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1. 发明申请

US20100292201A1 NOVEL STEROIDAL ESTERS OF 17-OXIMINO-5-ANDROSTEN-3BETA-OL 有权
标题翻译： 17-OXIMINO-5-ANDROSTEN-3BETA-OL的新型甾体酯
公开(公告)号：US20100292201A1
公开(公告)日：2010-11-18
申请号：US12733415
申请日：2008-08-14
申请人： Tilak Raj Bhardwaj , Manoj Kumar , Neelima Dhingra , Neeraj Mehta
发明人： Tilak Raj Bhardwaj , Manoj Kumar , Neelima Dhingra , Neeraj Mehta
IPC分类号： A61K31/568 , C07J41/00 , A61P5/28 , A61P13/08
CPC分类号： C07J41/0016
摘要： The present invention relates to steroidal esters of 17-oximino-5-androsten-3-ol, of compound of general formula (A) wherein R is selected from a group consisting of arylalkyl, aryl, substituted aryl. The ester derivatives are synthesized starting from Dehydroandrosterone acetate. The compounds were tested for their antiproliferative activity and 5α-reductase inhibitory activity in comparison to Finasteride. Decreased androgen level have been found in serum of animal treated with newly synthesized compounds. These compounds have also shown better cytotoxicity in comparison to reference drug Finasteride. Thus such compounds can be useful in treatment of androgen dependent disorder of prostate alone or by synergistic effect they can decrease the size of prostate due to their antiproliferative activity.
摘要翻译：本发明涉及通式（A）化合物，其中R选自芳烷基，芳基，取代芳基的17-肟基-5-雄甾-3-醇类甾体酯。酯衍生物是从乙酸脱氢睾酮开始合成的。与非那雄胺相比，测试了这些化合物的抗增殖活性和5α-还原酶抑制活性。在新合成的化合物处理的动物血清中发现雄激素水平降低。与参考药物非那雄胺相比，这些化合物也显示出更好的细胞毒性。因此，这样的化合物可用于治疗前列腺单独的雄激素依赖性病症或通过协同作用，由于它们的抗增殖活性，它们可以减少前列腺的大小。

2. 发明申请

US20100234472A1 NITRIC OXIDE RELEASING DERIVATIVES OF PARACETAMOL 有权
标题翻译： PARACETAMOL的氮氧化物释放衍生物
公开(公告)号：US20100234472A1
公开(公告)日：2010-09-16
申请号：US12707410
申请日：2010-02-17
申请人： Tilak Raj BHARDWAJ , Manoj Kumar , Neeraj Mehta , Neelima Dhingra
发明人： Tilak Raj BHARDWAJ , Manoj Kumar , Neeraj Mehta , Neelima Dhingra
IPC分类号： A61K31/167 , C07C233/74 , A61P29/00
CPC分类号： C07C233/25
摘要： The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the corresponding nitrate ester derivatives. The nitrate esters of paracetamol are useful as analgesic, anti-inflammatory agents.
摘要翻译：本发明特别涉及新型的扑热息痛的硝酸酯。对乙酰氨基酚的硝酸酯通过使对乙酰氨基酚与二卤烷基化合物反应，随后与硝酸银反应得到相应的硝酸酯衍生物。对乙酰氨基酚的硝酸酯可用作止痛剂，抗炎剂。

3. 发明授权

US08207222B2 Nitric oxide releasing derivatives of paracetamol 有权
标题翻译：扑热息痛的一氧化氮释放衍生物
公开(公告)号：US08207222B2
公开(公告)日：2012-06-26
申请号：US12707410
申请日：2010-02-17
申请人： Tilak Raj Bhardwaj , Manoj Kumar , Necraj Mehta , Neelima Dhingra
发明人： Tilak Raj Bhardwaj , Manoj Kumar , Necraj Mehta , Neelima Dhingra
IPC分类号： C07C203/04 , A61K31/167
CPC分类号： C07C233/25
摘要： The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the corresponding nitrate ester derivatives. The nitrate esters of paracetamol are useful as analgesic, anti-inflammatory agents.
摘要翻译：本发明特别涉及新型的扑热息痛的硝酸酯。对乙酰氨基酚的硝酸酯通过使对乙酰氨基酚与二卤烷基化合物反应，随后与硝酸银反应得到相应的硝酸酯衍生物。对乙酰氨基酚的硝酸酯可用作止痛剂，抗炎剂。

4. 发明授权

US08435975B2 Steroidal esters of 17-oximino-5-androsten-3beta-ol 有权
标题翻译： 17-肟基-5-雄甾-3β-醇的甾体酯
公开(公告)号：US08435975B2
公开(公告)日：2013-05-07
申请号：US12733415
申请日：2008-08-14
申请人： Tilak Raj Bhardwaj , Manoj Kumar , Neelima Dhingra , Neraj Mehta
发明人： Tilak Raj Bhardwaj , Manoj Kumar , Neelima Dhingra , Neraj Mehta
IPC分类号： A61K31/568 , C07J41/00 , A61P5/28
CPC分类号： C07J41/0016
摘要： The present invention relates to steroidal esters of 17-oximino-5-androsten-3-ol, of compound of general formula (A) wherein R is selected from a group consisting of arylalkyl, aryl, substituted aryl. The ester derivatives are synthesized starting from Dehydroandrosterone acetate. The compounds were tested for their antiproliferative activity and 5α-reductase inhibitory activity in comparison to Finasteride. Decreased androgen level have been found in serum of animal treated with newly synthesized compounds. These compounds have also shown better cytotoxicity in comparison to reference drug Finasteride. Thus such compounds can be useful in treatment of androgen dependent disorder of prostate alone or by synergistic effect they can decrease the size of prostate due to their antiproliferative activity.
摘要翻译：本发明涉及通式（A）化合物，其中R选自芳烷基，芳基，取代芳基的17-肟基-5-雄甾-3-醇类甾体酯。酯衍生物是从乙酸脱氢睾酮开始合成的。与非那雄胺相比，测试化合物的抗增殖活性和5α-还原酶抑制活性。在新合成的化合物处理的动物血清中发现雄激素水平降低。与参考药物非那雄胺相比，这些化合物也显示出更好的细胞毒性。因此，这样的化合物可用于治疗前列腺单独的雄激素依赖性病症或通过协同作用，由于它们的抗增殖活性，它们可以减少前列腺的大小。

5. 发明授权

US08597927B2 Enzymatic prevention and control of biofilm 有权
标题翻译：生物膜的酶促预防和控制
公开(公告)号：US08597927B2
公开(公告)日：2013-12-03
申请号：US12810004
申请日：2008-12-16
申请人： Christopher C. Barnett , Manoj Kumar , Gregory M. Whited
发明人： Christopher C. Barnett , Manoj Kumar , Gregory M. Whited
IPC分类号： C12N9/14 , C12N9/16 , C12N9/18 , C12N9/26 , C12N9/44 , C12N9/48 , C12N9/54 , C12N9/58 , C11D7/42
CPC分类号： A01N63/02 , C11D3/386 , C11D3/38636
摘要： The invention provides methods, compositions, and kits for removal of biofilms from surfaces. The methods described herein comprise simultaneous or sequential application of a perhydrolase enzyme and a mixture of other enzymes, such as proteases, glucanases, esterases, mannanases, phospholipases, cellulases, and/or amylases, to a biofilm on a surface, to effect removal of the biofilm.
摘要翻译：本发明提供从表面去除生物膜的方法，组合物和试剂盒。本文描述的方法包括同时或顺序地将表面上的生物膜同时或顺序施用过水解酶和其它酶（例如蛋白酶，葡聚糖酶，酯酶，甘露聚糖酶，磷脂酶，纤维素酶和/或淀粉酶）的混合物，以去除生物膜。

6. 发明授权

US08551748B2 Process for upgrading of liquid hydrocarbon fuels 有权
标题翻译：液化碳氢燃料的升级工艺
公开(公告)号：US08551748B2
公开(公告)日：2013-10-08
申请号：US12684390
申请日：2010-01-08
申请人： Manoj Kumar , Mahendra Pratap Singh , Maya Chakradhar , Dheer Singh , Veena Bansal , Vijay Kumar Chhatwal , Ravinder Kumar Malhotra , Anand Kumar
发明人： Manoj Kumar , Mahendra Pratap Singh , Maya Chakradhar , Dheer Singh , Veena Bansal , Vijay Kumar Chhatwal , Ravinder Kumar Malhotra , Anand Kumar
IPC分类号： C12P5/00
CPC分类号： C12N15/01 , C10G21/12 , C10G21/27 , C10G32/00 , C10G33/00 , C10G53/04 , C12N1/20
摘要： Disclosed herein a process for upgrading the liquid hydrocarbon fuels by reducing aromatic content, sulfur content and nitrogen content wherein the process comprising isolating polycyclic aromatic hydrocarbon (PAH) transforming microbes and preparing biocatalyst by mutagenesis, contacting the biocatalyst with the liquid hydrocarbon fuel in an aqueous medium for transforming the aromatic, sulfur, and nitrogen containing compounds to polar substances, subjecting the mixture of biocatalyst and the liquid hydrocarbon fuel to a process of bioconversion, removing the polar substances by liquid-liquid extraction with a polar solvent to obtain dearomatized, desulphurised and denitrogenated liquid hydrocarbon fuel and recovering the upgraded liquid hydrocarbon fuel.
摘要翻译：本文公开了通过降低芳烃含量，硫含量和氮含量来提高液体烃燃料的方法，其中所述方法包括通过诱变分离多环芳烃（PAH）转化微生物并制备生物催化剂，使生物催化剂与液体烃燃料在水溶液用于将芳族，硫和氮的化合物转化为极性物质的介质，使生物催化剂和液体烃燃料的混合物经历生物转化过程，通过用极性溶剂液 - 液萃取除去极性物质，得到脱芳香，脱硫和脱氮液态烃燃料，并回收升级液化烃燃料。

7. 发明申请

US20120214209A1 Methods For Producing End-Products From Carbon Substrates 审中-公开
标题翻译：从碳基材生产最终产品的方法
公开(公告)号：US20120214209A1
公开(公告)日：2012-08-23
申请号：US13458548
申请日：2012-04-27
申请人： Gopal K. Chotani , Manoj Kumar , Jeff P. Pucci , Karl J. Sanford , Jayarama K. Shetty
发明人： Gopal K. Chotani , Manoj Kumar , Jeff P. Pucci , Karl J. Sanford , Jayarama K. Shetty
IPC分类号： C12P19/20 , C12P7/20 , C12P7/56 , C12P7/04 , C12P7/58 , C12P17/04 , C12P7/46 , C12P7/14 , C12P7/18 , C12P7/60
CPC分类号： C12P7/56 , C12P7/06 , C12P7/10 , C12P7/18 , C12P7/20 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/58 , C12P7/60 , C12P19/02 , C12P2201/00 , Y02E50/16 , Y02E50/17
摘要： The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction of the substrate.
摘要翻译：本发明提供了生产基于生物质的原料基质的体外和/或体内生物转化所需的终产物的方法，包括但不限于淀粉和纤维素等材料。在特别优选的实施方案中，本发明的方法不需要基质的凝胶化和/或液化。

8. 发明授权

US08048859B2 Use of repeat sequence protein polymers in personal care compositions 失效
标题翻译：在个人护理组合物中使用重复序列蛋白聚合物
公开(公告)号：US08048859B2
公开(公告)日：2011-11-01
申请号：US11860911
申请日：2007-09-25
申请人： Manoj Kumar , William A. Cuevas
发明人： Manoj Kumar , William A. Cuevas
IPC分类号： A61K38/19 , A61K38/17
CPC分类号： A61K8/0212 , A61K8/0229 , A61K8/64 , A61K38/1709 , A61K2800/28 , A61Q1/02 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q3/00 , A61Q3/02 , A61Q5/006 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/002 , A61Q19/10
摘要： A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.
摘要翻译：提供个人护理组合物并且包括有效量的重复序列蛋白质聚合物。个人护理组合物可以是护发组合物，护肤组合物，指甲护理组合物，化妆品组合物或非处方药物组合物。

9. 发明授权

US08034583B2 Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters 有权
标题翻译：具有非功能性内源葡萄糖酸盐转运蛋白的代谢改造的细菌菌株
公开(公告)号：US08034583B2
公开(公告)日：2011-10-11
申请号：US12141522
申请日：2008-06-18
申请人： Timothy C. Dodge , Manoj Kumar , M. Harunur Rashid , Fernando Valle
发明人： Timothy C. Dodge , Manoj Kumar , M. Harunur Rashid , Fernando Valle
IPC分类号： C12P21/06
CPC分类号： C12P7/58 , C07K14/24 , C12P7/60
摘要： The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
摘要翻译：本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。

10. 发明授权

US07919295B2 Polyol oxidases 有权
标题翻译：多元氧化酶
公开(公告)号：US07919295B2
公开(公告)日：2011-04-05
申请号：US11875788
申请日：2007-10-19
申请人： Manoj Kumar , Susan M. Madrid , Hugh C. McDonald , Ayrookaran J. Poulose , Thomas Rand , Huaming Wang
发明人： Manoj Kumar , Susan M. Madrid , Hugh C. McDonald , Ayrookaran J. Poulose , Thomas Rand , Huaming Wang
IPC分类号： C12N9/00 , C12N9/02 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/0006 , C07K2319/02 , C11D3/38654 , C12Y101/03
摘要： The present invention provides compositions and methods for producing a polyol oxidase in microorganisms, and the use of polyol oxidases in cleaning compositions. The invention includes cleaning compositions that contain combinations of two or more POx oxidases, and cleaning compositions that contain combinations of two or more POx oxidases and a perhydrolase. In particular, the invention provides methods for expressing polyol oxidases in bacterial hosts for use in detergent applications for cleaning, bleaching and disinfecting.
摘要翻译：本发明提供了用于在微生物中生产多元醇氧化酶的组合物和方法，以及在清洁组合物中使用多元醇氧化酶。本发明包括含有两种或更多种POx氧化酶的组合的清洁组合物和含有两种或更多种POx氧化酶和过水解酶的组合的清洁组合物。特别地，本发明提供了用于在洗涤剂应用中用于清洁，漂白和消毒的细菌宿主中表达多元氧化酶的方法。

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