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1. 发明授权

US5958894A Amphiphilic biguanide derivatives 失效
标题翻译：两亲双胍衍生物
公开(公告)号：US5958894A
公开(公告)日：1999-09-28
申请号：US825854
申请日：1997-04-04
申请人： Timothy D. Heath , Igor Solodin , Jinkang Wang , Yi-Lin Zhang
发明人： Timothy D. Heath , Igor Solodin , Jinkang Wang , Yi-Lin Zhang
IPC分类号： A61K9/127 , A61K48/00 , C07C279/26
CPC分类号： C07C279/26 , A61K48/00 , A61K9/1272
摘要： Cationic derivatives of biguanide are provided, which are useful in the preparation of lipid carriers for mediating transfection of mammalian cells in vivo and in vitro.
摘要翻译：提供了双胍的阳离子衍生物，其可用于制备体内和体外介导哺乳动物细胞转染的脂质载体。

2. 发明授权

US06235310B1 Methods of delivery using cationic lipids and helper lipids 失效
标题翻译：使用阳离子脂质和辅助脂质的递送方法
公开(公告)号：US06235310B1
公开(公告)日：2001-05-22
申请号：US09054769
申请日：1998-04-03
申请人： Jinkang Wang , Yi-Lin Zhang
发明人： Jinkang Wang , Yi-Lin Zhang
IPC分类号： A61K9127
CPC分类号： A61K9/1272
摘要： Methods and compositions are provided for the introduction of polyanionic molecules, in particular, nucleic acids, into mammalian cells using certain phosphatidyl ethanolamines as helper lipids in conjunction with various cationic lipids. In particular, cationic lipid-mediated transfection of mammalian cells is improved by the use of lipid carriers comprising DLPE or DiPPE and cationic lipids.
摘要翻译：提供了使用某些磷脂酰乙醇胺作为辅助脂质与各种阳离子脂质结合使用聚阴离子分子，特别是核酸引入哺乳动物细胞的方法和组合物。特别地，通过使用包含DLPE或DiPPE和阳离子脂质的脂质载体来改善哺乳动物细胞的阳离子脂质介导的转染。

3. 发明申请

US20060286392A1 Housing and method for making the same 审中-公开
标题翻译：住房和制作方法
公开(公告)号：US20060286392A1
公开(公告)日：2006-12-21
申请号：US11396838
申请日：2006-04-03
申请人： Chih-Pen Lin , Yong-Ming Li , Yi-Lin Zhang , Cheng-Guo Zhang , Nai-Juan Ren , Xian-Feng Luo
发明人： Chih-Pen Lin , Yong-Ming Li , Yi-Lin Zhang , Cheng-Guo Zhang , Nai-Juan Ren , Xian-Feng Luo
IPC分类号： B32B15/04 , B32B9/00 , C23C14/00
CPC分类号： C23C14/165 , B32B15/01 , B32B15/013 , B32B15/017 , C23C14/0635 , C23C28/322 , C23C28/341 , G06F1/1613 , G06F1/1684 , G06F1/181 , H05K5/02 , Y10T428/12576 , Y10T428/31678
摘要： A housing (100) includes a housing base (10), a chromium film (12), and a chromium carbide film (14). The housing base is made of a material of metal or metal alloys. The chromium film is formed on a surface of the housing base, and the chromium carbide film is formed on a surface of the chromium film. The present invention also provides a method for making the housing.
摘要翻译：壳体（100）包括壳体基座（10），铬膜（12）和碳化铬膜（14）。外壳基座由金属或金属合金材料制成。在壳体基体的表面上形成铬膜，在铬膜的表面上形成碳化铬膜。本发明还提供一种制造该壳体的方法。

4. 发明授权

US5332811A Etopside analogs 失效
标题翻译： Etopside类似物
公开(公告)号：US5332811A
公开(公告)日：1994-07-26
申请号：US693300
申请日：1991-05-01
申请人： Kuo-Hsiung Lee , Xiao-Ming Zhou , Zhe-Qing Wang , Jang-Yang Chang , Hong-Xing Chen , Yung-Chi Cheng , Ya-Ching Shen , Fu-Shen Han , Hong Hu , Yi-Lin Zhang
发明人： Kuo-Hsiung Lee , Xiao-Ming Zhou , Zhe-Qing Wang , Jang-Yang Chang , Hong-Xing Chen , Yung-Chi Cheng , Ya-Ching Shen , Fu-Shen Han , Hong Hu , Yi-Lin Zhang
IPC分类号： C07D493/04 , C07D413/02 , C07D307/77
CPC分类号： C07D493/04
摘要： Compounds which are analogs of etoposide and which exhibit anti-tumor activity are disclosed. These compounds having the following structure: ##STR1## wherein R is selected from ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each independently selected from H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, i--C.sub.3 H.sub.7, C.sub.4 H.sub.9, CF.sub.3, OCH.sub.3, OC.sub.2 H.sub.5 , OC.sub.3 H.sub.7, OC.sub.4 H.sub.9, O--i--C.sub.3 H.sub.7, O--i--C.sub.4 H.sub.9, --OCH.sub.2 O--, --OCH.sub.2 CH.sub.2 O--, CH.sub.2 OH, C.sub.2 H.sub.4 OH, CH.sub.2 Cl C.sub.2 H.sub.4 Cl, CH.sub.2 F, C.sub.2 H.sub.4 F, CH.sub.2 OCH.sub.3, COCH.sub.3, COC.sub.2 H.sub.5, CO.sub.2 CH.sub.3, CO.sub.2 C.sub.2 H.sub.5, NO.sub.2, NH.sub.2, NH.sub.2.HCl, NH.sub.2.HAc, NH.sub.2.1/2H.sub.2 SO.sub.4 , NH.sub.2.1/3H.sub.3 PO.sub.4, N(CH.sub.3).sub.2, N(C.sub.2 H.sub.5).sub.2, OH, CN, N.sub.3, SO.sub.2 H, SO.sub.2 NH.sub.2 , SO.sub.2 Cl, phenyl, substituted phenyl, phenoxy, substituted phenoxy, anilinyl, substituted anilinyl, cyclohexyl, piperidine, ##STR3## wherein R.sub.6 is selected from hydrogen, methyl, ethyl, n-propyl, i-propyl, butyl and bridged methylene;wherein R.sub.7 is selected from ##STR4##
摘要翻译：公开了依托泊苷的类似物并表现出抗肿瘤活性的化合物。这些具有以下结构的化合物：其中R选自和，其中R1，R2，R3，R4和R5各自独立地选自H，CH3，C2H5，C3H7，i-C3H7，C4H9 ，CF3，OCH3，OC2H5，OC3H7，OC4H9，Oi-C3H7，O_4H9，-OCH2O-，-OCH2CH2O-，CH2OH，C2H4OH，CH2Cl C2H4Cl，CH2F，C2H4F，CH2OCH3，COCH3，COC2H5，CO2CH3，CO2C2H5，，NH2，NH2HCl，NH2HAc，NH2 / 2H2SO4，NH2 / 3H3PO4，N（CH3）2，N（C2H5）2，OH，CN，N3，SO2H，SO2NH2，SO2Cl，苯基，苯氧基，取代的苯氧基，苯乙烯基，取代的苯乙烯基，环己基，哌啶，其中R 6选自氢，甲基，乙基，正丙基，异丙基，丁基和桥连亚甲基; 其中R7选自

5. 发明授权

US5300500A 4 beta-amino podophyllotoxin analog compounds and methods 失效
标题翻译： 4种β-氨基鬼臼毒素类似物和方法
公开(公告)号：US5300500A
公开(公告)日：1994-04-05
申请号：US987765
申请日：1992-12-08
申请人： Kuo-Hsiung Lee , Yung-Chi Cheng , Yi-Lin Zhang
发明人： Kuo-Hsiung Lee , Yung-Chi Cheng , Yi-Lin Zhang
IPC分类号： C07D493/04 , A61K31/535 , A61K31/365 , C07D413/02
CPC分类号： C07D493/04
摘要： Novel podophyllotoxin compounds and their use in treating tumors are disclosed. In one embodiment, the compounds have the general formula: ##STR1## wherein NH-R is a selected from the from the group consisting of: ##STR2##
摘要翻译：公开了新型鬼臼毒素化合物及其在治疗肿瘤中的用途。在一个实施方案中，化合物具有以下通式：（*化学结构*）其中NH-R选自：（*化学结构*）（*化学结构*）（*化学结构*）（*化学结构*）

6. 发明申请

US20070023095A1 Vacuum chamber inlet device 审中-公开
标题翻译：真空室入口装置
公开(公告)号：US20070023095A1
公开(公告)日：2007-02-01
申请号：US11448568
申请日：2006-06-07
申请人： Chih-Pen Lin , Yong-Ming Li , Yi-Lin Zhang
发明人： Chih-Pen Lin , Yong-Ming Li , Yi-Lin Zhang
IPC分类号： F16K11/22
CPC分类号： F16K51/02 , H01L21/67017 , Y10T137/87877
摘要： A vacuum chamber inlet device includes a gas providing element (10), a plurality of flow control element (20), and a plurality of gas input elements (30). The gas providing element has an inlet (11) and a plurality of outlets (12). The flow control elements are connected to the outlets of the gas input element. Each of the gas input elements has a first end (31) and a second end (32). The first end is connected to the flow control elements, and the second end is disposed in the vacuum chamber. A gas vent (33) is formed on the second end.
摘要翻译：真空室入口装置包括气体提供元件（10），多个流量控制元件（20）和多个气体输入元件（30）。气体提供元件具有入口（11）和多个出口（12）。流量控制元件连接到气体输入元件的出口。每个气体输入元件具有第一端（31）和第二端（32）。第一端连接流量控制元件，第二端设置在真空室中。在第二端形成有排气口（33）。

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