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1. 发明授权

US07970581B2 Methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional 有权
标题翻译：通过置换的溶剂功能计算同系配体对之间的结合亲和力差异的方法
公开(公告)号：US07970581B2
公开(公告)日：2011-06-28
申请号：US12791493
申请日：2010-06-01
申请人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
发明人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
IPC分类号： G01N33/48
CPC分类号： G06F19/706 , G06F19/704 , G06F19/708
摘要： Described is a technique to exhaustively enumerate the thermodynamic properties of the water molecules solvating the active site of a protein in its apostate and calculate the relative binding affinities of congeneric compounds that bind to this protein. The subject matter includes sampling the configurations of the solvating water in the active site; extracting the thermodynamic information about the solvating water from these configurations by clustering the observed water configurations into regions of high water occupancy (e.g., “hydration sites”), computing the average system interaction energies of water molecules occupying the various hydrations sites, computing excess entropies of water molecules occupying the hydration sites; constructing a 3 dimensional hydration thermodynamics map of the protein active site; and computing relative binding affinities of congeneric ligands based on the principle that tighter binding ligands can displace more entropically structured and energetically depleted hydration sites from the active site into the bulk fluid.
摘要翻译：描述了一种全面列举溶剂化其脱保护素中蛋白质的活性位点的水分子的热力学性质并计算结合该蛋白质的同源化合物的相对结合亲和力的技术。主题包括抽取活性部位溶剂化水的结构; 通过将观察到的水配置聚集到高占有率的区域（例如“水合位点”），从这些构造提取溶解水的热力学信息，计算占据各种水合位点的水分子的平均系统相互作用能量，计算过量熵的水分子占据水合位置; 构建蛋白活性位点的三维水合热力学图; 并计算同源配体的相对结合亲和力，其原理是更紧密的结合配体可以将更多的熵结构化和能量耗尽的水合位点从活性位点移动到体液中。

2. 发明申请

US20090037136A1 Methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional 有权
标题翻译：通过置换的溶剂功能计算同系配体对之间的结合亲和力差异的方法
公开(公告)号：US20090037136A1
公开(公告)日：2009-02-05
申请号：US11982783
申请日：2007-11-05
申请人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
发明人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
IPC分类号： G01K13/00 , G06F17/18
CPC分类号： G06F19/706 , G06F19/704 , G06F19/708
摘要： Described is a technique to exhaustively enumerate the thermodynamic properties of the water molecules solvating the active site of a protein in its apostate and calculate the relative binding affinities of congeneric compounds that bind to this protein. The subject matter includes sampling the configurations of the solvating water in the active site; extracting the thermodynamic information about the solvating water from these configurations by clustering the observed water configurations into regions of high water occupancy (e.g., “hydration sites”), computing the average system interaction energies of water molecules occupying the various hydrations sites, computing excess entropies of water molecules occupying the hydration sites; constructing a 3 dimensional hydration thermodynamics map of the protein active site; and computing relative binding affinities of congeneric ligands based on the principle that tighter binding ligands can displace more entropically structured and energetically depleted hydration sites from the active site into the bulk fluid.
摘要翻译：描述了一种全面列举溶剂化其脱保护素中蛋白质的活性位点的水分子的热力学性质并计算结合该蛋白质的同源化合物的相对结合亲和力的技术。主题包括抽取活性部位溶剂化水的结构; 通过将观察到的水配置聚集到高占有率的区域（例如“水合位点”），从这些构造提取溶解水的热力学信息，计算占据各种水合位点的水分子的平均系统相互作用能量，计算过量熵的水分子占据水合位置; 构建蛋白活性位点的三维水合热力学图; 并计算同源配体的相对结合亲和力，其原理是更紧密的结合配体可以将更多的熵结构化和能量耗尽的水合位点从活性位点移动到体液中。

3. 发明授权

US07756674B2 Methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional 有权
标题翻译：通过置换的溶剂功能计算同系配体对之间的结合亲和力差异的方法
公开(公告)号：US07756674B2
公开(公告)日：2010-07-13
申请号：US11982783
申请日：2007-11-05
申请人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
发明人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
IPC分类号： G06F17/18 , G01N33/53
CPC分类号： G06F19/706 , G06F19/704 , G06F19/708
摘要： Described is a technique to exhaustively enumerate the thermodynamic properties of the water molecules solvating the active site of a protein in its apostate and calculate the relative binding affinities of congeneric compounds that bind to this protein. The subject matter includes sampling the configurations of the solvating water in the active site; extracting the thermodynamic information about the solvating water from these configurations by clustering the observed water configurations into regions of high water occupancy (e.g., “hydration sites”), computing the average system interaction energies of water molecules occupying the various hydrations sites, computing excess entropies of water molecules occupying the hydration sites; constructing a 3 dimensional hydration thermodynamics map of the protein active site; and computing relative binding affinities of congeneric ligands based on the principle that tighter binding ligands can displace more entropically structured and energetically depleted hydration sites from the active site into the bulk fluid.
摘要翻译：描述了一种全面列举溶剂化其脱保护素中蛋白质的活性位点的水分子的热力学性质并计算结合该蛋白质的同源化合物的相对结合亲和力的技术。主题包括抽取活性部位溶剂化水的结构; 通过将观察到的水配置聚集到高占有率的区域（例如“水合位点”），从这些构造提取溶解水的热力学信息，计算占据各种水合位点的水分子的平均系统相互作用能量，计算过量熵的水分子占据水合位置; 构建蛋白活性位点的三维水合热力学图; 并计算同源配体的相对结合亲和力，其原理是更紧密的结合配体可以将更多的熵结构化和能量耗尽的水合位点从活性位点移动到体液中。

4. 发明授权

US07970580B2 Methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional 有权
公开(公告)号：US07970580B2
公开(公告)日：2011-06-28
申请号：US12791448
申请日：2010-06-01
申请人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
发明人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
IPC分类号： G01N33/48
CPC分类号： G06F19/706 , G06F19/704 , G06F19/708
摘要： Described is a technique to exhaustively enumerate the thermodynamic properties of the water molecules solvating the active site of a protein in its apostate and calculate the relative binding affinities of congeneric compounds that bind to this protein. The subject matter includes sampling the configurations of the solvating water in the active site; extracting the thermodynamic information about the solvating water from these configurations by clustering the observed water configurations into regions of high water occupancy (e.g., “hydration sites”), computing the average system interaction energies of water molecules occupying the various hydrations sites, computing excess entropies of water molecules occupying the hydration sites; constructing a 3 dimensional hydration thermodynamics map of the protein active site; and computing relative binding affinities of congeneric ligands based on the principle that tighter binding ligands can displace more entropically structured and energetically depleted hydration sites from the active site into the bulk fluid.

5. 发明申请

US20100241412A1 Methods of Calculating Differences of Binding Affinities Between Congeneric Pairs of Ligands by Way of a Displaced Solvent Functional 有权
公开(公告)号：US20100241412A1
公开(公告)日：2010-09-23
申请号：US12791493
申请日：2010-06-01
申请人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
发明人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
IPC分类号： G06G7/58
CPC分类号： G06F19/706 , G06F19/704 , G06F19/708
摘要： Described is a technique to exhaustively enumerate the thermodynamic properties of the water molecules solvating the active site of a protein in its apostate and calculate the relative binding affinities of congeneric compounds that bind to this protein. The subject matter includes sampling the configurations of the solvating water in the active site; extracting the thermodynamic information about the solvating water from these configurations by clustering the observed water configurations into regions of high water occupancy (e.g., “hydration sites”), computing the average system interaction energies of water molecules occupying the various hydrations sites, computing excess entropies of water molecules occupying the hydration sites; constructing a 3 dimensional hydration thermodynamics map of the protein active site; and computing relative binding affinities of congeneric ligands based on the principle that tighter binding ligands can displace more entropically structured and energetically depleted hydration sites from the active site into the bulk fluid.

6. 发明申请

US20100241411A1 Methods of Calculating Differences of Binding Affinities Between Congeneric Pairs of Ligands by Way of a Displaced Solvent Functional 有权
标题翻译：通过置换溶剂功能计算配体同系对之间的结合亲和力差异的方法
公开(公告)号：US20100241411A1
公开(公告)日：2010-09-23
申请号：US12791448
申请日：2010-06-01
申请人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
发明人： Thomas Young , Robert Abel , Richard A. Friesner , Bruce J. Berne
IPC分类号： G06G7/58
CPC分类号： G06F19/706 , G06F19/704 , G06F19/708
摘要： Described is a technique to exhaustively enumerate the thermodynamic properties of the water molecules solvating the active site of a protein in its apostate and calculate the relative binding affinities of congeneric compounds that bind to this protein. The subject matter includes sampling the configurations of the solvating water in the active site; extracting the thermodynamic information about the solvating water from these configurations by clustering the observed water configurations into regions of high water occupancy (e.g., “hydration sites”), computing the average system interaction energies of water molecules occupying the various hydrations sites, computing excess entropies of water molecules occupying the hydration sites; constructing a 3 dimensional hydration thermodynamics map of the protein active site; and computing relative binding affinities of congeneric ligands based on the principle that tighter binding ligands can displace more entropically structured and energetically depleted hydration sites from the active site into the bulk fluid.
摘要翻译：描述了一种全面列举溶剂化其脱保护素中蛋白质的活性位点的水分子的热力学性质并计算结合该蛋白质的同源化合物的相对结合亲和力的技术。主题包括抽取活性部位溶剂化水的结构; 通过将观察到的水配置聚集到高占有率的区域（例如“水合位点”），从这些构造提取溶解水的热力学信息，计算占据各种水合位点的水分子的平均系统相互作用能量，计算过量熵的水分子占据水合位置; 构建蛋白活性位点的三维水合热力学图; 并计算同源配体的相对结合亲和力，其原理是更紧密的结合配体可以将更多的熵结构化和能量耗尽的水合位点从活性位点移动到体液中。

7. 发明申请

US20060014986A1 Process for purifying bisphenol-a 有权
标题翻译：双酚-A的纯化方法
公开(公告)号：US20060014986A1
公开(公告)日：2006-01-19
申请号：US10530432
申请日：2003-11-12
申请人： Thomas Young , Damian Feord , Johann-Wilhelm Frey
发明人： Thomas Young , Damian Feord , Johann-Wilhelm Frey
IPC分类号： C07C37/68
CPC分类号： C07C37/68 , C07C37/00 , C07C37/685 , C07C37/72 , C07C37/74 , C07C37/84 , C07C39/16
摘要： Bisphenol-A is purified in a process which comprises the following steps: a) cooling a liquid mixture comprising bisphenol-A and water in a bisphenol-A crystallizer to form bisphenol-A crystals in a liquid phase; b) separating the bisphenol-A crystals from the liquid phase; c) dividing at least a portion of the liquid phase into a bisphenol-rich organic phase and a water-rich phase; d) feeding phenol and at least a portion of the bisphenol-rich organic phase into a adduct crystallizer to form a crystalline adduct of phenol and bisphenol-A in a mother liquor, and e) separating the crystalline adduct from the mother liquor. Bisphenol-A of high purity at a high yield is obtained.
摘要翻译：双酚A在包括以下步骤的方法中纯化：a）在双酚A结晶器中冷却包含双酚A和水的液体混合物以形成液相中的双酚A晶体; b）从液相中分离出双酚A晶体; c）将至少一部分液相分成富含双酚的有机相和富水相; d）将苯酚和至少一部分富含双酚的有机相加入到加合物结晶器中以在母液中形成苯酚和双酚-A的结晶加合物，和e）从母液中分离结晶加合物。获得高纯度的双酚A。

8. 发明授权

US06334441B1 Phonation valve for breathing tube 有权
标题翻译：呼吸管用呼吸阀
公开(公告)号：US06334441B1
公开(公告)日：2002-01-01
申请号：US09197669
申请日：1998-11-23
申请人： John Zowtiak , Thomas Young , Tony Wondka
发明人： John Zowtiak , Thomas Young , Tony Wondka
IPC分类号： A61M1600
CPC分类号： A61M16/0468 , F16K15/148
摘要： In accordance with the present invention, a phonation valve which is cooperatively connectable to a breathing tube connected to a patient's airway, includes a valve body having first and second ends through which gas passes into and out of the valve. The first end is connectable to the breathing tube for passage of gas between the breathing tube and the valve. A valve seat is located within the valve body between the first and second ends. A thin, flexible diaphragm is provided, which is seated against the valve seat when the patient exhales. The diaphragm has a comfort-improving structural feature which can be 1) a shape which is at least partly concave on a side of the diaphragm facing the seat, and/or 2) a web of substantially uniform thickness with a plurality of discrete areas of different thicknesses dispersed around the web, which are capable of damping resonance vibration of the diaphragm during breathing by the patient.
摘要翻译：根据本发明，一种能够与连接到患者气道的呼吸管协同连接的发音阀包括具有第一和第二端的阀体，气体通过该阀体进入和流出阀。第一端可连接到呼吸管，用于呼吸管和阀之间的气体通过。阀座位于第一和第二端之间的阀体内。提供了一种薄而柔软的隔膜，当患者呼气时，该隔膜位于阀座上。隔膜具有舒适性改善的结构特征，其可以是1）在面向座椅的隔膜的侧面上至少部分凹陷的形状，和/或2）具有基本均匀厚度的腹板，其具有多个离散区域分散在腹板周围的不同厚度，其能够在患者呼吸期间阻尼隔膜的共振振动。

9. 发明授权

US08702335B2 Module clamp and fastener apparatus 有权
标题翻译：模块夹和紧固件装置
公开(公告)号：US08702335B2
公开(公告)日：2014-04-22
申请号：US12792928
申请日：2010-06-03
申请人： Thomas Young
发明人： Thomas Young
IPC分类号： F16B21/02
CPC分类号： H02S20/23 , F16B5/0068 , F16B35/06 , F16B37/045 , F16B2200/20 , F16B2200/205 , F24S25/33 , F24S25/636 , Y02B10/12 , Y02E10/47 , Y10T403/1691 , Y10T403/7005
摘要： An apparatus and method of employing modified twist-to-engage bolts that attach a photovoltaic (PV) module to an extrusion rail or channel within a rail are disclosed. In addition to a modified twist-to-engage bolt (e.g., “t-bolt”), a complementary bracket portion having alignment tabs locks in place and clamps the modules to the rail. The anti-rotation locking system prevents twist-to-engage bolts from disengaging without the removal of the complementary bracket.
摘要翻译：公开了一种使用将光伏（PV）模块连接到轨道内的挤压轨道或通道的改进的扭转接合螺栓的装置和方法。除了改进的扭转接合螺栓（例如，“t螺栓”）之外，具有对准翼片的互补支架部分锁定在适当位置并且将模块夹紧到轨道。防旋转锁定系统防止扭转接合螺栓脱离而不移除互补支架。

10. 发明申请

US20100226441A1 Frame Capture, Encoding, and Transmission Management 审中-公开
标题翻译：帧捕获，编码和传输管理
公开(公告)号：US20100226441A1
公开(公告)日：2010-09-09
申请号：US12399302
申请日：2009-03-06
申请人： Jackson Tung , Thomas Young , Kai Chee Li , Jeff B. Widergren , Hao Guo , Francis A. Palita , Hua Zhou
发明人： Jackson Tung , Thomas Young , Kai Chee Li , Jeff B. Widergren , Hao Guo , Francis A. Palita , Hua Zhou
IPC分类号： H04N7/26
CPC分类号： H04N21/2343 , H04N19/124 , H04N19/13 , H04N19/132 , H04N19/137 , H04N19/154 , H04N19/164 , H04N19/169 , H04N19/172 , H04N19/174 , H04N19/423 , H04N19/436 , H04N19/61 , H04N19/63 , H04N19/93 , H04N21/2662 , H04N21/631
摘要： Example embodiments of the present disclosure provide techniques for improving the rendering and management of client desktops and the subsequent transmission to the remote client. The techniques may minimize the movement of frame data within the server, the amount of data to be compressed, the amount of data transmitted over the network, and the amount of data to be decompressed. Various embodiments are disclosed for merging rendering functions and encoding functions onto the same chip so that frame data does not need to be transferred, calculation of a tile-based checksum for determining which tiles have changed from frame to frame, the dropping of tiles waiting to be transmitted if network bandwidth or decode speed is limiting the transmission and an equivalent tile in a subsequent frame is available to replace it, and the transfer of the frame buffer into the chip from an external GPU using one of three modes.
摘要翻译：本公开的示例实施例提供用于改进客户端桌面的呈现和管理以及随后向远程客户端传输的技术。这些技术可以最小化服务器内的帧数据的移动，要压缩的数据量，通过网络发送的数据量以及要解压缩的数据量。公开了各种实施例，用于将渲染功能和编码功能合并到相同的芯片上，使得不需要传送帧数据，计算基于瓦片的校验和，以确定哪些瓦片已经相互改变，等待到如果网络带宽或解码速度限制了传输，并且后续帧中的等效块可用于替换它，并且使用三种模式之一从外部GPU将帧缓冲器传送到芯片中，则将其发送。

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