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1. 发明授权

US06399144B2 Medical device for delivering a therapeutic substance and method therefor 有权
标题翻译：用于递送治疗物质的医疗装置及其方法
公开(公告)号：US06399144B2
公开(公告)日：2002-06-04
申请号：US09780513
申请日：2001-02-12
申请人： Thomas Q. Dinh , Rodney G. Wolff , Eric P. Berg
发明人： Thomas Q. Dinh , Rodney G. Wolff , Eric P. Berg
IPC分类号： A61L1554
CPC分类号： A61F2/88 , A61F2/86 , A61F2250/0067 , A61N5/1002
摘要： A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The porous material can be made of a polymer other than fibrin with fibrin incorporated into the pores, which can be the only layer of polymeric material on the medical device (e.g., stent). A new method for preparing a porous polymer material on a medical device.
摘要翻译：提供了一种可用于局部递送治疗材料的装置。该装置包括包括多孔材料的结构; 和分散在多孔材料中的治疗材料的水不溶性盐。通过使治疗盐的水溶液与分散在多孔材料的大部分中的重金属水溶性盐接触而形成水不溶性盐。多孔材料可以由除了纤维蛋白之外的聚合物制成，纤维蛋白结合到孔中，孔可以是医疗装置（例如，支架）上的唯一的聚合物材料层。一种用于在医疗装置上制备多孔聚合物材料的新方法。

2. 发明授权

US06187370B1 Medical device for delivering a therapeutic substance and method therefor 有权
公开(公告)号：US06187370B1
公开(公告)日：2001-02-13
申请号：US09397678
申请日：1999-09-16
申请人： Thomas Q. Dinh , Rodney G. Wolff , Eric P. Berg
发明人： Thomas Q. Dinh , Rodney G. Wolff , Eric P. Berg
IPC分类号： B05D512
CPC分类号： A61F2/88 , A61F2/86 , A61F2250/0067 , A61N5/1002
摘要： A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The porous material can be made of a polymer other than fibrin with fibrin incorporated into the pores, which can be the only layer of polymeric material on the medical device (e.g., stent). A new method for preparing a porous polymer material on a medical device.

3. 发明授权

US6013099A Medical device for delivering a water-insoluble therapeutic salt or substance 失效
标题翻译：用于递送水不溶性治疗盐或物质的医疗装置
公开(公告)号：US6013099A
公开(公告)日：2000-01-11
申请号：US69659
申请日：1998-04-29
申请人： Thomas Q. Dinh , Rodney G. Wolff , Eric P. Berg
发明人： Thomas Q. Dinh , Rodney G. Wolff , Eric P. Berg
IPC分类号： A61F2/00 , A61F2/86 , A61F2/88 , A61N5/10 , A61F2/06
CPC分类号： A61F2/88 , A61F2/86 , A61F2250/0067 , A61N5/1002
摘要： A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The porous material can be made of a polymer other than fibrin with fibrin incorporated into the pores, which can be the only layer of polymeric material on the medical device (e.g., stent). A new method for preparing a porous polymer material on a medical device.
摘要翻译：提供了一种可用于局部递送治疗材料的装置。该装置包括包括多孔材料的结构; 和分散在多孔材料中的治疗材料的水不溶性盐。通过使治疗盐的水溶液与分散在多孔材料的大部分中的重金属水溶性盐接触而形成水不溶性盐。多孔材料可以由除了纤维蛋白之外的聚合物制成，纤维蛋白结合到孔中，孔可以是医疗装置（例如，支架）上的唯一的聚合物材料层。一种用于在医疗装置上制备多孔聚合物材料的新方法。

4. 发明授权

US6106454A Medical device for delivering localized radiation 失效
标题翻译：用于递送局部辐射的医疗设备
公开(公告)号：US6106454A
公开(公告)日：2000-08-22
申请号：US877426
申请日：1997-06-17
申请人： Eric P. Berg , Thomas Q. Dinh
发明人： Eric P. Berg , Thomas Q. Dinh
IPC分类号： A61M36/04 , A61N5/10 , A61B17/00 , A61B5/00
CPC分类号： A61N5/1002
摘要： A medical device useful for localized delivery of radiation in vivo is provided. The medical device includes a structure including a porous material; and a plurality of discrete particles including a water-insoluble radioactive salt dispersed throughout a substantial portion of the porous material. The water-insoluble radioactive salt is formed by contacting an aqueous radioactive salt solution with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The heavy metal water-soluble salt can be dispersed in the porous material so that the device can be sterilized and the radioactive material can be loaded in the device in situ, for example, just prior to implantation.
摘要翻译：提供了可用于体内局部放射辐射的医疗装置。医疗装置包括包括多孔材料的结构; 以及包括分散在多孔材料的大部分中的水不溶性放射性盐的多个离散颗粒。通过使放射性水溶液与分散在多孔材料的大部分中的重金属水溶性盐接触而形成水不溶性放射性盐。重金属水溶性盐可以分散在多孔材料中，使得该装置可以被灭菌，并且放射性物质可以在植入之前就地装载在装置中。

5. 发明授权

US06730120B2 Medical device for delivering a therapeutic substance and method therefor 失效
标题翻译：用于递送治疗物质的医疗装置及其方法
公开(公告)号：US06730120B2
公开(公告)日：2004-05-04
申请号：US09769423
申请日：2001-01-26
申请人： Eric P. Berg , Thomas Q. Dinh
发明人： Eric P. Berg , Thomas Q. Dinh
IPC分类号： A61F206
CPC分类号： A61L33/007 , A61L33/0011
摘要： A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The heavy metal water-soluble salt can be dispersed in the porous material so that the device can be sterilized and the therapeutic material can be loaded in the device in situ, for example, just prior to use. The therapeutic material is preferably a heparin or heparin derivative or analog which renders the material antithrombotic as an implantable or invasive device.
摘要翻译：提供了一种可用于局部递送治疗材料的装置。该装置包括包括多孔材料的结构; 和分散在多孔材料中的治疗材料的水不溶性盐。通过使治疗盐的水溶液与分散在多孔材料的大部分中的重金属水溶性盐接触而形成水不溶性盐。重金属水溶性盐可以分散在多孔材料中，使得该装置可以被灭菌，并且治疗材料可以在即将使用之前就地装载在装置中。治疗材料优选是肝素或肝素衍生物或类似物，其使材料抗血栓形成为可植入或侵入性装置。

6. 发明授权

US06203536B1 Medical device for delivering a therapeutic substance and method therefor 失效
标题翻译：用于递送治疗物质的医疗装置及其方法
公开(公告)号：US06203536B1
公开(公告)日：2001-03-20
申请号：US08877532
申请日：1997-06-17
申请人： Eric P. Berg , Thomas Q. Dinh
发明人： Eric P. Berg , Thomas Q. Dinh
IPC分类号： A61M3100
CPC分类号： A61L33/007 , A61L33/0011
摘要： A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The heavy metal water-soluble salt can be dispersed in the porous material so that the device can be sterilized and the therapeutic material can be loaded in the device in situ, for example, just prior to use. The therapeutic material is preferably a heparin or heparin derivative or analog which renders the material antithrombotic as an implantable or invasive device.
摘要翻译：提供了一种可用于局部递送治疗材料的装置。该装置包括包括多孔材料的结构; 和分散在多孔材料中的治疗材料的水不溶性盐。通过使治疗盐的水溶液与分散在多孔材料的大部分中的重金属水溶性盐接触而形成水不溶性盐。重金属水溶性盐可以分散在多孔材料中，使得该装置可以被灭菌，并且治疗材料可以在即将使用之前就地装载在装置中。治疗材料优选是肝素或肝素衍生物或类似物，其使材料抗血栓形成为可植入或侵入性装置。

7. 发明申请

US20120022321A1 Coated Pelvic Implant Device and Method 审中-公开
标题翻译：涂层骨盆植入装置及方法
公开(公告)号：US20120022321A1
公开(公告)日：2012-01-26
申请号：US13188797
申请日：2011-07-22
申请人： Thomas Q. Dinh , Rosa K. Canifax
发明人： Thomas Q. Dinh , Rosa K. Canifax
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2250/0067
摘要： Implant systems and methods are provided to include a treatment material with a pelvic implant device. The pelvic implant device, such as an incontinence sling, can include the treatment coating combination of polycarbonate (PC) and an infection prevention material, such as InhibiZone® (IZ) technology. The treatment material can be coated onto, or impregnation or integrated with, polypropylene mesh in order to prevent infection and promote healing.
摘要翻译：提供植入系统和方法以包括具有盆腔植入装置的治疗材料。诸如失禁吊带的骨盆植入装置可以包括聚碳酸酯（PC）和感染预防材料（例如InhibiZone（IZ））技术的治疗涂层组合。处理材料可以涂覆在聚丙烯网上，或浸渍或与聚丙烯网结合，以防止感染并促进愈合。

8. 发明申请

US20090043295A1 Fibroid Treatment Methods and Devices 审中-公开
标题翻译：纤维治疗方法和装置
公开(公告)号：US20090043295A1
公开(公告)日：2009-02-12
申请号：US12210558
申请日：2008-09-15
申请人： Kevin R. Arnal , Thomas Q. Dinh , Gerald M. Mitchell , William Stephen Tremulis , Douglas G. Stinson , Edouard A. Koullick
发明人： Kevin R. Arnal , Thomas Q. Dinh , Gerald M. Mitchell , William Stephen Tremulis , Douglas G. Stinson , Edouard A. Koullick
IPC分类号： A61B18/20 , A61B18/18 , A61B18/02 , A61N7/02
CPC分类号： A61B17/122 , A61B17/02 , A61B17/0625 , A61B17/12013 , A61B17/42 , A61B2017/0472 , A61B2017/06028 , A61B2017/2926
摘要： A system for ligating a uterine artery in a patient generally includes a suture transfer tool, suture transfer darts, and one or more sutures. Others systems and implants are described herein for treating and/or eliminating fibroids or fibrous masses in males and females.
摘要翻译：用于在患者中连接子宫动脉的系统通常包括缝线转移工具，缝合线转移飞镖和一个或多个缝合线。本文描述了其它系统和植入物，用于治疗和/或消除雄性和雌性中的肌瘤或纤维块。

9. 发明申请

US20130197300A1 IMPLANTS WITH ABSORBALBE AND NON-ABSORBABLE FEATURES FOR THE TREATMENT OF FEMALE PELVIC CONDITIONS 有权
标题翻译：具有吸收性和非吸收性特征的植入物用于治疗女性皮肤病
公开(公告)号：US20130197300A1
公开(公告)日：2013-08-01
申请号：US13877695
申请日：2011-10-06
申请人： Edouard A. Koullick , Thomas Q. Dinh , Robert C. Grant
发明人： Edouard A. Koullick , Thomas Q. Dinh , Robert C. Grant
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2/0063 , A61F2002/0068 , A61F2002/0072 , A61F2210/0076 , A61F2250/0031 , A61F2250/0067 , A61L31/048 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2400/18 , A61L2420/00 , C08L23/06
摘要： Described are methods, devices, and systems related to implants for the treatment of a female pelvic condition. The implants include absorbable and non-absorbable materials and can be introduced into the pelvic area transvaginally. Meshes of the invention provide benefits relating to improved tissue integration into the mesh, reduced infection likelihood, improved patient comfort following implantation, or combinations of thereof.
摘要翻译：描述了与用于治疗女性盆腔病症的植入物相关的方法，装置和系统。植入物包括可吸收和不可吸收的材料，并可经阴道引入骨盆区域。本发明的网格提供了与改进的组织整合到网中有关的益处，降低的感染可能性，植入后改善的患者舒适度或其组合。

10. 发明授权

US5591227A Drug eluting stent 失效
公开(公告)号：US5591227A
公开(公告)日：1997-01-07
申请号：US429459
申请日：1995-04-27
申请人： Thomas Q. Dinh , Ronald J. Tuch , Robert S. Schwartz
发明人： Thomas Q. Dinh , Ronald J. Tuch , Robert S. Schwartz
IPC分类号： A61F2/00 , A61F2/82 , A61L31/04 , A61L31/10 , A61L31/12 , A61L31/16 , B05C3/20 , A61F2/06 , A61F2/04
CPC分类号： A61F2/82 , A61L31/041 , A61L31/046 , A61L31/047 , A61L31/10 , A61L31/128 , A61L31/16 , A61F2/0077 , A61F2240/001 , A61F2250/0067 , A61L2300/00 , A61L2300/252 , A61L2300/416 , A61L2300/606 , A61L2420/08 , B05C3/20 , Y10S623/921
摘要： An intraluminal stent comprising fibrin and an elutable drug is capable of providing a treatment of restenosis.

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