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1. 发明授权

US6048856A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US6048856A
公开(公告)日：2000-04-11
申请号：US211378
申请日：1998-12-14
申请人： Tine Krogh J.o slashed.rgensen , Erik Fischer , Rolf Hohlweg , Knud Erik Andersen , Uffe Bang Olsen , Karel Sindelar , Alexandra Silhankova , Otylie Konigova , Zdenek Polivka
发明人： Tine Krogh J.o slashed.rgensen , Erik Fischer , Rolf Hohlweg , Knud Erik Andersen , Uffe Bang Olsen , Karel Sindelar , Alexandra Silhankova , Otylie Konigova , Zdenek Polivka
IPC分类号： C07D211/14 , C07D211/34 , C07D211/64 , C07D211/66 , C07D401/06 , A61K31/55 , A61K31/435 , C07D211/06 , C07D223/18
CPC分类号： C07D401/06 , C07D211/14 , C07D211/34 , C07D211/64 , C07D211/66
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the formula ##STR1## wherein X, Y, R.sup.1, R.sup.1a, R.sup.2, R.sup.2a, R.sup.12, R.sup.13, A, r and s are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation. These compounds are also useful for treating indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g., non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及下式的新的N-取代的氮杂杂环化合物其中X，Y，R1，R1a，R2，R2a，R12，R13，A，r和s如本说明书的详细部分所定义，或盐其制备方法，含有它们的组合物，以及其用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用。这些化合物还可用于治疗由胰岛素拮抗肽（例如非胰岛素依赖性糖尿病（NIDDM））和老龄化相关性肥胖症引起或与胰岛素拮抗肽分泌和循环有关的适应症。

2. 发明授权

US6066632A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US6066632A
公开(公告)日：2000-05-23
申请号：US376735
申请日：1999-08-17
申请人： Knud Erik Andersen , Tine Krogh J.o slashed.rgensen , Rolf Hohlweg , Erik Fischer , Uffe Bang Olsen , Zdenek Polivka , Karel Sindelar , Vladimir Valenta
发明人： Knud Erik Andersen , Tine Krogh J.o slashed.rgensen , Rolf Hohlweg , Erik Fischer , Uffe Bang Olsen , Zdenek Polivka , Karel Sindelar , Vladimir Valenta
IPC分类号： C07D211/34 , C07D401/06 , C07D405/06 , C07D409/06 , A01N43/46 , A61K31/44 , C07D219/00 , C07D487/00 , C07D513/00
CPC分类号： C07D401/06 , C07D211/34 , C07D405/06 , C07D409/06
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分中所定义，或其盐，其制备方法，含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由或由胰岛素拮抗肽的分泌和循环，例如非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

3. 发明授权

US6040318A Tricycle substituted with azaheterocyclic carboxylic acids 失效
标题翻译：用氮杂环羧酸取代三环
公开(公告)号：US6040318A
公开(公告)日：2000-03-21
申请号：US98579
申请日：1998-06-17
申请人： Knud Erik Andersen , Tine Krogh J.o slashed.rgensen , Rolf Hohlweg , Erik Fischer , Uffe Bang Olsen , Zdenek Polivka , Karel Sindelar , Vladimir Valenta
发明人： Knud Erik Andersen , Tine Krogh J.o slashed.rgensen , Rolf Hohlweg , Erik Fischer , Uffe Bang Olsen , Zdenek Polivka , Karel Sindelar , Vladimir Valenta
IPC分类号： C07D211/34 , C07D401/06 , C07D405/06 , C07D409/06 , A01N43/40 , A01N43/36 , C07D211/06
CPC分类号： C07D401/06 , C07D211/34 , C07D405/06 , C07D409/06
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分中所定义，或其盐，其制备方法，含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由或由胰岛素拮抗肽的分泌和循环，例如非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

4. 发明授权

US6060468A N-substituted azaheterocyclic compounds 失效
标题翻译： N-取代的氮杂环化合物
公开(公告)号：US6060468A
公开(公告)日：2000-05-09
申请号：US943368
申请日：1997-10-03
申请人： Tine Krogh J.o slashed.rgensen , Erik Fischer , Rolf Hohlweg , Knud Erik Andersen , Uffe Bang Olsen , Zdenek Polivka , Vladimir Valenta , Karel Sindelar
发明人： Tine Krogh J.o slashed.rgensen , Erik Fischer , Rolf Hohlweg , Knud Erik Andersen , Uffe Bang Olsen , Zdenek Polivka , Vladimir Valenta , Karel Sindelar
IPC分类号： A61K31/4523 , A61K31/4535 , A61P3/08 , A61P17/04 , A61P25/06 , A61P29/00 , C07D405/12 , C07D409/12 , C07D411/06 , C07D411/12 , C07D491/113 , C07D337/14 , A61K31/445 , C07D211/90
CPC分类号： C07D405/12 , C07D409/12 , C07D411/12
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.1a, R.sup.2, R.sup.2a, p, r and s are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to secretion and circulation of insulin antagonising peptides.
摘要翻译：本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 1a，R 2，R 2a，p，r和s如在本说明书的详细部分或其盐中所定义，其制备方法，含有它们的组合物，以及其用于临床治疗疼痛，痛觉过敏和/或炎症状况的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用以及其用于治疗由胰岛素拮抗肽分泌和循环引起或与之相关的适应症。

5. 发明授权

US6114354A N-substituted azaheterocyclic compounds 失效
标题翻译： N-取代的氮杂环化合物
公开(公告)号：US6114354A
公开(公告)日：2000-09-05
申请号：US375745
申请日：1999-08-17
申请人： Knud Erik Andersen , Tine Krogh J.o slashed.rgensen , Rolf Hohlweg , Erik Fischer , Uffe Bang Olsen , Zdenek Polivka , Karel Sindelar , Vladimir Valenta
发明人： Knud Erik Andersen , Tine Krogh J.o slashed.rgensen , Rolf Hohlweg , Erik Fischer , Uffe Bang Olsen , Zdenek Polivka , Karel Sindelar , Vladimir Valenta
IPC分类号： C07D211/34 , C07D401/06 , C07D405/06 , C07D409/06 , C07D211/62 , A61K31/445 , C07D211/60
CPC分类号： C07D401/06 , C07D211/34 , C07D405/06 , C07D409/06
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neuragenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分中所定义，或其盐，其制备方法，含有它们的组合物，以及其用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经痛或炎症而发挥病理生理学作用，以及其用于治疗由或由胰岛素拮抗肽的分泌和循环，例如非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

6. 发明授权

US6100253A Tricycle substituted with azaheterocyclic carboxylic acids 失效
标题翻译：用氮杂环羧酸取代三环
公开(公告)号：US6100253A
公开(公告)日：2000-08-08
申请号：US376734
申请日：1999-08-17
申请人： Knud Erik Andersen , Tine Krogh J.o slashed.rgensen , Rolf Hohlweg , Erik Fischer , Uffe Bang Olsen , Zdenek Polivka , Karel Sindelar , Vladimir Valenta
发明人： Knud Erik Andersen , Tine Krogh J.o slashed.rgensen , Rolf Hohlweg , Erik Fischer , Uffe Bang Olsen , Zdenek Polivka , Karel Sindelar , Vladimir Valenta
IPC分类号： C07D211/34 , C07D401/06 , C07D405/06 , C07D409/06 , A61K31/55 , A61K31/445 , C07D211/06 , C07D307/48 , C07J21/00
CPC分类号： C07D401/06 , C07D211/34 , C07D405/06 , C07D409/06
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分中所定义，或其盐，其制备方法，含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由或由胰岛素拮抗肽的分泌和循环，例如非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

7. 发明授权

US6054458A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US6054458A
公开(公告)日：2000-04-25
申请号：US102863
申请日：1998-06-23
申请人： Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Rolf Hohlweg , Uffe Bang Olsen , Erik Fischer , Zdenek Polivka , Kaler Sindelar
发明人： Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Rolf Hohlweg , Uffe Bang Olsen , Erik Fischer , Zdenek Polivka , Kaler Sindelar
IPC分类号： C07D211/70 , C07D295/15 , C07D409/04 , C07D409/14 , A61K31/496 , C07D241/04 , C07D407/04
CPC分类号： C07D295/15 , C07D211/70 , C07D409/04 , C07D409/14
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and m are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation, as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及以下通式的新的N-取代的氮杂杂环化合物：其中X，Y，Z，R 1，R 2和m如在本说明书的详细部分中所定义，或其盐，其制备方法，含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由或相关的指征对胰岛素拮抗肽的分泌和循环，例如，非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

8. 发明授权

US06391890B1 Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US06391890B1
公开(公告)日：2002-05-21
申请号：US09535216
申请日：2000-03-27
申请人： Tine Krogh Jørgensen , Knud Erik Andersen , Rolf Hohlweg , Uffe Bang Olsen , Erik Fischer , Zdenek Polivka , Kaler Sindelar
发明人： Tine Krogh Jørgensen , Knud Erik Andersen , Rolf Hohlweg , Uffe Bang Olsen , Erik Fischer , Zdenek Polivka , Kaler Sindelar
IPC分类号： A61K31445
CPC分类号： C07D295/15 , C07D211/70 , C07D409/04 , C07D409/14
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R1, R2 and m are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation, as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及X，Y，Z，R 1，R 2和m一般形式的新的N-取代的氮杂杂环化合物，如本说明书的详细部分或其盐，其制备方法，组合物并且用于临床治疗疼痛，痛觉过敏和/或炎症性疾病，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由...引起的或与之相关的适应症胰岛素拮抗肽的分泌和循环，例如非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

9. 发明申请

US20080034668A1 Window blind driven by a window lifter 失效
标题翻译：窗玻璃由窗户升降机驱动
公开(公告)号：US20080034668A1
公开(公告)日：2008-02-14
申请号：US11891275
申请日：2007-08-09
申请人： Erik Fischer
发明人： Erik Fischer
IPC分类号： B60J5/04
CPC分类号： B60J1/2027 , B60J1/2086
摘要： A window blind for motor vehicle doors including a winding shaft arranged underneath the window's lower edge is provided. One edge of the blind sheet is fastened to the winding shaft and its other edge is attached to a pull bar. The pull bar is connected to at least one support rod that is arranged approximately at a right angle to the pull bar and projects into the body of the door. The support rod is guided in the door body and it is provided at its inner end with a dog. The dog is designed to cooperate with a dog driven by the window lifter, so that the window blind is also opened semiautomatically when the window is opened.
摘要翻译：提供了一种用于机动车门的窗帘，包括布置在窗户下边缘下方的卷轴。盲板的一个边缘固定在卷轴上，其另一个边缘连接到拉杆上。拉杆连接到至少一个支撑杆，该支撑杆大致与拉杆成直角并且突出到门的主体中。支撑杆在门体内引导，其内端设有一只狗。狗被设计成与由窗户升降机驱动的狗配合，使得窗户在打开窗户时半自动地打开。

10. 发明授权

US07537039B2 Window blind driven by a window lifter 失效
标题翻译：窗玻璃由窗户升降机驱动
公开(公告)号：US07537039B2
公开(公告)日：2009-05-26
申请号：US11891275
申请日：2007-08-09
申请人： Erik Fischer
发明人： Erik Fischer
IPC分类号： A47G5/02
CPC分类号： B60J1/2027 , B60J1/2086
摘要： A window blind for motor vehicle doors including a winding shaft arranged underneath the window's lower edge is provided. One edge of the blind sheet is fastened to the winding shaft and its other edge is attached to a pull bar. The pull bar is connected to at least one support rod that is arranged approximately at a right angle to the pull bar and projects into the body of the door. The support rod is guided in the door body and it is provided at its inner end with a dog. The dog is designed to cooperate with a dog driven by the window lifter, so that the window blind is also opened semiautomatically when the window is opened.
摘要翻译：提供了一种用于机动车门的窗帘，包括布置在窗户下边缘下方的卷轴。盲板的一个边缘固定在卷轴上，其另一个边缘连接到拉杆上。拉杆连接到至少一个支撑杆，该支撑杆大致与拉杆成直角并且突出到门的主体中。支撑杆在门体内引导，其内端设有一只狗。狗被设计成与由窗户升降机驱动的狗配合，使得窗户在打开窗户时半自动地打开。

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