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1. 发明申请

US20080312175A1 METHODS AND COMPOSITIONS FOR REGULATING HDAC4 ACTIVITY 有权
标题翻译：用于调节HDAC4活性的方法和组合物
公开(公告)号：US20080312175A1
公开(公告)日：2008-12-18
申请号：US12130394
申请日：2008-05-30
申请人： Tso-Pang Yao , Todd Cohen , Tomasa Barrientos De Renshaw
发明人： Tso-Pang Yao , Todd Cohen , Tomasa Barrientos De Renshaw
IPC分类号： A61K31/7088 , C12N5/06 , A61P21/00
CPC分类号： C12N9/80 , C12N15/1137 , C12N2310/14 , C12Y305/01098
摘要： The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are methods and compositions for treating muscle atrophy and/or inflammation by inhibiting HDAC4 activity.
摘要翻译：本发明提供调节HDAC4活性并通过调节HDAC4活性调节细胞肌细胞转录途径中HDAC4下游蛋白活性的方法和组合物。还提供了通过抑制HDAC4活性来治疗肌肉萎缩和/或炎症的方法和组合物。

2. 发明授权

US5864623A Authentication system for driver licenses 失效
标题翻译：驾驶执照认证系统
公开(公告)号：US5864623A
公开(公告)日：1999-01-26
申请号：US680452
申请日：1996-07-15
申请人： Kevin M. Messina , Todd Cohen
发明人： Kevin M. Messina , Todd Cohen
IPC分类号： G07F7/12 , H04L9/32 , H04K1/00
CPC分类号： G07F7/08 , G07F7/12
摘要： A programming apparatus that authenticates the contents of driver licenses having both human recognizable information and machine readable information is disclosed. The contents of the driver licenses are verified without encountering any human error. The verified contents of the driver licenses may be transferred to a remote computer for other identification purposes such as preordained organ donors or possible criminal prosecution.
摘要翻译：公开了一种用于认证具有人可识别信息和机器可读信息的驾驶执照内容的编程装置。驱动程序许可证的内容将被验证，而不会遇到任何人为错误。驾驶执照的经过验证的内容可能被转移到远程计算机进行其他识别，例如预备的器官捐赠者或可能的刑事起诉。

3. 发明授权

US07737175B2 Methods and compositions for regulating HDAC4 activity 有权
标题翻译：调节HDAC4活性的方法和组合物
公开(公告)号：US07737175B2
公开(公告)日：2010-06-15
申请号：US12130394
申请日：2008-05-30
申请人： Tso-Pang Yao , Todd Cohen , Tomasa Barrientos De Renshaw
发明人： Tso-Pang Yao , Todd Cohen , Tomasa Barrientos De Renshaw
IPC分类号： A61K31/40 , A61K31/19 , A61K31/16
CPC分类号： C12N9/80 , C12N15/1137 , C12N2310/14 , C12Y305/01098
摘要： The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are methods and compositions for treating muscle atrophy and/or inflammation by inhibiting HDAC4 activity.
摘要翻译：本发明提供调节HDAC4活性并通过调节HDAC4活性调节细胞肌细胞转录途径中HDAC4下游蛋白活性的方法和组合物。还提供了通过抑制HDAC4活性来治疗肌肉萎缩和/或炎症的方法和组合物。

4. 发明申请

US20080009791A1 Remotely controlled catheter insertion system 有权
标题翻译：遥控导管插入系统
公开(公告)号：US20080009791A1
公开(公告)日：2008-01-10
申请号：US11485595
申请日：2006-07-11
申请人： Todd Cohen , Michael Eilenberg
发明人： Todd Cohen , Michael Eilenberg
IPC分类号： A61M31/00
CPC分类号： A61M25/0105 , A61B34/30 , A61B2034/301 , A61M25/0133
摘要： A remotely controlled insertion system for a medical device is described. The system comprises a robotic device and a remote control mechanism. The robotic device has a handle controller to receive and hold the control handle or proximal end of a medical device. The medical device is capable of moving in up to six ranges of motion. In ione embodiment a first motor is connected through a drive screw to a handle controller to move the medical device forward and backward. A second motor is connected to drive wheels effective to rotate the medical device clockwise and counter-clockwise. A third motor drives a series of gears that are connected to one or more control members on the medical device, this being effective to deflect a tip of the medical device so that movement of the third motor causes such deflection. A control unit is connected to all three motors.
摘要翻译：描述了用于医疗设备的遥控插入系统。该系统包括机器人装置和远程控制机构。机器人装置具有手柄控制器以接收和保持医疗装置的控制手柄或近端。医疗设备能够在多达六个运动范围内移动。在实施例中，第一电动机通过驱动螺杆连接到手柄控制器以使医疗装置向前和向后移动。第二马达连接到驱动轮，有效地顺时针和逆时针旋转医疗装置。第三马达驱动连接到医疗装置上的一个或多个控制构件的一系列齿轮，这有效地使医疗装置的尖端偏转，使得第三马达的运动引起这种偏转。控制单元连接到所有三台电机。

5. 发明授权

US08307469B1 Removable floor sink drain lock 有权
标题翻译：可移动地板水槽排水锁
公开(公告)号：US08307469B1
公开(公告)日：2012-11-13
申请号：US12387030
申请日：2009-04-28
申请人： Todd Cohen
发明人： Todd Cohen
IPC分类号： A47K1/14 , E03C1/26
CPC分类号： A47K1/14 , E03C1/264
摘要： Improved floor sink drain screen locks having expandable means for sealingly engaging the walls of a floor sink drain, yet being readily collapsible for quick and easy removal when desired.
摘要翻译：改进的地板下沉屏蔽锁具有可扩展的装置，用于密封地接合地板下沉排水道的壁，但是当需要时易于折叠以便快速且容易地移除。

6. 发明申请

US20050177050A1 System and method for storing, accessing, and displaying specialized patient information and other medical information 审中-公开
标题翻译：用于存储，访问和显示专门的患者信息和其他医疗信息的系统和方法
公开(公告)号：US20050177050A1
公开(公告)日：2005-08-11
申请号：US11054870
申请日：2005-02-10
申请人： Todd Cohen
发明人： Todd Cohen
IPC分类号： A61B5/04
CPC分类号： G06F19/322 , G06F19/00 , G16H10/60
摘要： The invention provides a system and method of providing a user with specialized patient information comprising: uploading, storing, requesting, receiving, and displaying cardiological patient information for a patient. The display of the cardiological information is configured to optimal care to be provided to a patient.
摘要翻译：本发明提供了向用户提供专门的患者信息的系统和方法，包括：上传，存储，请求，接收和显示患者的心脏病患者信息。心脏信息的显示被配置为提供给患者的最佳护理。

7. 发明申请

US20050131469A1 Hemodynamic optimization system for biventricular implants 有权
标题翻译：双心室植入物血液动力学优化系统
公开(公告)号：US20050131469A1
公开(公告)日：2005-06-16
申请号：US10989841
申请日：2004-11-16
申请人： Todd Cohen
发明人： Todd Cohen
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/3682 , A61N1/3684
摘要： A system for monitoring a patient and treating the malfunctioning heart of the patient, either in an automatic mode or in a semiautomatic mode, includes means which derive at least one physiologic signal from or related to the patient's circulatory system representative of hemodynamic status. A feedback loop is implemented in a biventricular implant, in order to automatically or selectively optimize the patient's clinical hemodynamic status. Accordingly, the biventricular implant will be programmed to go through a series of AV delay, RV-LV timing and heart rate sequences which scan a preselected range of programmable values and apply those values to the patient's heart. Hemodynamic patient measurements will be recorded and preferably graphed over those applied values. The optimal AV delay, RV-LV timing sequence and pacing rate can then be selected either manually by a technician, physician or other operator, or automatically via the implant in order to secure the best personalized timing sequence for the patient. Preferably, the implant will also be capable of automatically recording hemodynamic information and adjusting intervals, in order to optimize hemodynamics without third party intervention. Also preferably, the automatic adjusting feature can be selectively programmed on or off using the device programmer, to control manual or automatic intervention.
摘要翻译：用于监测患者并以自动模式或半自动模式治疗患者的心脏的系统包括从代表血液动力学状态的患者的循环系统导出至少一个生理信号或与患者的循环系统有关的装置。在双心室植入物中实现反馈回路，以便自动或选择性地优化患者的临床血液动力学状态。因此，双心室植入物将被编程以经历一系列AV延迟，RV-LV定时和心率序列，其扫描预选的可编程值的范围并将这些值应用于患者的心脏。血液动力学患者测量将被记录，并且优选地绘制在这些应用值上。然后可以由技术人员，医生或其他操作者手动选择最佳AV延迟，RV-LV定时序列和起搏速率，或者通过植入物自动选择，以确保患者的最佳个性化定时顺序。优选地，植入物还将能够自动记录血液动力学信息和调节间隔，以便在没有第三方干预的情况下优化血流动力学。还优选地，可以使用设备编程器将自动调节特征选择性地编程为开或关，以控制手动或自动干预。

8. 发明授权

US4899751A System for and method of therapeutic stimulation of a patient's heart 失效
公开(公告)号：US4899751A
公开(公告)日：1990-02-13
申请号：US378708
申请日：1989-07-12
申请人： Todd Cohen
发明人： Todd Cohen
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/36564 , A61N1/3918
摘要： A system for therapeutic stimulation of a patient's heart includes means for varying the escape interval or rate of a means for producing pacing pulses. Pressure sensing means sense pressure at a site in the circulatory system of a patient. Signal producing means respond to output from the sensing means to develop a variable first signal representative of mean pressure at the site over a period of predetermined duration. Signal producing means respond to output from the sensing means for developing a second signal representing mean pressure at the site over a period of given duration less than the period of predetermined duration. Control signal producing means responsive to the first signal and to the second signal develop a control signal upon the first signal and the second signal differing by at least a predetermined amount. Control means, responsive to the control signal, control the means for varying the escape interval or rate of the means for producing pacing pulses. The escape interval or rate may be additionally controlled by a second control signal related to the activity level of the patient either conjointly or contemporaneously. A method of therapeutic stimulation of a patient's heart is also disclosed. The method can be viewed as an analogue of the system.

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