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1. 发明授权

US08435765B2 Polypeptides and biosynthetic pathways for the production of monatin and its precursors 有权
公开(公告)号：US08435765B2
公开(公告)日：2013-05-07
申请号：US12124014
申请日：2008-05-20
申请人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , James R. Millis , John Rosazza , David P. Weiner , Lishan Zhao
发明人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , James R. Millis , John Rosazza , David P. Weiner , Lishan Zhao
IPC分类号： C12N9/02 , C12N1/21 , C12P13/22
CPC分类号： C12P17/10 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12N15/52
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.

2. 发明申请

US20090130285A1 Beverage Compositions Comprising Monatin and Methods of Making Same 审中-公开
标题翻译：包含Monatin的饮料组合及其制作方法
公开(公告)号：US20090130285A1
公开(公告)日：2009-05-21
申请号：US12271655
申请日：2008-11-14
申请人： Timothy W. Abraham , Douglas C. Cameron , Melanie J. Goulson , Paula M. Hicks , Michael G. Lindley , Sara C. McFarlan , James R. Millis , John Rosazza , Lishan Zhao , David P. Weiner
发明人： Timothy W. Abraham , Douglas C. Cameron , Melanie J. Goulson , Paula M. Hicks , Michael G. Lindley , Sara C. McFarlan , James R. Millis , John Rosazza , Lishan Zhao , David P. Weiner
IPC分类号： A23L1/236
CPC分类号： A23L2/60 , A23L27/31
摘要： The present invention relates to novel beverage compositions comprising monatin and methods for making such compositions. The present invention also relates to beverage compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
摘要翻译：本发明涉及包含莫纳甜的新型饮料组合物和制备这种组合物的方法。本发明还涉及包含特定莫纳甜立体异构体，莫纳甜立体异构体的特异性共混物和/或通过体内生物合成途径（例如细胞内）或体外产生的莫纳甜的饮料组合物。

3. 发明授权

US07572607B2 Polypeptides and biosynthetic pathways for the production of monatin and its precursors 有权
标题翻译：用于生产莫纳甜及其前体的多肽和生物合成途径
公开(公告)号：US07572607B2
公开(公告)日：2009-08-11
申请号：US11114922
申请日：2005-04-26
申请人： Paula M. Hicks , Sara C. McFarlan , Timothy W. Abraham , Douglas C. Cameron , James R. Millis , John Rosazza , Lishan Zhao , David Paul Weiner
发明人： Paula M. Hicks , Sara C. McFarlan , Timothy W. Abraham , Douglas C. Cameron , James R. Millis , John Rosazza , Lishan Zhao , David Paul Weiner
IPC分类号： C12P13/22 , C12N1/21
CPC分类号： C12P17/10 , C12N15/52
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：提供可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物。还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，体外方法包括化学反应。

4. 发明申请

US20090117625A1 Polypeptides and Biosynthetic Pathways for the Production of Monatin and Its Precursors 有权
标题翻译：用于生产莫纳甜及其前体的多肽和生物合成途径
公开(公告)号：US20090117625A1
公开(公告)日：2009-05-07
申请号：US12124014
申请日：2008-05-20
申请人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , Jim Millis , John Rosazza , Lishan Zhao , David P. Weiner
发明人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , Jim Millis , John Rosazza , Lishan Zhao , David P. Weiner
IPC分类号： C12N9/02
CPC分类号： C12P17/10 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12N15/52
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：提供可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物。还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，体外方法包括化学反应。

5. 发明授权

US08372989B2 Polypeptides and biosynthetic pathways for the production of monatin and its precursors 有权
公开(公告)号：US08372989B2
公开(公告)日：2013-02-12
申请号：US10979821
申请日：2004-11-03
申请人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , John Rosazza , Lishan Zhao , David P. Weiner
发明人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , John Rosazza , Lishan Zhao , David P. Weiner
IPC分类号： C07D209/18 , C12P13/22 , C12P21/06 , C07H21/04 , C12N9/10
CPC分类号： C12P17/10 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12N15/52
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.

6. 发明授权

US08206955B2 Production of monatin and monatin precursors 有权
标题翻译：莫纳甜和莫纳甜前体的生产
公开(公告)号：US08206955B2
公开(公告)日：2012-06-26
申请号：US10969245
申请日：2004-10-21
申请人： Sara C. McFarlan , Paula M. Hicks , Mary Jo Zidwick , Fernando A. Sanchez-Riera , Douglas C. Cameron , Mervyn L. deSouza , John Rosazza , Steven J. Gort , Timothy W. Abraham
发明人： Sara C. McFarlan , Paula M. Hicks , Mary Jo Zidwick , Fernando A. Sanchez-Riera , Douglas C. Cameron , Mervyn L. deSouza , John Rosazza , Steven J. Gort , Timothy W. Abraham
IPC分类号： C12P17/10 , C12N1/00
CPC分类号： C12N9/88 , C12P17/10 , Y02P20/582
摘要： Methods and compositions that can be used to make monatin or salt thereof from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸制备莫纳甜或其盐的方法和组合物，提供。还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，体外方法包括化学反应。

7. 发明授权

US08653780B2 Integrated upsampler and filtering for multi-rate controller for electro-mechanical flight actuation system 有权
标题翻译：用于机电飞行驱动系统的多速率控制器的集成上采样器和滤波器
公开(公告)号：US08653780B2
公开(公告)日：2014-02-18
申请号：US12892853
申请日：2010-09-28
申请人： Douglas C. Cameron
发明人： Douglas C. Cameron
IPC分类号： G05B6/02
CPC分类号： G05B6/02 , B64C19/00 , G05B11/01 , G05B2219/41427
摘要： Presented is a system and method for controlling an actuator in a multirate control system using an integrated upsampler and filter, comprising an incremental command limiter for changing a command from a first control system into a limited incremental command in a second control system, a lead-lag filter for filtering the limited incremental command to attenuate high frequencies, and a feed forward path for reducing phase loss in rate output signal at low frequencies. In embodiments, a command position signal received at the sampling rate of the first control system is interpolated into incremental command position signals at the sampling rate of the second control system. Position error signals and rate error signals from the devices being controlled are used as feedback to further stability the control loops.
摘要翻译：提出了一种使用集成的上采样器和滤波器来控制多速率控制系统中的致动器的系统和方法，包括用于在第二控制系统中将命令从第一控制系统改变为有限增量命令的增量命令限制器，用于滤除限制增量指令以衰减高频的滞后滤波器，以及用于减少低频率速率输出信号的相位损失的前馈路径。在实施例中，以第一控制系统的采样率接收的命令位置信号以第二控制系统的采样率内插到增量命令位置信号中。来自受控设备的位置误差信号和速率误差信号被用作反馈以进一步稳定控制回路。

8. 发明授权

US07142971B2 System and method for automatically controlling a path of travel of a vehicle 有权
标题翻译：用于自动控制车辆行驶路径的系统和方法
公开(公告)号：US07142971B2
公开(公告)日：2006-11-28
申请号：US10369285
申请日：2003-02-19
申请人： Eric D. Brown , Douglas C. Cameron , Krish R. Krothapalli , Walter von Klein, Jr. , Todd M. Williams
发明人： Eric D. Brown , Douglas C. Cameron , Krish R. Krothapalli , Walter von Klein, Jr. , Todd M. Williams
IPC分类号： G06F19/00
CPC分类号： G05D1/0061 , B64D45/0015 , B64D2045/0055
摘要： The method and system for automatically controlling a path of travel of a vehicle include engaging an automatic control system when the security of the onboard controls is jeopardized. Engagement may be automatic or manual from inside the vehicle or remotely via a communication link. Any onboard capability to supersede the automatic control system may then be disabled by disconnecting the onboard controls and/or providing uninterruptible power to the automatic control system via a path that does not include the onboard accessible power control element(s). The operation of the vehicle is then controlled via the processing element of the automatic control system. The control commands may be received from a remote location and/or from predetermined control commands that are stored onboard the vehicle.
摘要翻译：用于自动控制车辆行驶路径的方法和系统包括当车载控制器的安全性受到危害时，使自动控制系统接合。车辆内部可以自动或手动进行参与，也可以通过通信链路远程进行。然后可以通过断开板载控制和/或通过不包括车载可访问功率控制元件的路径向自动控制系统提供不间断电力来禁用取代自动控制系统的任何机载能力。然后通过自动控制系统的处理元件来控制车辆的操作。可以从远程位置和/或从车辆上存储的预定控制命令接收控制命令。

9. 发明授权

US06852517B1 Production of 3-hydroxypropionic acid in recombinant organisms 有权
标题翻译：在重组生物体中生产3-羟基丙酸
公开(公告)号：US06852517B1
公开(公告)日：2005-02-08
申请号：US09830751
申请日：2000-08-30
申请人： Patrick F. Suthers , Douglas C. Cameron
发明人： Patrick F. Suthers , Douglas C. Cameron
IPC分类号： C12N9/02 , C12N9/88 , C12P7/42 , C12P7/62 , C07H21/04 , C12N1/20 , C12N9/00 , C12N15/00
CPC分类号： C12N9/0008 , C12N9/88 , C12P7/42 , C12Y402/0103
摘要： The production of 3-hydroxypropionic acid (3-HP) from glycerol in a bacterial host is described. 3-HP is a useful feedstock for the production of polymeric materials. The genetic engineering of a bacterial host with two enzymes is sufficient to enable production of 3-HP. One enzyme is a glycerol dehydratase and the other is an aldehyde dehydrogenase.
摘要翻译：描述了在细菌宿主中从甘油生产3-羟基丙酸（3-HP）。 3-HP是生产聚合材料的有用原料。具有两种酶的细菌宿主的基因工程足以产生3-HP。一种酶是甘油脱水酶，另一种是醛脱氢酶。

10. 发明授权

US5733749A Glycerol phosphatase with stereo-specific activity 失效
标题翻译：具有立体特异性活性的甘油磷酸酶
公开(公告)号：US5733749A
公开(公告)日：1998-03-31
申请号：US514579
申请日：1995-08-14
申请人： Douglas C. Cameron , Frank A. Skraly
发明人： Douglas C. Cameron , Frank A. Skraly
IPC分类号： C12N15/09 , C12N1/21 , C12N9/16 , C12N15/00 , C12N15/55 , C12P7/20 , C12P41/00 , C12R1/07 , C12R1/10 , C12P19/00 , C07C31/22 , C07H21/04 , C12N1/20
CPC分类号： C12N9/16 , Y10S435/836
摘要： A biologically pure enzyme comprising D-.alpha.-glycerophosphatase from Bacillus licheniformis is disclosed. A genetic construction in a heterologous host capable of producing D-.alpha.-glycerophosphate is also disclosed, wherein the construction includes a protein coding sequence for D-.alpha.-glycerophosphatase from Bacillus licheniformis.
摘要翻译：公开了一种包含来自地衣芽孢杆菌的D-α-甘油磷酸酶的生物学纯酶。还公开了能够产生D-α-甘油磷酸酯的异源宿主中的遗传构建，其中构建包括来自地衣芽孢杆菌的D-α-甘油磷酸酶的蛋白质编码序列。

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