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1. 发明授权

US08110567B2 Phenyl-piperazine derivatives as serotonin reuptake inhibitors 有权
标题翻译：苯基哌嗪衍生物作为血清素再摄取抑制剂
公开(公告)号：US08110567B2
公开(公告)日：2012-02-07
申请号：US12700521
申请日：2010-02-04
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen , Ask Puschl
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen , Ask Puschl
IPC分类号： A61P25/22 , A61K31/55 , C07D403/00 , C07D243/00
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译：本发明提供由通式I表示的化合物，其中取代基在本申请中定义。这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。

2. 发明授权

US07144884B2 Phenyl-piperazine derivatives as serotonin reuptake inhibitors 有权
标题翻译：苯基哌嗪衍生物作为血清素再摄取抑制剂
公开(公告)号：US07144884B2
公开(公告)日：2006-12-05
申请号：US10488280
申请日：2002-10-02
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/495 , C07D295/096 , C07D241/04 , C07D211/54 , C07D211/70
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder
摘要翻译：本发明提供由通式I表示的化合物，其中取代基在本申请中定义。这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症和恐慌症以及强迫症

3. 发明授权

US07138407B2 Phenyl-piperazine derivatives as serotonin reuptake inhibitors 有权
公开(公告)号：US07138407B2
公开(公告)日：2006-11-21
申请号：US11296835
申请日：2005-12-06
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/4409 , C07D211/70
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

4. 发明授权

US07683053B2 Phenyl-piperazine derivatives as serotonin reuptake inhibitors 有权
标题翻译：苯基哌嗪衍生物作为血清素再摄取抑制剂
公开(公告)号：US07683053B2
公开(公告)日：2010-03-23
申请号：US11551188
申请日：2006-10-19
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61P25/00 , A61K31/55 , C07D243/08
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译：本发明提供由通式I表示的化合物，其中取代基在本申请中定义。这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。

5. 发明授权

US06743809B2 Indole Derivatives useful for the treatment of CNS disorders 失效
标题翻译：吲哚衍生物可用于治疗CNS疾病
公开(公告)号：US06743809B2
公开(公告)日：2004-06-01
申请号：US10347574
申请日：2003-01-17
申请人： Jakob Felding , Benny Bang-Andersen , Garrick Paul Smith , Kim Andersen
发明人： Jakob Felding , Benny Bang-Andersen , Garrick Paul Smith , Kim Andersen
IPC分类号： A61K31454
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to substituted indole derivatives of formula I wherein R1 is hydrogen or optionally substituted C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl or C3-8-cycloalkyl-C1-6-alkyl, or R1 is optionally substituted aryl, aryl-C1-6-alkyl, heteroaryl, heteroaryl-C1-6-alkyl or R1 is —NR′R″ wherein R′ and R″ are independently selected from hydrogen and optionally substituted C1-6-alkyl, aryl, aryl-C1-6-alkyl, heteroaryl and heteroaryl-C1-6-alkyl, or R1 is a saturated or partially saturated 5- to 6-membered ring containing one, two or three hetero atoms selected from O or S, and a group N—R9 wherein R9 is hydrogen or optionally substituted C1-6-alkyl; R2 is C1-6-alkyl W, n, X, R3-R8 are as defined in the description. The compounds of the invention are potent dopamine D4 ligands.
摘要翻译：本发明涉及式I的取代的吲哚衍生物，其中R 1是氢或任选取代的C 1-6 - 烷基，C 2-6烯基，C 2-6 - 炔基，C 3-8 - 环烷基或C 3-8 - C 1-6 - 烷基或R 1是任选取代的芳基，芳基-C 1-6 - 烷基，杂芳基，杂芳基-C 1-6 - 烷基或R 1是-NR'R“，其中R'和R “独立地选自氢和任选取代的C 1-6 - 烷基，芳基，芳基-C 1-6 - 烷基，杂芳基和杂芳基-C 1-6 - 烷基，或R 1是饱和或部分饱和的5-至含有一个，两个或三个选自O或S的杂原子的6元环和NR 9基团，其中R 9是氢或任选取代的C 1-6 - 烷基; R 2是C 1-6 - 烷基W，n，X，R 3 -R 8如说明书中所定义。本发明的化合物是有效的多巴胺D4配体。

6. 发明授权

US06476035B1 Indole and 2,3-dihydroindole derivatives, their preparation and use 失效
标题翻译：吲哚和2,3-二氢吲哚衍生物，其制备和用途
公开(公告)号：US06476035B1
公开(公告)日：2002-11-05
申请号：US09491204
申请日：2000-01-25
申请人： Ejner Knud Moltzen , Jens Kristian Perregaard , Ivan Mikkelsen , Garrick Paul Smith
发明人： Ejner Knud Moltzen , Jens Kristian Perregaard , Ivan Mikkelsen , Garrick Paul Smith
IPC分类号： A61K31496
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R2, R3, W, X, Y and Z are as described in the description. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
摘要翻译：本发明涉及具有式（I）的吲哚和2,3-二氢吲哚衍生物或其任何对映体或其任何混合物或其酸加成盐，其中A，R 1，R 2，R 3，W，X ，Y和Z如说明书所述。该化合物是有效的5-羟色胺再摄取抑制剂，具有5-HT1A受体拮抗作用。

7. 发明授权

US06727263B2 Indole and 2,3-dihydroindole derivatives, their preparation and use 失效
标题翻译：吲哚和2,3-二氢吲哚衍生物，其制备和用途
公开(公告)号：US06727263B2
公开(公告)日：2004-04-27
申请号：US10223046
申请日：2002-08-16
申请人： Ejner Knud Moltzen , Jens Kristian Perregaard , Ivan Mikkelsen , Garrick Paul Smith
发明人： Ejner Knud Moltzen , Jens Kristian Perregaard , Ivan Mikkelsen , Garrick Paul Smith
IPC分类号： A61K314439
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R2, R3, W, X, Y and Z are as described in the description. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
摘要翻译：本发明涉及具有式（I）的吲哚和2,3-二氢吲哚衍生物或其任何对映体或其任何混合物或其酸加成盐，其中A，R 1，R 2， R 3，W，X，Y和Z如说明书所述。该化合物是有效的5-羟色胺再摄取抑制剂，具有5-HT1A受体拮抗作用。

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