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1. 发明授权

US06635439B2 Hydrogen peroxide indicator employing enzyme and dye 有权
公开(公告)号：US06635439B2
公开(公告)日：2003-10-21
申请号：US09745212
申请日：2000-12-21
申请人： Todd Morrison , Veronica V. Thralls , Franklin A. Jurik
发明人： Todd Morrison , Veronica V. Thralls , Franklin A. Jurik
IPC分类号： C12Q128
CPC分类号： G01N31/228 , A61L2/28 , C12Q1/22 , C12Q1/28 , G01N21/8483
摘要： A method for determining exposure of a test sample to hydrogen peroxide in an atmosphere includes placing a substrate into the atmosphere, contacting the substrate with the hydrogen peroxide, reacting the hydrogen peroxide with a dye intermediate to produce a chromophore indicative of the integrated exposure of hydrogen peroxide in the atmosphere; and correlating the chromophore to the integrated exposure of hydrogen peroxide in the atmosphere. The dye intermediate may be a dye-couple of 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) and 3-dimethylaminobenzoic acid (DMAB). The intensity of the chromophore is indicative of an integrated hydrogen peroxide exposure.

2. 发明授权

US6162397A Visual blood glucose test strip 有权
公开(公告)号：US6162397A
公开(公告)日：2000-12-19
申请号：US133857
申请日：1998-08-13
申请人： Franklin A. Jurik , Andrea Stubbs , Mimi Diemmy Dao , Carol Chang
发明人： Franklin A. Jurik , Andrea Stubbs , Mimi Diemmy Dao , Carol Chang
IPC分类号： C12Q1/26 , G01N31/22 , G01N33/52 , G01N33/66
CPC分类号： G01N33/523 , G01N33/66 , Y10T436/144444
摘要： A visual blood glucose test strip has two membranes that each incorporate a reagent that reacts with glucose in a blood sample applied to the membranes to cause a color change. One of the membranes also includes an inhibitor and a dye. A blood sample applied to the strip causes the two membranes to form two different colors. Comparing the colors to a calibrated color chart permits a user to determine the glucose concentration in the blood sample.

3. 发明授权

US06572822B2 Visual blood glucose test strip 有权
公开(公告)号：US06572822B2
公开(公告)日：2003-06-03
申请号：US10210119
申请日：2002-08-01
申请人： Franklin A. Jurik , Andrea Stubbs , Mimi Diemmy Dao , Carol Chang
发明人： Franklin A. Jurik , Andrea Stubbs , Mimi Diemmy Dao , Carol Chang
IPC分类号： G01N3122
CPC分类号： G01N33/523 , G01N33/66 , Y10T436/144444
摘要： A visual blood glucose test strip has two membranes that each incorporate a reagent that reacts with glucose in a blood sample applied to the membranes to cause a color change. One of the membranes also includes an inhibitor and a dye. A blood sample applied to the strip causes the two membranes to form two different colors. Comparing the colors to a calibrated color chart permits a user to determine the glucose concentration in the blood sample.

4. 发明授权

US06531322B1 Visual blood glucose test strip 有权
公开(公告)号：US06531322B1
公开(公告)日：2003-03-11
申请号：US09724142
申请日：2000-11-27
申请人： Franklin A. Jurik , Andrea Stubbs , Mimi Diemmy Dao , Carol Chang
发明人： Franklin A. Jurik , Andrea Stubbs , Mimi Diemmy Dao , Carol Chang
IPC分类号： G01N3300
CPC分类号： G01N33/523 , G01N33/66 , Y10T436/144444
摘要： A visual blood glucose test strip has two membranes that each incorporate a reagent that reacts with glucose in a blood sample applied to the membranes to cause a color change. One of the membranes also includes an inhibitor and a dye. A blood sample applied to the strip causes the two membranes to form two different colors. Comparing the colors to a calibrated color chart permits a user to determine the glucose concentration in the blood sample.

5. 发明授权

US06268162B1 Reflectance measurement of analyte concentration with automatic initiation of timing 失效
标题翻译：分析物浓度的反射测量自动启动时序
公开(公告)号：US06268162B1
公开(公告)日：2001-07-31
申请号：US09323442
申请日：1999-05-28
申请人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
发明人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
IPC分类号： C12Q154
CPC分类号： G01N21/8483 , C12Q1/54 , G01N21/314 , G01N21/4738 , G01N33/52 , G01N33/521 , G01N33/523 , G01N33/66 , G01N35/1016 , G01N2021/4757 , G06F19/00 , Y02A90/26 , Y10S435/805 , Y10S435/808 , Y10S435/81 , Y10T436/112499 , Y10T436/144444
摘要： A method for measuring analyte concentration in a body fluid involves taking reflectance readings from a first surface of a porous reagent-containing matrix both before and after a sample of the fluid has been applied to a second surface of the matrix. A sequence of reflectance measurements is initiated upon a predetermined drop in reflectance, which indicates that sample has reached the first surface. The analyte concentration is calculated from the sequence of reflectance measurements.
摘要翻译：用于测量体液中的分析物浓度的方法包括在将流体样品施加到基质的第二表面之前和之后从含多孔试剂的基质的第一表面获取反射读数。反射率测量序列在预定的反射率下降开始，这表明样品已经到达第一表面。从反射率测量的顺序计算分析物浓度。

6. 发明授权

US5563042A Whole blood glucose test strip 失效
标题翻译：全血糖测试条
公开(公告)号：US5563042A
公开(公告)日：1996-10-08
申请号：US408064
申请日：1995-03-21
申请人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
发明人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
IPC分类号： C12M1/34 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N21/31 , G01N21/78 , G01N21/86 , G01N33/52 , G01N33/66 , G01N35/10 , G01N21/00 , G01N21/77
CPC分类号： G01N21/8483 , C12Q1/54 , G01N33/52 , G01N33/521 , G01N33/523 , G01N33/66 , G01N2021/4757 , G01N21/314 , G01N21/4738 , G01N35/1016 , Y10S435/805 , Y10S435/808 , Y10S435/81 , Y10T436/112499 , Y10T436/144444
摘要： A whole blood glucose test strip for measuring glucose in an unmeasured whole blood sample which does not require removal of excess sample, and which is adapted for use in a reflectance reading apparatus which measures reflectance at about 635 nm and about 700 nm, the test strip comprising a handle having an aperture defined therein; and a porous, hydrophilic matrix disposed over the aperture such that one surface of the matrix is exposed to the atmosphere adjacent to one side of the strip and the other surface of the matrix is exposed to the atmosphere on the other side of the strip through the aperture, one of the surfaces being an upper sample receiving surface adapted to receive the whole blood sample on one side of the matrix and the second of the surfaces being a lower testing surface from which diffuse reflected light is measurable, the testing surface being opposite to the sample receiving surface. The matrix allows the blood color of the blood sample to be observed from the testing surface, allows at least a portion of the blood sample to penetrate through the matrix from the sample receiving surface to the testing surface, and filters out red blood cells such that they do not reach the testing surface. The matrix comprises reagent means for chemically reacting with glucose to create a change in reflectance which is indicative of the concentration of glucose present in the sample.
摘要翻译：用于测量未测量的全血样品中的葡萄糖的全血糖测试条，其不需要去除多余的样品，并且适用于在约635nm和约700nm处测量反射率的反射率读数设备中使用的测试条包括具有限定在其中的孔的手柄; 以及设置在所述孔上的多孔亲水基体，使得所述基体的一个表面暴露于邻近所述带的一侧的大气，并且所述基体的另一表面通过所述带的另一面暴露于所述带的另一侧上的大气孔，其中一个表面是上样品接收表面，适于在基质的一侧接收全血样本，第二表面是可测量漫反射光的下测试表面，测试表面与样品接收面。基质允许从测试表面观察血液样品的血液颜色，允许血液样品的至少一部分从样品接收表面穿透基质到测试表面，并过滤出红细胞，使得它们没有到达测试面。该基质包括用于与葡萄糖化学反应以产生反映性变化的试剂装置，其指示样品中存在的葡萄糖的浓度。

7. 发明授权

US06821483B2 Reagents test strip with alignment notch 失效
标题翻译：试剂条带有对准凹口
公开(公告)号：US06821483B2
公开(公告)日：2004-11-23
申请号：US10179064
申请日：2002-06-24
申请人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
发明人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
IPC分类号： G01N2100
CPC分类号： G01N21/8483 , C12Q1/54 , G01N21/314 , G01N21/4738 , G01N33/52 , G01N33/521 , G01N33/523 , G01N33/66 , G01N35/1016 , G01N2021/4757 , G06F19/00 , Y02A90/26 , Y10S435/805 , Y10S435/808 , Y10S435/81 , Y10T436/112499 , Y10T436/144444
摘要： A reagent test strip for use in an apparatus for determining a blood glucose concentration of a sample of whole blood, the apparatus having optics for detecting intensity of light reflected from a reading surface portion of the reagent test strip. The reagent test strip includes a sample receiving surface portion for receiving an unmetered whole blood sample, a reading surface portion, other than the sample receiving surface portion, from which reflectance is read by the apparatus: and a notch for aligning the reagent test strip in the apparatus.
摘要翻译：一种用于确定全血样品的血糖浓度的装置中的试剂测试条，该装置具有用于检测从试剂测试条的读取表面部分反射的光强度的光学元件。试剂试片包括用于接收未测量的全血样品的样品接收表面部分，除了样品接收表面部分之外的读取表面部分，该装置读取反射率;以及凹口，用于将试剂测试条对准该装置。

8. 发明授权

US06489133B2 Apparatus for determinating the concentration of glucose in whole blood 失效
标题翻译：用于测定全血中葡萄糖浓度的装置
公开(公告)号：US06489133B2
公开(公告)日：2002-12-03
申请号：US09784993
申请日：2001-02-15
申请人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
发明人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
IPC分类号： C12Q154
CPC分类号： G01N21/8483 , C12Q1/54 , G01N21/314 , G01N21/4738 , G01N33/52 , G01N33/521 , G01N33/523 , G01N33/66 , G01N35/1016 , G01N2021/4757 , G06F19/00 , Y02A90/26 , Y10S435/805 , Y10S435/808 , Y10S435/81 , Y10T436/112499 , Y10T436/144444
摘要： A method for determining the presence of an analyte in a fluid is described along with various components of an apparatus specifically designed to carry out the method. The method involves taking a reflectance reading from one surface of an inert porous matrix impregnated with a reagent that will interact with the analyte to produce a light-absorbing reaction product when the fluid being analyzed is applied to another surface and migrates through the matrix to the surface being read. Reflectance measurements are made at two separate wavelengths in order to eliminate interferences, and a timing circuit is triggered by an initial decrease in reflectance by the wetting of the surface whose reflectance is being measured by the fluid which passes through the inert matrix. Repeatability is insured by a normalization technique performed on the light source before each reading, and an alignment method operated on the reagent strip prior to emplacement on the apparatus. The method and apparatus are particularly suitable for the measurement of flucose levels in blood without requiring separation of red blood cells from serum or plasma.
摘要翻译：描述了用于确定流体中分析物的存在的方法以及专门设计用于执行该方法的设备的各种组件。该方法包括从被分析物相互作用的试剂浸渍的惰性多孔基质的一个表面获取反射率读数，以便当将被分析的流体施加到另一表面并通过基质迁移到表面被读取。在两个分开的波长处进行反射测量以消除干扰，并且定时电路由反射率的初始降低由反射率通过通过惰性基质的流体测量的表面的润湿而触发。通过在每次读取之前在光源上执行的归一化技术来保证重复性，以及在放置在设备上之前在试剂条上操作的对准方法。该方法和装置特别适用于测量血液中的血液水平，而不需要从血清或血浆中分离出红细胞。

9. 发明授权

US5968760A Temperature-Independent Blood Glucose Measurement 失效
标题翻译：温度独立血糖测量
公开(公告)号：US5968760A
公开(公告)日：1999-10-19
申请号：US965745
申请日：1997-11-07
申请人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
发明人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
IPC分类号： C12M1/34 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N21/31 , G01N21/78 , G01N21/86 , G01N33/52 , G01N33/66 , G01N35/10
CPC分类号： G01N21/8483 , C12Q1/54 , G01N33/52 , G01N33/521 , G01N33/523 , G01N33/66 , G01N2021/4757 , G01N21/314 , G01N21/4738 , G01N35/1016 , Y10S435/805 , Y10S435/808 , Y10S435/81 , Y10T436/112499 , Y10T436/144444
摘要： A method for determining the presence of an analyte in a fluid is described along with various components of an apparatus specifically designed to carry out the method. The method involves taking a reflectance reading from one surface of an inert porous matrix impregnated with a reagent that will interact with the analyte to produce a light-absorbing reaction product when the fluid being analyzed is applied to another surface and migrates through the matrix to the surface being read. Reflectance measurements are made at two separate wavelengths in order to eliminate interferences, and a timing circuit is triggered by an initial decrease in reflectance by the wetting of the surface whose reflectance is being measured by the fluid which passes through the inert matrix. Repeatability in insured by a normalization technique performed on the light source before each reading, and an alignment method operated on the reagent strip prior to emplacement on the apparatus. The method and apparatus are particularly suitable for tho measurement of flucose levels in blood without requiring separation of red blood cells from serum or plasma.
摘要翻译：描述了用于确定流体中分析物的存在的方法以及专门设计用于执行该方法的设备的各种组件。该方法包括从被分析物相互作用的试剂浸渍的惰性多孔基质的一个表面上获得反射率读数，以便当被分析的流体被施加到另一个表面并通过基质迁移到表面被读取。在两个分开的波长处进行反射测量以消除干扰，并且定时电路由反射率的初始降低由反射率通过通过惰性基质的流体测量的表面的润湿而触发。在每次读取之前在光源上执行的归一化技术保证的重复性以及在放置在设备上之前在试剂条上操作的对准方法。该方法和装置特别适用于测量血液中的流感，而不需要从血清或血浆中分离出红细胞。

10. 发明授权

US5304468A Reagent test strip and apparatus for determination of blood glucose 失效
标题翻译：试剂试纸和血糖测定装置
公开(公告)号：US5304468A
公开(公告)日：1994-04-19
申请号：US9179
申请日：1993-01-26
申请人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
发明人： Roger Phillips , Geoffery McGarraugh , Franklin A. Jurik , Raymond D. Underwood
IPC分类号： C12M1/34 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N21/31 , G01N21/78 , G01N21/86 , G01N33/52 , G01N33/66 , G01N35/10 , G01N21/00 , G01N21/75
CPC分类号： G01N21/8483 , C12Q1/54 , G01N33/52 , G01N33/521 , G01N33/523 , G01N33/66 , G01N2021/4757 , G01N21/314 , G01N21/4738 , G01N35/1016 , Y10S435/805 , Y10S435/808 , Y10S435/81 , Y10T436/112499 , Y10T436/144444
摘要： A method for determining the presence of an analyte in a fluid is described along with various components of an apparatus specifically designed to carry out the method. The method involves taking a reflectance reading from one surface of an inert porous matrix impregnated with a reagent that will interact with the analyte to produce a light-absorbing reaction product when the fluid being analyzed is applied to another surface and migrates through the matrix to the surface being read. Reflectance measurements are made at two separate wavelengths in order to eliminate interferences, and a timing circuit is triggered by an initial decrease in reflectance by the wetting of the surface whose reflectance is being measured by the fluid which passes through the inert matrix. Repeatability is insured by a normalization technique performed on the light source before each reading, and an alignment method operated on the reagent strip prior to emplacement on the apparatus. The method and apparatus are particularly suitable for the measurement of glucose levels in blood without requiring separation of red blood cells from serum or plasma.
摘要翻译：描述了用于确定流体中分析物的存在的方法以及专门设计用于执行该方法的设备的各种组件。该方法包括从被分析物相互作用的试剂浸渍的惰性多孔基质的一个表面上获得反射率读数，以便当被分析的流体被施加到另一个表面并通过基质迁移到表面被读取。在两个分开的波长处进行反射测量以消除干扰，并且定时电路由反射率的初始降低由反射率通过通过惰性基质的流体测量的表面的润湿而触发。通过在每次读取之前在光源上执行的归一化技术来保证重复性，以及在放置在设备上之前在试剂条上操作的对准方法。该方法和装置特别适用于测量血液中的葡萄糖水平，而不需要从血清或血浆中分离出红细胞。

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