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1. 发明授权

US06439236B1 Methods for inducing atrial and ventricular rhythms using ultrasound and microbubbles 失效
标题翻译：使用超声和微泡诱导心房和心室节律的方法
公开(公告)号：US06439236B1
公开(公告)日：2002-08-27
申请号：US09426378
申请日：1999-10-25
申请人： Thomas R. Porter , Feng Xie
发明人： Thomas R. Porter , Feng Xie
IPC分类号： A61B1900
CPC分类号： A61K49/0002 , A61K41/0028 , A61K41/0033 , A61K47/6925
摘要： A new and improved method for inducing or pacing atrial and ventricular arrhythmias in animals Embodiments of the invention involve using microbubbles enhanced with an insoluble gas in combination with low frequency ultrasound for its pacing activity. The methods and compositions can be used to pace patients, convert patients out of atrial fibrillation, and as a diagnostic to assess a patient's risk for arrhythmias.
摘要翻译：用于在动物中诱导或起搏心房和室性心律失常的新的和改进的方法本发明的实施方案涉及使用不稳定气体增强的微泡与低频超声波结合起搏活动。方法和组合物可用于调节患者，将患者转换为心房颤动，并作为评估患者心律失常风险的诊断。

2. 发明授权

US07025726B2 Detection of endothelial dysfunction by ultrasonic imaging 失效
标题翻译：通过超声成像检测内皮功能障碍
公开(公告)号：US07025726B2
公开(公告)日：2006-04-11
申请号：US10764294
申请日：2004-01-22
申请人： Thomas R. Porter , Feng Xie
发明人： Thomas R. Porter , Feng Xie
IPC分类号： A61B8/06
CPC分类号： A61B8/0858
摘要： A method for non-invasive detection of vascular endothelial dysfunction using ultrasonic imaging is provided.
摘要翻译：提供了一种使用超声成像进行非侵入性检测血管内皮功能障碍的方法。

3. 发明授权

US07198949B2 Compositions and methods for altering the biodistribution of biological agents 有权
标题翻译：用于改变生物制剂生物分布的组合物和方法
公开(公告)号：US07198949B2
公开(公告)日：2007-04-03
申请号：US10668448
申请日：2003-09-22
申请人： Thomas R. Porter , Patrick L. Iversen
发明人： Thomas R. Porter , Patrick L. Iversen
IPC分类号： C12N15/63 , C12Q1/68 , C12P19/34 , C07K1/00 , C07H21/04
CPC分类号： A61K41/0028 , A61K47/6925 , A61K49/223
摘要： The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.
摘要翻译：本发明涉及用于递送治疗剂的新的和改进的药物组合物和方法。本发明的方法和组合物可以与几种治疗剂一起使用，并且可以实现治疗或诊断物质的位点特异性递送。这可以允许较低剂量和用于改善传统上达到目标部位的药物的功效，并且可以导致药物如寡核苷酸和多核苷酸的改善效用，这些药物受到生物分布问题的困扰。

4. 发明授权

US5685310A Suspended ultra-sound microbubble imaging 失效
标题翻译：悬挂的超声微泡成像
公开(公告)号：US5685310A
公开(公告)日：1997-11-11
申请号：US540463
申请日：1995-10-10
申请人： Thomas R. Porter
发明人： Thomas R. Porter
IPC分类号： A61K49/00 , A61B8/00 , A61K49/18 , A61K49/22 , G01S7/52
CPC分类号： A61B8/481 , A61K49/1806 , A61K49/223 , G01S7/52038
摘要： An ultrasonic imaging technique is disclosed which uses microbubbles as echo contrast agents. In general the method employs maintenance of an ultrasound signal while the contrast agent is intravenously injected into a mammal. Once all the contrast agent has been injected and transmission of the signal is suspended for a period of time sufficient for the microbubbles perfuse the organ of interest. Transmission of the ultrasound signal is then resumed and peak contrast images are obtained which rival more complicated imaging procedures such as nuclear resonance imaging.
摘要翻译：公开了一种使用微泡作为回波造影剂的超声成像技术。通常，该方法采用维持超声波信号，同时将造影剂静脉内注射到哺乳动物中。一旦所有造影剂被注射并且信号的传播被暂停一段时间，足以使微泡灌注感兴趣的器官。然后恢复超声信号的传输，并获得峰值对比度图像，其与诸如核共振成像的更复杂的成像过程相竞争。

5. 发明授权

US06245747B1 Targeted site specific antisense oligodeoxynucleotide delivery method 失效
标题翻译：靶向位点特异性反义寡脱氧核苷酸递送方法
公开(公告)号：US06245747B1
公开(公告)日：2001-06-12
申请号：US09114399
申请日：1998-07-13
申请人： Thomas R. Porter , Patrick L. Iversen , Gary D. Meyer
发明人： Thomas R. Porter , Patrick L. Iversen , Gary D. Meyer
IPC分类号： A01N4304
CPC分类号： A61K9/0009 , A61K9/0019 , A61K9/5015 , A61K9/5052 , A61K41/0028 , A61K47/6925 , C12N15/1135 , C12N15/87 , C12N2310/315
摘要： The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in utility for agents such as oligonucleotides which are plagued with problems in reaching targeted sites in necessary therapeutic levels. The delivery system includes gas-filled microbubbles formed in a nitrogen-free environment. Microbubbles formed through sonication in a nitrogen-free environment are smaller and more stable than microbubbles sonicated in the presence of room air.
摘要翻译：本发明涉及用于递送治疗剂的新的和改进的药物组合物和方法。本发明的方法和组合物可以与几种治疗剂一起使用，并且可以实现治疗物质的位点特异性递送。这可以允许较低的剂量和用于改善传统上达到目标部位的药物的功效，并且可以导致药物如寡核苷酸的用途，所述药物如在需要治疗水平达到目标部位时遇到问题的寡核苷酸。递送系统包括形成的充气微泡在无氮环境中。在无氮环境中通过超声处理形成的微泡比在室内空气存在下超声处理的微泡更小，更稳定。

6. 发明授权

US5740807A Suspended ultra-sound induced microbubble cavitation imaging 失效
公开(公告)号：US5740807A
公开(公告)日：1998-04-21
申请号：US721507
申请日：1996-09-26
申请人： Thomas R. Porter
发明人： Thomas R. Porter
IPC分类号： A61K49/00 , A61B8/00 , A61K49/18 , A61K49/22 , G01S7/52
CPC分类号： A61B8/481 , A61K49/1806 , A61K49/223 , G01S7/52038
摘要： An ultrasonic imaging technique is disclosed which uses microbubbles as echo contrast agents. In general the method employs maitenance of an ultrasound signal while the contrast agent is intravenously injected into a mammal. Once all the contrast agent has been injected and transmission of the signal is suspended for a period of time sufficient for the microbubbles perfuse the organ of interest. Transmission of the ultrasound signal is then resumed and peak contrast images are obtained which rival more complicated imaging procedures such as nuclear resonance imaging.

7. 发明授权

US5648098A Thrombolytic agents and methods of treatment for thrombosis 失效
标题翻译：溶栓剂和治疗血栓形成的方法
公开(公告)号：US5648098A
公开(公告)日：1997-07-15
申请号：US544204
申请日：1995-10-17
申请人： Thomas R. Porter
发明人： Thomas R. Porter
IPC分类号： A61K9/50 , A61K31/02 , A61K41/00 , A61B8/00
CPC分类号： A61K41/0028 , A61K31/02 , A61K9/5052
摘要： The foregoing invention relates to a new microbubble preparation and thrombolytic therapy which relies on microbubbles and ultrasound for its lytic activity. The pharmaceutical composition of the invention comprises a liquid solution of microbubbles with an internal atmosphere enhanced with the perfluorocarbon gas which cavitate in the presence of an ultrasound field following intravenous injection or infusion of said composition into said host. For thrombolysis the area of a thrombus is exposed to an ultrasound field in the presence of the microbubbles and significant lysis is experienced. The method and pharmaceutical composition of the invention exhibit thrombolytic properties similar to those of other thrombolytic agents such as urokinase and are less toxic and are clot specific in that they do not introduce a systemic lytic state to a said animal.
摘要翻译：上述发明涉及一种新的微泡制剂和溶栓治疗，其依赖于微泡和超声波作为其溶解活性。本发明的药物组合物包含微泡液体溶液，其中内部气氛用全氟化碳气体增强，在静脉注射或将所述组合物输注入所述宿主之后，在存在超声场的情况下气蚀。对于血栓溶解，血栓的面积在微泡存在下暴露于超声场，并且经历显着的裂解。本发明的方法和药物组合物显示出与其它溶血栓剂如尿激酶相似的溶栓性质，并且毒性较小并且是凝块特异性的，因为它们不向所述动物引入全身溶解状态。

8. 发明授权

US07115583B2 Microbubble compositions and methods for oligonucleotide delivery 有权
标题翻译：微泡组合物和寡核苷酸递送方法
公开(公告)号：US07115583B2
公开(公告)日：2006-10-03
申请号：US10355388
申请日：2003-01-31
申请人： Thomas R. Porter , Patrick L. Iversen
发明人： Thomas R. Porter , Patrick L. Iversen
IPC分类号： A01N37/18 , A01N43/04 , C07K1/00 , C07H21/02 , C12P19/34
CPC分类号： A61K41/0028 , A61K47/6925 , A61K49/223
摘要： The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.
摘要翻译：本发明涉及用于递送治疗剂的新的和改进的药物组合物和方法。本发明的方法和组合物可以与几种治疗剂一起使用，并且可以实现治疗或诊断物质的位点特异性递送。这可以允许较低剂量和用于改善传统上达到目标部位的药物的功效，并且可以导致药物如寡核苷酸和多核苷酸的改善效用，这些药物受到生物分布问题的困扰。

9. 发明授权

US5849727A Compositions and methods for altering the biodistribution of biological agents 失效
标题翻译：用于改变生物制剂生物分布的组合物和方法
公开(公告)号：US5849727A
公开(公告)日：1998-12-15
申请号：US670999
申请日：1996-06-28
申请人： Thomas R. Porter , Patrick L. Iversen
发明人： Thomas R. Porter , Patrick L. Iversen
IPC分类号： A61K47/42 , A61K9/48 , A61K38/00 , A61K41/00 , A61K47/48 , A61K48/00 , A61K49/22 , A01N51/00
CPC分类号： A61K41/0028 , A61K47/48869 , A61K49/223
摘要： This invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic or bioactive agents. The methods and composition of the invention can be used with several therapeutic or bioactive agents and can achieve site-specific delivery of a therapeutic or biologically-active substance. This can allow for lower doses and for improved efficacy with drugs, particularly agents such as oligonucleotides which are plagued with problems in achieving therapeutic levels at targeted sites.
摘要翻译：本发明涉及用于递送治疗或生物活性剂的新的和改进的药物组合物和方法。本发明的方法和组合物可以与几种治疗或生物活性剂一起使用，并且可以实现治疗或生物活性物质的位点特异性递送。这可以允许较低的剂量和用于药物，特别是诸如寡核苷酸的药物的改善效果，这些药剂在靶点上达到治疗水平方面存在问题。

10. 发明授权

US5578291A Method and composition for optimizing left ventricular videointensity in echocardiography 失效
标题翻译：用于优化超声心动图左心室视力的方法和组成
公开(公告)号：US5578291A
公开(公告)日：1996-11-26
申请号：US301146
申请日：1994-09-06
申请人： Thomas R. Porter
发明人： Thomas R. Porter
IPC分类号： A61K49/22 , A61K49/00
CPC分类号： A61K49/223 , A61K49/22
摘要： This invention provides a new ultrasound contrast agent which is safe and can reach the left side of the heart in adequate amounts to determine blood flow to the muscle of the heart. The contrast agent comprises a simple sonicated mixture of a protein the body normally makes (albumin) combined with a naturally occurring sugar (dextrose). This mixture upon sonication contains small bubbles (microbubbles) and can be used following an intravenous injection to study blood flow to the muscle of the heart (myocardium) without the need of invasive catheters or radiation. In another embodiment, there is provided an inexpensive test to study blood flow in the heart using echocardiography, thus avoiding the more expensive nuclear procedures that are presently employed to determine blood flow in the heart muscle, and eliminating the risk of radiation.
摘要翻译：本发明提供了一种新的超声造影剂，其是安全的并且可以以足够的量到达心脏的左侧以确定到心脏肌肉的血液流动。造影剂包括身体通常蛋白质（白蛋白）与天然存在的糖（葡萄糖）组合的简单的超声处理混合物。超声处理后的混合物含有小气泡（微泡），静脉注射后可用于研究心脏（心肌）肌肉的血液流动，无需入侵导管或放射线。在另一个实施方案中，提供了一种廉价的用于使用超声心动图研究心脏血流的测试，从而避免了当前用于确定心肌中的血流的更昂贵的核手术，并消除了放射的风险。

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