专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050109659A1 Blister packages with frames and associated methods of fabricating dry powder drug containment systems 有权
标题翻译：具有框架的吸塑包装以及制造干粉药物容纳系统的相关方法
公开(公告)号：US20050109659A1
公开(公告)日：2005-05-26
申请号：US10970549
申请日：2004-10-21
申请人： Anthony Hickey , Timothy Crowder , Jeffrey Warden , Keith Johnson , Mark Ketner , Jay Fording , Michael Garten , William Riley , Sean Anderson , Bruce Ferris , Paul Rockwell
发明人： Anthony Hickey , Timothy Crowder , Jeffrey Warden , Keith Johnson , Mark Ketner , Jay Fording , Michael Garten , William Riley , Sean Anderson , Bruce Ferris , Paul Rockwell
IPC分类号： A61M15/00 , B65D75/32 , B65D75/34 , B65D83/06 , B65D83/04
CPC分类号： B65D75/327 , A61M15/001 , A61M15/0045 , A61M15/0048 , A61M2202/064 , B65D83/06
摘要： Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.
摘要翻译：干粉泡罩包装包括具有压电有源层的密封泡罩，其弯曲以使泡沫中的干粉振动以促进主动分散。

2. 发明申请

US20060191534A1 Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods 审中-公开
标题翻译：干粉吸入装置，多剂量干粉药物包装，控制系统及相关方法
公开(公告)号：US20060191534A1
公开(公告)日：2006-08-31
申请号：US11294681
申请日：2005-12-05
申请人： Anthony Hickey , Timothy Crowder
发明人： Anthony Hickey , Timothy Crowder
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M15/0085 , A61M15/0048 , A61M15/0051 , A61M2016/0021 , A61M2202/064 , A61M2205/50
摘要： Dry powder inhalers with integrated active energy patient assist dispersal systems are configured with control systems which provide adjustable energy output responsive to the user's inspiratory capabilities and/or the flowability of the dry powder drug being administered. The multi-dose dry drug package includes a piezoelectric polymer substrate (such as PVDF) which flexes to deform and provide mechanical oscillation in a selected region of the package corresponding to the dry powder drug dose in the exit flow path and is thus actively dispersed into the exit flow path of the inhaler during the user's inspiratory activity. Control systems employ fuzzy logic models of the flowability of particular drug formulations (also being able to compensate or allow for the particular type of excipient used) and/or adjust for the real-time measured inspiratory efforts of the user. Manufacturing process control systems can adjust certain parameters in response to a fuzzy logic model of the flowability of the dry powder and other conditions associated with the dry powder drug being produced and/or dispensed.
摘要翻译：具有集成的活跃能量患者辅助分散系统的干粉吸入器配置有控制系统，其响应于使用者的吸入能力和/或所施用的干粉药物的流动性而提供可调节的能量输出。多剂量干药包包括压电聚合物基材（例如PVDF），该压电聚合物基体在与出口流动路径中的干粉药物剂量相对应的包装的选定区域中弯曲变形并提供机械振荡，因此主动分散于用户吸气活动期间吸入器的出口流动路径。控制系统使用特定药物制剂的流动性的模糊逻辑模型（也能够补偿或允许所使用的特定类型的赋形剂）和/或调节用户实时测量的吸气努力。制造过程控制系统可以响应于干粉流动性的模糊逻辑模型和与所生产和/或分配的干粉药物相关的其它条件来调节某些参数。

3. 发明申请

US20050267628A1 Dry powder dose filling systems and related methods 有权
标题翻译：干粉剂量灌装系统及相关方法
公开(公告)号：US20050267628A1
公开(公告)日：2005-12-01
申请号：US11179163
申请日：2005-07-12
申请人： Timothy Crowder , Anthony Hickey
发明人： Timothy Crowder , Anthony Hickey
IPC分类号： B65B1/08 , A61M13/00 , A61M15/00 , B65B37/04 , B65D88/66 , B65G53/40 , B65G53/66 , G01F11/00
CPC分类号： B65D88/66 , A61M15/0003 , A61M15/0005 , A61M15/001 , A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0065 , A61M15/0068 , A61M15/0075 , A61M2202/064 , A61M2205/18 , A61M2205/35 , A61M2205/52 , A61M2205/8206 , B65B37/04 , B65G53/66
摘要： Systems for flowably dispensing dry powders include means for generating a first non-linear vibration input signal, the first non-linear input signal comprising a carrier frequency modulated by a plurality of different selected frequencies that correspond to a first dry powder formulation whereby first meted quantities of the first dry powder are serially dispensed to a receiving member. Related devices and computer program products for dispensing dry powders are also described.
摘要翻译：用于流动分配干燥粉末的系统包括用于产生第一非线性振动输入信号的装置，第一非线性输入信号包括由对应于第一干粉配方的多个不同选定频率调制的载波频率，的第一干粉末被顺序地分配到接收构件。还描述了用于分配干粉的相关设备和计算机程序产品。

4. 发明申请

US20050126569A1 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 有权
标题翻译：干粉吸入器，相关的泡罩装置以及分配干粉物质的相关方法和制造吸塑包装
公开(公告)号：US20050126569A1
公开(公告)日：2005-06-16
申请号：US11043363
申请日：2005-01-26
申请人： Timothy Crowder , Anthony Hickey , Jeffrey Warden
发明人： Timothy Crowder , Anthony Hickey , Jeffrey Warden
IPC分类号： B65B1/08 , A61M15/00 , B65B37/04 , B65D88/66 , B65G53/40 , B65G53/66 , B05D7/14 , A61M16/00
CPC分类号： B65D88/66 , A61M15/0003 , A61M15/0005 , A61M15/001 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0065 , A61M15/0075 , A61M2202/064 , A61M2205/18 , A61M2205/35 , A61M2205/52 , A61M2205/8206 , B65B37/04 , B65G53/66
摘要： The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.
摘要翻译：本发明包括用于分配和/或保持吸入剂配制干粉物质的干粉吸入器以及相关的制造和分配方法，其可采用包括多个叠加频率的调幅非线性信号，该频率对应于先验流特征频率的干粉被分配。本发明还包括具有弹性柔性枢转盖的口袋式吸入器。

5. 发明授权

US07196059B2 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 有权
标题翻译：胰岛素药物 - 低聚物共轭物的药物组合物及其治疗疾病的方法
公开(公告)号：US07196059B2
公开(公告)日：2007-03-27
申请号：US10382155
申请日：2003-03-05
申请人： Richard Soltero , Balasingam Radhakrishan , Nnochiri N. Ekwuribe , Bruce Rehlaender , Anthony Hickey , Li Li Bovet
发明人： Richard Soltero , Balasingam Radhakrishan , Nnochiri N. Ekwuribe , Bruce Rehlaender , Anthony Hickey , Li Li Bovet
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： A61K47/554 , A61K47/542 , A61K47/60
摘要： Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component, when together, can be present in a weight-to-weight ratio of between 1:15 and 15:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
摘要翻译：描述了包括胰岛素，胰岛素药物 - 低聚物缀合物，脂肪酸组分和胆汁盐组分或不含脂肪酸组分的胆汁盐组分的药物组合物。胰岛素药物与低聚部分共价偶联。当一起时，脂肪酸组分和胆汁盐组分可以以1:15至15:1的重量比重存在。还提供了使用这种药物组合物治疗需要这种治疗的受试者的胰岛素缺乏症的方法，以及提供这种药物组合物的方法。

6. 发明授权

US06770625B2 Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith 有权
标题翻译：降钙素药物 - 低聚物共轭物的药物组合物及其治疗疾病的方法
公开(公告)号：US06770625B2
公开(公告)日：2004-08-03
申请号：US10235284
申请日：2002-09-05
申请人： Richard Soltero , Nnochiri N. Ekwuribe , Foyeke Opawale , Bruce Rehlaender , Anthony Hickey , Li Li Bovet
发明人： Richard Soltero , Nnochiri N. Ekwuribe , Foyeke Opawale , Bruce Rehlaender , Anthony Hickey , Li Li Bovet
IPC分类号： A61K3802
CPC分类号： A61K47/554 , A61K47/542 , A61K47/60 , Y10S514/808
摘要： Pharmaceutical compositions that include a drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating diseases in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
摘要翻译：描述了包括药物 - 低聚物缀合物，脂肪酸组分和胆汁盐组分的药物组合物。该药物与低聚部分共价偶联。脂肪酸组分和胆汁盐组分以1:5至5:1的重量比重存在。还提供了使用这种药物组合物治疗需要这种治疗的受试者的疾病的方法，以及提供这种药物组合物的方法。

7. 发明授权

US07030082B2 Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith 有权
标题翻译：药物 - 低聚物共轭物的药物组合物及其治疗疾病的方法
公开(公告)号：US07030082B2
公开(公告)日：2006-04-18
申请号：US10382069
申请日：2003-03-05
申请人： Richard Soltero , Nnochiri N. Ekwuribe , Foyeke Opawale , Bruce Rehlaender , Anthony Hickey , Li Li Bovet
发明人： Richard Soltero , Nnochiri N. Ekwuribe , Foyeke Opawale , Bruce Rehlaender , Anthony Hickey , Li Li Bovet
IPC分类号： A61K38/02 , A61K38/23
CPC分类号： A61K47/554 , A61K47/542 , A61K47/60
摘要： Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component, when together, can be present in a weight-to-weight ratio of between 1:15 and 15:1 or any value between. Methods of treating diseases in a subject in need of such treatment using the pharmaceutical compositions of this invention are also provided, as well as methods of providing such pharmaceutical compositions.
摘要翻译：描述了包含药物和/或药物 - 低聚物缀合物，脂肪酸组分和胆汁盐组分的药物组合物或不含脂肪酸组分的胆汁盐组分。该药物可共价偶联至寡聚部分。当一起时，脂肪酸组分和胆汁盐组分可以以1:15至15:1的重量比或两者之间的任何值存在。还提供了使用本发明的药物组合物治疗需要这种治疗的受试者的疾病的方法以及提供这种药物组合物的方法。

8. 发明授权

US06867183B2 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 有权
标题翻译：胰岛素药物 - 低聚物共轭物的药物组合物及其治疗疾病的方法
公开(公告)号：US06867183B2
公开(公告)日：2005-03-15
申请号：US10235381
申请日：2002-09-05
申请人： Richard Soltero , Balasingam Radhakrishan , Nnochiri N. Ekwuribe , Bruce Rehlaender , Anthony Hickey , Li Li Bovet
发明人： Richard Soltero , Balasingam Radhakrishan , Nnochiri N. Ekwuribe , Bruce Rehlaender , Anthony Hickey , Li Li Bovet
IPC分类号： A61K47/48 , A61K38/28 , C07K14/62
CPC分类号： A61K47/554 , A61K47/542 , A61K47/60
摘要： Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
摘要翻译：描述了包括胰岛素药物 - 低聚物缀合物，脂肪酸组分和胆汁盐组分的药物组合物。胰岛素药物与低聚部分共价偶联。脂肪酸组分和胆汁盐组分以1:5至5:1的重量比重存在。还提供了使用这种药物组合物治疗需要这种治疗的受试者的胰岛素缺乏症的方法，以及提供这种药物组合物的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式