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1. 发明授权

US5541328A Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane 失效
标题翻译：制备取代的2,5-二氨基-3-羟基己烷的方法
公开(公告)号：US5541328A
公开(公告)日：1996-07-30
申请号：US415385
申请日：1995-04-03
申请人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao , David Scarpetti
发明人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao , David Scarpetti
IPC分类号： C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C251/78 , C07C209/44 , C07C221/14
CPC分类号： C07D221/14 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07B2200/07
摘要： A substantially pure compound of formula: ##STR1## wherein R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; andR.sub.g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.
摘要翻译：（I）其中R a和R b独立地选自氢，低级烷基和苯基，R c，R d和R 10独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; （ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，且R 7为R 7aa（O） - ，其中R 7a为低级烷基; 或者R 6和R 7与它们所键合的氮原子一起是其中R f，R g，R h和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基; R g为氢，低级烷基或苄基; 或其酸加成盐。

2. 发明授权

US5543551A Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane 失效
标题翻译：制备取代的2.5-二氨基-3-羟基己烷的方法
公开(公告)号：US5543551A
公开(公告)日：1996-08-06
申请号：US419301
申请日：1995-04-10
申请人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , Hing L. Sham , Thomas J. Sowin , Jien-heh J. Tien , Chen Zhao , David Scarpetti
发明人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , Hing L. Sham , Thomas J. Sowin , Jien-heh J. Tien , Chen Zhao , David Scarpetti
IPC分类号： C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C261/00 , C07C233/00 , C07D209/04
CPC分类号： C07D221/14 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07B2200/07
摘要： Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.8 is hydrogen or --C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
摘要翻译：公开了用于制备基本上纯的下式化合物的中间体和方法：其中R 6和R 7各自为氢或R 6和R 7独立地选自（ⅰ）其中R a和R b独立地为选自氢，低级烷基和苯基，R c，R d和R e独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; （ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，R 7为R 7aa（O） - ，其中R 7a为低级烷基或苄基; 其中R f，R g，Rh和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基，并且R 8是氢或-C（O） R“其中R”为低级烷基，烷氧基，苄氧基或苯基，其中苯环未被取代或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或其酸加成盐。

3. 发明授权

US5491253A Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane 失效
标题翻译：制备取代的2,5-二氨基-3-羟基己烷的方法
公开(公告)号：US5491253A
公开(公告)日：1996-02-13
申请号：US281502
申请日：1994-07-27
申请人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , David Scarpetti , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao
发明人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , David Scarpetti , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao
IPC分类号： C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C261/00 , C07C233/00
CPC分类号： C07D221/14 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07B2200/07
摘要： Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)--wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.8 is hydrogen or --C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
摘要翻译：公开了用于制备基本上纯的下式化合物的中间体和方法：其中R 6和R 7各自为氢或R 6和R 7独立地选自（ⅰ）其中R a和R b独立地为选自氢，低级烷基和苯基，R c，R d和R e独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; （ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，且R 7为R 7 a OC（O） - 其中R 7a为低级烷基或苄基; 其中R f，R g，Rh和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基，并且R 8是氢或-C（O） R“其中R”为低级烷基，烷氧基，苄氧基或苯基，其中苯环未被取代或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或其酸加成盐。

4. 发明授权

US5625092A Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane 失效
标题翻译：制备取代的2.5-二氨基-3-羟基己烷的方法
公开(公告)号：US5625092A
公开(公告)日：1997-04-29
申请号：US419168
申请日：1995-04-10
申请人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. J. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , David Scarpetti , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao
发明人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. J. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , David Scarpetti , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao
IPC分类号： C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C261/00 , C07C233/00 , C07D209/04
CPC分类号： C07D221/14 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07B2200/07
摘要： Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.8 is hydrogen or --C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
摘要翻译：公开了用于制备基本上纯的下式化合物的中间体和方法：其中R 6和R 7各自为氢或R 6和R 7独立地选自（ⅰ）其中R a和R b独立地为选自氢，低级烷基和苯基，R c，R d和R e独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; （ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，R 7为R 7aa（O） - ，其中R 7a为低级烷基或苄基; 其中R f，R g，Rh和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基，并且R 8是氢或-C（O） R“其中R”为低级烷基，烷氧基，苄氧基或苯基，其中苯环未被取代或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或其酸加成盐。

5. 发明授权

US5616776A Process for the preparation of a substituted 2.5-diamono-3-hydroxy-hexane 失效
标题翻译：制备取代的2.5-二氨基-3-羟基己烷的方法
公开(公告)号：US5616776A
公开(公告)日：1997-04-01
申请号：US418705
申请日：1995-04-07
申请人： Timothy L. Stuk , Anthony R. Haight , Francis A. J. Kerdesky , M. Robert Leanna , Howard E. Morton , Timothy A. Robbins , David Scarpetti , Jien-Heh J. Tien
发明人： Timothy L. Stuk , Anthony R. Haight , Francis A. J. Kerdesky , M. Robert Leanna , Howard E. Morton , Timothy A. Robbins , David Scarpetti , Jien-Heh J. Tien
IPC分类号： C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C261/00 , C07C233/00
CPC分类号： C07D221/14 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07B2200/07
摘要： Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.8 is hydrogen or --C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
摘要翻译：公开了用于制备基本上纯的下式化合物的中间体和方法：其中R 6和R 7各自为氢或R 6和R 7独立地选自（ⅰ）其中R a和R b独立地为选自氢，低级烷基和苯基，R c，R d和R e独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; 或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，R 7为R 7aa（O） - ，其中R 7a为低级烷基或苄基; 或R 6和R 7与它们所键合的氮原子一起为氢，低级烷基，烷氧基，卤素和三氟甲基，R8为氢或-C（O）R“，其中R”为低级烷基，烷氧基，苄氧基或苯基，其中苯环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或其酸加成盐。

6. 发明授权

US5569777A Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane 失效
公开(公告)号：US5569777A
公开(公告)日：1996-10-29
申请号：US418727
申请日：1995-04-07
申请人： Timothy L. Stuk , Anthony R. Haight , Howard E. Morton , Timothy A. Robbins , David Scarpetti , Jien-Heh J. Tien
发明人： Timothy L. Stuk , Anthony R. Haight , Howard E. Morton , Timothy A. Robbins , David Scarpetti , Jien-Heh J. Tien
IPC分类号： C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C261/00 , C07C233/00 , C07D209/04
CPC分类号： C07D221/14 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07B2200/07
摘要： Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.8 is hydrogen or --C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

7. 发明授权

US5672706A Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane 失效
标题翻译：制备取代的2,5-二氨基-3-羟基己烷的方法
公开(公告)号：US5672706A
公开(公告)日：1997-09-30
申请号：US633605
申请日：1996-04-17
申请人： Anthony R. Haight , Owen J. Goodmonson , Shyamal I. Parekh , Timothy A. Robbins , Lou S. Seif
发明人： Anthony R. Haight , Owen J. Goodmonson , Shyamal I. Parekh , Timothy A. Robbins , Lou S. Seif
IPC分类号： B01J23/42 , B01J31/06 , B01J32/00 , C07B61/00 , C07C213/00 , C07C215/28 , C07C215/32 , C07D209/44 , C07C209/68 , C07D221/14
CPC分类号： C07C213/00 , C07C215/32
摘要： A process is disclosed for the preparation of the substantially pure compound of the formula: ##STR1## comprising catalytic hydrogenation of a compound of the formula: ##STR2## wherein R.sub.6 and R.sub.7 are independently selected from ##STR3## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR4## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR5## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; or an acid addition salt thereof.
摘要翻译：公开了用于制备基本上纯的下式化合物的方法：包括下式化合物的催化氢化：其中R6和R7独立地选自（i）其中Ra和Rb 独立地选自氢，低级烷基和苯基，R c，R d和R e独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; （ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或者R 6和R 7与它们所键合的氮原子一起是其中R f，R g，Rh和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基; 或其酸加成盐。

8. 发明授权

US06698110B1 Spiked shoe having a spike cleaning cushion 失效
标题翻译：具有尖峰清洁垫的尖刺鞋
公开(公告)号：US06698110B1
公开(公告)日：2004-03-02
申请号：US10280659
申请日：2002-10-28
申请人： Timothy A. Robbins
发明人： Timothy A. Robbins
IPC分类号： A43B1500
CPC分类号： A43B5/185 , A43B13/187
摘要： A spike shoe has a cushion mounted on the outer sole thereof. The cushion has spike-accommodating bores defined therein and each spike is accommodated in a bore. The cushion compresses as the wearer of the shoe places his or her weight on the sole of the shoe. The spike-accommodating bores are sized and shaped so the cushion adjacent to each bore contacts the spike accommodated in the bore during the compression of the cushion and prior to the cushion being fully compressed whereby each spike is wiped by the cushion every time the wearer places his or her weight on the shoe during a walking or running movement.
摘要翻译：钉鞋具有安装在其外底上的缓冲垫。衬垫具有限定在其中的穗形容纳孔，并且每个穗状物容纳在孔中。当鞋的佩戴者将他或她的重量放在鞋底上时，衬垫压缩。钉子容纳孔的尺寸和形状使得与每个孔相邻的衬垫在垫压缩期间接触容纳在孔中的钉，并且在衬垫被完全压缩之前，每次穿戴者放置时每个钉被缓冲垫擦拭他或她在步行或跑步运动时的重量。

9. 发明申请

US20090203664A1 (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6- DIAZABICYCLO[3.2.0]HEPTANE 审中-公开
标题翻译：（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷
公开(公告)号：US20090203664A1
公开(公告)日：2009-08-13
申请号：US12426511
申请日：2009-04-20
申请人： Michael J. Buckley , Jianguo Ji , Geoff G.Z. Zhang , Rodger F. Henry , Weili W. Wang , Gregory S. Wayne , Wenke Li , Timothy B. Towne , Steven J. Wittenberger , Steven M. Hannick , Brian J. Kotecki , Bryan S. Macri , Timothy A. Robbins
发明人： Michael J. Buckley , Jianguo Ji , Geoff G.Z. Zhang , Rodger F. Henry , Weili W. Wang , Gregory S. Wayne , Wenke Li , Timothy B. Towne , Steven J. Wittenberger , Steven M. Hannick , Brian J. Kotecki , Bryan S. Macri , Timothy A. Robbins
IPC分类号： A61K31/397 , A61P25/00 , A61P25/28 , C07D401/14
CPC分类号： C07D487/04 , A61K31/397
摘要： The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
摘要翻译：本发明公开了（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷及其盐，其用于治疗与烟碱乙酰胆碱受体。

10. 发明授权

US07354937B2 (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane 有权
标题翻译：（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷
公开(公告)号：US07354937B2
公开(公告)日：2008-04-08
申请号：US11176087
申请日：2005-07-07
申请人： Michael J. Buckley , Jianguo Ji , Geoff G. Z. Zhang , Rodger F. Henry , Weili W. Wang , Gregory S. Wayne , Wenke Li , Timothy B. Towne , Steven J. Wittenberger , Steven M. Hannick , Brian J. Kotecki , Bryan S. Macri , Timothy A. Robbins
发明人： Michael J. Buckley , Jianguo Ji , Geoff G. Z. Zhang , Rodger F. Henry , Weili W. Wang , Gregory S. Wayne , Wenke Li , Timothy B. Towne , Steven J. Wittenberger , Steven M. Hannick , Brian J. Kotecki , Bryan S. Macri , Timothy A. Robbins
IPC分类号： A61K31/4745 , C07D487/04
CPC分类号： C07D487/04 , A61K31/397
摘要： The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
摘要翻译：本发明公开了（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷及其盐，其用于治疗与烟碱乙酰胆碱受体。

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