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    • 6. 发明授权
    • Streptomyces spectabilis strains employed for producing streptovaricin C
    • 用于产生链脲霉素C的链霉菌属菌株
    • US5266484A
    • 1993-11-30
    • US872518
    • 1992-04-23
    • Kaname InoueMotohide YamazakiKanji MurofushiRichard W. Armentrout
    • Kaname InoueMotohide YamazakiKanji MurofushiRichard W. Armentrout
    • C12P17/18C12R1/465C12P17/08
    • C12R1/465C12P17/18Y10S435/803Y10S435/886
    • Disclosed is a method for selecting a mutant strain belonging to the genus Streptomyces which is a hyper-producer of Streptovaricin C superior to those know heretofore. This is accomplished by first subjecting a natural strain of Streptomyces spectabilis to conditions so as to isolate organisms which are streptovaricin resistant. The streptovaricin resistant organisms thus isolated are then subjected to mutagenesis and then cultured. The colonies which are asporogenous are individually cultured in fermentation batches such that the strains take the form of pellets of varying sizes and colors. From the batch having the most heterogeneous mixture of pellets, the smallest pellet or the pellet(s) having the deepest color (usually deep red or crimson) is isolated. We have discovered that the strain of this pellet has a high likelihood of being a hyperproducer of streptovaricin. The strain of this pellet may then be subjected to fermentation conditions to produce streptovaricin. The nutrient broth containing fumaric acid or water-soluble salts thereof, and adsorbent polymer beads and the streptovaricin produced are recovered in the usual manner. In another embodiment, the fermentation may be carried out in a nutrient broth wherein fumaric acid or its water-soluble salts are deliberately excluded to achieve even higher productivity.
    • 公开了一种选择属于链霉菌属(Streptomyces)属的突变菌株的方法,其是链节链球菌C的超级生产者,其比迄今所知道的更高。 这是通过首先对天然链霉菌链霉菌进行条件来分离的,以分离链霉素抗性的生物体。 然后将如此分离的链脲霉素抗性生物体进行诱变,然后进行培养。 在发酵批次中单独培养异源菌落,使得菌株呈不同大小和颜色的颗粒的形式。 从具有最不均匀的颗粒混合物的批料中,分离出具有最深颜色(通常深红色或深红色)的最小颗粒或颗粒。 我们已经发现,这种颗粒的菌株很可能成为链球菌素的超生产菌。 然后可以将该颗粒的菌株进行发酵条件以产生链脲霉素。 以通常的方式回收含有富马酸或其水溶性盐的营养液,以及生成的吸附性聚合物珠粒和链球菌素。 在另一个实施方案中,发酵可以在营养肉汤中进行,其中富马酸或其水溶性盐被有意排除以达到更高的生产率。
    • 10. 发明授权
    • Process for producing vinyl chloride polymer in the presence of a chelating agent
    • 在螯合剂存在下生产氯乙烯聚合物的方法
    • US06355743B1
    • 2002-03-12
    • US09410628
    • 1999-10-01
    • Makoto OouraKaname InoueMasakuni YamamotoTadashi Amano
    • Makoto OouraKaname InoueMasakuni YamamotoTadashi Amano
    • C08F220
    • C08F2/004B01J19/18B01J2219/00081
    • In a process for producing vinyl chloride polymers including polymerization of vinyl chloride or a monomer mixture containing it in an aqueous medium using a polymerization initiator, the polymerization is carried out in the presence of a chelating agent. The chelating agent is capable of chelating iron (II) and iron (III). This process makes it possible to prevent polymer scales from adhering to, e.g. baffle surfaces facing inner walls of the polymerization vessel, which has been hitherto difficult to do so, and less cause initial discoloration of polymer products to improve quality. It is more effective to use a polymerization vessel previously provided with coating films of a polymer scale preventive agent on the inner walls of the polymerization vessel and the other portions with which monomers come into contact in the course of polymerization.
    • 在使用聚合引发剂的含水介质中使用氯乙烯聚合或含有它们的单体混合物的氯乙烯聚合物的制造方法中,在螯合剂的存在下进行聚合。 螯合剂能够螯合铁(II)和铁(III)。 该方法使得可以防止聚合物垢附着到例如 面对迄今为止难以做到的聚合容器的内壁的挡板表面,并且较少导致聚合物产品的初始变色以改善质量。 在聚合容器的内壁和聚合反应过程中单体接触的其它部分使用预先设有聚合物防垢剂的涂膜的聚合容器更为有效。