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1. 发明授权

US5340726A Protein for inhibiting collagen-stimulated platelet aggregation 失效
标题翻译：用于抑制胶原刺激的血小板聚集的蛋白质
公开(公告)号：US5340726A
公开(公告)日：1994-08-23
申请号：US107411
申请日：1993-08-16
申请人： Thomas M. Connolly , Paul M. Keller , Lloyd H. Waxman
发明人： Thomas M. Connolly , Paul M. Keller , Lloyd H. Waxman
IPC分类号： A61K38/00 , C07K14/435 , C12N5/00 , C07H15/12 , C07K3/00 , C12P21/06
CPC分类号： C07K14/43531 , A61K38/00
摘要： A protein which inhibits collagen-stimulated platelet aggregation. The protein has a molecular weight of approximately 17,000. A method of isolating the protein from Ornithodoros moubata and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.
摘要翻译：抑制胶原刺激的血小板聚集的蛋白质。蛋白质的分子量约为17,000。还描述了从Ornithodoros moubata中分离蛋白质并使用该蛋白质来阻止或延缓血液凝固的方法，该方法是阻止胶原对血小板聚集的刺激。该蛋白质可用于预防，预防，治疗和治疗血栓性疾病。

2. 发明授权

US5324715A Protein for inhibiting collagen-stimulated platelet aggregation 失效
标题翻译：用于抑制胶原刺激的血小板聚集的蛋白质
公开(公告)号：US5324715A
公开(公告)日：1994-06-28
申请号：US44547
申请日：1993-04-07
申请人： Thomas M. Connolly , Paul M. Keller
发明人： Thomas M. Connolly , Paul M. Keller
IPC分类号： A61K35/62 , A61K38/00 , A61K38/36 , A61P7/02 , C07K1/22 , C07K1/30 , C07K14/435 , C07K14/815 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/865 , A61K37/00
CPC分类号： C07K14/815 , C07K14/43536 , A61K38/00 , Y10S530/855
摘要： A protein isolated from crude Haementeria officinalis extract which blocks stimulation of platelet aggregation by collagen. The protein has a molecular weight of approximately 16,000. A method of isolating the protein and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.
摘要翻译：从原始海草提取物中分离的蛋白质，其阻断胶原蛋白刺激血小板聚集。蛋白质的分子量约为16,000。还描述了分离蛋白质并使用蛋白质以通过阻断胶原对血小板聚集的刺激来预防或延迟凝血的方法。该蛋白质可用于预防，预防，治疗和治疗血栓性疾病。

3. 发明授权

US5321010A Proteins for inhibiting adhesion of platelets to collagen 失效
标题翻译：用于抑制血小板粘附到胶原蛋白的蛋白质
公开(公告)号：US5321010A
公开(公告)日：1994-06-14
申请号：US807022
申请日：1991-12-10
申请人： Thomas M. Connolly , Michael Neeper , Lloyd Waxman
发明人： Thomas M. Connolly , Michael Neeper , Lloyd Waxman
IPC分类号： A61K38/00 , A61P7/02 , C07K14/00 , C07K14/435 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , A61K37/00
CPC分类号： C07K14/43527 , A61K38/00 , Y10S530/858
摘要： The invention comprises proteinaceous substances isolated from crude Ornithodoros moubata extract which inhibit adhesion of platelets to collagen. These substances do not inhibit platelet adhesion to fibrinogen, and are therefore particularly useful for inhibiting adhesion of platelets to collagen when simultaneous inhibition of platelet adhesion to fibrinogen is undesired. They are particularly useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.
摘要翻译：本发明包括从粗制的Ornithodoros moubata提取物中分离的抑制血小板粘附到胶原上的蛋白质物质。这些物质不会抑制血小板粘附于纤维蛋白原，因此特别适用于抑制血小板粘附于纤维蛋白原的同时抑制血小板粘附于胶原蛋白。它们在预防，预防，治疗和治疗血栓性疾病方面特别有用。

4. 发明授权

US06838291B2 Radioligand and binding assay 失效
标题翻译：放射性配体和结合测定
公开(公告)号：US06838291B2
公开(公告)日：2005-01-04
申请号：US09904045
申请日：2001-07-12
申请人： John W. Butcher , David A. Claremon , Thomas M. Connolly , Jerzy Karczewski , Kenneth S. Koblan , Matthew J. Kostura , Nigel J. Liverton , Dennis C. Dean , David G. Melillo
发明人： John W. Butcher , David A. Claremon , Thomas M. Connolly , Jerzy Karczewski , Kenneth S. Koblan , Matthew J. Kostura , Nigel J. Liverton , Dennis C. Dean , David G. Melillo
IPC分类号： G01N33/566 , A61K51/04 , C07D491/10 , C07D491/107 , C07D491/20 , C07F7/18 , C12N15/09 , C12Q1/02 , G01N33/58 , G01N33/60 , G01N33/68 , G01N33/534 , G01N33/567
CPC分类号： G01N33/6872 , A61K51/0455 , A61K51/0476 , C07B2200/05 , C07D491/10 , C07F7/1804 , G01N33/60
摘要： The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1′-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4′-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
摘要翻译：本发明涉及放射性配体化合物[35 S] - 放射性标记的（+） - N- [1' - （6-氰基-1,2,3,4-四氢-2（R） - 萘基） -3,4-二氢-4（R） - 氧代氧杂螺[2H-1-苯并吡喃-2,4'-哌啶] -6-基]甲磺酰胺。本发明的范围也是用于鉴定结合IKr通道的化合物的方法，并且可能具有抗心律失常活性。

5. 发明授权

US06515023B2 Thrombin receptor antagonists 失效
标题翻译：凝血酶受体拮抗剂
公开(公告)号：US06515023B2
公开(公告)日：2003-02-04
申请号：US09772353
申请日：2001-01-30
申请人： James C. Barrow , Philippe G. Nantermet , Harold G. Selnick , John H. Hutchinson , Michael J. Breslin , Kristen L. Glass , Thomas M. Connolly , Andrew Stern
发明人： James C. Barrow , Philippe G. Nantermet , Harold G. Selnick , John H. Hutchinson , Michael J. Breslin , Kristen L. Glass , Thomas M. Connolly , Andrew Stern
IPC分类号： A61K3144
CPC分类号： C07D213/81 , C07B2200/07 , C07C275/40 , C07C2601/02 , C07C2601/04 , C07D207/16 , C07D213/82 , C07D233/90 , C07D235/06 , C07D333/24 , C07D333/38 , C07D471/04
摘要： A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic amount of such compound to a mammal, preferably a human.
摘要翻译：具有抑制血小板凝集功能的凝血酶受体拮抗剂。该化合物可用于作用于凝血酶受体的方法，该方法包括向哺乳动物，优选人类施用治疗有效但无毒量的此类化合物。

6. 发明授权

US4038660A Microwave absorbers 失效
标题翻译：微波吸收器
公开(公告)号：US4038660A
公开(公告)日：1977-07-26
申请号：US602168
申请日：1975-08-05
申请人： Thomas M. Connolly , Eino J. Luoma
发明人： Thomas M. Connolly , Eino J. Luoma
IPC分类号： H01Q17/00
CPC分类号： H01Q17/004
摘要： Microwave absorbers reduce radar cross-sections of airborne objects by attenuating reflectivity values. In Jaumann absorbers laminated layers are placed on the reflecting surfaces, the laminated layers being lossy layers separated by dielectric spacing layers. From the point of view of accuracy and reproducibility Jaumann absorbers have been difficult to construct. A mode of fabrication overcoming these difficulties is provided herein.

7. 发明授权

US5613676A Sporting net 失效
标题翻译：运动网
公开(公告)号：US5613676A
公开(公告)日：1997-03-25
申请号：US625247
申请日：1996-04-01
申请人： Thomas M. Connolly
发明人： Thomas M. Connolly
IPC分类号： A63B63/00 , A63B63/08 , A63B71/02
CPC分类号： A63B63/004 , A63B63/083
摘要： A sporting net which can be utilized either as a hockey net or a basketball hoop. The apparatus includes a center post having a basketball hoop and its upper end. Furthermore, two linkages are pivotally secured at opposing locations at the intermediate extent of the center post. A hockey net is secured in between these two linkages. In order to facilitate storage of the sporting net, the linkages are pivotal between a first use orientation, wherein they extend laterally from the post then downwardly to abut a recipient surface and a second storage orientation wherein they are positioned generally next to the post.
摘要翻译：可以用作曲棍球网或篮球圈的运动网。该装置包括具有篮球圈及其上端的中心柱。此外，在中心柱的中间部分处的相对位置枢转地固定两个连杆。这两个联系之间有一个曲棍球网。为了便于运动网的储存，连接件在第一使用方向之间是枢转的，其中它们从柱子横向延伸，然后向下延伸以邻接接收器表面和第二存储方向，其中它们通常位于柱的旁边。

8. 发明授权

US5179082A Method for blocking platelet adhesion to collagen 失效
标题翻译：阻止胶原粘连胶原蛋白的方法
公开(公告)号：US5179082A
公开(公告)日：1993-01-12
申请号：US662225
申请日：1991-02-27
申请人： Thomas M. Connolly , Jerzy Karczewski
发明人： Thomas M. Connolly , Jerzy Karczewski
IPC分类号： A61K38/00 , A61P7/02 , C07K14/46 , C07K14/78
CPC分类号： C07K14/78 , A61K38/00
摘要： A method for blocking platelet adhesion to collagen by contacting platelets with a polypeptide having one of the following sequences:NH.sub.2 (Ch) Ala Arg Gly Asp (Cx) COOH (i)NH.sub.2 (Ch) Ala Ala Gly Asp (Cx) COOH (ii)NH.sub.2 (Ch) Ala Arg Tyr Asp (CX) COOH (iii)NH.sub.2 (Ch) Ala Arg Gly Asp (Cy) Z (iv)wherein Ch, Cx, Cy are defined amino acid sequences or conservatively substituted amino acid sequences, and Z is NH.sub.2 or COOH.

9. 发明授权

US5681926A Thrombin receptor binding peptides 失效
标题翻译：凝血酶受体结合肽
公开(公告)号：US5681926A
公开(公告)日：1997-10-28
申请号：US564254
申请日：1995-12-15
申请人： Daniel F. Veber , Ruth F. Nutt , Dong-Mei Feng , Robert J. Gould , Thomas M. Connolly
发明人： Daniel F. Veber , Ruth F. Nutt , Dong-Mei Feng , Robert J. Gould , Thomas M. Connolly
IPC分类号： G01N33/53 , A61K51/08 , C07K7/06 , C07K14/705 , C07K14/745 , G01N33/566 , A61K38/04 , A61K38/07 , A61K38/08 , C07K7/00
CPC分类号： C07K14/705 , A61K51/08 , A61K2123/00
摘要： Peptides having the general sequence A-B-C-D-E-F-Z wherein A is Ala, B is pFPhe, C is, for example, Arg, D is Cha, E is, for example, hArg, F is, for example, Tyr, and Z is, for example NH.sub.2. The peptides are useful for promoting wound healing and arresting bleeding in a patient.
摘要翻译： PCT No.PCT / US94 / 06672 Sec。 371 1995年12月15日第 102（e）日期1995年12月15日PCT提交1994年6月14日PCT公布。公开号WO94 / 29338 日期为1994年12月22日具有一般序列ABCDEFZ的肽，其中A为Ala，B为pFPhe，C为例如Arg，D为Cha，E为例如hArg，F为例如Tyr和Z 是例如NH 2。这些肽可用于促进伤口愈合并阻止患者出血。

10. 发明授权

US5457177A Thrombin receptor radioligands 失效
标题翻译：凝血酶受体放射性配体
公开(公告)号：US5457177A
公开(公告)日：1995-10-10
申请号：US77850
申请日：1993-06-16
申请人： Daniel F. Veber , Ruth F. Nutt , Dong-mei Feng , Robert J. Gould , Thomas M. Connolly
发明人： Daniel F. Veber , Ruth F. Nutt , Dong-mei Feng , Robert J. Gould , Thomas M. Connolly
IPC分类号： G01N33/53 , A61K51/08 , C07K7/06 , C07K14/705 , C07K14/745 , G01N33/566 , A61K38/08
CPC分类号： C07K14/705 , A61K51/08 , A61K2123/00
摘要： The radioligands are six amino acid peptides having iodinated tyrosine at amino acid position six, including Ala-pFPhe-hArg-Cha-hArg-Tyr(I)-NH.sub.2, which mimic the activated form of the thrombin receptor protein. Thrombin receptor radioligands of the present invention are useful for screening for thrombin receptor antagonists.
摘要翻译：放射性配体是在氨基酸位置六处具有碘化酪氨酸的六个氨基酸肽，包括模拟凝血酶受体蛋白的活化形式的Ala-pFPhe-hArg-Cha-hArg-Tyr（I）-NH 2。本发明的凝血酶受体放射性配体可用于筛选凝血酶受体拮抗剂。

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