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1. 发明授权

US09434719B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH 有权
标题翻译： 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
公开(公告)号：US09434719B2
公开(公告)日：2016-09-06
申请号：US14408418
申请日：2014-03-12
申请人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
发明人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
IPC分类号： C07D413/04 , A61K31/506 , C07D413/14 , C07D417/14 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

2. 发明授权

US08957068B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH 有权
标题翻译： 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
公开(公告)号：US08957068B2
公开(公告)日：2015-02-17
申请号：US14347481
申请日：2012-09-26
申请人： Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
发明人： Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
IPC分类号： C07D413/04 , C07D413/14 , A61K31/506 , C07D487/04 , C07D471/04 , C07D487/08 , C07D417/14 , C07D498/10
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/10 , C07D513/04
摘要： The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 6在本文中定义。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

3. 发明授权

US08841455B2 Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as cFMS inhibitors 有权
标题翻译：取代的N-（1H-吲唑-4-基）咪唑并[1,2-a]吡啶-3-甲酰胺化合物，为cFMS抑制剂
公开(公告)号：US08841455B2
公开(公告)日：2014-09-23
申请号：US13517938
申请日：2010-12-20
申请人： Mark Laurence Boys , Michael F. Bradley , Robert Kirk DeLisle , D. David Hennings , April L. Kennedy , Fredrik P. Marmsater , Matthew David Medina , Mark C. Munson , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
发明人： Mark Laurence Boys , Michael F. Bradley , Robert Kirk DeLisle , D. David Hennings , April L. Kennedy , Fredrik P. Marmsater , Matthew David Medina , Mark C. Munson , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
IPC分类号： C07D491/02 , C07D231/56
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4 and R5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.
摘要翻译：其中R1，R2，R3，R4和R5具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是cFMS的抑制剂，可用于治疗骨相关疾病，癌症，自身免疫疾病，炎性疾病，心血管疾病和疼痛。

4. 发明申请

US20140062468A1 DEVICE FOR GLOBALLY MEASURING THICKNESS OF METAL FILM 有权
标题翻译：用于全球测量金属薄膜厚度的装置
公开(公告)号：US20140062468A1
公开(公告)日：2014-03-06
申请号：US13985789
申请日：2011-11-17
申请人： Xinchun Lu , Dewen Zhao , Zilian Qu , Qian Zhao , Yongyong He , Yonggang Meng
发明人： Xinchun Lu , Dewen Zhao , Zilian Qu , Qian Zhao , Yongyong He , Yonggang Meng
IPC分类号： G01B7/06
CPC分类号： G01B7/10 , G01B1/00 , G01B7/105 , G01R1/00 , H01L2221/00
摘要： A device for globally measuring a thickness of a metal film (901), comprises: a base (10); a rotating unit (20) comprising a fixed member (21) fixed on the base (10) and a rotating member (22) having a rotating joint (23); a working table (50) fixed on the rotating member (22) and having a vacuum passage which is formed therein and connected with the rotating joint (23); a linear driving unit (30) including a guide rail (31) fixed on the base (10) and a sliding block (32) slidable along the guide rail (31); a cantilever beam (40) disposed horizontally and defining a first end fixed with the sliding block (32) and a second end; a measuring head (80) connected to the second end of the cantilever beam (40), facing a surface of the working table (50) and having an eddy current probe (82) disposed therein.
摘要翻译：用于全面测量金属膜（901）的厚度的装置包括：基座（10）; 旋转单元（20）包括固定在基座（10）上的固定构件（21）和具有旋转接头（23）的旋转构件（22）; 固定在旋转构件（22）上并具有形成在其中并与旋转接头（23）连接的真空通道的工作台（50）; 线性驱动单元（30），其包括固定在基座（10）上的导轨（31）和可沿导轨（31）滑动的滑块（32）; 悬臂梁（40）水平设置并且限定固定有滑块（32）的第一端和第二端; 连接到所述悬臂梁（40）的第二端的测量头（80）面向所述工作台（50）的表面并且具有布置在其中的涡流探针（82）。

5. 发明授权

US08623895B2 Mitotic kinesin inhibitors and methods of use thereof 有权
标题翻译：有丝分裂驱动蛋白抑制剂及其使用方法
公开(公告)号：US08623895B2
公开(公告)日：2014-01-07
申请号：US13538698
申请日：2012-06-29
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC分类号： A61K31/433 , A61K31/4439 , C07D417/12 , C07D285/12
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译：本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。

6. 发明授权

US08586584B2 Compounds for the treatment of hepatitis C 有权
公开(公告)号：US08586584B2
公开(公告)日：2013-11-19
申请号：US12904264
申请日：2010-10-14
申请人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
发明人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
IPC分类号： A61K31/53 , C07D251/72 , C07D487/00
CPC分类号： C07D487/08 , C07D498/08
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

7. 发明授权

US08580828B2 Mitotic kinesin inhibitors and methods of use thereof 有权
公开(公告)号：US08580828B2
公开(公告)日：2013-11-12
申请号：US13586355
申请日：2012-08-15
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtil
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtil
IPC分类号： A61K31/41 , C07D417/04
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

8. 发明授权

US08575145B2 Triazolopyridine compounds as PIM kinase inhibitors 有权
标题翻译：三唑并吡啶化合物作为PIM激酶抑制剂
公开(公告)号：US08575145B2
公开(公告)日：2013-11-05
申请号：US13059902
申请日：2009-08-18
申请人： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Greschuk , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
发明人： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Greschuk , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
IPC分类号： A61K31/55 , A61K31/437 , A61K31/513 , A61K31/5377 , C07D471/04 , A61P35/00 , A61P25/00 , A61P29/00
CPC分类号： C07D471/04
摘要： Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.
摘要翻译：其中A，B，R1，R1a，R2，R3，R4，R5，R6和R7具有本说明书中给出的含义的式（I）化合物是可用于治疗免疫细胞相关的受体酪氨酸抑制剂疾病和病症，例如炎性和自身免疫性疾病。

9. 发明授权

US08138181B2 Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors 有权
标题翻译：咪唑并[1,2-a]吡啶化合物作为受体酪氨酸激酶抑制剂
公开(公告)号：US08138181B2
公开(公告)日：2012-03-20
申请号：US12593879
申请日：2008-03-27
申请人： Shelley Allen , Julie Marie Greschuk , Nicholas C. Kallan , Fredrik P. Marmsäter , Mark C. Munson , James P. Rizzi , John E. Robinson , Stephen T. Schlachter , George T. Topalov , Qian Zhao , Joseph P. Lyssikatos
发明人： Shelley Allen , Julie Marie Greschuk , Nicholas C. Kallan , Fredrik P. Marmsäter , Mark C. Munson , James P. Rizzi , John E. Robinson , Stephen T. Schlachter , George T. Topalov , Qian Zhao , Joseph P. Lyssikatos
IPC分类号： A61K31/5386 , A61K31/437 , A61K31/506 , C07D471/02 , C07D401/14 , C07D498/08 , A61P35/04
CPC分类号： C07D471/04
摘要： Compounds of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5 R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1.
摘要翻译：式I化合物：其中A，B，R 1，R 1a，R 2，R 3，R 4，R 5，R 6，R 7和R 8具有说明书中给出的含义，是受体酪氨酸抑制剂，其可用于治疗由3类和 5类受体酪氨酸激酶。本发明的具体化合物也被发现是Pim-1的抑制剂。

10. 发明申请

US20110172224A1 NOVEL HETEROCYCLES 失效
标题翻译：新型杂环
公开(公告)号：US20110172224A1
公开(公告)日：2011-07-14
申请号：US11662416
申请日：2005-08-19
申请人： Chengzhi Zhang , Jacques Dumas , Qingming Zhu , Roger Smith , Qingjie Liu , Sharad Verma , Jason Duquette , Qian Zhao , Dongping Fan , Georgiy Bondar , Philip Coish
发明人： Chengzhi Zhang , Jacques Dumas , Qingming Zhu , Roger Smith , Qingjie Liu , Sharad Verma , Jason Duquette , Qian Zhao , Dongping Fan , Georgiy Bondar , Philip Coish
IPC分类号： A61K31/5377 , C07D471/14 , C07D413/14 , A61K31/496 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , C07D495/14
摘要： The invention relates to novel heterocycles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
摘要翻译：本发明涉及式（I）的新型杂环，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途。

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