专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06696090B1 Electro-powder 失效
标题翻译：电粉
公开(公告)号：US06696090B1
公开(公告)日：2004-02-24
申请号：US09636548
申请日：2000-08-11
申请人： Thomas Nilsson , Lars-Gunnar Nilsson
发明人： Thomas Nilsson , Lars-Gunnar Nilsson
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/0009 , A61M15/02 , A61M2202/064
摘要： A method and a process are disclosed for preparation of medical electro-powders. The electro-powder results from preparations of chemical and biological substances to form electro-powders suitable for electrostatic charging and dosing for functionality in a dry powder inhaler device. The electro-powder resulting from the method and process forms an active powder substance or a dry powder medical formulation with a fine particle fraction representing of the order 50% or more of the content having a size ranging between 0.5-5 &mgr;m and provides electrostatic properties with an absolute specific charge per mass after charging of the order 0.1×10−6 to 25×10−6 C/g and presenting a charge decay rate constant Q50>0.1 sec with a tap density of less than 0.8 g/ml and a water activity aw of less than 0.5. In the processing the active substance is a generally pharmaceutical active chemical or biological substance, for instance a polyeptide or any other corresponding substance selected alone or mixed or blended together with one or more excipients being a compound to improve electrostatic properties of the medical dry powder substance or dry powder medical formulation. Further the electro-powder may even be formed as a micro-encapsulation by coating micronized powder with the excipient in such a way that the active substance is capsulated, whereby the powder electrostatic properties mainly comes from the excipient.
摘要翻译：公开了用于制备医用电子粉末的方法和方法。电粉由化学和生物物质的制备产生，以形成适于静电充电的电粉和在干粉吸入器装置中用于功能的剂量。由该方法和方法得到的电粉形成活性粉末物质或干粉医药制剂，其细颗粒级分表示尺寸范围在0.5-5μm之间的含量的50％以上，并提供静电特性在0.1×10 -6至25×10 -6 C / g的量的充电之后具有绝对的特定电荷/质量，并且具有小于0.8g / ml的振实密度的电荷衰减速率常数Q 50> 0.1秒，水分活度小于0.5。在加工过程中，活性物质是通常为药物活性的化学或生物物质，例如单独选择或与一种或多种赋形剂混合或混合在一起的多肽或任何其它相应的物质，以提高医用干粉物质的静电特性或干粉医药制剂。此外，电子粉末甚至可以通过用赋形剂涂覆微粉化粉末以使活性物质被包封的方式形成为微胶囊，由此粉末静电性质主要来自赋形剂。

2. 发明授权

US06526969B2 Method and device for releasing powder 失效
标题翻译：粉剂释放方法及装置
公开(公告)号：US06526969B2
公开(公告)日：2003-03-04
申请号：US09875048
申请日：2001-06-07
申请人： Lars-Gunnar Nilsson , Thomas Nilsson
发明人： Lars-Gunnar Nilsson , Thomas Nilsson
IPC分类号： A61M1500
CPC分类号： A61M15/0045 , A61M15/0048 , A61M15/005 , A61M15/0091 , A61M15/02 , A61M2202/064
摘要： An inhaler device and a method in which powder for inhalation is jetted off a prepared device surface containing a defined pre-metered quantity of finely divided powder. The jetting function is obtained by a directed air stream pushing or cutting free a medical powder applied to a carrier surface and by creating a stream of air dispersing the powder into inspiratory air at the moment it is being inhaled. The inhaler device includes active (air permeable) porous walls for preventing finely divided powder from sticking to the inner faces of the inhaler device by creating a pressure gradient across the active wall, thus forcing a small flow of air through the active wall thereby keeping the powder from sticking to the inner faces.
摘要翻译：吸入器装置和其中用于吸入的粉末从制备的装置表面喷射出来，该装置表面含有限定的预定量的细粉末。喷射功能是通过推送或切割施加到载体表面上的医用粉末的定向气流获得的，并且通过产生将粉末分散到吸入空气中的空气流。吸入器装置包括主动（透气的）多孔壁，用于通过在主动壁上产生压力梯度来防止细碎的粉末粘附到吸入器装置的内表面，从而迫使空气流过活动壁从而保持粉末粘在内表面上。

3. 发明授权

US06536426B1 Active walls 失效
公开(公告)号：US06536426B1
公开(公告)日：2003-03-25
申请号：US09665064
申请日：2000-09-19
申请人： Thomas Nilsson , Lars-Gunnar Nilsson
发明人： Thomas Nilsson , Lars-Gunnar Nilsson
IPC分类号： B65D8306
CPC分类号： A61M15/02 , A61M2202/064 , A61M2205/0233 , B08B17/06 , B65G53/521
摘要： A powder distribution device for transporting and mixing a fine powder with a gas is disclosed. The device presents a distribution member forming a connection between a source of fine powder and a discharge opening. The distribution member has a first inlet portion (10) and an outlet portion (12) for a stream of a first gas (1) mixed with the fine powder. The main body of the distribution member constitutes a porous body portion (16) being surrounded by a second gas (2). If a pressure gradient is created between the second gas (2) and the first gas (1), i.e. the first gas (1) being at a slightly lower pressure, the second gas (2) will leak trough the porous body (16) and thereby preventing powder, in the mix of the first gas and fine powder, from sticking or clogging within the distribution member, which thereby forms an active non-sticking wall relative to of the fine powder.

4. 发明授权

US06868853B1 Metered electro-dose 失效
标题翻译：计量电子剂量
公开(公告)号：US06868853B1
公开(公告)日：2005-03-22
申请号：US09664385
申请日：2000-09-18
申请人： Thomas Nilsson , Lars-Gunnar Nilsson
发明人： Thomas Nilsson , Lars-Gunnar Nilsson
IPC分类号： A61M15/00 , A61M15/02
CPC分类号： A61M15/02 , A61M15/0065 , A61M2202/064
摘要： An electro-dose constitutes a metered medical powder and is formed from an electro-powder constituting an active powder substance or a dry powder medical formulation being transferred onto a device member forming a dose carrier. The electro-dose prepared from an electro-powder presents a fine particle fraction (FPF) having of the order 50% or more of its content with a particle size between 0.5-5 μm. The electro-powder of such a metered electro-dose further provides electrostatic properties regarding absolute specific charge per mass after charging of the order 0.1 to 25 μC/g and presents a charge decay rate constant Q50 of more than 0.1 sec with a tap density of less than 0.8 g/ml and a water activity aw of less than 0.5. The electro-dose porosity is adjusted to obtain an optimized porosity value in percent of 75 to 99.9 calculated as 100−100×(Densityelectro-dose/Densityelectro-powder).
摘要翻译：电子剂量构成计量医用粉末，并由构成活性粉末物质或干粉医药制剂的电粉形成，转移到形成剂量载体的装置构件上。由电粉制备的电子剂量具有粒径在0.5-5μm之间的其含量为50％以上的细颗粒级分（FPF）。这种计量电子剂量的电粉还在充电0.1至25μC/ g之后提供关于每质量的绝对特定电荷的静电特性，并且具有大于0.1秒的电荷衰减速率常数Q 50，振荡密度为小于0.8g / ml，水活度aw小于0.5。调整电子剂量孔隙率以获得优化的孔隙度值，其百分数为75至99.9，以100-100x（密度电子剂量/密度电解粉末）计算。

5. 发明授权

US06722365B2 Active walls 失效
标题翻译：活动墙
公开(公告)号：US06722365B2
公开(公告)日：2004-04-20
申请号：US10337398
申请日：2003-01-07
申请人： Thomas Nilsson , Lars-Gunnar Nilsson
发明人： Thomas Nilsson , Lars-Gunnar Nilsson
IPC分类号： B65D8306
CPC分类号： A61M15/02 , A61M2202/064 , A61M2205/0233 , B08B17/06 , B65G53/521
摘要： A powder distribution device for transporting and mixing a fine powder with a gas is disclosed. The device presents a distribution member forming a connection between a source of fine powder and a discharge opening. The distribution member has a first inlet portion (10) and an outlet portion (12) for a stream of a first gas (1) mixed with the fine powder. The main body of the distribution member constitutes a porous body portion (16) being surrounded by a second gas (2). If a pressure gradient is created between the second gas (2) and the first gas (1), i.e. the first gas (1) being at a slightly lower pressure, the second gas (2) will leak trough the porous body (16) and thereby preventing powder, in the mix of the first gas and fine powder, from sticking or clogging within the distribution member, which thereby forms an active non-sticking wall relative to of the fine powder.
摘要翻译：公开了一种用于将细粉末与气体输送和混合的粉末分配装置。该装置呈现形成细粉源和排出口之间的连接的分配构件。分配构件具有用于与细粉末混合的第一气体（1）的流的第一入口部分（10）和出口部分（12）。分配构件的主体构成被第二气体（2）包围的多孔体部（16）。如果在第二气体（2）和第一气体（1）之间产生压力梯度，即第一气体（1）处于稍低的压力下，则第二气体（2）将通过多孔体（16）泄漏，从而防止第一气体和细粉末的混合物中的粉末在分配构件内发生粘连或堵塞，由此形成相对于细粉末的活性不粘壁。

6. 发明授权

US06622723B1 Inhaler dosing device 失效
标题翻译：吸入剂计量装置
公开(公告)号：US06622723B1
公开(公告)日：2003-09-23
申请号：US09703796
申请日：2000-11-02
申请人： Thomas Nilsson , Lars-Gunnar Nilsson
发明人： Thomas Nilsson , Lars-Gunnar Nilsson
IPC分类号： A61M1500
CPC分类号： A61M15/0045 , A61M2202/064
摘要： A dosing device of an inhaler for administration of a pharmaceutical composition during a prolonged time period is disclosed. The principle of the inspiratory administration is basically utilizing known techniques for administering of the pharmaceutical composition, whereby the fine powder to be administered is gathered as extended doses (15, 16) of powder onto a surface of a dosing member. The disposable dosing member (10) contains a number of prefabricated dose strings to be accessed. A dosing element (7) having an adapted opening moves along an extended string of the dosing member during the administration to in this manner prolong the time period, during which the pharmaceutical composition is released from the dosing member (10) into an air-stream of the inhaler during the inspiration. The relative motion of the dosing element (7) is either obtained by rotating the dosing member itself or moving the dosing element along the surface of the dosing member. Thereby an evenly distributed amount of powder in the inspiration air is obtained during, for instance, one to two seconds of inspiration in accordance with the motion of the dosing element (7) relative to the extended dose of pharmaceutical composition.
摘要翻译：公开了一种用于在延长的时间段内施用药物组合物的吸入器的计量装置。吸气给药的原理基本上是利用已知的药物组合物施用技术，由此将待施用的细粉末以一定剂量（15,16）的粉末聚集在定量给药组件的表面上。一次性配量构件（10）包含若干待访问的预制剂量串。具有适配开口的配量元件（7）在给药期间沿着剂量构件的延长线移动，以这种方式延长了药物组合物从定剂量构件（10）释放到空气流中的时间段的吸入器。剂量元件（7）的相对运动可以通过旋转定量给料件本身或者沿剂量元件的表面移动计量元件获得。因此，根据剂量元件（7）相对于延长剂量的药物组合物的运动，在例如1至2秒的吸气期间获得在吸入空气中的均匀分布量的粉末。

7. 发明授权

US06575161B1 Powder classification device 失效
标题翻译：粉末分级装置
公开(公告)号：US06575161B1
公开(公告)日：2003-06-10
申请号：US09744740
申请日：2001-01-29
申请人： Lars-Gunnar Nilsson
发明人： Lars-Gunnar Nilsson
IPC分类号： A61M1500
CPC分类号： A61M15/0065 , A61M15/02 , A61M2202/066
摘要： The invention discloses a method and a device for classification and, if required, electrostatic charging of a resulting separated decomposed powder preferably in the form of a substance intended for inhalation purposes. The classification takes place in that the powder is released from a device decomposing the suitable substance, whereby the powder is given a velocity perpendicular to in applied electric field (8). By adapting the strength of the electric field decomposed powder, i.e. individual particles resembling dust, will by means of the electric field (8) be attracted to a device (9) from which dosing of the individual particles then takes place. Larger particles (agglomerates) then will proceed straight ahead in an initial velocity direction as their kinetic energy is essentially larger than that for the small particles. In this manner a desirable separation of individual particles is obtained from the heavier agglomerated particles not desired to be administered and the conditions for a very good dosing of the substance thereby will result.
摘要翻译：本发明公开了一种用于分类的方法和装置，如果需要，所得到的分离的分解粉末优选以旨在用于吸入目的的物质的形式静电。进行分类是因为粉末从分解合适物质的装置中释放出来，由此给予粉末垂直于所施加的电场（8）的速度。通过使电场分解的粉末（即，类似于灰尘的单个颗粒）的强度适应将通过电场（8）被吸引到装置（9）上，然后发生单个颗粒的计量。然后，较大的颗粒（团聚体）将在初始速度方向上直线前进，因为它们的动能基本上大于小颗粒的动能。以这种方式，从不需要施用的较重的附聚颗粒获得单个颗粒的理想分离，因此将导致物质非常好的剂量的条件。

8. 发明授权

US06513663B1 Powder feeding device 失效
标题翻译：送粉装置
公开(公告)号：US06513663B1
公开(公告)日：2003-02-04
申请号：US09744744
申请日：2001-01-29
申请人： Lars-Gunnar Nilsson
发明人： Lars-Gunnar Nilsson
IPC分类号： B03C700
CPC分类号： B05B7/144 , A61M15/0065 , A61M15/02 , A61M2202/064 , B05B5/1683
摘要： The invention discloses a method and a device for de-agglomeration and electrostatic charging of a fine powder preferably intended for inhalation purposes. The electrostatic charging takes place by means of tribo, corona and/or inductive charging. The device according to the invention is particularly intended for being able to dose decomposed powder directly into the inspiration air for administering of, for instance, active pharmaceutical substances, alternatively provide a further dosing device with electrostatically charged de-agglomerated powder for an even more controlled dosing of the substance into the inspiration air. De-agglomeration preferably takes place in that two rotating brushes containing powder are touching each other. The bristles are rubbed against each other and thereby decompose the powder agglomerates. The rotation speed of the brushes is suitably optimized to achieve the best possible result for different powder substances. The design of the brushes is further optimized for the substances, which are to be de-agglomerated and electrostatically charged prior to an administering step.
摘要翻译：本发明公开了一种优选用于吸入目的的细粉末的去附聚和静电充电的方法和装置。静电充电通过摩擦，电晕和/或感应充电进行。根据本发明的装置特别用于能够将分解的粉末直接剂量分配到用于施用例如活性药物物质的吸入空气中，或者提供具有静电电荷的去附聚粉末的另外的给药装置，用于甚至更受控制将物质加入到吸气空气中。脱附聚合优选发生在含有粉末的两个旋转刷子彼此接触。刷毛彼此摩擦，从而分解粉末附聚物。适当地优化刷子的旋转速度，以实现不同粉末物质的最佳效果。对于在施用步骤之前要去附聚和静电充电的物质，刷子的设计进一步优化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式