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1. 发明授权

US06197292B1 Therapeutic agent and treatment for canine intractable dermatitis 有权
标题翻译：犬顽固性皮炎的治疗剂和治疗
公开(公告)号：US06197292B1
公开(公告)日：2001-03-06
申请号：US09240004
申请日：1999-01-29
申请人： Tomiya Uchino , Katsushige Yamada , Fumiyoshi Okano , Masahiro Satoh , Isao Kawakami
发明人： Tomiya Uchino , Katsushige Yamada , Fumiyoshi Okano , Masahiro Satoh , Isao Kawakami
IPC分类号： A61K3821
CPC分类号： C07K14/57 , A61K38/00
摘要： The present invention relates to a therapeutic agent, composed of canine interferon-&ggr;, for canine intractable dermatitis and a treatment for canine intractable dermatitis using the agent.
摘要翻译：本发明涉及一种由犬干扰素-γ组成的治疗剂，用于犬难治性皮炎，以及使用该药物治疗犬顽固性皮炎。

2. 发明授权

US5955069A Use of canine interferon-.gamma.(IFN-.gamma.) to treat non-atopic dermatitis 失效
标题翻译：使用犬干扰素-γ（IFN-γ）治疗非特应性皮炎
公开(公告)号：US5955069A
公开(公告)日：1999-09-21
申请号：US1944
申请日：1997-12-31
申请人： Tomiya Uchino , Katsushige Yamada , Fumiyoshi Okano , Masahiro Satoh , Isao Kawakami
发明人： Tomiya Uchino , Katsushige Yamada , Fumiyoshi Okano , Masahiro Satoh , Isao Kawakami
IPC分类号： A61K38/00 , C07K14/57 , C12N15/20 , C12N15/23 , A61K38/21
CPC分类号： C07K14/57 , A61K38/00
摘要： Methods for treating intractable dermatitis in dogs are described. The methods involve the administration by injection of formulations comprising canine interferon-.gamma. and, optionally, other agents. The canine IFN-.gamma. may be produced in recombinant expression systems such as E. coli or B. mori.
摘要翻译：描述了狗治疗难治性皮炎的方法。所述方法包括通过注射包含犬干扰素-γ和任选的其它试剂的制剂进行给药。犬IFN-γ可以在重组表达系统如大肠杆菌或禾谷镰孢中产生。

3. 发明授权

US06231850B1 Canine interleukin 12 失效
标题翻译：犬白细胞介素12
公开(公告)号：US06231850B1
公开(公告)日：2001-05-15
申请号：US09079984
申请日：1998-05-15
申请人： Fumiyoshi Okano , Masahiro Satoh , Katsushige Yamada
发明人： Fumiyoshi Okano , Masahiro Satoh , Katsushige Yamada
IPC分类号： A61K3819
CPC分类号： C07K14/5434 , A61K38/00 , C12N2799/026 , Y10S514/885
摘要： Canine interleukin 12 and a method for producing it by genetic engineering are disclosed. The canine interleukin 12 includes a protein having an amino acid sequence substantially the same as SEQ ID NO:1 or SEQ ID NO:11 or corresponds to part of either of SEQ ID NOS:1 and 11, and a protein having an amino acid sequence substantially the same as SEQ ID NO:2 or SEQ ID NO:12 or corresponds to part of either of SEQ ID NOS:2 and 12, and relates to a production method thereof. There is also an immune disease remedy and preventive agent for dogs and cats containing canine interleukin 12, and a method of treating immune disease and a preventive method for dogs and cats using the immune disease remedy or preventive agent.
摘要翻译：公开了犬白细胞介素12及其遗传工程方法。犬白细胞介素12包括具有与SEQ ID NO：1或SEQ ID NO：11基本相同的氨基酸序列或对应于SEQ ID NO：1和11中的任一个的氨基酸序列的蛋白质，以及具有氨基酸序列基本上与SEQ ID NO：2或SEQ ID NO：12相同或对应于SEQ ID NO：2和12中的任一个的一部分，并且涉及其制备方法。还有一种针对含有犬白介素12的狗和猫的免疫疾病补救和预防剂，以及使用免疫疾病治疗或预防剂治疗免疫疾病的方法和狗和猫的预防方法。

4. 发明授权

US06562334B1 Canine interleukin 12 administration as an immune disease treatment 有权
标题翻译：犬白细胞介素12作为免疫疾病的治疗和预防方法
公开(公告)号：US06562334B1
公开(公告)日：2003-05-13
申请号：US09390729
申请日：1999-09-07
申请人： Fumiyoshi Okano , Masahiro Satoh , Katsushige Yamada
发明人： Fumiyoshi Okano , Masahiro Satoh , Katsushige Yamada
IPC分类号： A61K3819
CPC分类号： C07K14/5434 , A61K38/00 , C12N2799/026 , Y10S514/885
摘要： Canine interleukin 12 and a method for producing it by genetic engineering are disclosed. The canine interleukin 12 includes a protein having an amino acid sequence substantially the same as SEQ ID NO:1 or SEQ ID NO:11 or corresponds to part of either of SEQ ID NOS: 1 and 11, and a protein having an amino acid sequence substantially the same as SEQ ID NO:2 or SEQ ID NO:12 or corresponds to part of either of SEQ ID NOS:2 and 12, and relates to a production method thereof. There is also an immune disease remedy and preventive agent for dogs and cats containing canine interleukin 12, and a method of treating immune disease and a preventive method for dogs and cats using the immune disease remedy or preventive agent.
摘要翻译：公开了犬白细胞介素12及其遗传工程方法。犬白细胞介素12包括具有与SEQ ID NO：1或SEQ ID NO：11基本相同的氨基酸序列或对应于SEQ ID NO：1和11中的任一个的氨基酸序列的蛋白质，以及具有氨基酸序列基本上与SEQ ID NO：2或SEQ ID NO：12相同或对应于SEQ ID NO：2和12中的任一个的一部分，并且涉及其制备方法。还有一种针对含有犬白介素12的狗和猫的免疫疾病补救和预防剂，以及使用免疫疾病治疗或预防剂治疗免疫疾病的方法和狗和猫的预防方法。

5. 发明授权

US06391296B1 Method of stabilizing useful protein and useful protein compositions 有权
标题翻译：稳定有用蛋白质和有用的蛋白质组成的方法
公开(公告)号：US06391296B1
公开(公告)日：2002-05-21
申请号：US09269833
申请日：1999-04-26
申请人： Fumiyoshi Okano , Katsushige Yamada , Masatoshi Watanabe , Naomi Hara , Akira Yanai
发明人： Fumiyoshi Okano , Katsushige Yamada , Masatoshi Watanabe , Naomi Hara , Akira Yanai
IPC分类号： A61K4500
CPC分类号： C07K14/555 , A61K38/00
摘要： A method of stabilizing a useful protein by mixing a useful protein and an aqueous solution of a compound having the basic structure of arabic acid, and a stabilizied useful protein compositon containing a useful protein and a compound having the basic structure of arabic acid; gum arabic is preferred as a compound having the basic structure of arabic acid, and examples of a useful protein include cytokine and interferon; and a production method for canine interferon-&ggr; and stabilization thereof.
摘要翻译：通过混合有用蛋白质和具有阿拉伯酸碱性结构的化合物的水溶液和含有有用蛋白质的稳定化有用蛋白质组合物和具有阿拉伯酸碱性结构的化合物来稳定有用蛋白质的方法; 优选阿拉伯树胶作为具有阿拉伯酸碱性结构的化合物，有用的蛋白质的实例包括细胞因子和干扰素; 以及犬干扰素γ的制造方法及其稳定化。

6. 发明授权

US09796775B2 Method for detecting pancreatic cancer 有权
公开(公告)号：US09796775B2
公开(公告)日：2017-10-24
申请号：US14236807
申请日：2012-08-03
申请人： Takayoshi Ido , Fumiyoshi Okano
发明人： Takayoshi Ido , Fumiyoshi Okano
IPC分类号： A61K39/395 , A61K47/48 , A61K39/00 , A61K35/39 , C07K16/18 , C07K14/47 , G01N33/574 , C07K16/30 , C12Q1/68
CPC分类号： C07K16/18 , C07K14/47 , C07K14/4738 , C07K16/30 , C07K16/303 , C07K2317/34 , C07K2317/56 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/705
摘要： This invention relates to a method for detecting pancreatic cancer using novel tumor markers. Specifically, the invention provides a method for detecting pancreatic cancer comprising measuring the presence or an amount of a polypeptide having an reactivity of binding via an antigen-antibody reaction to an antibody against CAPRIN-1 protein in a sample separated from a subject, and to a reagent or kit for detecting pancreatic cancer comprising a CAPRIN-1 protein or a fragment thereof, an antibody against the same, or a polynucleotide encoding the same.

7. 发明授权

US09504737B2 Immune response inducer 有权
标题翻译：免疫反应诱导剂
公开(公告)号：US09504737B2
公开(公告)日：2016-11-29
申请号：US12739723
申请日：2008-10-23
申请人： Masaki Ishibashi , Fumiyoshi Okano
发明人： Masaki Ishibashi , Fumiyoshi Okano
IPC分类号： A61K39/00 , A61K38/20 , A61K38/21
CPC分类号： A61K39/0011 , A61K38/208 , A61K38/212 , A61K38/215 , A61K2039/53 , A61K2300/00
摘要： An immunity-inducing agent comprising as an effective ingredient a specific polypeptide is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing specifically in serum derived from a cancer-bearing living body. The polypeptides can induce immunity in a living body and cause regression of a tumor in a cancer-bearing living body. Therefore, these polypeptides are especially effective as a therapeutic and/or prophylactic agent for a cancer(s).
摘要翻译：公开了包含特定多肽作为有效成分的免疫诱导剂。通过使用来自犬睾丸的cDNA文库和来自携带癌症的狗的血清的SEREX方法，分离这些多肽作为与存在于来自携带癌的活体的血清中特异性存在的抗体结合的多肽。多肽可以在活体中诱导免疫，并引起携带癌的生物体中的肿瘤消退。因此，这些多肽作为癌症的治疗和/或预防剂是特别有效的。

8. 发明授权

US09273128B2 Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US09273128B2
公开(公告)日：2016-03-01
申请号：US14236793
申请日：2012-08-03
申请人： Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
发明人： Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
IPC分类号： C07K16/30 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/28
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.
摘要翻译：本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。

9. 发明授权

US09180188B2 Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US09180188B2
公开(公告)日：2015-11-10
申请号：US14236795
申请日：2012-08-03
申请人： Shinichi Kobayashi , Fumiyoshi Okano , Yoshitaka Minamida , Takanori Saito
发明人： Shinichi Kobayashi , Fumiyoshi Okano , Yoshitaka Minamida , Takanori Saito
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/732 , A61K2300/00
摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.
摘要翻译：旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

10. 发明申请

US20140178373A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER 有权
公开(公告)号：US20140178373A1
公开(公告)日：2014-06-26
申请号：US14236665
申请日：2012-08-03
申请人： Shinichi Kobayashi , Fumiyoshi Okano , Takanori Saito
发明人： Shinichi Kobayashi , Fumiyoshi Okano , Takanori Saito
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6865 , A61K47/6869 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.

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