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1. 发明申请

US20050215832A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE NITROALCOHOLS 失效
标题翻译：生产光学活性硝基醇的方法
公开(公告)号：US20050215832A1
公开(公告)日：2005-09-29
申请号：US10979795
申请日：2004-11-02
申请人： Tohru Yamada , Taketo Ikeno
发明人： Tohru Yamada , Taketo Ikeno
IPC分类号： C07C201/12 , C07B53/00 , C07B61/00 , C07C205/14 , C07C205/15 , C07C205/16 , C07C205/26 , C07C205/28 , C07C205/37 , C07C25/14
CPC分类号： C07C201/12 , C07B2200/07 , C07C2601/14 , C07C205/15 , C07C205/16 , C07C205/26 , C07C205/37
摘要： The present invention relates to a process for producing optically active β-nitroalcohols wherein nitroaldol reactions of aldehydes and nitroalkanes are carried out in the presence of a base and an optically active metal complex catalyst represented by the following formula (c): (where R4, R5, and R6 represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an acyl group, an alkoxycarbonyl group, or an aryloxycarbonyl group, and R5 and R6 may be linked together to form a ring; X* represents a hydrocarbon group having an asymmetric carbon atom or axial asymmetry; M represents a cobalt ion or a chromium ion; and Y represents an anion capable of forming a salt when the valence of M is larger than that of a ligand).
摘要翻译：本发明涉及一种制备光学活性β-硝基醇的方法，其中醛和硝基烷烃的硝基醛反应在碱存在下进行，和由下式（c）表示的光学活性金属络合物催化剂进行：（其中R' O 4，R 5，R 6和R 6表示氢原子，烷基，烯基，芳基，酰基，烷氧基羰基或芳氧基羰基，R 5和R 6可以连接在一起以形成环; X *表示烃基具有不对称碳原子或轴向不对称; M表示钴离子或铬离子; Y表示当M的化合价大于配体的化合价时能形成盐的阴离子）。

2. 发明授权

US06977315B2 Process for producing optically active nitroalcohols 失效
标题翻译：光学活性硝基醇的制备方法
公开(公告)号：US06977315B2
公开(公告)日：2005-12-20
申请号：US10979795
申请日：2004-11-02
申请人： Tohru Yamada , Taketo Ikeno
发明人： Tohru Yamada , Taketo Ikeno
IPC分类号： C07C201/12 , C07B53/00 , C07B61/00 , C07C205/14 , C07C205/15 , C07C205/16 , C07C205/26 , C07C205/28 , C07C205/37 , C07L205/00
CPC分类号： C07C201/12 , C07B2200/07 , C07C2601/14 , C07C205/15 , C07C205/16 , C07C205/26 , C07C205/37
摘要： The present invention relates to a process for producing optically active β-nitroalcohols wherein nitroaldol reactions of aldehydes and nitroalkanes are carried out in the presence of a base and an optically active metal complex catalyst represented by the following formula (c): (where R4, R5, and R6 represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an acyl group, an alkoxycarbonyl group, or an aryloxycarbonyl group, and R5 and R6 may be linked together to form a ring; X* represents a hydrocarbon group having an asymmetric carbon atom or axial asymmetry; M represents a cobalt ion or a chromium ion; and Y represents an anion capable of forming a salt when the valence of M is larger than that of a ligand).
摘要翻译：本发明涉及一种制备光学活性β-硝基醇的方法，其中醛和硝基烷烃的硝基醛反应在碱存在下进行，和由下式（c）表示的光学活性金属络合物催化剂进行：（其中R' O 4，R 5，R 6和R 6表示氢原子，烷基，烯基，芳基，酰基，烷氧基羰基或芳氧基羰基，R 5和R 6可以连接在一起形成环; X *表示具有不对称碳原子或轴向的烃基不对称; M表示钴离子或铬离子; Y表示当M的化合价大于配体的价数时能形成盐的阴离子）。

3. 发明授权

US08530635B2 Cupredoxin derived transport agents and methods of use thereof 有权
公开(公告)号：US08530635B2
公开(公告)日：2013-09-10
申请号：US13531832
申请日：2012-06-25
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Arsenio Fialho
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Arsenio Fialho
IPC分类号： C07H21/02 , C07H21/04 , A61K49/00
CPC分类号： C07K14/28 , A61K35/13 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/164 , A61K45/06 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/221 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K2319/02
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.

4. 发明授权

US08232244B2 Compositions and methods to prevent cancer with cupredoxins 有权
标题翻译：用氧化还原铁预防癌症的组合物和方法
公开(公告)号：US08232244B2
公开(公告)日：2012-07-31
申请号：US12028683
申请日：2008-02-08
申请人： Tapas Das Gupta , Ananda Chakrabarty , Craig Beattie , Tohru Yamada
发明人： Tapas Das Gupta , Ananda Chakrabarty , Craig Beattie , Tohru Yamada
IPC分类号： C07K14/00
CPC分类号： A61K38/164 , A61K38/00 , A61K47/549 , A61K47/64 , A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/14 , A61M5/00 , B82Y5/00 , C07K14/00 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C07K14/415 , C12Q1/025 , C12Q1/04
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译：本发明公开了将货物化合物输送到癌细胞中的方法和材料。货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。货物化合物可以是核酸，特别是DNA，RNA或反义词。本发明还公开了治疗癌症和诊断癌症的方法。

5. 发明授权

US07795410B2 Compositions and methods for treating HIV infection with cupredoxin and cytochrome c 有权
标题翻译：用氧还蛋白和细胞色素c治疗HIV感染的组合物和方法
公开(公告)号：US07795410B2
公开(公告)日：2010-09-14
申请号：US12398708
申请日：2009-03-05
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
IPC分类号： C07H21/02 , C12N15/63
CPC分类号： C12Q1/18 , A61K38/00 , C12N9/0004 , G01N2333/16 , G01N2500/10 , Y02A50/386 , Y02A50/466
摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
摘要翻译：本发明涉及铜绿假单胞菌，特别是铜绿假单胞菌azurin和/或铜绿假单胞菌细胞色素c551及其在抑制病毒感染中的用途，特别是人类免疫缺陷病毒（HIV）感染哺乳动物细胞。本发明还涉及保留抑制病毒感染的能力，特别是人类免疫缺陷病毒（HIV）的感染的铜氧还蛋白和细胞色素C的变体和衍生物。本发明还涉及用于研究哺乳动物细胞中病毒和细菌感染的研究方法。

6. 发明申请

US20090250728A1 SOLID STATE IMAGING DEVICE AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：固态成像装置及其制造方法
公开(公告)号：US20090250728A1
公开(公告)日：2009-10-08
申请号：US12416506
申请日：2009-04-01
申请人： Ikuo Mizuno , Tohru Yamada
发明人： Ikuo Mizuno , Tohru Yamada
IPC分类号： H01L27/148 , H01L21/28
CPC分类号： H01L27/14818
摘要： A solid state imaging device has a plurality of photodetector parts 11 arranged in matrix, a plurality of vertical charge transfer electrodes 13 that read out signal charge from the photodetector parts and transfer the signal charge in the vertical direction, and a first light-shielding film 5 that shields the plural vertical charge transfer parts from incident light. Each of the vertical charge transfer electrodes includes: a transfer channel 12 provided along the vertical array of the plural photodetector parts, a plurality of first transfer electrodes 3a that are formed on the transfer channel so as to traverse the transfer channel and that is coupled in the horizontal direction in spacing between the photodetector parts; and second transfer electrodes 3b provided on the transfer channel and arranged between the first transfer electrodes. The first light-shielding film is formed continuously in the horizontal direction and has openings formed on the photodetector parts. Isolation regions having electroconductivity are formed between the photodetector parts and connected electrically to the second transfer electrode. Thereby, a shunt wiring structure capable of a high-speed transfer at a high sensitivity and with reduced smearing is obtained.
摘要翻译：固态成像装置具有多个以矩阵形式布置的光电检测器部分11，多个垂直电荷转移电极13，其从光电检测器部分读出信号电荷并在垂直方向上传送信号电荷;以及第一遮光膜 5从入射光屏蔽多个垂直电荷转移部分。每个垂直电荷转移电极包括：沿着多个光电检测器部分的垂直阵列设置的传输通道12，多个第一传输电极3a，其形成在传送通道上，以穿过传输通道并耦合在光电检测器部分之间的间隔的水平方向; 以及设置在传送通道上并布置在第一传输电极之间的第二传输电极3b。第一遮光膜在水平方向上连续地形成并且在光电检测器部分上形成有开口。在光检测器部分之间形成具有导电性的隔离区，并与第二转印电极电连接。由此，可以获得能够以高灵敏度高速转印并且减少拖尾的并联布线结构。

7. 发明授权

US07541631B2 Solid-state imaging device 失效
标题翻译：固态成像装置
公开(公告)号：US07541631B2
公开(公告)日：2009-06-02
申请号：US11854077
申请日：2007-09-12
申请人： Tohru Yamada , Michiyo Ichikawa , Mamoru Honjo , Atsuo Nakagawa
发明人： Tohru Yamada , Michiyo Ichikawa , Mamoru Honjo , Atsuo Nakagawa
IPC分类号： H01L31/062 , H01L31/113
CPC分类号： H01L27/14837 , H01L27/14812
摘要： A solid-state imaging device including: a plurality of photodiode parts (1); a plurality of vertical charge transfer parts (2) each of which reads out a signal charge and transfers the signal charge in a vertical direction; and a plurality of shade films (5) that have conductivity, which supplies a transfer pulse via the shade film (5), is used. The vertical charge transfer parts (2) respectively have transfer channels (13) and transfer electrodes (3). The shade film (5) is formed above the corresponding vertical charge transfer part (2) via an insulation layer (21) that insulates the shade film (5) from the transfer electrodes (3). The insulation layer (21) has a thick part (8) in a part of the insulation layer (21) where the shade film (5) is overlapped on a side of the photodiode part (1) that is a subject to be read out by the vertical charge transfer part (2).
摘要翻译：一种固态成像装置，包括：多个光电二极管部分（1）; 多个垂直电荷转移部分（2），每个垂直电荷转移部分（2）读出信号电荷并在垂直方向上传送信号电荷; 并且使用具有导电性的多个遮光膜（5），其通过遮光膜（5）提供转印脉冲。垂直电荷转移部分（2）分别具有转移通道（13）和转移电极（3）。遮光膜（5）通过使遮光膜（5）与转印电极（3）绝缘的绝缘层（21）形成在相应的垂直电荷转移部分（2）的上方。绝缘层（21）在绝缘层（21）的一部分中具有厚度部分（8），其中遮光膜（5）重叠在作为待读取对象的光电二极管部分（1）的一侧通过垂直电荷转移部分（2）。

8. 发明申请

US20080131873A1 COMPOSITIONS AND METHODS FOR TREATING HIV INFECTION WITH CUPREDOXIN AND CYTOCHROME C 有权
标题翻译：用丙泊酚和细胞色素C治疗艾滋病毒感染的组合物和方法C
公开(公告)号：US20080131873A1
公开(公告)日：2008-06-05
申请号：US11943034
申请日：2007-11-20
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
IPC分类号： C12Q1/70
CPC分类号： C12Q1/18 , A61K38/00 , C12N9/0004 , G01N2333/16 , G01N2500/10 , Y02A50/386 , Y02A50/466
摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
摘要翻译：本发明涉及铜绿假单胞菌，特别是铜绿假单胞菌azurin，和/或绿脓假单胞菌细胞色素c551及其在抑制病毒感染中的用途，特别是人免疫缺陷病毒（HIV）感染哺乳动物细胞）。本发明还涉及保留抑制病毒感染的能力，特别是人类免疫缺陷病毒（HIV）的感染的铜氧还蛋白和细胞色素C的变体和衍生物。本发明还涉及用于研究哺乳动物细胞中病毒和细菌感染的研究方法。

9. 发明申请

US20060251669A1 Compositions and methods for treating malaria with cupredoxin and cytochrome 有权
标题翻译：用氧还蛋白和细胞色素治疗疟疾的组合物和方法
公开(公告)号：US20060251669A1
公开(公告)日：2006-11-09
申请号：US11436590
申请日：2006-05-19
申请人： Ananda Chakrabarty , Tapas Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Hong
发明人： Ananda Chakrabarty , Tapas Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Hong
IPC分类号： A61K38/44 , A61K39/00 , C12N9/02
CPC分类号： C07K14/195 , A61K38/00 , C07K14/35 , C07K14/80 , C12N9/0006
摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.
摘要翻译：本发明涉及氧还蛋白和细胞色素及其分别或一起用于抑制哺乳动物红细胞和其他感染疟原虫的组织中寄生虫血症的扩散，特别是恶性疟原虫人红细胞的寄生虫血症。本发明提供了分离的肽，其是铜氧还蛋白或细胞色素c的变体，衍生物或结构等同物，以及可用于治疗或预防哺乳动物疟疾感染的铜氧还蛋白和/或细胞色素c或其变体，衍生物或其结构等同物的组合物。此外，本发明提供了治疗哺乳动物患者预防或抑制哺乳动物疟疾感染生长的方法。本发明还提供了防止昆虫载体中疟疾感染生长的方法。

10. 发明授权

US5895944A Charge coupled device image sensor and method of driving the same 失效
标题翻译：电荷耦合器件图像传感器及其驱动方法
公开(公告)号：US5895944A
公开(公告)日：1999-04-20
申请号：US963928
申请日：1997-11-04
申请人： Tohru Yamada
发明人： Tohru Yamada
IPC分类号： H01L21/339 , H01L27/148 , H01L29/762 , H01L29/768
CPC分类号： H01L27/14843 , H01L27/14812
摘要： There is provided an imager sensor including a semiconductor substrate, a plurality of photodiode regions arranged on the semiconductor substrate in row and column directions, a plurality of charge transfer regions each disposed at a space between the photodiode regions in the row direction, the charge transfer regions transferring in the row direction signal charges generated from the photodiode regions, and an electrically conductive photoshield film covering the charge transfer regions therewith. Each of the charge transfer regions includes at least three independent transfer electrodes per a photodiode region. At least one of the three independent transfer electrodes is surrounded by the photodiode region to thereby have an isolated island shape, the rest of the transfer electrodes extend through a space between the photodiode regions in the column direction, and make electrical connection with a bus line disposed outside the semiconductor substrate. The electrically conductive photoshield film makes electrical connection with both the island-shaped transfer electrodes and the bus line. The image sensor has the less number of steps and more excellent optical characteristics than conventional ones.
摘要翻译：提供一种成像传感器，其包括半导体衬底，在行和列方向上布置在半导体衬底上的多个光电二极管区域，多个电荷转移区域，各自设置在行方向上的光电二极管区域之间的空间，电荷转移在行方向上传输信号的区域从光电二极管区域产生的电荷以及覆盖电荷转移区域的导电性遮光膜。每个电荷转移区域每个光电二极管区域包括至少三个独立的转移电极。三个独立转移电极中的至少一个被光电二极管区域包围，从而具有孤立的岛状，其余的转移电极在列方向上延伸穿过光电二极管区域之间的空间，并与总线电连接设置在半导体衬底之外。导电性遮光膜与岛状转印电极和总线线路电连接。图像传感器具有比传统的更少的步数和更优异的光学特性。

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