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1. 发明授权

US07355079B2 Thyronamine derivatives and analogs and methods of use thereof 失效
标题翻译：噻吩胺衍生物及其类似物及其使用方法
公开(公告)号：US07355079B2
公开(公告)日：2008-04-08
申请号：US11099959
申请日：2005-04-05
申请人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow , Motonori Miyakawa , Edwin Saavedra Tan , Katherine L. Suchland
发明人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow , Motonori Miyakawa , Edwin Saavedra Tan , Katherine L. Suchland
IPC分类号： C07C211/27 , A61K31/135
CPC分类号： C07C217/60 , C07C215/52 , C07C217/16 , C07C217/20 , C07C217/54 , C07C235/50 , C07C235/60 , C07C255/37 , C07C271/16 , C07C271/20
摘要： Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.
摘要翻译：公开了甲状腺胺衍生物和类似物，使用这些化合物的方法，以及含有它们的药物组合物。还公开了制备这些化合物的方法。

2. 发明授权

US07321065B2 Thyronamine derivatives and analogs and methods of use thereof 有权
公开(公告)号：US07321065B2
公开(公告)日：2008-01-22
申请号：US10825881
申请日：2004-04-16
申请人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow , Motonori Miyakawa , Edwin Saavedra Tan , Katherine L. Suchland
发明人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow , Motonori Miyakawa , Edwin Saavedra Tan , Katherine L. Suchland
IPC分类号： C07C211/27 , A61K31/135
CPC分类号： C07C217/60 , C07C215/52 , C07C217/16 , C07C217/20 , C07C217/54 , C07C235/50 , C07C235/60 , C07C255/37 , C07C271/16 , C07C271/20
摘要： Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.

3. 发明申请

US20090105347A1 THYRONAMINE DERIVATIVES AND ANALOGS AND METHODS OF USE THEREOF 审中-公开
标题翻译：噻吩衍生物及其类似物及其使用方法
公开(公告)号：US20090105347A1
公开(公告)日：2009-04-23
申请号：US11948902
申请日：2007-11-30
申请人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow , Mononori Miyakawa , Edwin Saavedra Tan , Katherine L. Suchland
发明人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow , Mononori Miyakawa , Edwin Saavedra Tan , Katherine L. Suchland
IPC分类号： A61K31/137 , A61P9/00 , C07C211/27 , A61K31/138 , C07F5/02 , C07C209/00 , C07K16/00 , C07C237/34 , A61K31/166
CPC分类号： C07C217/60 , C07C215/52 , C07C217/16 , C07C217/20 , C07C217/54 , C07C235/50 , C07C235/60 , C07C255/37 , C07C271/16 , C07C271/20
摘要： Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed
摘要翻译：公开了甲状腺胺衍生物和类似物，使用这些化合物的方法，以及含有它们的药物组合物。还公开了制备这些化合物的方法

4. 发明授权

US07339079B2 Thyronamine derivatives and analogs and methods of use thereof 失效
公开(公告)号：US07339079B2
公开(公告)日：2008-03-04
申请号：US11155345
申请日：2005-06-17
申请人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow
发明人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow
IPC分类号： C07C211/27 , A61K31/135
CPC分类号： C07C215/52 , C07C217/16 , C07C217/54 , C07C235/50 , C07C255/37 , C07C271/16 , C07C271/20
摘要： Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.

5. 发明授权

US06979750B1 Thyronamine derivatives and analogs and methods of use thereof 失效
标题翻译：噻吩胺衍生物及其类似物及其使用方法
公开(公告)号：US06979750B1
公开(公告)日：2005-12-27
申请号：US10418399
申请日：2003-04-18
申请人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow
发明人： Thomas S. Scanlan , Matthew E. Hart , David K. Grandy , James R. Bunzow
IPC分类号： A61K31/137 , A61K31/277 , A61K31/35 , C07C211/27 , C07C233/77 , C07C323/32
CPC分类号： C07C215/52 , C07C217/16 , C07C217/54 , C07C235/50 , C07C255/37 , C07C271/16 , C07C271/20
摘要： Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.
摘要翻译：公开了甲状腺胺衍生物和类似物，使用这些化合物的方法，以及含有它们的药物组合物。还公开了制备这些化合物的方法。

6. 发明授权

US06406866B1 Method of screening of a compound for binding to MSOR 失效
标题翻译：筛选化合物结合MSOR的方法
公开(公告)号：US06406866B1
公开(公告)日：2002-06-18
申请号：US09048916
申请日：1998-03-26
申请人： David K. Grandy , James R. Bunzow , Olivier Civelli , Rainer Klaus Reinscheid , Hans-Peter Nothacker , Frederick James Monsma
发明人： David K. Grandy , James R. Bunzow , Olivier Civelli , Rainer Klaus Reinscheid , Hans-Peter Nothacker , Frederick James Monsma
IPC分类号： G01N3353
CPC分类号： C07K14/665 , A61K38/00 , A61K39/00 , C07K14/705 , C07K2319/00 , C12N2799/023
摘要： The present invention relates to a novel mammalian opioid receptor protein and ligands that bind to such proteins. The invention is directed toward the isolation, characterization and pharmacological use of an endogenous ligand that specifically binds to a novel mammalian opioid receptor protein heterologously expressed in mammalian cells. The invention specifically provides the isolated peptide ligand and analogues, derivatives and variants thereof. The invention specifically provides tyrosine substitution variants of the peptide ligand that specifically bind to the opioid receptor and can be radioiodinated. Also provided are methods of making such peptide ligands and methods of using the ligands for diagnostic and therapeutic uses and for the identification of other naturally-occurring or synthetic opioid receptor ligands.
摘要翻译：本发明涉及新型的哺乳动物阿片受体蛋白质和与这些蛋白质结合的配体。本发明涉及特异性结合在哺乳动物细胞中异源表达的新型哺乳动物阿片受体蛋白的内源性配体的分离，表征和药理学应用。本发明特别提供了分离的肽配体及其类似物，衍生物和变体。本发明具体提供肽配体的酪氨酸取代变体，其特异性结合阿片受体并可以放射性碘化。还提供了制备这种肽配体的方法和使用配体用于诊断和治疗用途以及鉴定其它天然存在或合成的阿片受体配体的方法。

7. 发明授权

US5880260A Dopamine receptors and genes 失效
公开(公告)号：US5880260A
公开(公告)日：1999-03-09
申请号：US474892
申请日：1995-06-07
申请人： Olivier Civelli , James R. Bunzow , David K. Grandy , Curtis A. Machida
发明人： Olivier Civelli , James R. Bunzow , David K. Grandy , Curtis A. Machida
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28 , C12N15/00 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/70571 , C07K16/286 , C12N15/00 , C12Q1/6876 , A01K2217/05 , A61K38/00 , C12Q2600/158
摘要： A mammalian D.sub.2 dopamine receptor gene has been cloned. Thus, DNA sequences encoding all or a part of the dopamine receptor are provided, as well as the corresponding polypeptide sequences and methods for producing the same both synthetically and via expression of a corresponding sequence from a host transformed with a suitable vector carrying the corresponding DNA sequence. The various structural information provided by this invention enables the preparation of labeled or unlabeled immunospecific species, particularly antibodies, as well as nucleic acid probes labeled in conventional fashion. Pharmaceutical compositions and methods of using various products of this invention are also provided.

8. 发明授权

US5389543A Cloned genes encoding the D.sub.1 dopamine receptor 失效
标题翻译：编码D1多巴胺受体的克隆基因
公开(公告)号：US5389543A
公开(公告)日：1995-02-14
申请号：US908654
申请日：1992-07-02
申请人： James R. Bunzow , Olivier Civelli , David K. Grandy , Qun Y. Zhou , Marc G. Caron , Allen Dearry , Pierre Falardeau , Jay A. Gingrich
发明人： James R. Bunzow , Olivier Civelli , David K. Grandy , Qun Y. Zhou , Marc G. Caron , Allen Dearry , Pierre Falardeau , Jay A. Gingrich
IPC分类号： C07H21/00 , C07K14/705 , C12N15/12 , C12Q1/68 , C12N15/63
CPC分类号： C07H21/00 , C07K14/70571 , C12Q1/6876 , C12Q2600/158
摘要： Cloned genes which code for the D.sub.1 dopamine receptor are disclosed. The receptors coded for by these clones bind dopamine ligands with the proper pharmacological profile and, when expressed in the cell membrane of a suitable host and so bound, stimulate adenylyl cyclase. Also disclosed are vectors comprising a cloned gene encoding a D.sub.1 -dopamine receptor, cells transformed with such vectors, and oligonucleotide probes capable of selectively hybridizing to DNA comprising a portion of a gene coding for a D.sub.1 -dopamine receptor. The cloned genes are useful for making proteins and cell membrane preparations which can be used to screen compounds for D.sub.1 -dopamine receptor binding activity, are useful in molecular biology, and are useful as diagnostic probes.
摘要翻译：公开了编码D1多巴胺受体的克隆基因。由这些克隆编码的受体结合具有适当药理学特征的多巴胺配体，并且当在合适的宿主的细胞膜中表达并如此结合时，刺激腺苷酸环化酶。还公开了包含编码D1-多巴胺受体的克隆基因，用这些载体转化的细胞和能够与包含编码D1-多巴胺受体的基因的一部分的DNA选择性杂交的寡核苷酸探针的载体。克隆的基因可用于制备可用于筛选化合物的多巴胺受体结合活性的蛋白质和细胞膜制剂，可用于分子生物学，并且可用作诊断探针。

9. 发明授权

US06280973B1 Mammalian methadone-specific opioid receptor gene and uses 失效
标题翻译：哺乳动物美沙酮特异性阿片受体基因及用途
公开(公告)号：US06280973B1
公开(公告)日：2001-08-28
申请号：US09510473
申请日：2000-02-22
申请人： David K. Grandy , James R. Bunzow , Olivier Civelli
发明人： David K. Grandy , James R. Bunzow , Olivier Civelli
IPC分类号： C12P2106
CPC分类号： C07K14/705 , A61K39/00 , C07K2319/00 , C12N2799/023
摘要： The present invention relates to a novel-mammalian methadone-specific opioid receptor protein and genes that encode such a protein. The invention is directed toward the isolation, characterization and pharmacological use of mammalian methadone-specific opioid receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to the rat homologue of the mammalian methadone-specific opioid receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian methadone-specific opioid receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian methadone-specific opioid receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian methadone-specific opioid receptor proteins of the invention, and further characterizing the binding properties of such compounds in comparison with known opioid receptor agonists and antagonists.
摘要翻译：本发明涉及新型哺乳动物美沙酮特异性阿片受体蛋白质和编码这种蛋白质的基因。本发明涉及哺乳动物美沙酮特异性阿片受体蛋白的分离，表征和药理学应用。本发明具体提供了与哺乳动物美沙酮特异性阿片受体基因的大鼠同系物相对应的mRNA的分离的互补DNA拷贝。还提供能够在转化的原核和真核细胞的培养物中表达本发明的哺乳动物美沙酮特异性阿片受体基因以及合成其中编码的哺乳动物美沙酮特异性阿片受体蛋白质的转化细胞的这种培养物的重组表达构建体。本发明还提供了在体外筛选能够结合本发明的哺乳动物美沙酮特异性阿片受体蛋白质的方法，并且与已知的阿片受体激动剂和拮抗剂相比进一步表征了这些化合物的结合性质。

10. 发明授权

US06277591B1 Dopamine receptors and genes 失效
标题翻译：多巴胺受体和基因
公开(公告)号：US06277591B1
公开(公告)日：2001-08-21
申请号：US08480390
申请日：1995-06-07
申请人： Olivier Civelli , James R. Bunzow , David K. Grandy , Curtis A. Machida
发明人： Olivier Civelli , James R. Bunzow , David K. Grandy , Curtis A. Machida
IPC分类号： C07K14705
CPC分类号： C07K14/70571 , A01K2217/05 , A61K38/00 , C07K16/286 , C12N15/00 , C12Q1/6876 , C12Q2600/158
摘要： A mammalian D2 dopamine receptor gene has been cloned. Thus, DNA sequences encoding all or a part of the dopamine receptor are provided, as well as the corresponding polypeptide sequences and methods for producing the same both synthetically and via expression of a corresponding sequence from a host transformed with a suitable vector carrying the corresponding DNA sequence. The various structural information provided by this invention enables the preparation of labeled or unlabeled immunospecific species, particularly antibodies, as well as nucleic acid probes labeled in conventional fashion. Pharmaceutical compositions and methods of using various products of this invention are also provided.
摘要翻译：已经克隆了哺乳动物D2多巴胺受体基因。因此，提供了编码全部或部分多巴胺受体的DNA序列，以及相应的多肽序列及其制备方法，合成和通过表达相应序列的宿主，所述宿主用携带相应DNA的合适载体转化序列。由本发明提供的各种结构信息使得能够制备标记或未标记的免疫特异性物种，特别是抗体，以及以常规方式标记的核酸探针。还提供了使用本发明的各种产品的药物组合物和方法。

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