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1. 发明授权

US4968422A Pulsatile flow hemodialysis 失效
标题翻译：脉动血液透析
公开(公告)号：US4968422A
公开(公告)日：1990-11-06
申请号：US156809
申请日：1988-02-17
申请人： Thomas M. Runge , Michael R. Sheller
发明人： Thomas M. Runge , Michael R. Sheller
IPC分类号： A61M1/10 , A61M1/16 , A61M1/36
CPC分类号： A61M1/3621 , A61M1/1005 , A61M1/16
摘要： The use of a pulsatile flow blood pump in a hemodialysis system is disclosed. In comparison to the customary steady flow blood pump of the prior art, the pulsatile flow blood pump clears urea, a low molecular weight molecule, from the bood approximately three times as fast as does the steady flow roller pump commonly used on a worldwide basis for hemodialysis. Large molecules, such as vitamin B.sub.12 are also cleared more rapidly by the pulsatile flow pump, but less rapidly than the smaller molecules. Total time of dialysis is reduced and the results obtained by using the pulsatile flow blood pump are more physiologic, in that the more harmful molecules, urea, are selectively cleared more rapidly while the larger more desirable molecules, vitamin B.sub.12, are retained.
摘要翻译：公开了在血液透析系统中使用脉动流血泵。与现有技术的常规恒流血泵相比，脉动血液泵将尿素（低分子量分子）从常规使用的通常用于世界范围内的稳流辊泵清除约三倍，血液透析大分子如维生素B12也被脉动流泵更快地清除，但比较小的分子快得多。透析的总时间减少，通过使用脉动血泵获得的结果更生理，因为更有害的分子尿素被更快地选择性地清除，而保留较大的更理想的分子维生素B12。

2. 发明授权

US5437601A Blood conduit and pulsatile cardiopulmonary bypass pump system 失效
标题翻译：血管和搏动心肺旁路泵系统
公开(公告)号：US5437601A
公开(公告)日：1995-08-01
申请号：US197877
申请日：1994-02-17
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61M1/10 , A61M1/16 , A61M1/36
CPC分类号： A61M1/367 , A61M1/1041 , A61M1/1051 , A61M1/1046 , A61M1/1698 , A61M1/3666
摘要： A valveless blood conduit for pulsatile cardiopulmonary bypass pump constructed and arranged to provide a surge chamber, a pumping chamber and a reservoir portion, externally valved for use in a pre-load responsive pulsatile pump. The blood conduit precludes the necessity of employing a large volume venous reservoir in a cardiopulmonary bypass system employing a pre-load responsive pump, thus reducing a patient's blood to exposure to large air-blood interfaces and large non-endothelial surface areas.
摘要翻译：用于脉动心肺旁路泵的无血管血管构造和布置成提供用于预负荷响应性脉动泵的外部阀门的喘振室，泵送室和储存器部分。血液导管阻止了在使用预负荷响应泵的心肺分流系统中使用大体积静脉血管的必要性，从而减少患者的血液暴露于大的空气 - 血液界面和大的非内皮表面区域。

3. 发明授权

US5823930A Cam controlled pulsatile flow pump for neonatal and biventricular cardiac support systems 失效
标题翻译：用于新生儿和双心室心脏支持系统的凸轮控制脉动流量泵
公开(公告)号：US5823930A
公开(公告)日：1998-10-20
申请号：US600686
申请日：1996-02-13
申请人： Thomas M. Runge , Fred O. Bohls
发明人： Thomas M. Runge , Fred O. Bohls
IPC分类号： A61M1/10
CPC分类号： A61M1/1046 , A61M1/1039 , A61M1/1041 , A61M1/1051 , A61M1/1089
摘要： A cam controlled pulsatile flow pump for neonatal and biventricular cardiac support systems wherein cylindrical cams having various profiles designed for a particular patient are selectively mounted on the output shaft of a motor. A roller follower engages the cam and is operatively connected to a compression plate under which at least one compressible conduit containing the patient's blood extends. The stroke volume of blood contained in the conduit can also be controlled.
摘要翻译：一种用于新生儿和双心室心脏支持系统的凸轮控制的脉动流量泵，其具有为特定患者设计的各种轮廓的圆柱形凸轮选择性地安装在马达的输出轴上。滚子从动件接合凸轮并且可操作地连接到压缩板，在压缩板下方至少包含患者血液的可压缩导管延伸。包含在导管中的血液的行程体积也可以被控制。

4. 发明授权

US4004299A Cardiac replacement and assist devices 失效
标题翻译：心脏置换和辅助装置
公开(公告)号：US4004299A
公开(公告)日：1977-01-25
申请号：US657703
申请日：1976-02-12
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61M1/10 , A61M1/12 , A61F1/24 , A61M1/03
CPC分类号： A61M1/1046 , A61M1/1051 , A61M1/12 , Y10T74/18312
摘要： In accordance with one embodiment of the invention, a total cardiac replacement device or four chambered heart for orthotopic placement is provided. This device is a pulsatile flow, synchronous ventricular ejection pump which closely simulates the action of the human heart. An internal electrical drive motor is powered by radio frequency induction across intact skin without external connections. A grooved rotary shaft driven by the motor powers a linear follower disc in one direction to compress two blood compatible sacs which simulate the left ventricle and right ventricle of the heart by pumping blood through the aorta and pulmonary artery, respectively. Return movement of the follower disc in terms of rate is a function of right atrial and left atrial pressure and volume. Stroke volume of each simulated ventricle is independent of the other, as in the natural heart. In a second embodiment of the invention, a left ventricle cardiac assist device shunts and pumps blood from the left atrium into the aorta while the recipient's natural heart is left intact. The assist device can also be utilized for pulmonary circulation as a right ventricular assist means, shunting and pumping blood from the right atrium into the pulmonary artery.
摘要翻译：根据本发明的一个实施例，提供了用于原位放置的总心脏置换装置或四腔心脏。该装置是脉动流动，同步心室喷射泵，其紧密地模拟人心脏的作用。内部电动驱动电机由完整皮肤的射频感应供电，无需外部连接。由电机驱动的开槽旋转轴在一个方向上驱动线性随动盘，以分别通过泵送血液通过主动脉和肺动脉来压缩模拟左心室和右心室的两个血液相容囊。从动盘的速率返回运动是右心房和左心房压力和体积的函数。每个模拟心室的中风量独立于另一个，如在自然心脏中。在本发明的第二实施例中，左心室心脏辅助装置将来自左心房的血液分流并泵送到主动脉，而接收者的天然心脏保持完整。辅助装置还可以用作肺循环，作为右心室辅助装置，将血液从右心房分流并泵入肺动脉。

5. 发明授权

US5827220A Cannula system for a biventricular cardic support system or a cardiopulmonary bypass system and method 失效
标题翻译：用于双心室支持系统或体外循环系统和方法的插管系统
公开(公告)号：US5827220A
公开(公告)日：1998-10-27
申请号：US892911
申请日：1997-07-15
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61F2/958 , A61M1/12 , A61M1/36 , A61M25/00 , A61M31/00
CPC分类号： A61M25/10 , A61M1/3659 , A61M25/0021 , A61M1/12 , A61M1/3666 , A61M2025/0037 , A61M2025/1052 , A61M2202/0472 , A61M2210/127 , A61M25/007
摘要： A cannula system for a biventricular cardiac support system or a cardiopulmonary bypass system wherein a first cannula having a pair of side-by-side lumens is adapted to be positioned within the left atrium and left ventricle and aorta of a patient. Blood from the left atrium and left ventricle drains into one of the lumens in the first cannula and is conveyed to the inlet of a pulsatile flow cardiopulmonary bypass pump from where it is pumped through the other lumen into the aorta of the patient. An inflatable balloon is provided at the distal end of the first cannula for holding the distal end of the cannula in the aorta above the aortic valve, The first cannula includes an axially extending bore communicating with a space in the aorta between the inflated balloon and the aortic valve for conveying cardioplegic solution to the space communicating with the left and right arteries of the patient. A second cannula having a pair of side-by-side lumens is adapted to be positioned within the right atrium and right ventricle and pulmonary artery of the patient. Blood from the right atrium and right ventricle flows into one of the lumens in the second cannula and is conveyed to the pulsatile flow cardiopulmonary bypass pump from where it is pumped through the other lumen into the pulmonary artery of the patient.
摘要翻译：用于双心室心脏支持系统或体外循环系统的插管系统，其中具有一对并排腔的第一套管适于定位在患者的左心房和左心室和主动脉内。来自左心房和左心室的血液排入第一套管中的一个管腔中，并被输送到脉动流动心肺旁路泵的入口，从那里泵入另一内腔进入患者的主动脉。在第一套管的远端处设置可膨胀的气囊，用于将插管的远端保持在主动脉瓣上方的主动脉中。第一插管包括与充气球囊和主动脉瓣之间的主动脉中的空间连通的轴向延伸的孔主动脉瓣用于将心脏停搏液输送到与患者的左右动脉连通的空间。具有一对并排腔的第二套管适于定位在患者的右心房和右心室和肺动脉内。来自右心房和右心室的血液流入第二套管中的一个管腔，并被传送到脉动流心肺旁路泵，从那里泵送通过另一内腔进入患者的肺动脉。

6. 发明授权

US5300015A Blood conduit for pulsatile cardiopulmonary bypass pump 失效
标题翻译：脉动心肺旁路泵血管
公开(公告)号：US5300015A
公开(公告)日：1994-04-05
申请号：US845017
申请日：1992-03-03
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61M1/10 , A61M1/16 , A61M1/36 , A61M1/03
CPC分类号： A61M1/367 , A61M1/1041 , A61M1/1051 , A61M1/1046 , A61M1/1698 , A61M1/3666
摘要： A blood conduit for a pulsatile cardiopulmonary bypass pump constructed and arranged to provide a surge chamber, a pumping chamber, and a reservoir portion. The blood conduit precludes the necessity of employing a separate reservoir in a closed cardiopulmonary bypass system so that there is a direct continuity of blood from the atrium of the patient's heart to the pulsatile pump. With a preload responsive pulsatile pump, the system can be utilized with a gravity flow oxygenator.
摘要翻译：用于脉动心肺旁路泵的血液导管，其构造和布置成提供喘振室，泵送室和储存器部分。血液导管排除了在封闭的心肺分流系统中使用单独储存器的必要性，使得从患者心脏的心房到脉动泵的血液直接连续。使用预负荷响应性脉动泵，该系统可以与重力流动氧合器一起使用。

7. 发明授权

US4293961A Pulsatile flow cardiopulmonary bypass pump 失效
标题翻译：脉动流量心肺旁路泵
公开(公告)号：US4293961A
公开(公告)日：1981-10-13
申请号：US134089
申请日：1980-03-26
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61M1/10 , A61F1/00 , A61B19/00 , F04B43/00
CPC分类号： A61M1/1046 , A61M1/1041 , A61M1/1051 , Y10T74/18312
摘要： A pulsatile flow cardiopulmonary bypass pump for use outside of the body during cardiac surgery and/or in the period immediately thereafter is disclosed. A grooved spinner is motor driven through a fluid coupling which enables idling of the spinner during diastole. The shell of the pump has a roof to which the spinner drive motor is attached, and the roof can move axially of the shell body and is biased resiliently in one axial direction. The roof of the shell moves as a function of duration of systole and magnitude of afterload, reducing stroke volume in the presence of high afterload. A groove rider having a friction reducing ball bearing drives a ring follower housing during rotation of the spinner. The groove rider is positively displaced from engagement with a holding magnet on the ring follower housing by relatively stationary camming element external to the spinner, and a camming part on the far end of the spinner positively displaces the groove rider from the driving groove of the spinner into engagement with the holding magnet at the end of systole. A rough ride of the groove rider along the spinner during diastole is avoided, and the groove rider is not depenedent on spring action.
摘要翻译：公开了在心脏手术期间和/或其后立即期间在体外使用的脉动流动心肺旁路泵。带槽的旋转器由马达驱动通过流体联轴器，在舒张期间能够使旋转器空转。泵的壳体具有安装旋转驱动马达的屋顶，并且屋顶可以沿着壳体的轴向移动并且在一个轴向上被弹性偏压。壳的顶部作为收缩持续时间和后负荷的大小的函数移动，在高后负荷的情况下减少行程体积。具有减摩球轴承的凹槽骑手在旋转器旋转期间驱动环形随动件壳体。沟槽骑乘者通过在旋转器外部的相对固定的凸轮元件与环形从动件壳体上的保持磁体接合而主动地移位，并且在旋转器的远端上的凸轮部分使凹槽骑手从旋转器的驱动槽在收缩结束时与保持磁体接合。在舒张期期间避免了沿着旋转器的凹槽骑手的粗略骑行，并且槽骑乘者不依赖于弹簧作用。

8. 发明授权

US4117995A Aircraft wing lift augmentation device 失效
标题翻译：飞机机翼升降装置
公开(公告)号：US4117995A
公开(公告)日：1978-10-03
申请号：US772669
申请日：1977-02-28
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： B64C9/14 , B64C21/04
CPC分类号： B64C21/04 , B64C9/146 , B64C2230/04 , B64C2230/06 , Y02T50/166
摘要： A wing duct near and parallel to the leading edge of an aircraft wing receives air from the jet engines of the craft. The wing duct is spiral-like in cross section with an exit slit for directing high velociy air rearwardly over the dorsal wing surface and toward the trailing edge of the wing. A vertically movable slat matching the contour of the wing adjacent to the duct covers the exit slit leading from the duct when in a lowered position. The slat is raised automatically by the high velocity air stream blasting out of the exit slit and the slat directs this air stream rearwardly and prevents it from flowing forwardly. The slat is attached to the top of a gridwork through which the high velocity air stream from the exit slit must flow and the gridwork, in conjunction with the elevated slat, produces laminar flow of air across the top of the wing and minimizes turbulence. When the slat is retracted to lie flush against the top of the wing, the gridwork enters a wing recess or well immediately rearwardly of the duct. The slat can be retracted by a state of the art hydraulic mechanism in the wing which allows extension of the slat and gridwork responsive to the air stream coming from the exit slit.
摘要翻译：靠近并平行于飞行器机翼前缘的翼管从飞机的喷气发动机接收空气。翼导管的横截面为螺旋状，具有用于将高velociy空气向后指向背翼表面并朝向翼的后缘的出口狭缝。在靠近管道的情况下匹配翼的轮廓的可垂直移动的板条在处于降低位置时覆盖从导管引出的出口狭缝。通过从出口狭缝喷出的高速气流自动升高板条，并且板条向后引导该空气流并防止其向前流动。板条连接到格栅的顶部，通过该顶板，来自出口狭缝的高速空气流必须流动，并且格栅与高架板条一起产生横跨翼的顶部的空气流，并使湍流最小化。当板条缩回以与翼的顶部齐平时，格栅进入导管的紧邻后方的翼凹槽或井。翼板可以通过机翼中的最先进的液压机构缩回，其允许响应于来自出口狭缝的气流延伸板条和格栅。

9. 发明授权

US4326686A Fan jet engine bypass air delivery system for blown wing aircraft lift augmentation device 失效
标题翻译：风机喷气发动机旁路送风系统，用于吹风机升降机增压装置
公开(公告)号：US4326686A
公开(公告)日：1982-04-27
申请号：US118999
申请日：1980-02-15
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： B64C9/14 , B64C21/04
CPC分类号： B64C21/04 , B64C9/146 , B64C2230/04 , B64C2230/06 , Y02T50/166
摘要： Comparatively cool fan bypass air in the annular space surrounding the air compressor of a fan jet engine is diverted near the front of the engine into a duct leading to right and left hand aircraft wing leading edge ducts which in turn deliver the bypass air to a wing blowing device to augment wing lift. All of the fan-generated bypass air can be positively forced into the common duct or manifold by operation of a guided flexible metal strip of sufficient length to form a concave helical diverter vane extending for one complete turn in the annular bypass air engine space when activated by a power control mechanism. Fixed coacting guides shape the normally flat metal strip into the proper cross sectional configuration when the strip is driven to its active bypass air diverting position.
摘要翻译：在风扇喷气发动机的空气压缩机周围的环形空间中相对较冷的风扇旁路空气在发动机前部附近被转向通向右侧和左侧的飞行器机翼前缘导管的导管，从而将旁路空气输送到翼吹风装置增加机翼升力。所有风扇产生的旁路空气可以通过操作具有足够长度的导向的柔性金属带而被积极地推入公共管道或歧管中，以形成在激活时在环形旁路空气引擎空间中延伸一整圈的凹形螺旋导向叶片通过功率控制机制。当带被驱动到其主动旁路空气分流位置时，固定的共同引导件将正常平坦的金属条形成正确的横截面构造。

10. 发明授权

US4302854A Electrically activated ferromagnetic/diamagnetic vascular shunt for left ventricular assist 失效
标题翻译：用于左心室辅助的电激活铁磁/反磁血管分流
公开(公告)号：US4302854A
公开(公告)日：1981-12-01
申请号：US156510
申请日：1980-06-04
申请人： Thomas M. Runge
发明人： Thomas M. Runge
IPC分类号： A61M1/10 , A61M1/12 , A61F1/24 , A61M1/03
CPC分类号： A61M1/1053 , A61M1/1048 , A61M1/1055 , A61M1/122
摘要： A valved compressible state of the art Dacron shunt is sutured to the left atrium and to the descending thoracic aorta. One ferromagnetic and one diamagnetic shunt compression plate is positioned on one side of the shunt with the two plates in opposing relationship. A state of the art electromagnet and synchronizing mechanism exteriorly of the body cyclically, in accordance with the patient's QRS complex, generates a pulsating magnetic field which drives the ferromagnetic plate toward the diamagnetic plate, thereby cyclically compressing the shunt during diastole and giving assistance to the left ventricle of the heart.
摘要翻译： Dacron分流器的可压缩状态被缝合到左心房和下降的胸主动脉。一个铁磁和一个反磁性分流压缩板位于分流器的一侧，两个板以相反的关系。根据病人的QRS波段，身体周围的电磁体和同步机构的状态循环地产生脉动磁场，其驱动铁磁板朝向抗磁性板，从而在舒张期期间周期性地压缩分流器并且帮助心脏左心室

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