (5A) advances from one of opposite poles to the other of the magnetic field sources, a magnetic field applied to the magnetic element changes, causing a large Barkhausen jump in the magnetic element, thus causing the detection member to generate a pulse signal.
摘要翻译：一种脉冲信号发生器，包括能够（1）产生大的巴克豪森跳跃的磁性元件; 检测构件（2），用于检测所述磁性元件的磁变化以产生脉冲信号; 以及一对在磁性元件的两侧彼此平行地设置的磁场源（3,4,6和7），使得它们的极（3A，4A）彼此相对，使得当物体（如图5A所示，从一个相反的极点前进到另一个磁场源，施加到磁性元件的磁场发生变化，导致在磁性元件中大的巴克豪森跳跃，从而导致检测部件产生脉冲信号。

2. 发明授权

US06717400B2 Pulse signal generator with movable magnetic element 失效
标题翻译：具有可移动磁性元件的脉冲信号发生器
公开(公告)号：US06717400B2
公开(公告)日：2004-04-06
申请号：US09983424
申请日：2001-10-24
申请人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
发明人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
IPC分类号： G01B714
CPC分类号： H03K17/9515
摘要： A pulse signal generator comprises a magnetic element (1) capable of producing large Barkhausen jumps; a generating unit for generating a magnetic field, which is changed by the object to be detected (5) to cause the magnetic element to produce the large Barkhausen jumps; the generating unit consists of a pair of elongated magnet/yoke combinations (3,6 and 4,7) provided on opposite sides of the magnetic element (1) such that their poles are oriented in opposite directions, forming a detecting area at an end thereof (3A, 4A); a detecting unit (2) for detecting the large Barkhausen jumps to produce a corresponding pulse signal; the magnetic element (1) having a first length between a second length of the magnet/yoke combinations and a half of the second length and provided toward the detecting area; and an adjusting yoke (8) movable along one of the elongated magnet/yoke combinations (3, 6).
摘要翻译：脉冲信号发生器包括能够产生大的巴克豪森跳跃的磁性元件（1）; 用于产生由被检测物体（5）改变的磁场的发生单元，以使磁性元件产生大的巴克豪森跳跃; 所述发电单元由设置在所述磁性元件（1）的相对侧上的一对细长磁体/磁轭组合（3,6和4,7）组成，使得它们的磁极相反方向定向，从而在端部形成检测区域（3A，4A）; 检测单元（2），用于检测大的巴克豪森跳跃以产生对应的脉冲信号; 所述磁性元件（1）具有在所述磁体/磁轭组合的第二长度和所述第二长度的一半之间的第一长度并朝向所述检测区域提供; 以及可沿着所述细长磁体/轭组合（3,6）之一移动的调节轭（8）。

3. 发明授权

US06667611B2 Pulse signal generator, coil bobbin for the generator, and method of making the coil bobbin 失效
标题翻译：脉冲信号发生器，发电机用线圈架及线圈筒管的制作方法
公开(公告)号：US06667611B2
公开(公告)日：2003-12-23
申请号：US09983924
申请日：2001-10-26
申请人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
发明人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
IPC分类号： H03K1795
CPC分类号： H03K17/9515 , H01F7/20 , Y10T29/49007
摘要： A pulse signal generator comprises a pair of magnets (3a, 3b) for producing a magnetic field, a magnetic element wire (5) provided in the magnetic field and capable of producing large Barkhausen jumps, a wire coil (2) provided around the magnetic element wire (5) to output a pulse signal. The magnetic element wire (5) is embedded in a coil bobbin (6) as a unit.
摘要翻译：脉冲信号发生器包括用于产生磁场的一对磁体（3a，3b），设置在磁场中的能够产生大的巴克豪森跳跃的磁性元件线（5），设置在磁体周围的线圈（2）元件线（5）输出脉冲信号。磁性元件线（5）作为一个单元嵌入在线圈架（6）中。

4. 发明授权

US06600309B2 Pulse signal generator and method of making same 失效
标题翻译：脉冲信号发生器及其制作方法
公开(公告)号：US06600309B2
公开(公告)日：2003-07-29
申请号：US10012485
申请日：2001-12-12
申请人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
发明人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
IPC分类号： G01R3302
CPC分类号： G01D11/245 , G01D5/2013
摘要： A pulse signal generator comprises a detection assembly including a magnetic field generator and a magnetic element wire able to cause a large Barkhausen jump such that it produces a pulse signal responsive to the movement of the object to be detected; a case for housing the detection assembly; an attaching member; and a positioning guide provided on the inside surface of the case to position the detection assembly at the desired position with respect to the object to be detected.
摘要翻译：脉冲信号发生器包括检测组件，其包括磁场发生器和能够引起大的巴克豪森跳跃的磁性元件线，使得其响应于待检测对象的移动而产生脉冲信号; 用于容纳检测组件的壳体; 附接构件; 以及设置在所述壳体的内表面上的定位引导件，用于将所述检测组件相对于要检测的物体定位在期望的位置。

5. 发明授权

US06549002B2 Pulse signal generator having integrally made detecting assembly and waveform shaping circuit 失效
标题翻译：具有整体检测组件和波形整形电路的脉冲信号发生器
公开(公告)号：US06549002B2
公开(公告)日：2003-04-15
申请号：US09981710
申请日：2001-10-19
申请人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
发明人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
IPC分类号： G01B730
CPC分类号： H03K17/9515 , G01D5/2013 , G01P3/4815
摘要： A pulse signal generator comprises a detecting assembly including a magnetic element wire (5) and a coil (2) wound around a bobbin (6) to generate electric pulses and a waveform shaping circuit integrated with the detecting assembly so as to shape the waveform of the electric pulses to output a pulse signal.
摘要翻译：脉冲信号发生器包括检测组件，该检测组件包括磁性线（5）和缠绕在线轴（6）上以产生电脉冲的线圈（2），以及与检测组件集成的波形整形电路，以便形成波形电脉冲输出脉冲信号。

6. 发明授权

US06566861B2 Pulse signal generator 失效
标题翻译：脉冲信号发生器
公开(公告)号：US06566861B2
公开(公告)日：2003-05-20
申请号：US09986179
申请日：2001-11-07
申请人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
发明人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki
IPC分类号： G01B714
CPC分类号： H03K17/9515
摘要： According to the invention there is provided a pulse signal generator comprising a plurality of magnetic elements arranged in an imaginable plane and capable of producing large Barkhausen jumps; a first unit for generating a magnetic field, which is changed by the object to be detected to cause the magnetic elements to produce the large Barkhausen jumps, the first unit consisting of a pair of magnet/yoke combinations provided on opposite sides of said imaginable plane such that their poles are oriented in opposite directions, forming a detecting area at an end thereof; a second unit for detecting the large Barkhausen jumps to produce corresponding pulse signals; and first and second adjusting yokes being movable on one of the magnet/yoke combinations along one of the magnetic elements and on the other of the magnet/yoke combinations along the other of said magnetic elements, respectively.
摘要翻译：根据本发明，提供了一种脉冲信号发生器，其包括布置在可以想象的平面内的多个磁性元件，能够产生大的巴克豪森跳跃; 用于产生磁场的第一单元，其被被检测物体改变以使得磁性元件产生大的巴克豪森跳跃，第一单元包括设置在所述可想像平面的相对侧上的一对磁体/磁轭组合使得它们的极定向在相反方向，在其末端形成检测区域; 用于检测大型Barkhausen跳跃产生相应脉冲信号的第二单元; 并且第一和第二调节磁轭可以分别沿着磁性元件中的一个磁体/磁轭组合中的一个磁体/磁轭组合和另一个磁体/磁轭组件沿另一个磁性元件移动。

7. 发明授权

US06384595B1 Method of and apparatus for generating a pulse signal 失效
标题翻译：用于产生脉冲信号的方法和装置
公开(公告)号：US06384595B1
公开(公告)日：2002-05-07
申请号：US09383931
申请日：1999-08-26
申请人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki , Osamu Uchiyama
发明人： Tomoaki Ito , Masami Tanaka , Tadashi Kubota , Yasuhiro Masuzaki , Osamu Uchiyama
IPC分类号： G01B730
CPC分类号： G01D5/145 , G01D5/2451 , G01P3/488
摘要： A pulse signal generator comprising a magnetic element (1) able to cause a large Barkhausen jump; a detection member (2) for detecting a magnetic change in the magnetic element (1) to generate a pulse signal; and a pair of magnets (3, 4) provided on both sides of the magnetic element (1) such that their poles are opposed to each other; a magnetic circuit formation adjusting member (8, 9) attached to at least one of the magnets (3) so that when an object (5A) passes a pair of poles (3A, 4A) on one end of the magnets (3, 4), a magnetic field applied to the magnetic element changes to cause a large Barkhausen jump in the magnetic element (1), thus causing the detection member (2) to generate a pulse signal.
摘要翻译：一种脉冲信号发生器，包括能够引起大的巴克豪森跳跃的磁性元件（1）; 检测构件（2），用于检测所述磁性元件（1）中的磁变化以产生脉冲信号; 以及设置在所述磁性元件（1）的两侧上使得它们的极彼此相对的一对磁体（3,4）; 安装在所述磁体（3）中的至少一个上的磁路形成调整部件（8,9），使得当所述物体（5A）在所述磁体（3,4）的一端通过一对磁极（3A，4A）时，），施加到磁性元件的磁场发生变化，导致在磁性元件（1）中产生大的巴克豪森（Barkhausen）跳跃，从而使检测部件（2）产生脉冲信号。

8. 发明授权

US07268539B2 Pulse signal generator 失效
标题翻译：脉冲信号发生器
公开(公告)号：US07268539B2
公开(公告)日：2007-09-11
申请号：US11541148
申请日：2006-09-28
申请人： Kensaku Sato , Masami Tanaka , Tadashi Kubota , Hideki Sakamoto , Makoto Kobayashi , Satoshi Yamaguchi , Mamoru Hasegawa , Yuichi Shimasaki
发明人： Kensaku Sato , Masami Tanaka , Tadashi Kubota , Hideki Sakamoto , Makoto Kobayashi , Satoshi Yamaguchi , Mamoru Hasegawa , Yuichi Shimasaki
IPC分类号： G01B7/30
CPC分类号： G01D5/147
摘要： A pulse signal generator using a magnetic device that can cause a large Barkhausen effect, comprises means having a number of pits and projections and generates pulses according to the behavior of these, the means being capable of moving the pits and projections in a first or second direction, the pits and projections being disposed in the moving direction with some of the projections missing or some of the pits filled. The value of the ratio between the time interval of pulses generated by portions other than a projection-missing portion and the time interval of pulses generated by the projection-missing portion or the value of the ratio between the time interval of pulses generated by portions other than a pit-filled portion and the time interval of pulses generated by the pit-filled portion differs between when the pits and projections move in the first or second direction.
摘要翻译：使用可引起大的巴克豪森效应的磁性装置的脉冲信号发生器包括具有多个凹坑和突起的装置，并且根据这些的行为产生脉冲，该装置能够将凹坑和突起移动到第一或第二方向，凹坑和突起沿着移动方向设置，其中一些突起丢失或一些凹坑被填充。由投射缺失部分以外的部分产生的脉冲的时间间隔与由投影缺失部分产生的脉冲的时间间隔之间的比率的值或由其他部分产生的脉冲的时间间隔之间的比率的值之间的值并且由凹坑填充部分产生的脉冲的时间间隔在凹坑和突起在第一或第二方向上移动时不同。

9. 发明申请

US20070075704A1 Pulse signal generator 失效
公开(公告)号：US20070075704A1
公开(公告)日：2007-04-05
申请号：US11541148
申请日：2006-09-28
申请人： Kensaku Sato , Masami Tanaka , Tadashi Kubota , Hideki Sakamoto , Makoto Kobayashi , Satoshi Yamaguchi , Mamoru Hasegawa , Yuichi Shimasaki
发明人： Kensaku Sato , Masami Tanaka , Tadashi Kubota , Hideki Sakamoto , Makoto Kobayashi , Satoshi Yamaguchi , Mamoru Hasegawa , Yuichi Shimasaki
IPC分类号： G01B7/30 , G01B7/14
CPC分类号： G01D5/147
摘要： A pulse signal generator using a magnetic device that can cause a large Barkhausen effect, comprises means having a number of pits and projections and generates pulses according to the behavior of these, the means being capable of moving the pits and projections in a first or second direction, the pits and projections being disposed in the moving direction with some of the projections missing or some of the pits filled. The value of the ratio between the time interval of pulses generated by portions other than a projection-missing portion and the time interval of pulses generated by the projection-missing portion or the value of the ratio between the time interval of pulses generated by portions other than a pit-filled portion and the time interval of pulses generated by the pit-filled portion differs between when the pits and projections move in the first or second direction.

10. 发明授权

US09169520B2 Cancer marker, method for evaluation of cancer by using the cancer marker, and evaluation reagent 有权
标题翻译：癌症标记，通过使用癌症标记物评估癌症的方法和评估试剂
公开(公告)号：US09169520B2
公开(公告)日：2015-10-27
申请号：US14039835
申请日：2013-09-27
申请人： Masahiko Kuroda , Masami Tanaka , Kosuke Oikawa , Takayuki Mizutani , Masakatsu Takanashi , Seiko Iizuka , Yoshinori Kosugi , Kazuma Ohyashiki , Akihiko Tsuchida
发明人： Masahiko Kuroda , Masami Tanaka , Kosuke Oikawa , Takayuki Mizutani , Masakatsu Takanashi , Seiko Iizuka , Yoshinori Kosugi , Kazuma Ohyashiki , Akihiko Tsuchida
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention provides a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject, and an evaluation method using the same. A cancer marker containing at least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as a marker for cancers excluding breast cancer. A method for evaluating the possibility of cancers excluding breast cancer includes the step of detecting the expression level of a cancer marker in a biological sample collected from a subject. In this method, the cancer marker contains at least one miRNA selected from hsa-miR-92 and hsa-miR-494.
摘要翻译：本发明提供了用于评估受试者的癌症的发病，临床前期，临床阶段或预后的新型癌症标志物及其评价方法。使用含有至少一种选自hsa-miR-92和hsa-miR-494的miRNA的癌症标记物作为不包括乳腺癌的癌症的标志物。用于评估除乳腺癌之外的癌症的可能性的方法包括检测从受试者收集的生物样品中癌症标志物的表达水平的步骤。在该方法中，癌标记物含有至少一种选自hsa-miR-92和hsa-miR-494的miRNA。

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