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1. 发明授权

US09796982B2 Use of Cry1Da in combination with Cry1Ca for management of resistant insects 有权
公开(公告)号：US09796982B2
公开(公告)日：2017-10-24
申请号：US13516663
申请日：2010-12-16
申请人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
发明人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
IPC分类号： C12N15/82 , A01N63/02
CPC分类号： C12N15/8286 , A01N63/02 , Y02A40/162 , A01N65/00
摘要： The subject invention includes methods and plants for controlling fall armyworm lepidopteran insects, said plants comprising a Cry1Da insecticidal protein and a Cry1Ca insecticidal protein, and various combinations of other proteins comprising this pair of proteins, to delay or prevent development of resistance by the insects.

2. 发明申请

US20120311746A1 INSECT RESISTANCE MANAGEMENT WITH COMBINATIONS OF CRY1BE AND CRY1F PROTEINS 有权
标题翻译： CRY1BE和CRY1F蛋白质组合的耐药性管理
公开(公告)号：US20120311746A1
公开(公告)日：2012-12-06
申请号：US13516629
申请日：2010-12-16
申请人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Stephanie L. Burton , Aaron T. Woosley
发明人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Stephanie L. Burton , Aaron T. Woosley
IPC分类号： A01H5/00 , C12N5/10 , A01N63/00 , A01C11/00 , A01N37/18 , C12N15/82 , A01G1/00 , A01H5/10 , A01P7/04
CPC分类号： C12N15/8286 , A01N63/02 , A01N65/00 , Y02A40/162 , A01N2300/00
摘要： The subject invention relates in part to stacking Cry1Be toxins along with Cry1Fa toxins to prevent insects from developing resistance towards either toxin by itself. As discussed in more detail herein, the subject pair of proteins is a particularly advantageous combination, as no other pair of proteins is known to provide high levels of control and non-cross-resistant activity against both Spodoptera frugiperda (FAW) and Ostrinia nubilalis (ECB) insects. This dual, non-cross-resistant activity is also advantageous because it can reduce the number of proteins/genes needed to target these insects with multiple, non-cross-resistant proteins. This can reduce or eliminate the need for refuge acreage. Accordingly, the subject invention also relates generally to using four genes to provide three proteins for non-cross-resistant control of a first insect, and three proteins for non-cross-resistant control of a second insect. In preferred embodiments, the targeted insects are FAW and ECB.
摘要翻译：本发明部分涉及将Cry1Be毒素与Cry1Fa毒素一起堆叠以防止昆虫本身对毒素产生抗性。如本文更详细讨论的那样，本发明的对象蛋白质是特别有利的组合，因为没有其他蛋白质对可以提供针对草地贪夜蛾（Spodoptera frugiperda）（FAW）和鸵鸟鸵鸟（Ostrinia nubilalis）的高水平的控制和非交叉抗性活性 ECB）昆虫。这种双重非交叉抗性活性也是有利的，因为它可以减少用多种非交叉抗性蛋白质靶向这些昆虫所需的蛋白质/基因的数量。这可以减少或消除避难所面积的需要。因此，本发明还通常涉及使用四个基因提供用于第一昆虫的非交叉耐药性控制的三种蛋白质和用于第二种昆虫的非交叉耐药性控制的三种蛋白质。在优选的实施方式中，目标昆虫是FAW和ECB。

3. 发明授权

US09663795B2 Use of Cry1Ab in combination with Cry1Be for management of resistant insects 有权
公开(公告)号：US09663795B2
公开(公告)日：2017-05-30
申请号：US13516668
申请日：2010-12-16
申请人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
发明人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
IPC分类号： C12N15/82 , A01H5/00 , A01N63/02 , A01N65/00
CPC分类号： C12N15/8286 , A01N63/02 , A01N65/00 , Y02A40/162 , A01N2300/00
摘要： The subject invention includes methods and plants for controlling European corn borer and/or fall armyworm insects, said plants comprising a Cry1Ab insecticidal protein and a Cry1Be insecticidal protein, and various combinations of other proteins comprising this pair of proteins, to delay or prevent development of resistance by the insects.

4. 发明授权

US09499835B2 Use of Cry1Da in combination with Cry1Be for management of resistant insects 有权
标题翻译：使用Cry1Da与Cry1Be联合治疗抗性昆虫
公开(公告)号：US09499835B2
公开(公告)日：2016-11-22
申请号：US13516665
申请日：2010-12-16
申请人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
发明人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
IPC分类号： C12N15/82 , C07K14/325 , A01N63/02
CPC分类号： C12N15/8286 , A01N63/02 , C07K14/325 , Y02A40/162 , A01N65/00
摘要： The subject invention includes methods and plants for controlling fall army worm insects, said plants comprising a Cry1Da insecticidal protein and a Cry1Be insecticidal protein, and various combinations of other proteins comprising this pair of proteins, to delay or prevent development of resistance by the insects.
摘要翻译：本发明包括用于防治秋季昆虫的方法和植物，所述植物包含Cry1Da杀虫蛋白和Cry1Be杀虫蛋白，以及包含该对蛋白质的其它蛋白质的各种组合，以延迟或防止昆虫的抗性发展。

5. 发明授权

US09139844B2 Combined use of Cry1Ca and Cry1Ab proteins for insect resistance management 有权
标题翻译：结合使用Cry1Ca和Cry1Ab蛋白进行昆虫抗性管理
公开(公告)号：US09139844B2
公开(公告)日：2015-09-22
申请号：US13516615
申请日：2010-12-16
申请人： Thomas Meade , Aaron T. Woosley , Kenneth Narva , Stephanie L. Burton , Nicholas P. Storer , Joel J. Sheets
发明人： Thomas Meade , Aaron T. Woosley , Kenneth Narva , Stephanie L. Burton , Nicholas P. Storer , Joel J. Sheets
IPC分类号： C12N15/82 , A01N63/02
CPC分类号： C12N15/8286 , A01N63/02 , Y02A40/162 , A01N25/00
摘要： The subject invention includes methods and plants for controlling lepidopteran insects, said plants comprising Cry1Ca insecticidal protein and a Cry1Ab insecticidal protein in combination to delay or prevent development of resistance by the insects.
摘要翻译：本发明包括用于控制鳞翅目昆虫的方法和植物，所述植物包含Cry1Ca杀虫蛋白和Cry1Ab杀虫蛋白，以延迟或预防昆虫的抗性发展。

6. 发明申请

US20120324606A1 USE OF CRY 1AB IN COMBINATION WITH CRY1BE FOR MANAGEMENT OF RESISTANT INSECTS 有权
标题翻译：使用CRY 1AB与CRY1BE组合用于治疗耐药性
公开(公告)号：US20120324606A1
公开(公告)日：2012-12-20
申请号：US13516668
申请日：2010-12-16
申请人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
发明人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
IPC分类号： A01H5/00 , A01C11/00 , A01N37/46 , A01P7/04 , A01H5/10 , C12N5/10
CPC分类号： C12N15/8286 , A01N63/02 , A01N65/00 , Y02A40/162 , A01N2300/00
摘要： The subject invention includes methods and plants for controlling European corn borer and/or fall armyworm insects, said plants comprising a Cry1Ab insecticidal protein and a Cry1Be insecticidal protein, and various combinations of other proteins comprising this pair of proteins, to delay or prevent development of resistance by the insects.
摘要翻译：本发明包括用于控制欧洲玉米螟虫和/或秋季粘虫的方法和植物，所述植物包含Cry1Ab杀虫蛋白和Cry1Be杀虫蛋白，以及包含该对蛋白质的其它蛋白质的各种组合，以延迟或预防昆虫的抵抗力。

7. 发明申请

US20120317682A1 COMBINED USE OF VIP3AB AND CRY1FA FOR MANAGEMENT OF RESISTANT INSECTS 审中-公开
标题翻译：联合使用VIP3AB和CRY1FA进行耐药性管理
公开(公告)号：US20120317682A1
公开(公告)日：2012-12-13
申请号：US13516647
申请日：2010-12-16
申请人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
发明人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
IPC分类号： A01H5/00 , C12N5/10 , C12N1/21 , C12N1/19 , A01C11/00 , A01N63/04 , A01N63/00 , A01P7/04 , A01G1/00 , A01H5/10 , C12N1/13
CPC分类号： C12N15/8286 , A01N63/02 , Y02A40/162 , A01N65/00 , A01N2300/00
摘要： The subject invention includes methods and plants for controlling lepidopteran insects, said plants comprising a Vip3Ab insecticidal protein in combination with a Cry 1Fa insecticidal protein to delay or prevent development of resistance by the insect(s).
摘要翻译：本发明包括用于控制鳞翅目昆虫的方法和植物，所述植物包含与Cry 1Fa杀虫蛋白结合的Vip3Ab杀虫蛋白，以延迟或防止昆虫发生抗性。

8. 发明授权

US09556453B2 Insect resistance management with combinations of Cry1Be and Cry1F proteins 有权
标题翻译：昆虫抗性管理与Cry1Be和Cry1F蛋白的组合
公开(公告)号：US09556453B2
公开(公告)日：2017-01-31
申请号：US13516629
申请日：2010-12-16
申请人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Stephanie L. Burton , Aaron T. Woosley
发明人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Stephanie L. Burton , Aaron T. Woosley
IPC分类号： C12N15/82 , A01N63/02 , A01N65/00
CPC分类号： C12N15/8286 , A01N63/02 , A01N65/00 , Y02A40/162 , A01N2300/00
摘要： The subject invention relates in part to stacking Cry1Be toxins along with Cry1Fa toxins to prevent insects from developing resistance towards either toxin by itself. As discussed in more detail herein, the subject pair of proteins is a particularly advantageous combination, as no other pair of proteins is known to provide high levels of control and non-cross-resistant activity against both Spodoptera frugiperda (FAW) and Ostrinia nubilalis (ECB) insects. This dual, non-cross-resistant activity is also advantageous because it can reduce the number of proteins/genes needed to target these insects with multiple, non-cross-resistant proteins. This can reduce or eliminate the need for refuge acreage. Accordingly, the subject invention also relates generally to using four genes to provide three proteins for non-cross-resistant control of a first insect, and three proteins for non-cross-resistant control of a second insect. In preferred embodiments, the targeted insects are FAW and ECB.
摘要翻译：本发明部分涉及将Cry1Be毒素与Cry1Fa毒素一起堆叠以防止昆虫本身对毒素产生抗性。如本文更详细讨论的那样，本发明的对象蛋白质是特别有利的组合，因为没有其他蛋白质对可以提供针对草地贪夜蛾（Spodoptera frugiperda）（FAW）和鸵鸟鸵鸟（Ostrinia nubilalis）的高水平的控制和非交叉抗性活性 ECB）昆虫。这种双重非交叉抗性活性也是有利的，因为它可以减少用多种非交叉抗性蛋白质靶向这些昆虫所需的蛋白质/基因的数量。这可以减少或消除避难所面积的需要。因此，本发明还通常涉及使用四个基因提供用于第一昆虫的非交叉耐药性控制的三种蛋白质和用于第二种昆虫的非交叉耐药性控制的三种蛋白质。在优选的实施方式中，目标昆虫是FAW和ECB。

9. 发明申请

US20120317681A1 COMBINED USE OF CRY1Ca AND CRY1Fa PROTEINS FOR INSECT RESISTANCE MANAGEMENT 有权
标题翻译：联合使用CRY1Ca和CRY1Fa蛋白进行耐药性管理
公开(公告)号：US20120317681A1
公开(公告)日：2012-12-13
申请号：US13516611
申请日：2010-12-16
申请人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
发明人： Thomas Meade , Kenneth Narva , Nicholas P. Storer , Joel J. Sheets , Aaron T. Woosley , Stephanie L. Burton
IPC分类号： A01H5/00 , C12N5/10 , C12N1/21 , C12N1/19 , A01C11/00 , A01N63/00 , A01N63/04 , A01P7/04 , A01G1/00 , A01H5/10 , C12N1/13
CPC分类号： C12N15/8286 , A01N63/02 , Y02A40/162 , A01N65/00 , A01N2300/00
摘要： The subject invention includes methods and plants for controlling lepidopteran insects, said plants comprising a Cry1Fa insecticidal protein and a Cry1Ca insecticidal protein, in combination, to delay or prevent development of resistance by the insect(s).
摘要翻译：本发明包括组合用于控制鳞翅目昆虫的方法和植物，所述植物包含Cry1Fa杀虫蛋白和Cry1Ca杀虫蛋白，以延迟或预防昆虫的抗性发展。

10. 发明授权

US09045766B2 Combined use of Vip3Ab and Cry1Ab for management of resistant insects 有权
标题翻译：结合使用Vip3Ab和Cry1Ab来管理抗性昆虫
公开(公告)号：US09045766B2
公开(公告)日：2015-06-02
申请号：US13329013
申请日：2011-12-16
申请人： Thomas Meade , Kenneth Narva , Joel J. Sheets , Nicholas P. Storer , Stephanie L. Burton , Aaron T. Woosley
发明人： Thomas Meade , Kenneth Narva , Joel J. Sheets , Nicholas P. Storer , Stephanie L. Burton , Aaron T. Woosley
IPC分类号： C12N15/82 , C07K14/325 , C07K14/32
CPC分类号： C12N15/8286 , C07K14/32 , C07K14/325 , Y02A40/162
摘要： The subject invention includes methods and plants for controlling lepidopteran insects, said plants comprising a Vip3Ab insecticidal protein in combination with a Cry1Ab protein to delay or prevent development of resistance by the insect(s)—particularly corn earworm.
摘要翻译：本发明包括用于控制鳞翅目昆虫的方法和植物，所述植物包含与Cry1Ab蛋白结合的Vip3Ab杀虫蛋白，以延迟或防止由昆虫特别是玉米蛀虫发展的抗性。

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