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1. 发明授权

US5618735A Fluorescent lipid polymer-macromolecular ligand compositions 失效
标题翻译：荧光脂质聚合物 - 大分子配体组合物
公开(公告)号：US5618735A
公开(公告)日：1997-04-08
申请号：US405549
申请日：1995-03-16
申请人： Tom Saul , Georges Der-Balian , Paul Kenney , Heidi Mathis , Shirley Johnson , Hans Ribi , Tom Witty
发明人： Tom Saul , Georges Der-Balian , Paul Kenney , Heidi Mathis , Shirley Johnson , Hans Ribi , Tom Witty
IPC分类号： G01N33/53 , G01N33/543 , G01N33/545 , G01N33/58 , G01N33/78
CPC分类号： G01N33/54353 , G01N33/54306 , G01N33/545 , G01N33/582 , G01N33/78 , Y10S435/968 , Y10S436/805
摘要： Methods and compositions are provided for the detection of analytes. The method employs a fluorescence production layer which comprises a fluorescent polymerized polyunsaturated lipid layer in association with a ligand which is a member of a specific binding pair, where the ligand is competitive with the analyte for the complementary binding member or is a complementary binding member. By providing for a fluorescence modulation reagent which binds to the fluorescence production layer in proportion to the amount of analyte in the sample, by measuring the resulting fluorescence after carrying out the assay methodology, the amount of analyte can be determined quantitatively.
摘要翻译：提供了检测分析物的方法和组成。该方法使用荧光生产层，其包含与作为特异性结合对成员的配体相结合的荧光聚合多不饱和脂质层，其中配体与用于互补结合成员的分析物竞争或是互补结合成员。通过提供与荧光产生层成比例的荧光调节剂，其与样品中分析物的量成比例，通过在进行测定方法后测量所得到的荧光，可以定量测定分析物的量。

2. 发明申请

US20090269759A1 UNNATURAL POLYMERASE SUBSTRATES THAT CAN SUSTAIN ENZYMATIC SYNTHESIS OF DOUBLE STRANDED NUCLEIC ACIDS FROM A NUCLEIC ACID TEMPLATE AND METHODS OF USE 有权
标题翻译：可以从核酸模板维持双重拉伸的核酸的酶合成和使用方法的UNNATURAL POLYMERASE底物
公开(公告)号：US20090269759A1
公开(公告)日：2009-10-29
申请号：US12355487
申请日：2009-01-16
申请人： Steven M. Menchen, JR. , Barnett Rosenblum , Paul Kenney , Shoeb I. Khan , Zhaochun Ma , Jer-Kang Chen , Joe Lam , Boli Huang
发明人： Steven M. Menchen, JR. , Barnett Rosenblum , Paul Kenney , Shoeb I. Khan , Zhaochun Ma , Jer-Kang Chen , Joe Lam , Boli Huang
IPC分类号： C12Q1/68 , C07F9/02
CPC分类号： C07H21/04 , C07H19/073 , C07H19/173 , C12Q1/6874 , C12Q2523/107 , C12Q2525/186 , C12Q2525/197
摘要： Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3′ hydroxyl group. Methods of sequencing DNA using the substrates are also described.
摘要翻译：描述了可以维持来自核酸模板的双链核酸的酶合成的核苷酸类似物。核苷酸类似物包括：（i）选自腺嘌呤，鸟嘌呤，胞嘧啶，胸腺嘧啶，尿嘧啶及其类似物的碱基; （ii）通过可切割连接体连接到碱基或类似物的标签; （iii）脱氧核糖; 和（iv）一个或多个磷酸酯基团。接头和/或标记物将另外的核苷酸底物的模板定向聚合酶掺入到延伸的引物链上。此外，接头的切割物留下连接到碱基上的残基，其不存在于天然核苷酸中，并且不抑制引物链的延伸。因此，核苷酸类似物因此可以通过合成方法进行测序而不会阻断3'羟基作为可逆终止子。还描述了使用底物测序DNA的方法。

3. 发明授权

US08932813B2 Polymerization of nucleic acids using activation by polyphosphorolysis (APP) reactions 有权
标题翻译：通过多磷酸裂解（APP）反应的活化聚合核酸
公开(公告)号：US08932813B2
公开(公告)日：2015-01-13
申请号：US13324676
申请日：2011-12-13
申请人： Lei (Larry) Xi , Paul Kenney , Zhaochun Ma , Dennis Prosen , Stephen Hendricks , Roland Nagel
发明人： Lei (Larry) Xi , Paul Kenney , Zhaochun Ma , Dennis Prosen , Stephen Hendricks , Roland Nagel
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , C07H21/00 , C07H21/02 , C12N9/1252 , C12N15/10 , C12Q1/6869 , C12Y207/07007
摘要： This disclosure relates to methods of performing activation by polyphosphorolysis (APP) reactions using at least one of the polyphosphorylating agents triphosphate, polyphosphate, imidodiphosphate, thiodiphosphate (or μ-monothiopyrophosphate), and related compounds.
摘要翻译：本公开涉及使用多磷酸盐，多磷酸盐，亚氨基二磷酸盐，硫代磷酸盐（或μ-一硫代焦磷酸盐）和相关化合物中的至少一种进行多磷酸解（APP）反应进行活化的方法。

4. 发明申请

US20120196329A1 POLYMERIZATION OF NUCLEIC ACIDS USING ACTIVATION BY POLYPHOSPHOROLYSIS (APP) REACTIONS 有权
标题翻译：使用多磷酸（APP）反应活化的核酸的聚合
公开(公告)号：US20120196329A1
公开(公告)日：2012-08-02
申请号：US13324676
申请日：2011-12-13
申请人： Lei (Larry) XI , Paul Kenney , Zhaochun Ma , Dennis Prosen , Stephen Hendricks , Roland Nagel
发明人： Lei (Larry) XI , Paul Kenney , Zhaochun Ma , Dennis Prosen , Stephen Hendricks , Roland Nagel
IPC分类号： C12P19/34
CPC分类号： C12Q1/686 , C07H21/00 , C07H21/02 , C12N9/1252 , C12N15/10 , C12Q1/6869 , C12Y207/07007
摘要： This disclosure relates to methods of performing activation by polyphosphorolysis (APP) reactions using at least one of the polyphosphorylating agents triphosphate, polyphosphate, imidodiphosphate, thiodiphosphate (or μ-monothiopyrophosphate), and related compounds.
摘要翻译：本公开涉及使用多磷酸盐，多磷酸盐，亚氨基二磷酸盐，硫代磷酸盐（或μ-一硫代焦磷酸盐）和相关化合物中的至少一种进行多磷酸解（APP）反应进行活化的方法。

5. 发明授权

US11107322B1 No rake platform 有权
公开(公告)号：US11107322B1
公开(公告)日：2021-08-31
申请号：US16739915
申请日：2020-01-10
申请人： Paul Kenney
发明人： Paul Kenney
IPC分类号： G07F17/32
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for implementing no rake line wagering. In one aspect, a method includes accessing rake line data for an event. The accessed rake line data is converted into a no rake line. The no rake line is published to a wagering platform accessible by multiple members. The wagering platform includes multiple separate wagering groups that each include multiple members. At a pre-specified time relative to a start time of the sports event, locking any wagers made within a particular group based on the no rake line. An outcome of the sporting event is obtained. From among the wagers, winning wagers and losing wagers in the particular group are determined based on the outcome of the sports event and the no rake line. Accounts of the members in the particular group that wagered on the sporting event are updated.

6. 发明授权

US08058414B2 Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use 有权
标题翻译：可以维持来自核酸模板的双链核酸酶的合成和使用方法的非天然聚合酶底物
公开(公告)号：US08058414B2
公开(公告)日：2011-11-15
申请号：US12355487
申请日：2009-01-16
申请人： Steven Menchen , Barnett Rosenblum , Paul Kenney , Shoeb Khan , Zhaochun Ma , Jer-Kang Chen , Joe Y. Lam , Boli Huang
发明人： Steven Menchen , Barnett Rosenblum , Paul Kenney , Shoeb Khan , Zhaochun Ma , Jer-Kang Chen , Joe Y. Lam , Boli Huang
IPC分类号： C07G3/00 , C07H21/02 , C07H21/04 , C07H19/04 , C12Q1/68 , C12P19/34
CPC分类号： C07H21/04 , C07H19/073 , C07H19/173 , C12Q1/6874 , C12Q2523/107 , C12Q2525/186 , C12Q2525/197
摘要： Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3′ hydroxyl group. Methods of sequencing DNA using the substrates are also described.
摘要翻译：描述了可以维持来自核酸模板的双链核酸的酶合成的核苷酸类似物。核苷酸类似物包括：（i）选自腺嘌呤，鸟嘌呤，胞嘧啶，胸腺嘧啶，尿嘧啶及其类似物的碱基; （ii）通过可切割连接体连接到碱基或类似物的标签; （iii）脱氧核糖; 和（iv）一个或多个磷酸酯基团。接头和/或标记物将另外的核苷酸底物的模板定向聚合酶掺入到延伸的引物链上。此外，接头的切割物留下连接到碱基上的残基，其不存在于天然核苷酸中，并且不抑制引物链的延伸。因此，核苷酸类似物因此可以通过合成方法进行测序而不会阻断3'羟基作为可逆终止子。还描述了使用底物测序DNA的方法。

7. 发明申请

US20080071070A1 Reagents Useful for Synthesizing Rhodamine-Labeled Oligonucleotides 有权
标题翻译：用于合成罗丹明标记的寡核苷酸的试剂
公开(公告)号：US20080071070A1
公开(公告)日：2008-03-20
申请号：US11695548
申请日：2007-04-02
申请人： Scott Benson , Ruiming Zou , Krishna Upadhya , Paul Kenney , Jonathan Cassel
发明人： Scott Benson , Ruiming Zou , Krishna Upadhya , Paul Kenney , Jonathan Cassel
IPC分类号： C07H19/06 , C07D491/22 , C07H19/16 , C07H21/00 , C07D493/10
CPC分类号： C07F9/6561 , C07D311/96 , C07F9/2408 , C07F9/242 , C07F9/650952 , C07F9/65312 , C07F9/65515 , C07H19/04 , C07H21/04 , C09B11/24
摘要： The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
摘要翻译：本公开提供可用于使用含有罗丹明染料的罗丹明染料或染料网络来标记合成寡核苷酸的试剂。

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