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1. 发明申请

US20060206056A1 Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents 审中-公开
公开(公告)号：US20060206056A1
公开(公告)日：2006-09-14
申请号：US11432398
申请日：2006-05-12
申请人： Toby Freyman , Wendy Naimark , Tim Mickley , Samuel Epstein
发明人： Toby Freyman , Wendy Naimark , Tim Mickley , Samuel Epstein
IPC分类号： A61M5/178
CPC分类号： A61M5/1582
摘要： Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.

2. 发明申请

US20050158450A1 Method for roll coating multiple stents 审中-公开
标题翻译：多支架辊涂方法
公开(公告)号：US20050158450A1
公开(公告)日：2005-07-21
申请号：US11073848
申请日：2005-03-08
申请人： Maria Palasis , Wendy Naimark , Tim Mickley , Toby Freyman
发明人： Maria Palasis , Wendy Naimark , Tim Mickley , Toby Freyman
IPC分类号： A61L31/08 , B05B13/02 , B05C3/10 , B05D1/00 , B05D1/02 , B05D3/00
CPC分类号： B05D1/02 , A61L31/08 , B05B13/0235 , B05C3/10 , B05D1/002 , B05D2258/00
摘要： An improved method and apparatus for high-volume production of coated stents with highly uniform stent coatings using a roll coating technique is provided. In a first embodiment, uncoated stents are placed onto rotating stent holders with automated stent handling equipment. The holders are mounted on an endless conveyer belt which advances the stents toward a stent coater. As the stents advance through the coater, the holders rotate, thereby rolling the stents about their longitudinal axes as coating material is sprayed toward them, ensuring the stents are uniformly coated on their exterior and interior surfaces. After the conveyer turns to carry the coated stents back toward the loading area, the rotating stents pass again through the coating spray, downstream of the initial coating location, thereby increasing the efficient utilization of the coating material. The conveyer then advances the coated stents to an unloading area for removal before the holders return to the stent loading area to receive new stents.
摘要翻译：提供了一种用于使用辊涂技术高度均匀支架涂层的大量生产涂层支架的改进方法和装置。在第一实施例中，将未涂覆的支架放置在具有自动支架处理设备的旋转支架支架上。保持器安装在环形输送带上，将支架推向支架涂布机。当支架通过涂布机前进时，保持器旋转，从而当涂层材料向其喷射时，支架围绕其纵向轴线滚动，确保支架均匀地涂覆在其外表面和内表面上。在输送机转动以将涂覆的支架运送回装载区域之后，旋转的支架再次通过涂层喷涂，在初始涂覆位置的下游，从而增加涂层材料的有效利用。然后，输送机将涂层支架前进到卸载区域，以便在支架返回到支架装载区域之前进行移除以接收新的支架。

3. 发明授权

US07070582B2 Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents 有权
标题翻译：提供减少治疗剂流出的注射装置和递送治疗剂的方法
公开(公告)号：US07070582B2
公开(公告)日：2006-07-04
申请号：US10215034
申请日：2002-08-09
申请人： Toby Freyman , Wendy Naimark , Tim Mickley , Samuel J. Epstein
发明人： Toby Freyman , Wendy Naimark , Tim Mickley , Samuel J. Epstein
IPC分类号： A61M5/32
CPC分类号： A61M5/1582
摘要： Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.
摘要翻译：提供了注射装置，其减少治疗剂从注射部位的潜在流出。提供了具有至少包含一种或多种治疗剂的第一腔和包含用于注射到组织中的第二种材料的第二腔的装置。提供其他装置，其具有带有注射针的内腔，以注射治疗剂和在注射针和针轨之间提供真空密封的外腔。还提供了将治疗剂递送至组织的方法。

4. 发明授权

US06984411B2 Method for roll coating multiple stents 有权
标题翻译：多支架辊涂方法
公开(公告)号：US06984411B2
公开(公告)日：2006-01-10
申请号：US10684131
申请日：2003-10-14
申请人： Maria Palasis , Wendy Naimark , Tim Mickley , Toby Freyman
发明人： Maria Palasis , Wendy Naimark , Tim Mickley , Toby Freyman
IPC分类号： B05D1/02
CPC分类号： B05D1/02 , A61L31/08 , B05B13/0235 , B05C3/10 , B05D1/002 , B05D2258/00
摘要： An improved method for high-volume production of coated stents with highly uniform stent coatings using a roll coating technique is provided. In a first embodiment, uncoated stents are placed onto rotating stent holders with automated stent handling equipment. The holders are mounted on an endless conveyer belt which advances the stents toward a stent coater. As the stents advance through the coater, the holders rotate, thereby rolling the stents about their longitudinal axes as coating material is sprayed toward them, ensuring the stents are uniformly coated on their exterior and interior surfaces. After the conveyer turns to carry the coated stents back toward the loading area, the rotating stents pass again through the coating spray, downstream of the initial coating location, thereby increasing the efficient utilization of the coating material. The conveyer then advances the coated stents to an unloading area for removal before the holders return to the stent loading area to receive new stents.
摘要翻译：提供了一种用于使用辊涂技术高度均匀的支架涂层的大量生产涂层支架的改进方法。在第一实施例中，将未涂覆的支架放置在具有自动支架处理设备的旋转支架支架上。保持器安装在环形输送带上，将支架推向支架涂布机。当支架通过涂布机前进时，保持器旋转，从而当涂层材料向其喷射时，支架围绕其纵向轴线滚动，确保支架均匀地涂覆在其外表面和内表面上。在输送机转动以将涂覆的支架运送回装载区域之后，旋转支架再次通过涂层喷涂，在初始涂覆位置的下游，从而增加了涂层材料的有效利用。然后，输送机将涂层支架前进到卸载区域，以便在支架返回到支架装载区域之前进行移除以接收新的支架。

5. 发明申请

US20050079274A1 METHOD FOR COATING MULTIPLE STENTS 有权
标题翻译：用于涂抹多个椎弓根的方法
公开(公告)号：US20050079274A1
公开(公告)日：2005-04-14
申请号：US10684131
申请日：2003-10-14
申请人： Maria Palasis , Wendy Naimark , Tim Mickley , Toby Freyman
发明人： Maria Palasis , Wendy Naimark , Tim Mickley , Toby Freyman
IPC分类号： A61L31/08 , B05B13/02 , B05C3/10 , B05D1/00 , B05D1/02 , A61L2/00
CPC分类号： B05D1/02 , A61L31/08 , B05B13/0235 , B05C3/10 , B05D1/002 , B05D2258/00
摘要： An improved method for high-volume production of coated stents with highly uniform stent coatings using a roll coating technique is provided. In a first embodiment, uncoated stents are placed onto rotating stent holders with automated stent handling equipment. The holders are mounted on an endless conveyer belt which advances the stents toward a stent coater. As the stents advance through the coater, the holders rotate, thereby rolling the stents about their longitudinal axes as coating material is sprayed toward them, ensuring the stents are uniformly coated on their exterior and interior surfaces. After the conveyer turns to carry the coated stents back toward the loading area, the rotating stents pass again through the coating spray, downstream of the initial coating location, thereby increasing the efficient utilization of the coating material. The conveyer then advances the coated stents to an unloading area for removal before the holders return to the stent loading area to receive new stents.
摘要翻译：提供了一种用于使用辊涂技术高度均匀的支架涂层的大量生产涂层支架的改进方法。在第一实施例中，将未涂覆的支架放置在具有自动支架处理设备的旋转支架支架上。保持器安装在环形输送带上，将支架推向支架涂布机。当支架通过涂布机前进时，保持器旋转，从而当涂层材料向其喷射时，支架绕其纵向轴线滚动，确保支架均匀地涂覆在其外表面和内表面上。在输送机转动以将涂覆的支架运送回装载区域之后，旋转支架再次通过涂层喷涂，在初始涂覆位置的下游，从而增加了涂层材料的有效利用。然后，输送机将涂层支架前进到卸载区域，以便在支架返回到支架装载区域之前进行移除以接收新的支架。

6. 发明授权

US07892205B2 Device and method for delivering micronized therapeutic agents in the body 失效
标题翻译：在体内递送微粉治疗剂的装置和方法
公开(公告)号：US07892205B2
公开(公告)日：2011-02-22
申请号：US10455298
申请日：2003-06-06
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M37/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译：本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。微粉化治疗剂以气溶胶形式或干粉形式递送。本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

7. 发明申请

US20060029720A1 Methods and apparatus for injection coating a medical device 审中-公开
标题翻译：用于注射涂覆医疗装置的方法和装置
公开(公告)号：US20060029720A1
公开(公告)日：2006-02-09
申请号：US10909408
申请日：2004-08-03
申请人： Anastasia Panos , Wendy Naimark , Maria Palasis , Toby Freyman , Samuel Epstein
发明人： Anastasia Panos , Wendy Naimark , Maria Palasis , Toby Freyman , Samuel Epstein
IPC分类号： A61L33/00 , B05C5/00
CPC分类号： B05C5/0208 , A61F2/86 , A61F2002/072 , A61L31/08 , A61L31/10 , A61L2420/02 , B05C13/025 , B05D1/002 , B05D1/26 , B05D1/30
摘要： Methods and apparatus for coating at least a portion of the surface of medical devices using an injection coating device are disclosed. In one embodiment, the invention includes a coating method wherein an orifice of the injection coating device is placed adjacent a vertically positioned medical device, coating material is ejected from the orifice onto the medical device, and the coating material gravitationally flows downward coating the medical device. In another embodiment, an orifice of an injection coating device is positioned adjacent a horizontally positioned medical device to gravitationally flow and deposit coating material onto the medical device. These methods may be used to apply one or more coating materials, simultaneously or in sequence. In another embodiment, multiple injection coating devices may be utilized. In certain embodiments of the invention, the coating materials include therapeutic or biologically active agents.
摘要翻译：公开了使用注射涂覆装置涂覆医疗装置的表面的至少一部分的方法和装置。在一个实施方案中，本发明包括一种涂覆方法，其中注射涂覆装置的孔口邻近垂直定位的医疗装置放置，涂层材料从孔口喷射到医疗装置上，并且涂覆材料重力地向下流动涂覆医疗装置。在另一个实施例中，注射涂覆装置的孔口邻近水平定位的医疗装置定位以重力地流动并将涂层材料沉积到医疗装置上。这些方法可以同时或按顺序施用一种或多种涂料。在另一个实施例中，可以使用多个注射涂覆装置。在本发明的某些实施方案中，涂层材料包括治疗或生物活性剂。

8. 发明申请

US20110130715A1 Device and Method for Delivering Micronized Therapeutic Agents in the Body 有权
标题翻译：在体内递送微粉治疗剂的装置和方法
公开(公告)号：US20110130715A1
公开(公告)日：2011-06-02
申请号：US13022217
申请日：2011-02-07
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M5/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译：本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。微粉化治疗剂以气溶胶形式或干粉形式递送。本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

9. 发明申请

US20070055352A1 Stent with pockets for containing a therapeutic agent 审中-公开
标题翻译：支架用于含有治疗剂
公开(公告)号：US20070055352A1
公开(公告)日：2007-03-08
申请号：US11221647
申请日：2005-09-07
申请人： Wendy Naimark , Peter Shank , Maria Palasis , Toby Freyman , Anastasia Panos , Samuel Epstein , Alexandra Rousseau
发明人： Wendy Naimark , Peter Shank , Maria Palasis , Toby Freyman , Anastasia Panos , Samuel Epstein , Alexandra Rousseau
IPC分类号： A61F2/90
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/0008 , A61F2230/0013 , A61F2250/0068 , A61L2300/606
摘要： A medical device for: delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.
摘要翻译：描述了用于将治疗剂递送到体腔的医疗装置。该装置通常可以是具有内侧壁表面和外侧壁表面的支架，多个支柱在其中具有多个开口。内层和外层可以施加到支架上，在开口的至少一部分内形成袋。口袋可以填充有至少一种治疗剂。口袋可以采取各种形状和尺寸，并且可以设计为以各种方式释放或破裂。

10. 发明授权

US08235937B2 Device and method for delivering micronized therapeutic agents in the body 有权
标题翻译：在体内递送微粉治疗剂的装置和方法
公开(公告)号：US08235937B2
公开(公告)日：2012-08-07
申请号：US13022217
申请日：2011-02-07
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M31/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译：本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。微粉化治疗剂以气溶胶形式或干粉形式递送。本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

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