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1. 发明授权

US06531612B2 Nitrile derivatives that inhibit cathepsin K 失效
标题翻译：抑制组织蛋白酶K的腈衍生物
公开(公告)号：US06531612B2
公开(公告)日：2003-03-11
申请号：US09745675
申请日：2000-12-21
申请人： Tobias Gabriel , Michael Pech , Sabine Wallbaum
发明人： Tobias Gabriel , Michael Pech , Sabine Wallbaum
IPC分类号： C07D20716
CPC分类号： C07D403/06 , C07D207/16 , C07D207/48 , C07D209/52 , C07D277/06 , C07D405/12 , C07D405/14
摘要： Compounds of the formula: wherein R1 to R7 and Y are as defined in the specification, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof, are useful for treating diseases associated with cystein proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
摘要翻译：下式的化合物：其中R 1至R 7和Y如说明书中所定义，及其药学上可接受的盐和/或其药学上可接受的酯可用于治疗与半胱氨酸蛋白酶相关的疾病，例如骨质疏松症，骨关节炎，类风湿性关节炎，肿瘤转移，肾小球性肾炎，动脉粥样硬化，心肌梗塞，心绞痛，不稳定性心绞痛，中风，斑块破裂，短暂性脑缺血发作，黑素瘤假体，外周动脉闭塞性疾病，血管成形术后再狭窄和支架置入，腹主动脉瘤形成，炎症，自身免疫性疾病，疟疾，眼底组织细胞病变和呼吸系统疾病。

2. 发明授权

US06462076B2 Beta-amino acid nitrile derivatives as cathepsin K inhibitors 失效
公开(公告)号：US06462076B2
公开(公告)日：2002-10-08
申请号：US09872927
申请日：2001-06-01
申请人： Tobias Gabriel , Michael Pech , Rosa Maria Rodriguez Sarmiento
发明人： Tobias Gabriel , Michael Pech , Rosa Maria Rodriguez Sarmiento
IPC分类号： A61K4326
CPC分类号： C07C311/20 , C07C255/29 , C07C255/44 , C07C271/24 , C07C311/13 , C07C311/46 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D307/85 , C07D317/60 , C07D333/32
摘要： The present invention relates to beta-amino acid nitrile derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are cysteine protease inhibitors useful for the treatment of diseases associated with cysteine proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.

3. 发明授权

US5767268A Sulfuric acid esters of amino sugars 失效
标题翻译：氨基糖的硫酸酯
公开(公告)号：US5767268A
公开(公告)日：1998-06-16
申请号：US639985
申请日：1996-04-26
申请人： Alexander Chucholowski , Jurgen Fingerle , Niggi Iberg , Hans Peter Marki , Rita Muller , Michael Pech , Marianne Rouge , Gerard Schmid , Thomas Tschopp , Hans Peter Wessel
发明人： Alexander Chucholowski , Jurgen Fingerle , Niggi Iberg , Hans Peter Marki , Rita Muller , Michael Pech , Marianne Rouge , Gerard Schmid , Thomas Tschopp , Hans Peter Wessel
IPC分类号： C07H5/04 , A61K31/70 , A61K31/7008 , A61P9/10 , A61P43/00 , C07H5/06 , C07H11/00 , C07H13/08 , C07H13/10 , C07H15/18 , C07H15/00
CPC分类号： C07H13/08 , C07H13/10 , C07H15/18
摘要： Compounds of formulas ##STR1## wherein, B is lower alkylene or an optionally substituted aromatic ring system; G.sup.1, G.sup.2 and G.sup.3 each independently signify a residue of a glycopyranoside, a glycopyranose or a derivative thereof, with at least one hydroxy group of residue G.sup.1, G.sup.2 or G.sup.3 being esterified with sulfuric acid, and pharmaceutically usable salts thereof, are useful for the treatment of disorders which are characterized by excessive or destructive proliferation of smooth muscle cells.
摘要翻译：其中B为低级亚烷基或任选取代的芳族环系;其中B为低级亚烷基或任选取代的芳族环系; G1，G2和G3各自独立地表示具有至少一个残基G1，G2或G3的羟基被硫酸酯化的糖吡喃糖苷，糖吡喃糖或其衍生物的残基，及其药学上可用的盐可用于治疗以平滑肌细胞过度或破坏性增殖为特征的疾病。

4. 发明申请

US20120211578A1 Tensioning Device for a Safety Belt 有权
标题翻译：安全带张紧装置
公开(公告)号：US20120211578A1
公开(公告)日：2012-08-23
申请号：US13505164
申请日：2010-10-12
申请人： Christian Fischer , Martin Schmidt , Matthias Steinberg , Michael Pech , Tobias Voss , Thomas Schmidt , Simone Mesecke-Rischmann
发明人： Christian Fischer , Martin Schmidt , Matthias Steinberg , Michael Pech , Tobias Voss , Thomas Schmidt , Simone Mesecke-Rischmann
IPC分类号： B60R22/46
CPC分类号： B60R22/1954 , B60R22/4628 , B60R2022/4642
摘要： A tensioning device (10) for a seat belt, in particular in a motor vehicle, having a gas generator (17) and a piston (21) guided in a tube (16) that closes a pressure space (20) in the tube (16), whereas the pressure space (20) can be pressurized by the gas generator (17), as a result of which the piston (21) can be driven to perform a tensioning operation which can be transmitted to the seat belt by means of the force transmission means. The piston (21) having a closed or constricted opening (1, 1a), and the opening (1, 1a) can be enlarged and/or opened by the material erosion caused by the pressure and/or pressure conditions in the pressure space (20).
摘要翻译：一种用于安全带，特别是机动车辆的张紧装置（10），具有气体发生器（17）和引导管（16）的活塞（21），所述管子封闭管中的压力空间（20） 16），而压力空间（20）可以由气体发生器（17）加压，结果可以驱动活塞（21）进行张紧操作，该张紧操作可通过以下方式传递到安全带力传递装置。具有闭合或缩小的开口（1,1a）的活塞（21）和开口（1,1a）可以通过由压力空间中的压力和/或压力条件引起的材料侵蚀而被扩大和/或打开（ 20）。

5. 发明授权

US07429012B2 High performance tightener 失效
标题翻译：高性能拉链机
公开(公告)号：US07429012B2
公开(公告)日：2008-09-30
申请号：US10516033
申请日：2003-03-28
申请人： Kay Löffler , Michael Pech , Martin Schmidt , Thomas Schmidt , Thomas Schneider , Stefan Suhr , Stefan Bösch
发明人： Kay Löffler , Michael Pech , Martin Schmidt , Thomas Schmidt , Thomas Schneider , Stefan Suhr , Stefan Bösch
IPC分类号： B65H75/48 , B60R22/46
CPC分类号： B60R22/405 , B60R22/343 , B60R22/36 , B60R22/46 , B60R22/4628 , B60R22/4676 , B60R2022/287 , B60R2022/4642 , B60R2022/468
摘要： A self stopping seat belt retractor is provided with a belt shaft for winding a seat belt thereonto and unwinding a wound seat belt therefrom and a housing rotatably supporting the belt shaft and having a locking device that includes a locking means for the belt shaft that can be controlled in a vehicle sensitive and/or belt sensitive manner into engagement with a toothed gearing system on that side of the housing. A tightening device operating on the belt shaft includes a drive wheel, which is, prior to the release of the tightening device, secured in a force-transmitting manner on the housing, is connectable upon release of the tightening device with the belt shaft, whereby the drive wheel of the tightening device is connectable via the locking device with the belt shaft for the transmission of force to the belt shaft.
摘要翻译：自动停止安全带卷收器设置有用于将安全带卷绕在其上并从其上展开伤口安全带的带轴和可旋转地支撑带轴的壳体，并且具有锁定装置，该锁定装置包括用于带轴的锁定装置，控制在车辆敏感和/或带敏感的方式与壳体的该侧上的齿形传动系统接合。在带轴上操作的紧固装置包括驱动轮，该驱动轮在紧固装置释放之前以力传递的方式固定在壳体上，在紧固装置与皮带轴释放时可连接，由此紧固装置的驱动轮可通过锁定装置与皮带轴连接，以将力传递到皮带轴。

6. 发明授权

US08684413B2 Pretensioning device for a safety belt 有权
标题翻译：安全带预张紧装置
公开(公告)号：US08684413B2
公开(公告)日：2014-04-01
申请号：US13643125
申请日：2011-03-03
申请人： Thomas Schmidt , Martin Schmidt , Christian Fischer , Michael Pech , Matthias Steinberg , Tobias Voss
发明人： Thomas Schmidt , Martin Schmidt , Christian Fischer , Michael Pech , Matthias Steinberg , Tobias Voss
IPC分类号： B60R22/405
CPC分类号： B60R22/4628 , B60R2022/4642 , B60R2022/4661
摘要： A pretensioning device (10) for a safety belt, of a motor vehicle, having a gas generator (17), a piston (21) guided in a tube (16), which closes a pressure area (20) in the tube (16) that is pressurized by the gas generator (17) whereupon the piston (21) is able to move in a pretensioning movement which is able to be conveyed to the safety belt by means of an inertia body (19a) resting on a front face (9) of the piston (21). The piston (21) forms a pass-through opening (1) releasable upon exceeding of a predetermined pressure and a recess (26) is provided in the front face (9) with an inertia body (19a) resting thereon, so that a flow connection is created from the pass-through opening (1) to the area (25) located behind the piston (21) in the direction of the pretensioning movement (S).
摘要翻译：一种用于机动车辆的安全带的预张紧装置（10），具有气体发生器（17），在管（16）中引导的活塞（21），其封闭管（16）中的压力区域（20）），由气体发生器（17）加压，于是活塞（21）能够通过借助于静止在正面上的惯性体（19a）被传送到安全带的预张紧运动中移动 9）。活塞（21）形成可以超过预定压力而可释放的通过开口（1），并且在前表面（9）上设置有一个在其上放置有惯性体（19a）的凹部（26）在预张紧运动（S）的方向上从穿通开口（1）到位于活塞（21）后面的区域（25）形成连接。

7. 发明授权

US5521160A Sulfuric acid esters of sugar alcohols 失效
标题翻译：糖醇的硫酸酯
公开(公告)号：US5521160A
公开(公告)日：1996-05-28
申请号：US368519
申请日：1995-01-04
申请人： Alexander Chucholowski , Jurgen Fingerle , Niggi Iberg , Hans P. Marki , Rita Muller , Michael Pech , Marianne Rouge , Gerard Schmid , Thomas Tschopp , Hans P. Wessel
发明人： Alexander Chucholowski , Jurgen Fingerle , Niggi Iberg , Hans P. Marki , Rita Muller , Michael Pech , Marianne Rouge , Gerard Schmid , Thomas Tschopp , Hans P. Wessel
IPC分类号： C07D307/42 , A61K31/17 , A61K31/225 , A61K31/255 , A61K31/7024 , A61P9/10 , A61P9/14 , C07C31/18 , C07C31/27 , C07C305/04 , C07C305/06 , C07C305/10 , C07C305/16 , C07C309/02 , C07C311/17 , C07C311/23 , C07C317/22 , C07C317/36 , C07C317/44 , C07C335/06 , C07C335/16 , C07D303/46 , C07D307/68 , C07D311/82 , C07H7/00 , C07H11/00 , C07H5/04
CPC分类号： C07C305/10 , C07C305/06 , C07C311/17 , C07C317/22 , C07C317/36 , C07C317/44 , C07C335/16 , C07D307/68 , C07D311/82
摘要： The present invention is concerned with novel sulfuric acid esters of sugar alcohols and sugar alcohol-like compounds of the formula ##STR1## Also described are methods for the treatment and/or prophylaxis of arteriosclerotic changes in the vascular wall as well as a process for the manufacture of the compounds of formula I and their salts.
摘要翻译：本发明涉及糖醇的新型硫酸酯和下式的糖醇类化合物（I）。还描述了治疗和/或预防血管壁动脉硬化变化的方法以及用于制备式I化合物及其盐的方法。

8. 发明申请

US20130038047A1 Pretensioning Device for a Safety Belt 有权
标题翻译：安全带预张紧装置
公开(公告)号：US20130038047A1
公开(公告)日：2013-02-14
申请号：US13643125
申请日：2011-03-03
申请人： Thomas Schmidt , Martin Schmidt , Christian Fischer , Michael Pech , Matthias Steinberg , Tobias Voss
发明人： Thomas Schmidt , Martin Schmidt , Christian Fischer , Michael Pech , Matthias Steinberg , Tobias Voss
IPC分类号： B60R22/46
CPC分类号： B60R22/4628 , B60R2022/4642 , B60R2022/4661
摘要： A pretensioning device (10) for a safety belt, of a motor vehicle, having a gas generator (17), a piston (21) guided in a tube (16), which closes a pressure area (20) in the tube (16) that is pressurized by the gas generator (17) whereupon the piston (21) is able to move in a pretensioning movement which is able to be conveyed to the safety belt by means of an inertia body (19a) resting on a front face (9) of the piston (21). The piston (21) forms a pass-through opening (1) releasable upon exceeding of a predetermined pressure and a recess (26) is provided in the front face (9) with an inertia body (19a) resting thereon, so that a flow connection is created from the pass-through opening (1) to the area (25) located behind the piston (21) in the direction of the pretensioning movement (S).
摘要翻译：一种用于机动车辆的安全带的预张紧装置（10），具有气体发生器（17），在管（16）中引导的活塞（21），其封闭管（16）中的压力区域（20）），由气体发生器（17）加压，于是活塞（21）能够通过借助于静止在正面上的惯性体（19a）被传送到安全带的预张紧运动中移动 9）。活塞（21）形成可以超过预定压力而可释放的通过开口（1），并且在前表面（9）上设置有一个在其上放置有惯性体（19a）的凹部（26）在预张紧运动（S）的方向上从穿通开口（1）到位于活塞（21）后面的区域（25）形成连接。

9. 发明申请

US20050178870A1 High performance tightener 失效
标题翻译：高性能拉链机
公开(公告)号：US20050178870A1
公开(公告)日：2005-08-18
申请号：US10516033
申请日：2003-03-28
申请人： Kay Loffler , Michael Pech , Martin Schmidt , Thomas Schneider , Stefan Suhr , Stefan Bosch
发明人： Kay Loffler , Michael Pech , Martin Schmidt , Thomas Schneider , Stefan Suhr , Stefan Bosch
IPC分类号： B60R22/28 , B60R22/343 , B60R22/405 , B60R22/46
CPC分类号： B60R22/405 , B60R22/343 , B60R22/36 , B60R22/46 , B60R22/4628 , B60R22/4676 , B60R2022/287 , B60R2022/4642 , B60R2022/468
摘要： A self stopping seat belt retractor is provided with a belt shaft for winding a seat belt thereonto and unwinding a wound seat belt therefrom and a housing rotatably supporting the belt shaft and having a locking device that includes a locking means for the belt shaft that can be controlled in a vehicle sensitive and/or belt sensitive manner into engagement with a toothed gearing system on the side of the housing. A tightening device operating on the belt shaft includes a drive wheel, which is, prior to the release of the tightening device, secured in a force-transmitting manner on the housing, is connectable upon release of the tightening device with the belt shaft, whereby the drive wheel of the tightening device is connectable via the locking device with the belt shaft for the transmission of force to the belt shaft.
摘要翻译：自动停止安全带卷收器设置有用于将安全带卷绕在其上并从其上展开伤口安全带的带轴和可旋转地支撑带轴的壳体，并且具有锁定装置，该锁定装置包括用于带轴的锁定装置，控制在车辆敏感和/或带敏感的方式与壳体侧面上的齿形传动系统接合。在带轴上操作的紧固装置包括驱动轮，该驱动轮在紧固装置释放之前以力传递的方式固定在壳体上，在紧固装置与皮带轴释放时可连接，由此紧固装置的驱动轮可通过锁定装置与皮带轴连接，以将力传递到皮带轴。

10. 发明授权

US5830920A Sulfuric acid esters of sugar alcohols 失效
标题翻译：糖醇的硫酸酯
公开(公告)号：US5830920A
公开(公告)日：1998-11-03
申请号：US639986
申请日：1996-04-26
申请人： Alexander Chucholowski , Jurgen Fingerle , Niggi Iberg , Hans Peter Marki , Rita Muller , Michael Pech , Marianne Rouge , Gerard Schmid , Thomas Tschopp , Hans Peter Wessel
发明人： Alexander Chucholowski , Jurgen Fingerle , Niggi Iberg , Hans Peter Marki , Rita Muller , Michael Pech , Marianne Rouge , Gerard Schmid , Thomas Tschopp , Hans Peter Wessel
IPC分类号： C07D251/70 , A61K31/165 , A61K31/27 , A61K31/35 , A61K31/352 , A61K31/53 , A61K31/70 , A61K31/7028 , A61P7/02 , A61P9/10 , A61P31/12 , A61P43/00 , C07C305/06 , C07C305/10 , C07D311/22 , C07H15/18 , A61K31/045 , C07C205/00
CPC分类号： C07H15/18 , C07C305/06 , C07C305/10
摘要： Compounds of the formula ##STR1## wherein n.sup.1 -n.sup.9 are each independently 0 or 1; m.sup.1 -m.sup.9 are each independently 0 or 1, but with the proviso that at least one of m.sup.1, m.sup.2 and m.sup.3, at least one of m.sup.4, m.sup.5 and m.sup.6 and, when present, at least one of m.sup.7, m.sup.8 and m.sup.9 is 1; and wherein X.sup.1 -X.sup.18 each independently is --O--, --CONR.sup.1,--NR.sup.1 CO-- or --NR.sup.1 --; R.sup.1 is hydrogen or lower alkyl; W is a benzene or s-triazine; Y.sup.1 -Y.sup.9 each independently is an aromatic ring systems; A.sup.1 -A.sup.3 each independently is a residue of a sugar alcohol devoid of the 1-hydroxy group or a derivative thereof, a residue of a sugar acid devoid of the 1-carboxy group or a derivative thereof or tris-(hydroxymethyl)-methyl; D is the di-residue of a sugar alcohol devoid of 2 hydroxy groups or a derivative thereof or the di-residue of a sugar dicarboxylic acid devoid of 2 carboxy group or a derivative thereof; Q.sup.1 -Q.sup.3 and Z.sup.1 -Z3 each independently are the di-residue of a sugar alcohol devoid of 2 hydroxy groups or a derivative thereof or the di-residue of a sugar dicarboxylic acid devoid of 2 carboxy groups or a derivative thereof or didesoxyglycopyranoside or a derivative thereof, wherein at least one hydroxy group of residues A.sup.1 -A.sup.3, D, Q.sup.1 -Q.sup.3 and Z.sup.1 -Z.sup.3 is esterified with sulfuric acid, and pharmaceutically usable salts thereof are useful for the treatment of disorders which are characterized by excessive or destructive proliferation of smooth muscle cells.
摘要翻译：式Ia的化合物或其中n1-n9各自独立地为0或1; m1-m9各自独立地为0或1，但条件是m1，m2和m3中的至少一个，m4，m5和m6中的至少一个，并且当存在时，m7，m8和m9中的至少一个为1 ; 并且其中X1-X18各自独立地为-O - ， - CONR1，-NR1CO-或-NR1-; R1是氢或低级烷基; W是苯或s-三嗪; Y1-Y9各自独立为芳环体系; A1-A3各自独立地为不含1-羟基或其衍生物的糖醇的残基，不含1-羧基的糖酸或其衍生物的残基或三 - （羟甲基） - 甲基; D是不含2个羟基的糖醇或其衍生物或不含2个羧基的糖二羧酸的二残基或其衍生物的二残基; Q1-Q3和Z1-Z3各自独立地为不含2个羟基的糖醇或其衍生物或不含2个羧基的糖二羧酸的二残基或其衍生物或二脱氧吡喃葡萄糖苷或二其衍生物，其中残基A1-A3，D，Q1-Q3和Z1-Z3中的至少一个羟基用硫酸酯化，其药学上可用的盐可用于治疗以过度或破坏性增殖为特征的病症的平滑肌细胞。

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