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1. 发明授权

US06548676B1 Preparation of thiazoles 失效
标题翻译：噻唑的制备
公开(公告)号：US06548676B1
公开(公告)日：2003-04-15
申请号：US09331433
申请日：1999-06-18
申请人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan
发明人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan
IPC分类号： C07D27732
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D277/70 , C07D277/74
摘要： Described is a process for the preparation of a compound of formula (I) wherein R is unsubstituted or substituted C1-C12alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, aryl or heteroaryl, or —SR1; R1 is unsubstituted or substituted C1-C12alkyl, C2-C4alkenyl, C2-C4alkynyl, cycloalkyl, aryl or heteroaryl; and X is a leaving group; which comprises: a) reacting a compound of formula (II) wherein R is as defined for formula (I), with a water-removing reagent; or b) for the preparation of a compound of formula (I) wherein X is halogen or a sulfonate, reacting a compound of the formula (III) wherein R is as defined for formula (I), with a halogenating or a sulfonylating agent; or c) for the preparation of a compound of formula (I) wherein X is halogen, reacting a compound of formula (IV) wherein R is as defined for formula (I); and wherein R2 and R3 are for example H, C1-C6alkyl, C3-C6cycloalkyl, phenyl or benzyl; with a compound of the formula halogen-C(═O)—O—C1-C8alkyl, halogen-C(═O)—O-aryl or halogen-C(═O)—O-benzyl. Intermediates for the preparation of the synthesis of compounds (II) to (IV) and method of the preparation thereof.
摘要翻译：描述了制备式（I）化合物的方法，其中R是未取代的或取代的C 1 -C 12烷基，C 2 -C 4烯基，C 2 -C 4炔基，C 3 -C 6环烷基，芳基或杂芳基或-SR 1; R1是未取代的或取代的C1-C12烷基，C2-C4链烯基，C2-C4炔基，环烷基，芳基或杂芳基; X为离去群; 其包括：a）使其中R如式（I）所定义的式（II）化合物与除水试剂反应; 或者b）用于制备其中X为卤素或磺酸盐的式（I）化合物，其中R为式（I）所定义的式（III）化合物与卤化剂或磺酰化剂反应; 或c）用于制备其中X为卤素的式（I）化合物，其中R为式（I）所定义的式（IV）化合物; 并且其中R 2和R 3是例如H，C 1 -C 6烷基，C 3 -C 6环烷基，苯基或苄基; 与卤素-C（= O）-O-C 1 -C 8烷基，卤素-C（= O）-O-芳基或卤素-C（= O）-O-苄基的化合物反应。用于制备化合物（II）至（IV）的合成的中间体及其制备方法。

2. 发明授权

US06369233B1 Process for the preparation of thiazole derivatives 失效
标题翻译：噻唑衍生物的制备方法
公开(公告)号：US06369233B1
公开(公告)日：2002-04-09
申请号：US09628392
申请日：2000-08-01
申请人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan , Gottfried Seifert
发明人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan , Gottfried Seifert
IPC分类号： C07D27716
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D417/06
摘要： The Invention relates to a process for the preparation of a compound of the formula wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting a compound of the formula with a halogenating agent to form a compound of the formula b) converting a compound of formula (II) by means of a halogenating agent into a compound of the formula optionally c) converting the compound of formula (IV) into a compound of formula (III); d) converting a compound of formula (III) by means of a compound of the formula e) converting a compound (IV) by means of a compound (V) into a compound (VI); and f) converting a compound (VI) by means of a chlorinating agent into a compound (I); a compound (IV); to a process for the preparation of a compound (III) and to a process for the preparation of a compound (IV).
摘要翻译：本发明涉及制备糠醛的化合物的方法，其中Q，Y，Z，R 1，R 2，R 3，R 4和R 5如本说明书中所定义，其包括：a）使下式的化合物与卤化剂将式（II）化合物通过卤化剂转化成式的化合物，任选地c）将式（Ⅳ）化合物转化为式（Ⅳ）化合物; d）转化将化合物（Ⅳ）用化合物（Ⅴ）转化成化合物（Ⅵ），将式（Ⅳ）化合物与下式化合物反应; 和（f）通过氯化剂将化合物（VI）转化为化合物（I）;化合物（IV）; 涉及制备化合物（III）的方法和制备化合物（IV）的方法。

3. 发明授权

US07161011B2 Preparation of thiazoles 失效
标题翻译：噻唑的制备
公开(公告)号：US07161011B2
公开(公告)日：2007-01-09
申请号：US10400826
申请日：2003-03-27
申请人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan
发明人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan
IPC分类号： C07D277/36
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D277/70 , C07D277/74
摘要： Described is a process for the preparation of a compound of the formula wherein R is unsubstituted or substituted C1–C12alkyl, C2–C4alkenyl, C2–C4alkynyl, C3–C6cycloalkyl, aryl or heteroaryl, or —SR1; R1 is unsubstituted or substituted C1–C12alkyl, C2–C4alkenyl, C2–C4alkenyl, C2–C4alkynyl, cycloalkyl, aryl or heteroaryl; and X is a leaving group; which comprises a) reacting a compound of the formula wherein R is as defined for formula (I), with a water removing reagent.
摘要翻译：描述了制备下式化合物的方法，其中R是未取代的或取代的C 1 -C 12烷基，C 2 - C 4链烯基，C 2 -C 4炔基，C 3 -C 6亚烷基，C 3 -C 4炔基，C 3 -C 4炔基，C 3 -C 6亚烷基， >环烷基，芳基或杂芳基，或-SR 1 N; R 1是未取代的或取代的C 1 -C 12烷基，C 2 -C 4烷基， /亚烷基，C 2 -C 4链烯基，C 2 -C 4 - 炔基，环烷基，芳基或杂芳基; X为离去群; 其包括a）使式（I）化合物与式（I）所定义的化合物与除水试剂反应。

4. 发明授权

US06677457B2 Process for the preparation of thiazole derivatives 失效
标题翻译：噻唑衍生物的制备方法
公开(公告)号：US06677457B2
公开(公告)日：2004-01-13
申请号：US10047807
申请日：2002-01-15
申请人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan , Gottfried Seifert
发明人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan , Gottfried Seifert
IPC分类号： C07D27716
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D417/06
摘要： The invention relates to a process for the preparation of a compound of the formula wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting a compound of the formula with a halogenating agent to form a compound of the formula or b) converting a compound of formula (II) by means of a halogenating agent into a compound of the formula optionally c) converting the compound of formula (IV) into a compound of formula (III); d) converting a compound of formula (III) by means of a compound of the formula into a compound of the formula or e) converting a compound (IV) by means of a compound (V) into a compound (VI); and f) converting a compound (VI) by means of a chlorinating agent into a compound (I); a compound (IV); to a process for the preparation of a compound (III) and to a process for the preparation of a compound (IV).
摘要翻译：本发明涉及制备糠醛的化合物的方法，其中Q，Y，Z，R 1，R 2，R 3，R 4和R 5如本说明书中所定义，其包括：a）将卤化剂的化合物与将式（II）化合物通过卤化剂转化成式（Ⅲ）的化合物，将式（Ⅳ）化合物转化为式（Ⅳ）化合物; d）将化合物通过化学式（Ⅳ）将化合物（Ⅳ）转化为化合物（Ⅵ）;将式（Ⅳ）化合物与式和（f）通过氯化剂将化合物（VI）转化为化合物（I）;化合物（IV）; 涉及制备化合物（III）的方法和制备化合物（IV）的方法。

5. 发明授权

US06211381B1 Thiazole compounds 失效
标题翻译：噻唑化合物
公开(公告)号：US06211381B1
公开(公告)日：2001-04-03
申请号：US09077569
申请日：1998-06-01
申请人： Henry Szczepanski , Thomas Göbel , Ottmar Franz Hüter , Anthony Cornelius O'Sullivan , Marcel Senn , Thomas Rapold , Peter Maienfisch , Thomas Pitterna
发明人： Henry Szczepanski , Thomas Göbel , Ottmar Franz Hüter , Anthony Cornelius O'Sullivan , Marcel Senn , Thomas Rapold , Peter Maienfisch , Thomas Pitterna
IPC分类号： C07D27732
CPC分类号： C07D277/32 , C07D277/36 , C07D417/06
摘要： The invention relates to a process for preparing a compound of formula (I), in which X is CH or N, Y is NO2 or CN, Z is CHR3, O, NR3 or S, R1 and R2 are either each, independently of the other, hydrogen or unsubstituted or R4-substituted alkyl or together a two- or three-membered alkylene bridge or a two- or three-membered alkylene bridge in which one member is replaced by a hetero member selected from the group, consisting of NR5, O and S, R3 is H or unsubstituted or R4-substituted alkyl, R4 is an unsubstituted or substituted aryl or heteroaryl group, and R5 is H or alkyl, which comprises a) reacting a compound of formula (II) with a chlorinating agent or b1) initially reacting a compound of formula (IV) with a compound of formula (V) and b2) further reacting the compound of formula (II) obtainable thereby, with or without intermediate isolation, with a chlorinating agent, to intermediates used in this process, to the use of these intermediates and to a process for the preparation of these intermediates.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中X是CH或N，Y是NO 2或CN，Z是CHR 3，O，NR 3或S，R 1和R 2各自独立地是另一个，氢或未取代的或R4取代的烷基或二元或三元亚烷基桥或二元或三元亚烷基桥，其中一个成员被选自NR5， O和S，R 3是H或未取代的或R 4取代的烷基，R 4是未取代或取代的芳基或杂芳基，R 5是H或烷基，其包括a）使式（II）化合物与氯化剂或 b1）最初使式（Ⅳ）化合物与式（Ⅴ）化合物反应，和b2）使可得到的式（Ⅱ）化合物进一步与中间体分离与氯化剂反应，得到本发明的中间体过程，使用这些中间体和制备过程这些中间体。

6. 发明授权

US06224660B1 Ink mixture 失效
标题翻译：油墨混合物
公开(公告)号：US06224660B1
公开(公告)日：2001-05-01
申请号：US09417916
申请日：1999-10-13
申请人： Andreas Stübbe , Wolfgang Lortz , Thomas Göbel , Holger Glaum
发明人： Andreas Stübbe , Wolfgang Lortz , Thomas Göbel , Holger Glaum
IPC分类号： C09D1100
CPC分类号： C09D11/38 , C09D11/16 , C09D17/00
摘要： The ink mixture contains at least one organosilane and optionally at least one hydrophobic silicic acid. The ink mixture can be used as a printing ink, especially as an ink for ink-jet printing.
摘要翻译：油墨混合物含有至少一种有机硅烷和任选的至少一种疏水硅酸。墨水混合物可以用作印刷油墨，特别是作为喷墨印刷用油墨。

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