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1. 发明授权

US08895015B2 Norovirus capsid and rotavirus VP6 protein for use as combined vaccine 有权
标题翻译：诺如病毒衣壳和轮状病毒VP6蛋白用作联合疫苗
公开(公告)号：US08895015B2
公开(公告)日：2014-11-25
申请号：US13269326
申请日：2011-10-07
申请人： Timo Vesikari , Vesna Blazevic , Kirsi Nurminen , Leena Huhti , Suvi Lappalainen , Eeva Jokela
发明人： Timo Vesikari , Vesna Blazevic , Kirsi Nurminen , Leena Huhti , Suvi Lappalainen , Eeva Jokela
IPC分类号： A61K39/00 , A61K39/12 , A61K39/15 , A61K39/125 , C12Q1/70
CPC分类号： A61K39/125 , A61K39/12 , A61K39/15 , A61K2039/5258 , A61K2039/70 , C12N2710/14143 , C12N2720/12323 , C12N2720/12334 , C12N2770/16023 , C12N2770/16034 , C12N2799/026 , C12N2800/22
摘要： The present invention relates to a combined norovirus and rotavirus vaccine for prevention of norovirus and rotavirus infection and/or viral-induced diarrheal and vomiting diseases in man. More specifically, the invention comprises a method of preparing combination vaccine compositions comprising norovirus and rotavirus antigens, in particular mixtures of norovirus VLPs and rotavirus recombinant VP6 protein or double-layered VP2/VP6 VLPs. In addition, the invention relates to methods of inducing an immune response.
摘要翻译：本发明涉及用于预防诺如病毒和轮状病毒感染和/或病毒诱导的人体腹泻和呕吐疾病的组合诺瓦病毒和轮状病毒疫苗。更具体地，本发明包括制备包含诺如病毒和轮状病毒抗原，特别是诺如病毒VLP和轮状病毒重组VP6蛋白或双层VP2 / VP6 VLP的混合物的组合疫苗组合物的方法。此外，本发明涉及诱导免疫应答的方法。

2. 发明授权

US07510718B2 Expression vectors and uses thereof 有权
标题翻译：表达载体及其用途
公开(公告)号：US07510718B2
公开(公告)日：2009-03-31
申请号：US10476615
申请日：2002-05-03
申请人： Kai Krohn , Vesna Blazevic , Marja Tahtinen , Mart Ustav , Urve Toots , Andres Mannik , Annamari Ranki , Ene Ustav
发明人： Kai Krohn , Vesna Blazevic , Marja Tahtinen , Mart Ustav , Urve Toots , Andres Mannik , Annamari Ranki , Ene Ustav
IPC分类号： A61K39/00 , A61K39/40 , A61K39/42 , A61K39/295 , A61K39/385 , A61K49/00 , C12Q1/70 , C12N15/00
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/53 , C12N15/85 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing the vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics containing the vectors, and to therapeutic uses of the vectors. The novel vectors comprise (a) an expression cassette of a gene of a nuclear-anchoring protein, which contains (i) a DNA binding domain capable of binding to a specific DNA sequence and (ii) a functional domain capable of binding to a nuclear component and (b) a multimerized DNA sequence forming a binding site for the anchoring protein, and optionally (c) one or more expression cassettes of a DNA sequence of interest. The vectors lack a papilloma virus origin of replication.
摘要翻译：本发明涉及新载体，DNA疫苗和含有载体的基因治疗剂，载体和DNA疫苗的制备方法和含有载体的基因治疗剂以及载体的治疗用途。新载体包含（a）核锚定蛋白基因的表达盒，其包含（i）能够结合特异性DNA序列的DNA结合结构域和（ii）能够结合核的功能结构域组分和（b）形成锚定蛋白的结合位点的多聚DNA序列，以及（c）感兴趣的DNA序列的一个或多个表达盒。载体缺乏乳头瘤病毒复制起点。

3. 发明授权

US07498314B2 Expression vectors and uses thereof 有权
标题翻译：表达载体及其用途
公开(公告)号：US07498314B2
公开(公告)日：2009-03-03
申请号：US10138098
申请日：2002-05-03
申请人： Kai Krohn , Vesna Blazevic , Marja Tähtinen , Mart Ustav , Urve Toots , Andres Männik , Annamari Ranki , Ene Ustav
发明人： Kai Krohn , Vesna Blazevic , Marja Tähtinen , Mart Ustav , Urve Toots , Andres Männik , Annamari Ranki , Ene Ustav
IPC分类号： A61K48/00 , A61K31/711 , C07H21/04 , C12N5/10 , C12N1/21 , C12P21/00
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/53 , C12N15/85 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing said vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics, and to therapeutic uses of said vectors. More specifically, the present invention relates to novel vectors comprising an expression cassette of a gene of a nuclear-anchoring protein, which contains a DNA binding domain capable of binding to a specific DNA sequence and a functional domain capable of binding to a nuclear component and a multimerized DNA sequence forming a binding site for the nuclear-anchoring protein, and optionally an expression cassette of a gene, genes or a DNA sequence or DNA sequences of interest. The present invention further relates to DNA vaccines and gene therapeutics containing the novel vectors, to methods for the preparation of the novel vectors and the DNA vaccines and gene therapeutics.
摘要翻译：本发明涉及新型载体，DNA疫苗和含有所述载体的基因治疗剂，用于制备载体和DNA疫苗和基因治疗剂的方法以及所述载体的治疗用途。更具体地，本发明涉及包含核锚定蛋白的基因的表达盒的新载体，其包含能够结合特定DNA序列的DNA结合结构域和能够结合核成分的功能结构域，形成核 - 锚定蛋白的结合位点的多聚DNA序列，以及任选的基因的表达盒，感兴趣的DNA序列或DNA序列。本发明还涉及含有新载体的DNA疫苗和基因治疗剂，用于制备新载体和DNA疫苗和基因治疗剂的方法。

4. 发明申请

US20050026137A1 Novel expression vectors and uses thereof 有权
标题翻译：新型表达载体及其用途
公开(公告)号：US20050026137A1
公开(公告)日：2005-02-03
申请号：US10476615
申请日：2002-05-03
申请人： Kai Krohn , Vesna Blazevic , Marja Tahtinen , Mart Ustav , Urve Toots , Andres Mannjk , Annamari Ranki , Ene Ustav
发明人： Kai Krohn , Vesna Blazevic , Marja Tahtinen , Mart Ustav , Urve Toots , Andres Mannjk , Annamari Ranki , Ene Ustav
IPC分类号： A61K48/00 , C12N15/85 , C12Q1/70 , C12N15/86
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/53 , C12N15/85 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing said vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics containing the vectors, and to therapeutic uses of said vectors. More specifically, the present invention relates to novel vectors comprising (a) an expression cassette of a gene of a nuclear-anchoring protein, which contains (i) a DNA binding domain capable of binding to a specific DNA sequence and (ii) a functional domain capable of binding to a nuclear component and (b) a multimerized DNA sequence forming a binding site for the anchoring protein, and optionally (c) one or more expression cassettes of a DNA sequence of interest. In particular the invention relates to vectors that lack a papilloma virus origin of replication. The nuclear-anchoring protein might be the E2 protein of Bovine Papilloma Virus type 1 or Epstein-Barr Virus Nuclear Antigen 1. The invention also relates to vectors that lack an origin of replication functional in a mammalian cell. The invention further relates to methods for expressing a DNA sequence of interest in a subject.
摘要翻译：本发明涉及新载体，DNA疫苗和含有所述载体的基因治疗剂，用于制备载体和DNA疫苗的方法以及含有载体的基因治疗剂以及所述载体的治疗用途。更具体地说，本发明涉及包含（a）核锚定蛋白基因的表达盒的新载体，其包含（i）能够结合特定DNA序列的DNA结合结构域和（ii）功能性能够结合核组分的结构域和（b）形成锚定蛋白的结合位点的多聚化DNA序列，以及任选（c）感兴趣的DNA序列的一个或多个表达盒。特别地，本发明涉及缺乏乳头瘤病毒复制起点的载体。核锚定蛋白可能是牛乳头瘤病毒1型或爱泼斯坦 - 巴尔病毒核抗原1的E2蛋白。本发明还涉及在哺乳动物细胞中缺乏复制起点的载体。本发明还涉及在受试者中表达感兴趣的DNA序列的方法。

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