专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07071234B2 Methods of treating or preventing erectile dysfunction 失效
标题翻译：治疗或预防勃起功能障碍的方法
公开(公告)号：US07071234B2
公开(公告)日：2006-07-04
申请号：US10395298
申请日：2003-03-25
申请人： Thomas P Jerussi , Chrisantha H. Senanayake , Qun K. Fang
发明人： Thomas P Jerussi , Chrisantha H. Senanayake , Qun K. Fang
IPC分类号： A61K31/136 , A61K31/44
CPC分类号： A61K45/06 , A61K31/11 , A61K31/135 , A61K31/137 , A61K2300/00
摘要： Methods are disclosed for the treatment and prevention of disorders and conditions including, but are not limited to, erectile dysfunction, affective disorders, weight gain, cerebral functional disorders, pain, obsessive-compulsive disorder, substance abuse, chronic disorders, anxiety, eating disorders, migraines, and incontinence. The methods comprise the administration of a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Pharmaceutical compositions and dosage forms are also disclosed that comprise a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Preferred dopamine reuptake inhibitors are racemic or optically pure sibutramine metabolites and pharmaceutically acceptable salts, solvates, and clathrates thereof. Preferred additional pharmacologically active compounds include drugs that affect the central nervous system, such as 5-HT3 antagonists.
摘要翻译：公开了用于治疗和预防疾病和病症的方法，包括但不限于勃起功能障碍，情感障碍，体重增加，脑功能障碍，疼痛，强迫症，药物滥用，慢性障碍，焦虑，进食障碍，偏头痛和失禁。所述方法包括施用多巴胺再摄取抑制剂和任选的另外的药理活性化合物。还公开了包含多巴胺再摄取抑制剂和任选的另外的药理学活性化合物的药物组合物和剂型。优选的多巴胺再摄取抑制剂是外消旋或光学纯的西布曲明代谢物及其药学上可接受的盐，溶剂化物和包合物。优选的额外的药理活性化合物包括影响中枢神经系统的药物，例如5-HT 3拮抗剂。

2. 发明授权

US06476078B2 Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction 失效
标题翻译：使用西布曲明代谢物与磷酸二酯酶抑制剂联合治疗性功能障碍的方法
公开(公告)号：US06476078B2
公开(公告)日：2002-11-05
申请号：US09770663
申请日：2001-01-29
申请人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
发明人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
IPC分类号： A61K31135
CPC分类号： A61K31/50 , A61K9/2054 , A61K9/2059 , A61K31/11 , A61K31/135 , A61K31/137 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/475 , A61K31/495 , A61K31/505 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： Methods are disclosed for the treatment and prevention of male and female sexual function disorders which comprise a racemic or optically pure sibutramine metabolite and a phosphodiesterase inhibitor.
摘要翻译：公开了用于治疗和预防包括外消旋或光学纯的西布曲明代谢物和磷酸二酯酶抑制剂的男性和女性性功能障碍的方法。

3. 发明授权

US06974837B2 Compositions comprising sibutramine metabolites in combination with phosphodiesterase inhibitors 有权
标题翻译：包含西布曲明代谢物与磷酸二酯酶抑制剂组合的组合物
公开(公告)号：US06974837B2
公开(公告)日：2005-12-13
申请号：US10278097
申请日：2002-10-23
申请人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
发明人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
IPC分类号： A61K9/20 , A61K31/11 , A61K31/135 , A61K31/137 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/475 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/52 , A61K45/06 , A61P15/00 , A61P25/00 , A61K31/496
CPC分类号： A61K31/50 , A61K9/2054 , A61K9/2059 , A61K31/11 , A61K31/135 , A61K31/137 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/475 , A61K31/495 , A61K31/505 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions and dosage forms are disclosed that comprise a racemic or optically pure sibutramine metabolite and a phosphodiesterase inhibitor.
摘要翻译：公开了包含外消旋或光学纯的西布曲明代谢物和磷酸二酯酶抑制剂的药物组合物和剂型。

4. 发明授权

US06342496B1 Bupropion metabolites and methods of use 有权
标题翻译：安非他酮代谢物及使用方法
公开(公告)号：US06342496B1
公开(公告)日：2002-01-29
申请号：US09510241
申请日：2000-02-22
申请人： Thomas P. Jerussi , John R. McCullough , Chrisantha H. Senanayake , Qun K. Fang
发明人： Thomas P. Jerussi , John R. McCullough , Chrisantha H. Senanayake , Qun K. Fang
IPC分类号： A61K31535
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/415 , A61K31/43 , A61K31/435 , A61K31/46 , A61K31/465 , A61K31/50 , A61K31/53 , A61K31/535 , A61K45/06 , C07B2200/07 , C07C45/511 , C07C45/63 , C07C49/84 , C07D265/32 , A61K2300/00 , C07C49/82 , C07C49/80
摘要： Methods are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, cerebral function disorders, cigarette smoking, and incontinence.
摘要翻译：公开了利用安非他酮代谢物治疗通过抑制神经元单胺再摄取而改善的病症的方法。这些疾病包括脑功能障碍，吸烟和失禁。

5. 发明授权

US06339106B1 Methods and compositions for the treatment and prevention of sexual dysfunction 失效
标题翻译：用于治疗和预防性功能障碍的方法和组合物
公开(公告)号：US06339106B1
公开(公告)日：2002-01-15
申请号：US09662135
申请日：2000-09-14
申请人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
发明人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
IPC分类号： A61K31135
CPC分类号： A61K31/11 , A61K31/135 , A61K31/137 , A61K45/06 , A61K2300/00
摘要： Methods are disclosed for the treatment and prevention of sexual. The methods comprise the administration of a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Pharmaceutical compositions and dosage forms are also disclosed that comprise a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Preferred dopamine reuptake inhibitors are racemic or optically pure sibutramine metabolites and pharmaceutically acceptable salts, solvates, and clathrates thereof. Preferred additional pharmacologically active compounds include drugs that affect the central nervous system, such as 5-HT3 antagonists.
摘要翻译：公开了治疗和预防性的方法。所述方法包括施用多巴胺再摄取抑制剂和任选的另外的药理活性化合物。还公开了包含多巴胺再摄取抑制剂和任选的另外的药理学活性化合物的药物组合物和剂型。优选的多巴胺再摄取抑制剂是外消旋或光学纯的西布曲明代谢物及其药学上可接受的盐，溶剂化物和包合物。优选的额外的药理活性化合物包括影响中枢神经系统的药物，例如5-HT 3拮抗剂。

6. 发明授权

US06538034B2 Methods of treating or preventing weight gain, obesity, and related disorders 有权
标题翻译：治疗或预防体重增加，肥胖和相关疾病的方法
公开(公告)号：US06538034B2
公开(公告)日：2003-03-25
申请号：US10000806
申请日：2001-12-04
申请人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
发明人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
IPC分类号： A61K31135
CPC分类号： A61K45/06 , A61K31/11 , A61K31/135 , A61K31/137 , A61K2300/00
摘要： Methods are disclosed for the treatment and prevention of obesity, weight gain, and eating disorders. The methods comprise the administration of racemic or optically pure sibutramine metabolites and pharmaceutically acceptable salts, solvates, and clathrates thereof.
摘要翻译：公开了用于治疗和预防肥胖，体重增加和进食障碍的方法。所述方法包括给予外消旋或光学纯的西布曲明代谢物及其药学上可接受的盐，溶剂合物和笼形物。

7. 发明授权

US06331571B1 Methods of treating and preventing attention deficit disorders 有权
标题翻译：治疗和预防注意力缺陷障碍的方法
公开(公告)号：US06331571B1
公开(公告)日：2001-12-18
申请号：US09372158
申请日：1999-08-11
申请人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
发明人： Thomas P. Jerussi , Chrisantha H. Senanayake , Qun K. Fang
IPC分类号： A61K31135
CPC分类号： A61K45/06 , A61K31/11 , A61K31/135 , A61K31/137 , A61K2300/00
摘要： Methods are disclosed for the treatment and prevention of affective disorders with racemic or optically pure sibutramine metabolites and pharmaceutically acceptable salts, solvates, and clathrates thereof.
摘要翻译：公开了用外消旋或光学纯的西布曲明代谢物及其药学上可接受的盐，溶剂化物和包合物治疗和预防情感障碍的方法。

8. 发明授权

US06339086B1 Methods of making and using N-desmethylzopiclone 有权
标题翻译：制备和使用N-去甲基异佐匹克隆的方法
公开(公告)号：US06339086B1
公开(公告)日：2002-01-15
申请号：US09548607
申请日：2000-04-13
申请人： Thomas P. Jerussi , Chrisantha H. Senanayake , Paul D. Rubin , Fran A. McConville
发明人： Thomas P. Jerussi , Chrisantha H. Senanayake , Paul D. Rubin , Fran A. McConville
IPC分类号： A61K3150
CPC分类号： A61K31/4985 , A61K31/498 , C07B2200/07 , C07D487/04
摘要： The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.
摘要翻译：本发明涉及包含外消旋的N-去甲基佐氮克隆，光学纯的（+） - N-去甲基佐匹克隆和光学纯的（ - ） - N-去甲基佐匹克隆的组合物，其用于治疗和预防哺乳动物的疾病和病症。本发明进一步涉及制备N-去甲基异佐匹克隆，光学纯的（+） - N-去甲基佐匹克隆和光学纯的（ - ） - N-去甲基异佐匹克隆的新方法。

9. 发明授权

US08642662B2 Methods of using derivatives of (−)-venlafaxine 有权
标题翻译：使用（ - ） - 文拉法辛衍生物的方法
公开(公告)号：US08642662B2
公开(公告)日：2014-02-04
申请号：US13481584
申请日：2012-05-25
申请人： Thomas P. Jerussi , Chrisantha H. Senanayake , Nandkumar N. Bhongle
发明人： Thomas P. Jerussi , Chrisantha H. Senanayake , Nandkumar N. Bhongle
IPC分类号： A61K31/135
CPC分类号： C07C217/74 , A61K31/137 , A61K31/277 , C07B2200/07 , C07C213/00 , C07C213/02 , C07C215/64 , C07C2601/14
摘要： Methods of preparing, and compositions comprising, derivatives of (−)-venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.
摘要翻译：公开了制备方法和包含（ - ） - 文拉法辛的衍生物的组合物。还公开了治疗和预防疾病和病症的方法，包括但不限于情感障碍如抑郁，双相和躁狂症，注意力缺陷障碍，具有多动症的注意缺陷障碍，帕金森病，癫痫，脑功能障碍，肥胖症和体重增加，失禁，痴呆和相关疾病。

10. 发明申请

US20120302794A1 Derivatives of venlafaxine and methods of preparing and using the same 审中-公开
公开(公告)号：US20120302794A1
公开(公告)日：2012-11-29
申请号：US13570412
申请日：2012-08-09
申请人： Thomas P. Jerussi , Chrisantha H. Senanayake , Nandkumar N. Bhongle
发明人： Thomas P. Jerussi , Chrisantha H. Senanayake , Nandkumar N. Bhongle
IPC分类号： C07C211/27
CPC分类号： C07D295/192 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K31/135 , C07C215/64 , C07C217/74 , C07C233/18 , C07C255/36 , C07C255/37 , C07C2601/14
摘要： Methods of preparing, and compositions comprising, derivatives of venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式