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1. 发明申请

US20050049517A1 Electromyogram method and apparatus 审中-公开
标题翻译：电泳方法和仪器
公开(公告)号：US20050049517A1
公开(公告)日：2005-03-03
申请号：US10654495
申请日：2003-09-03
申请人： Thomas Mathew , Di-An Hong , George Valliath , William Olson
发明人： Thomas Mathew , Di-An Hong , George Valliath , William Olson
IPC分类号： A61B5/0488 , A61B5/04
CPC分类号： A61B5/0488 , A61B2562/164
摘要： An electromyogram device (10) have a conformable housing (11) that houses or otherwise supports an electromyogram signal processor (13), electromyogram sensors (14), and a display (15) that provides, for example, information corresponding to one or more muscle condition parameters such as muscular fatigue. In various embodiments, the device can further include additional displays (34), memory (31), audible alarm mechanisms (32), and/or a wireless receiver and/or transmitter (33). In one embodiment, such devices can communicate amongst one another to permit central and/or remote display of the resultant electromyogram information.
摘要翻译：肌电图装置（10）具有容纳或以其他方式支撑肌电图信号处理器（13），肌电图传感器（14）和显示器（15）的适形外壳（11），该显示器提供例如与一个或多个肌肉状况参数如肌肉疲劳。在各种实施例中，设备还可以包括附加显示器（34），存储器（31），可听报警机构（32）和/或无线接收器和/或发射器（33）。在一个实施例中，这样的装置可以彼此通信以允许所得到的肌电图信息的中心和/或远程显示。

2. 发明申请

US20230085435A1 UNTUCKING RESISTANT GARMENT 有权
公开(公告)号：US20230085435A1
公开(公告)日：2023-03-16
申请号：US17476581
申请日：2021-09-16
申请人： William Olson , Travis Buysse
发明人： William Olson , Travis Buysse
IPC分类号： A41B1/08 , A41D27/08
摘要： An untucking resistant garment resists becoming untucked while being worn. The garment includes a garment body and an inner band of tacky material coupled to an inside surface of the garment body positioned proximate to a bottom opening of the garment body. An outer band of the tacky material is coupled to an outside surface of the garment body positioned proximate to the bottom opening.

3. 发明申请

US20070274986A1 Compositions comprising anti-CCR5 antibody 审中-公开
标题翻译：包含抗CCR5抗体的组合物
公开(公告)号：US20070274986A1
公开(公告)日：2007-11-29
申请号：US11804746
申请日：2007-05-17
申请人： William Olson , Paul Maddon
发明人： William Olson , Paul Maddon
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： A61K39/395 , A61K39/39541 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/2866 , C07K2317/76 , A61K2300/00
摘要： This invention provides a composition which comprises a monoclonal antibody or a fragment of such antibody, wherein the monoclonal antibody or fragment of such antibody binds to the same epitope as antibody PA14 produced by a hybridoma cell line designated PA14 (ATCC Accession No. HB-12610) and a carrier. This invention also provides a method of treating a subject infected with HIV-1 which comprises administering to the subject an effective dose of the composition of the invention.
摘要翻译：本发明提供了包含单克隆抗体或该抗体片段的组合物，其中单克隆抗体或该抗体的片段与由指定为PA14（ATCC登录号HB-12610）的杂交瘤细胞系产生的抗体PA14相同的表位结合）和运营商。本发明还提供了一种治疗感染HIV-1的受试者的方法，其包括向受试者施用有效剂量的本发明组合物。

4. 发明申请

US20070031408A1 Anti-CCR5 antibody 有权
标题翻译：抗CCR5抗体
公开(公告)号：US20070031408A1
公开(公告)日：2007-02-08
申请号：US11581945
申请日：2006-10-16
申请人： William Olson , Paul Maddon , Naoya Tsurushita , Paul Hinton , Maximillano Vasquez
发明人： William Olson , Paul Maddon , Naoya Tsurushita , Paul Hinton , Maximillano Vasquez
IPC分类号： A61K39/395 , C07K16/28 , C07K16/10
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The invention is directed an anti-CCR5 antibody which comprises (i) two light chains, each light chain comprising the expression product of a plasmid designated pVK:HuPRO14O-VK (ATCC Deposit Designation PTA-4097), and (ii) two heavy chains, each heavy chain comprising an expression product of either a plasmid designated pVgl:HuPRO140 HG2-VH (ATCC Deposit Designation PTA-4098) or a plasmic designated pVgl:HuPRO140 (mutB+D+I)-VH (ATCC Deposit Designation PTA-4099) or a fragment thereof which binds to CCR5 on the surface of a human cell.
摘要翻译：本发明涉及抗CCR5抗体，其包含（i）两条轻链，每条轻链包含命名为pVK：HuPRO14O-VK（ATCC保藏号PTA-4097）的质粒的表达产物，和（ii）两条重链每个重链包含称为pVgl：HuPRO140HG2-VH（ATCC保藏号PTA-4098）或质粒命名为pVgl：HuPRO140（mutB + D + I）-VH（ATCC保藏号PTA-4099）的质粒的表达产物）或其与人细胞表面上的CCR5结合的片段。

5. 发明申请

US20060292151A1 L-SIGN polymorphisms and methods involving use of same 审中-公开
标题翻译： L-SIGN多态性及其使用方法
公开(公告)号：US20060292151A1
公开(公告)日：2006-12-28
申请号：US11093117
申请日：2005-03-28
申请人： Jason Gardner , William Olson
发明人： Jason Gardner , William Olson
IPC分类号： A61K39/395 , G01N33/53 , A61K31/715 , A61K31/716
CPC分类号： G01N33/5767 , C07K16/109 , C07K16/2851 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , G01N2500/00
摘要： This invention concerns methods for determining whether an agent preferentially binds to at least one allelic variant of L-SIGN. The invention is also directed to agents that preferentially bind to at least one allelic variant of L-SIGN. The invention also provides methods and agents for treating and preventing disorders associated with infection by pathogens, including hepatitis C virus, that bind to particular L-SIGN allelic variants. The invention further provides methods for predicting the resistance or susceptibility of a subject to pathogen infection.
摘要翻译：本发明涉及用于确定试剂优先与至少一种L-SIGN等位基因变体结合的方法。本发明还涉及优先结合至少一个L-SIGN等位基因变体的药剂。本发明还提供用于治疗和预防与特定L-SIGN等位基因变体结合的病原体（包括丙型肝炎病毒）感染相关疾病的方法和试剂。本发明还提供了用于预测受试者对病原体感染的抗性或易感性的方法。

6. 发明授权

US06605644B2 Analgesic regimen 有权
公开(公告)号：US06605644B2
公开(公告)日：2003-08-12
申请号：US10002249
申请日：2001-10-26
申请人： Marc Kamin , William Olson
发明人： Marc Kamin , William Olson
IPC分类号： A61K31135
CPC分类号： A61K31/135
摘要： A regimen for the administration of tramadol for the treatment of analgesia is described. The regimen involves a slower initial titration rate of tramadol which results in a significantly lower percentage of discontinuations of therapy due to a lower incidence and severity of side effects.

7. 发明授权

US06339105B1 Analgesic regimen 有权
标题翻译：止痛方案
公开(公告)号：US06339105B1
公开(公告)日：2002-01-15
申请号：US09415753
申请日：1999-10-12
申请人： Marc Kamin , William Olson
发明人： Marc Kamin , William Olson
IPC分类号： A61K31135
CPC分类号： A61K31/135
摘要： A regimen for the administration of tramadol for the treatment of analgesia is described. The regimen involves a slower initial titration rate of tramadol which results in a significantly lower percentage of discontinuations of therapy due to a lower incidence and severity of side effects.
摘要翻译：描述了用于治疗镇痛剂的曲马多的给药方案。该方案涉及曲马多的较慢的初始滴定速率，这导致治疗中断的百分比显着降低，因为副作用的发生率和严重程度较低。

8. 发明申请

US20050215472A1 PSMA formulations and uses thereof 审中-公开
标题翻译： PSMA制剂及其用途
公开(公告)号：US20050215472A1
公开(公告)日：2005-09-29
申请号：US10976352
申请日：2004-10-27
申请人： Norbert Schulke , Paul Maddon , William Olson
发明人： Norbert Schulke , Paul Maddon , William Olson
IPC分类号： A61K38/17 , A61K39/00 , C07K14/47
CPC分类号： C07K16/40 , A61K38/1709 , A61K39/0011 , A61K39/39558 , A61K47/6825 , A61K47/6869 , A61K51/1072 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07K14/4748 , C07K16/3069 , C07K2317/21 , C07K2317/565 , C07K2317/622 , G01N33/57434
摘要： The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.
摘要翻译：本发明包括稳定的多聚体，特别是二聚体形式的PSMA蛋白，含有二聚体PSMA蛋白的组合物和试剂盒，以及生产，纯化和使用这些组合物的方法。这些方法包括引发或增强对表达PSMA的细胞的免疫应答的方法，包括产生二聚体PSMA的抗体的方法以及治疗癌症的方法，例如前列腺癌。

9. 发明申请

US20050142139A1 CD4-IgG2 formulations 审中-公开
标题翻译： CD4-IgG2制剂
公开(公告)号：US20050142139A1
公开(公告)日：2005-06-30
申请号：US10804802
申请日：2004-03-19
申请人： Norbert Schulke , William Olson , Cherie Parkhurst-Lang , Indu Isaacs
发明人： Norbert Schulke , William Olson , Cherie Parkhurst-Lang , Indu Isaacs
IPC分类号： A61K20060101 , A61K31/4172 , A61K39/00 , A61K39/395 , C07K1/00 , C07K16/00 , C12N5/20
CPC分类号： C07K14/70514 , A61K47/6425 , A61K47/6835 , C07K2319/00 , C07K2319/30
摘要： This invention provides formulations of the anti-HIV therapeutic, CD4-IgG2, that contain higher concentrations of the therapeutic than were previously prepared, are stable, compatible with lyophilization, and safe to administer. These formulations are suitable for intravenous, subcutaneous and intramuscular delivery, the latter two routes being potentially useful for facilitating self-administration by HIV-infected individuals. This invention is also directed to methods of making the CD4-IgG2 formulations described in the disclosure, and methods of using the formulations to inhibit or prevent infect CD4+ cells from becoming infected with HIV, and to treat subjects having CD4+ cells infected with HIV.
摘要翻译：本发明提供了抗HIV治疗剂CD4-IgG2的制剂，其含有比先前制备的更高浓度的治疗剂，其是稳定的，与冻干相容并且安全施用。这些制剂适用于静脉内，皮下和肌内递送，后两种途径可能有助于促进HIV感染个体的自我施用。本发明还涉及制备本公开中描述的CD4-IgG2制剂的方法，以及使用制剂抑制或预防感染CD4 +细胞感染HIV的方法，以及治疗感染HIV的CD4 +细胞的受试者的方法。

10. 发明授权

US06475153B1 Method for obtaining blood pressure data from optical sensor 有权
标题翻译：从光学传感器获得血压数据的方法
公开(公告)号：US06475153B1
公开(公告)日：2002-11-05
申请号：US09568781
申请日：2000-05-10
申请人： Mohammad Khair , Salvador Lopez , Richard Ng , Sanjar Ghaem , William Olson
发明人： Mohammad Khair , Salvador Lopez , Richard Ng , Sanjar Ghaem , William Olson
IPC分类号： A61B502
CPC分类号： A61B5/6843 , A61B5/02007 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/681 , A61B5/7285 , A61B2562/0233 , A61B2562/046
摘要： An optical sensor generates blood pressure data by obtaining two dimensional images of the surface of the patient's body, such as in the vicinity of the radial artery in the wrist area. Blood flow in the patient causes light to be reflected off a flexible reflective surface applied against the patient with a hold down pressure, and the scattering of light is sensed with a two-dimensional array of photo-detectors. The output of the photo-detectors during systolic and diastolic events is calibrated against known blood pressure measurements taken with a conventional air-cuff sphygmomanometer. Linear calibration relationships between output signal and blood pressure are obtained during calibration for some set of the photo-detectors. When blood pressure data is obtained from the patient, the linear calibration relationship between output signals and blood pressure is applied to the output signals from the set of photo-detectors, resulting in blood pressure data. The method provides for compensation for changes in hold down pressure and translation or rotation of the optical sensor relative to the patient. A preferred optical sensor arrangement for use in performing the method is also described.
摘要翻译：光学传感器通过获得患者身体的表面的二维图像，例如在手腕区域中的桡动脉附近来产生血压数据。患者的血液流动导致光被从按压压力施加到患者上的柔性反射表面反射出来，并且用二维光电检测器阵列感测光的散射。收缩期和舒张期事件期间光电探测器的输出是用常规气袖血压计测量的已知血压进行校准。在一些光电检测器的校准期间，可以获得输出信号与血压之间的线性校准关系。当从患者获得血压数据时，输出信号和血压之间的线性校准关系被施加到来自该组光电检测器的输出信号，从而产生血压数据。该方法提供补偿压力压力和光学传感器相对于患者的平移或旋转的变化。还描述了用于执行该方法的优选光学传感器装置。

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