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1. 发明申请

US20100022639A1 Methods of Inducing Weight Loss 审中-公开
标题翻译：诱导减肥的方法
公开(公告)号：US20100022639A1
公开(公告)日：2010-01-28
申请号：US12558313
申请日：2009-09-11
申请人： Thomas M. Loftus , Craig A. Townsend , Gabriele Ronnett , M. Daniel Lane , Francis P. Kuhajda
发明人： Thomas M. Loftus , Craig A. Townsend , Gabriele Ronnett , M. Daniel Lane , Francis P. Kuhajda
IPC分类号： A61K31/365 , C12Q1/68 , A61K31/336
CPC分类号： C12Q1/6883 , A61K31/365 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect may be accomplished directly, indirectly, or humorally. Preferably, administration of this compound has the effect of increasing malonyl CoA levels in the animal. Compounds administered according to this invention may be inhibitors of fatty acid synthase (FAS), including substituted α-methylene-β-carboxyl-γ-butyrolactones, or inhibitors of malonyl Coenzyme A decarboxylase (MCD). Preferably, the compound is administered in an amount sufficient to reduce the amount and/or duration of expression and/or secretion of NPY to levels at or below those observed for lean animals. In another preferred embodiment, the administration will reduce expression and/or secretion to levels observed for fed or satiated animals; more preferably, administration will reduce the level of NPY below that of fed animals. In a particular embodiment, this invention provides a method for inducing weight loss in an animal by administering a compound which inhibits feeding behavior in the animal. The method is particularly useful for inducing weight loss in animals deficient in expression of the hormone leptin or animals resistant to the action of leptin.
摘要翻译：本发明提供一种通过向动物施用降低神经肽Y（NPY）的表达和/或分泌的化合物来诱导动物体内的体重减轻的方法。效果可以直接，间接或幽默地完成。优选地，该化合物的给药具有增加动物中丙二酰辅酶A水平的作用。根据本发明施用的化合物可以是脂肪酸合酶（FAS）的抑制剂，包括取代的α-亚甲基-β-羧基-γ-丁内酯或丙二酰辅酶A脱羧酶（MCD）的抑制剂。优选地，化合物以足以将NPY的表达和/或分泌的量和/或持续时间降低至对于瘦动物观察到的水平或以下的量施用。在另一个优选的实施方案中，施用将将表达和/或分泌降低至饲喂或饱食动物观察到的水平; 更优选地，施用将降低NPY的水平低于饲养动物的水平。在一个具体实施方案中，本发明提供了通过施用抑制动物中的进食行为的化合物来诱导动物体重减轻的方法。该方法特别可用于诱导缺乏激素瘦素或对瘦素作用的动物的表达的动物的体重减轻。

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