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1. 发明申请

US20050256168A1 Compositions for oral administration for the treatment of interferon-responsive disorders 审中-公开
标题翻译：用于治疗干扰素反应性疾病的口服给药组合物
公开(公告)号：US20050256168A1
公开(公告)日：2005-11-17
申请号：US11116088
申请日：2005-04-27
申请人： Timothy Block , Anand Mehta , Xuanyong Lu , Raymond Dwek
发明人： Timothy Block , Anand Mehta , Xuanyong Lu , Raymond Dwek
IPC分类号： A61K31/4015 , A61K31/445
CPC分类号： A61K31/4015 , A61K31/445
摘要： Compositions and methods of treatment of interferon-responsive disorders are provided wherein the methods, for example, comprise orally administering a composition which comprises a therapeutically effective amount of at least one alkylated imino sugar having an alkylated side chain, and a pharmaceutically acceptable carrier.
摘要翻译：提供了治疗干扰素反应性病症的组合物和方法，其中所述方法例如包括口服施用包含治疗有效量的至少一种具有烷基化侧链的烷基化亚氨基糖的组合物和药学上可接受的载体。

2. 发明申请

US20050053625A1 Method of treating viral infections 审中-公开
标题翻译：治疗病毒感染的方法
公开(公告)号：US20050053625A1
公开(公告)日：2005-03-10
申请号：US10494377
申请日：2002-10-30
申请人： Timothy Block , Anand Mehta , Raymond Dwek
发明人： Timothy Block , Anand Mehta , Raymond Dwek
IPC分类号： A61K31/445 , A61K38/16 , A61K39/29
CPC分类号： A61K31/445 , A61K38/162 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/5258 , C12N2730/10134 , A61K2300/00
摘要： The present invention relates to the treatment of viral infections, particularly HBV and HCV infections, with a combination comprising a vaccine against a virus antigen and compounds that inhibit glucosidase activity in the host cell.
摘要翻译：本发明涉及包含针对病毒抗原的疫苗和抑制宿主细胞中的葡糖苷酶活性的化合物的组合的病毒感染，特别是HBV和HCV感染的治疗。

3. 发明申请

US20120244160A1 IDENTIFICATION OF MODULATORS OF SERINE PROTEASE INHIBITOR KAZAL AND THEIR USE AS ANTI-CANCER AND ANTI-VIRAL AGENTS 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂KAZAL调节剂的鉴定及其作为抗癌剂和抗病毒剂的用途
公开(公告)号：US20120244160A1
公开(公告)日：2012-09-27
申请号：US13480886
申请日：2012-05-25
申请人： Xuanyong Lu , Timothy Block
发明人： Xuanyong Lu , Timothy Block
IPC分类号： A61K31/713 , C12Q1/02 , C07H21/02 , C07K16/40 , A61K39/395 , C40B30/08 , C12Q1/68
CPC分类号： C12Q1/37 , G01N2333/96433 , G01N2500/02
摘要： This disclosure describes a relevant etiology of cancer and a novel anti-cancer therapeutic strategy, based on the discovery that a protein named serine protease inhibitor (SPIK/SPINK/PSTI) was up-regulated by hepatitis B and C virus infections consequently suppressing the cell apoptosis. Accordingly, the present disclosure provides, inter alia, an inhibitor of SPIK and/or a technology of suppression of over-expression of SPIK in cells. The inhibitors include: 1) chemical compounds, which can inhibit SPIK transcripts, protein activity, and gene expression, 2) SPIK siRNA (RNAi gene silence or dsRNA of SPIK, 3) DNA anti-sense and anti-SPIK antibody. Further, this disclosure provides methods of using the inhibitor as an anti-cancer agent to re-instate cancer cell apoptosis (e.g., serine protease dependent cell apoptosis).
摘要翻译：本公开描述了癌症的相关病因和新型抗癌治疗策略，基于以下发现：称为丝氨酸蛋白酶抑制剂（SPIK / SPINK / PSTI）的蛋白质被乙型和丙型肝炎病毒感染上调，从而抑制细胞凋亡。因此，本公开尤其提供SPIK抑制剂和/或抑制细胞中SPIK过度表达的技术。抑制剂包括：1）可抑制SPIK转录物，蛋白质活性和基因表达的化合物，2）SPIK siRNA（SPIK的RNAi基因沉默或dsRNA，3）DNA反义和抗SPIK抗体。此外，本公开提供使用抑制剂作为抗癌剂来重新制备癌细胞凋亡（例如，丝氨酸蛋白酶依赖性细胞凋亡）的方法。

4. 发明授权

US08193328B2 Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents 失效
标题翻译：鉴定丝氨酸蛋白酶抑制剂Kazal的调节剂及其作为抗癌和抗病毒剂的用途
公开(公告)号：US08193328B2
公开(公告)日：2012-06-05
申请号：US12065840
申请日：2006-09-07
申请人： Xuanyong Lu , Timothy Block
发明人： Xuanyong Lu , Timothy Block
IPC分类号： C12N15/15 , C12N15/11 , C12N15/113
CPC分类号： C12Q1/37 , G01N2333/96433 , G01N2500/02
摘要： This invention describes a relevant etiology of cancer and a novel anti-cancer therapeutic strategy, based on the discovery that a protein named serine protease inhibitor (SPIK/SPINK/PSTI) was up-regulated by hepatitis B and C virus infections consequently suppressing the cell apoptosis. Accordingly, this invention provides an inhibitor of SPIK and/or a technology of suppression of over-expression of SPIK in cells. The inhibitors include: 1) chemical compounds, which can inhibit SPIK transcripts, protein activity, and gene expression, 2) SPIK siRNA (RNAi gene silence or dsRNA of SPIK, 3) DNA anti-sense and anti-SPIK antibody. Further, this invention provides a method of using the inhibitor as an anti-cancer agent to re-instate cancer cell apoptosis (e.g., serine protease dependent cell apoptosis).
摘要翻译：本发明描述了癌症的相关病因和新型抗癌治疗策略，基于以下发现：称为丝氨酸蛋白酶抑制剂（SPIK / SPINK / PSTI）的蛋白质被乙型和丙型肝炎病毒感染上调，从而抑制细胞凋亡。因此，本发明提供了SPIK抑制剂和/或抑制细胞中SPIK过度表达的技术。抑制剂包括：1）可抑制SPIK转录物，蛋白质活性和基因表达的化合物，2）SPIK siRNA（SPIK的RNAi基因沉默或dsRNA，3）DNA反义和抗SPIK抗体。此外，本发明提供了使用该抑制剂作为抗癌剂来重新制备癌细胞凋亡（如丝氨酸蛋白酶依赖性细胞凋亡）的方法。

5. 发明申请

US20090017457A1 IDENTIFICATION OF MODULATORS OF SERINE PROTEASE INHIBITOR KAZAL AND THEIR USE AS ANTI-CANCER AND ANTI-VIRAL AGENTS 失效
标题翻译：丝氨酸蛋白酶抑制剂KAZAL调节剂的鉴定及其作为抗癌剂和抗病毒剂的用途
公开(公告)号：US20090017457A1
公开(公告)日：2009-01-15
申请号：US12065840
申请日：2006-09-07
申请人： Xuanyong Lu , Timothy Block
发明人： Xuanyong Lu , Timothy Block
IPC分类号： C12Q1/68 , G01N33/573 , C07H21/02 , C12Q1/37 , C12Q1/02
CPC分类号： C12Q1/37 , G01N2333/96433 , G01N2500/02
摘要： This invention describes a relevant etiology of cancer and a novel anti-cancer therapeutic strategy, based on the discovery that a protein named serine protease inhibitor (SPIK/SPINK/PSTI) was up-regulated by hepatitis B and C virus infections consequently suppressing the cell apoptosis. Accordingly, this invention provides an inhibitor of SPIK and/or a technology of suppression of over-expression of SPIK in cells. The inhibitors include: 1) chemical compounds, which can inhibit SPIK transcripts, protein activity, and gene expression, 2) SPIK siRNA (RNAi gene silence or dsRNA of SPIK, 3) DNA anti-sense and anti-SPIK antibody. Further, this invention provides a method of using the inhibitor as an anti-cancer agent to re-instate cancer cell apoptosis (e.g., serine protease dependent cell apoptosis).
摘要翻译：本发明描述了癌症的相关病因和新型抗癌治疗策略，基于以下发现：称为丝氨酸蛋白酶抑制剂（SPIK / SPINK / PSTI）的蛋白质被乙型和丙型肝炎病毒感染上调，从而抑制细胞凋亡。因此，本发明提供了SPIK抑制剂和/或抑制细胞中SPIK过度表达的技术。抑制剂包括：1）可抑制SPIK转录物，蛋白质活性和基因表达的化合物，2）SPIK siRNA（SPIK的RNAi基因沉默或dsRNA，3）DNA反义和抗SPIK抗体。此外，本发明提供了使用该抑制剂作为抗癌剂来重新制备癌细胞凋亡（如丝氨酸蛋白酶依赖性细胞凋亡）的方法。

6. 发明申请

US20050267153A1 Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections 审中-公开
标题翻译：使用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物治疗肝炎病毒感染
公开(公告)号：US20050267153A1
公开(公告)日：2005-12-01
申请号：US10910197
申请日：2004-08-03
申请人： Richard Mueller , Martin Bryant , Richard Partis , Gary Jacob , Timothy Block , Raymond Dwek
发明人： Richard Mueller , Martin Bryant , Richard Partis , Gary Jacob , Timothy Block , Raymond Dwek
IPC分类号： A61K31/445 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K45/06 , A61P1/16 , A61P31/20 , C07D211/46 , C07H19/10
CPC分类号： C07D211/46 , A61K31/445 , A61K45/06
摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
摘要翻译：提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。方法包括（1）单独或与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂单独或组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2）单独或与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

7. 发明申请

US20060106065A1 Methods of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D- glucuitol compounds in combination therapy 审中-公开
标题翻译：联合治疗用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡聚糖化合物治疗肝炎病毒感染的方法
公开(公告)号：US20060106065A1
公开(公告)日：2006-05-18
申请号：US11300463
申请日：2005-12-15
申请人： Gary Jacob , Timothy Block , Raymond Dwek
发明人： Gary Jacob , Timothy Block , Raymond Dwek
IPC分类号： A61K31/445
CPC分类号： C07D211/46 , A61K31/445 , A61K45/06
摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.
摘要翻译：提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。方法包括（1）与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2 ）与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

8. 发明申请

US20060094671A1 Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy 失效
公开(公告)号：US20060094671A1
公开(公告)日：2006-05-04
申请号：US11300464
申请日：2005-12-15
申请人： Gary Jacob , Timothy Block , Raymond Dwek
发明人： Gary Jacob , Timothy Block , Raymond Dwek
IPC分类号： A61K31/7076 , A61K31/7072 , A61K31/7056 , A61K31/445
CPC分类号： C07D211/46 , A61K31/445 , A61K45/06
摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

9. 发明申请

US20070037221A1 Diagnosis of liver pathology through assessment of protein glycosylation 有权
标题翻译：通过评估蛋白质糖基化诊断肝脏病理学
公开(公告)号：US20070037221A1
公开(公告)日：2007-02-15
申请号：US11418598
申请日：2006-05-05
申请人： Timothy Block , Mary Comunale , Anand Mehta
发明人： Timothy Block , Mary Comunale , Anand Mehta
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/6893 , G01N33/57438 , G01N2333/4728 , G01N2800/08 , G01N2800/085 , G01N2800/7028
摘要： Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.
摘要翻译：公开了用于诊断怀疑患有这种病理学的受试者的肝脏病理学的方法。所述方法包括定量检测生物流体中的蛋白质上的糖基化，更具体地岩藻糖基化，并将检测到的糖基化与在健康或疾病状态下这些蛋白质糖基化的参考值进行比较。

10. 发明授权

US06355248B1 Method of modulating an immune response in an infected mammal by transmucosal administration of modulating agent 有权
标题翻译：通过经粘膜施用调节剂调节感染的哺乳动物的免疫应答的方法
公开(公告)号：US06355248B1
公开(公告)日：2002-03-12
申请号：US09334819
申请日：1999-06-17
申请人： Frank Michaels , Timothy Block
发明人： Frank Michaels , Timothy Block
IPC分类号： A61K3929
CPC分类号： C12N15/8257 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0381 , A61K38/162 , A61K38/164 , A61K39/12 , A61K39/292 , A61K2039/517 , A61K2039/5256 , A61K2039/542 , C12N15/8509 , C12N2710/24143 , C12N2730/10134 , C12N2770/00043 , Y02A50/41 , Y02A50/414
摘要： Methods and compositions for modulating an immune response in a mammal infected with a bacterium, a virus, or a parasite are provided. The methods and compositions are useful in mammals experiencing an acute infection and in mammals experiencing a chronic infection. The methods and compositions may be used in conjunction with a known treatment for infection of a mammal by an infectious agent. Methods and compositions for transmucosal delivery of a molecule comprising an epitope located in close proximity to the immune response are provided.
摘要翻译：提供了用于调节感染细菌，病毒或寄生虫的哺乳动物的免疫应答的方法和组合物。所述方法和组合物可用于经历急性感染的哺乳动物和经历慢性感染的哺乳动物。所述方法和组合物可以结合已知的治疗用于感染性感染哺乳动物的方法使用。提供了包含位于紧邻免疫应答的表位的分子的经粘膜递送的方法和组合物。

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