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1. 发明授权

US07399468B2 Diagnostic and therapeutic use of antibodies against the urokinase receptor 有权
标题翻译：诊断和治疗使用抗尿激酶受体的抗体
公开(公告)号：US07399468B2
公开(公告)日：2008-07-15
申请号：US11586579
申请日：2006-10-26
申请人： Thomas Luther , Martin Mueller , Sybille Albrecht , Viktor Magdolen , Olaf Wilhelm , Manfred Schmitt , Nadja Harbeck
发明人： Thomas Luther , Martin Mueller , Sybille Albrecht , Viktor Magdolen , Olaf Wilhelm , Manfred Schmitt , Nadja Harbeck
IPC分类号： A61K39/395 , A61K39/00 , C07K5/00
CPC分类号： C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/565 , C07K2317/622 , G01N33/574 , G01N33/57492 , G01N33/582
摘要： The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.
摘要翻译：本发明涉及一种用于使用双荧光技术检测生物样品中的细胞的方法和试剂盒，以及针对对肿瘤细胞表达受体具有高亲和力的尿激酶受体的氨基酸序列特异性抗体的诊断和治疗应用。

2. 发明申请

US20070066798A1 Diagnostic and therapeutic use of antibodies against the urokinase receptor 有权
公开(公告)号：US20070066798A1
公开(公告)日：2007-03-22
申请号：US11586579
申请日：2006-10-26
申请人： Manfred Schmitt , Viktor Magdolen , Thomas Luther , Sybille Albrecht , Martin Muller , Olaf Wilhelm , Nadja Harbeck
发明人： Manfred Schmitt , Viktor Magdolen , Thomas Luther , Sybille Albrecht , Martin Muller , Olaf Wilhelm , Nadja Harbeck
IPC分类号： C12Q1/68 , C07K14/00 , C07K16/00 , A61K38/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/565 , C07K2317/622 , G01N33/574 , G01N33/57492 , G01N33/582
摘要： The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.

3. 发明授权

US07407751B2 Methods for the detection and prognosis of breast tumors 有权
标题翻译：乳腺肿瘤检测和预后的方法
公开(公告)号：US07407751B2
公开(公告)日：2008-08-05
申请号：US10679951
申请日：2003-10-06
申请人： Thomas Luther , Viktor Magdolen , Manfred Schmitt , Matthias Kotzsch
发明人： Thomas Luther , Viktor Magdolen , Manfred Schmitt , Matthias Kotzsch
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34
摘要： This invention relates to the production of specific antibodies for the detection of human tumor associated urokinase-type plasminogen activator receptor (uPAR) deletion variants in biological samples as well as to their diagnostic and therapeutic application.
摘要翻译：本发明涉及生物样品中用于检测人肿瘤相关尿激酶型纤溶酶原激活物受体（uPAR）缺失变体的特异性抗体的产生及其诊断和治疗应用。

4. 发明授权

US08461321B2 Nucleic acids encoding a deletion variant of uPAR 失效
标题翻译：编码uPAR缺失变体的核酸
公开(公告)号：US08461321B2
公开(公告)日：2013-06-11
申请号：US12164881
申请日：2008-06-30
申请人： Thomas Luther , Viktor Magdolen , Manfred Schmitt , Bernd Muehlenweg , Matthias Kotzsch
发明人： Thomas Luther , Viktor Magdolen , Manfred Schmitt , Bernd Muehlenweg , Matthias Kotzsch
IPC分类号： C07H21/04 , C12N15/09 , C12Q1/68
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34
摘要： This invention relates to the production of specific antibodies for the detection of human tumor associated urokinase-type plasminogen activator receptor (uPAR) deletion variants in biological samples as well as to their diagnostic and therapeutic application.
摘要翻译：本发明涉及生物样品中用于检测人肿瘤相关尿激酶型纤溶酶原激活物受体（uPAR）缺失变体的特异性抗体的产生及其诊断和治疗应用。

5. 发明申请

US20050272880A1 Polybenzimidazole compounds, polymeric media, and methods of post-polymerization modifications 有权
标题翻译：聚苯并咪唑化合物，聚合物介质和后聚合修饰方法
公开(公告)号：US20050272880A1
公开(公告)日：2005-12-08
申请号：US10969456
申请日：2004-10-19
申请人： John Klaehn , Eric Peterson , Christopher Orme , Michael Jones , Alan Wertsching , Thomas Luther , Tammy Trowbridge
发明人： John Klaehn , Eric Peterson , Christopher Orme , Michael Jones , Alan Wertsching , Thomas Luther , Tammy Trowbridge
IPC分类号： C08G63/02 , C08G69/48 , C08G73/18 , C08J3/00
CPC分类号： C08F289/00 , C08F8/30 , C08F265/10 , C08F271/02 , C08G73/18
摘要： A PBI compound includes imidazole nitrogens at least a portion of which are substituted with a moiety containing a carbonyl group, the substituted imidazole nitrogens being bonded to carbon of the carbonyl group. At least 85% of the nitrogens may be substituted. The carbonyl-containing moiety may include RCO—, where R is alkoxy or haloalkyl. The PBI compound may exhibit a first temperature marking an onset of weight loss corresponding to reversion of the substituted PBI that is less than a second temperature marking an onset of decomposition of an otherwise identical PBI compound without the substituted moiety. The PBI compound may be included in separatory media. A substituted PBI synthesis method may include providing a parent PBI in a less than 5 wt % solvent solution. Substituting may use more than 5 equivalents in relation to the imidazole nitrogens to be substituted.
摘要翻译： PBI化合物包括其中至少一部分被含有羰基的部分取代的咪唑氮，取代的咪唑氮与羰基的碳键合。至少85％的氮可被取代。含羰基的部分可以包括RCO-，其中R是烷氧基或卤代烷基。 PBI化合物可以表现出第一温度，其标记了相应于取代的PBI的回复的重量开始的起始，该取代的PBI小于第二个温度，标记了没有取代部分的相同的PBI化合物的分解开始。 PBI化合物可以包含在分离介质中。取代的PBI合成方法可以包括在少于5重量％的溶剂溶液中提供亲本PBI。相对于被取代的咪唑氮可以使用超过5当量。

6. 发明申请

US20080096056A1 SAFE BATTERY SOLVENTS 审中-公开
标题翻译：安全电池解决方案
公开(公告)号：US20080096056A1
公开(公告)日：2008-04-24
申请号：US11847734
申请日：2007-08-30
申请人： Mason Harrup , Joseph Delmastro , Frederick Stewart , Thomas Luther
发明人： Mason Harrup , Joseph Delmastro , Frederick Stewart , Thomas Luther
IPC分类号： H01M10/40
CPC分类号： H01M10/4235 , H01M6/168 , H01M10/0565 , H01M10/0567 , H01M10/0569
摘要： An ion transporting solvent maintains very low vapor pressure, contains flame retarding elements, and is nontoxic. The solvent in combination with common battery electrolyte salts can be used to replace the current carbonate electrolyte solution, creating a safer battery. It can also be used in combination with polymer gels or solid polymer electrolytes to produce polymer batteries with enhanced conductivity characteristics. The solvents may comprise a class of cyclic and acyclic low molecular weight phosphazenes compounds, comprising repeating phosphorus and nitrogen units forming a core backbone and ion-carrying pendent groups bound to the phosphorus. In preferred embodiments, the cyclic phosphazene comprises at least 3 phosphorus and nitrogen units, and the pendent groups are polyethers, polythioethers, polyether/polythioethers or any combination thereof, and/or other groups preferably comprising other atoms from Group 6B of the periodic table of elements.
摘要翻译：离子输送溶剂保持非常低的蒸气压，含有阻燃元素，无毒。溶剂与普通电池电解质盐的组合可用于替代目前的碳酸盐电解质溶液，从而产生更安全的电池。它还可以与聚合物凝胶或固体聚合物电解质组合使用以产生具有增强的导电特性的聚合物电池。溶剂可以包括一类环状和非环状低分子量磷腈化合物，其包含重复形成核心主链的磷和氮单元和与磷结合的离子携带侧基。在优选的实施方案中，环状磷腈包含至少3个磷和氮单元，并且侧基是聚醚，聚硫醚，聚醚/聚硫醚或其任何组合，和/或优选包含周期表第6B族的其它原子的其它基团元素。

7. 发明授权

US07574113B2 Video and audio data recording apparatus, video and audio data recording method, video and audio data reproducing apparatus, and video and audio data reproducing method 失效
标题翻译：视频和音频数据记录装置，视频和音频数据记录方法，视频和音频数据再现装置以及视频和音频数据再现方法
公开(公告)号：US07574113B2
公开(公告)日：2009-08-11
申请号：US10408709
申请日：2003-04-07
申请人： Daizoh Nagahara , Thomas Luther , Hiroaki Eto , Kanchan Ranade , David Wang , Tetsuya Yamamoto
发明人： Daizoh Nagahara , Thomas Luther , Hiroaki Eto , Kanchan Ranade , David Wang , Tetsuya Yamamoto
IPC分类号： H04N5/91
CPC分类号： G11B27/105 , G11B27/034 , G11B27/3027 , G11B27/329 , G11B2220/20 , H04N5/85 , H04N9/7925 , H04N9/8063
摘要： Video data and audio data of multiplexed data are separated. Abstract video data is generated from the separated video data and abstract audio data is generated from the separated audio data. Then, the abstract video data and the abstract audio data are packed and a packed video and audio data management table is generated from packed video and audio data D2 and video and audio data synchronization information D3. The packed video and audio data management table comprehensively manages the packed video and audio data. Thus, data of various video formats, various audio formats and various multiplexing formats can be monistically managed.
摘要翻译：复用数据的视频数据和音频数据被分离。从分离的视频数据生成抽象视频数据，并且从分离的音频数据生成抽象音频数据。然后，抽取视频数据和抽象音频数据被打包，并且从打包的视频和音频数据D2以及视频和音频数据同步信息D3生成压缩视频和音频数据管理表。打包的视频和音频数据管理表全面管理打包的视频和音频数据。因此，可以单一地管理各种视频格式，各种音频格式和各种复用格式的数据。

8. 发明申请

US20050272859A1 Polybenzimidazole compounds, polymeric media, and methods of post-polymerization modifications 有权
标题翻译：聚苯并咪唑化合物，聚合物介质和后聚合修饰方法
公开(公告)号：US20050272859A1
公开(公告)日：2005-12-08
申请号：US10862921
申请日：2004-06-07
申请人： John Klaehn , Eric Peterson , Alan Wertsching , Christopher Orme , Thomas Luther , Michael Jones
发明人： John Klaehn , Eric Peterson , Alan Wertsching , Christopher Orme , Thomas Luther , Michael Jones
IPC分类号： C08G63/02 , C08G69/48 , C08G73/18 , C08J3/00
CPC分类号： C08J5/2256 , C08G73/18 , C08J2365/02 , C08J2379/06 , C08L79/04 , Y10S525/933
摘要： A PBI compound includes imidazole nitrogens at least a portion of which are substituted with an organic-inorganic hybrid moiety. At least 85% of the imidazole nitrogens may be substituted. The organic-inorganic hybrid moiety may be an organosilane moiety, for example, (R)Me2SiCH2—where R is selected from among methyl, phenyl, vinyl, and allyl. The PBI compound may exhibit similar thermal properties in comparison to the unsubstituted PBI. The PBI compound may exhibit a solubility in an organic solvent greater than the solubility of the unsubstituted PBI. The PBI compound may be included in separatory media. A substituted PBI synthesis method may include providing a parent PBI in a less than 5 wt % solvent solution. Substituting may occur at about room temperature and/or at about atmospheric pressure. Substituting may use at least 5 equivalents in relation to the imidazole nitrogens to be substituted or, preferably, about 15.
摘要翻译： PBI化合物包括至少一部分被有机 - 无机杂化部分取代的咪唑氮。至少85％的咪唑氮可以被取代。有机 - 无机杂化部分可以是有机硅烷部分，例如（R）Me 2 SiCH 2 - ，其中R选自甲基，苯基，乙烯基和烯丙基。与未取代的PBI相比，PBI化合物可以表现出相似的热性能。 PBI化合物可以在有机溶剂中表现出大于未取代的PBI的溶解度的溶解度。 PBI化合物可以包含在分离介质中。取代的PBI合成方法可以包括在少于5重量％的溶剂溶液中提供亲本PBI。在大约室温和/或大气压下可以进行取代。取代的咪唑氮可以使用至少5当量，优选约15。

9. 发明申请

US20060016331A1 PHOSPHAZENE MEMBRANES FOR GAS SEPARATIONS 有权
标题翻译：用于气体分离的PHOSPHAZENE膜
公开(公告)号：US20060016331A1
公开(公告)日：2006-01-26
申请号：US10846195
申请日：2004-05-13
申请人： Frederick Stewart , Mason Harrup , Christopher Orme , Thomas Luther
发明人： Frederick Stewart , Mason Harrup , Christopher Orme , Thomas Luther
IPC分类号： B01D53/22
CPC分类号： B01D71/76 , B01D53/228
摘要： A polyphosphazene having a glass transition temperature (“Tg”) of approximately −20° C. or less. The polyphosphazene has at least one pendant group attached to a backbone of the polyphosphazene, wherein the pendant group has no halogen atoms. In addition, no aromatic groups are attached to an oxygen atom that is bound to a phosphorus atom of the backbone. The polyphosphazene may have a Tg ranging from approximately −100° C. to approximately −20° C. The polyphosphazene may be selected from the group consisting of poly[bis-3-phenyl-1-propoxy) phosphazene], poly[bis-(2-phenyl-1-ethoxy)phosphazene], poly[bis-(dodecanoxypolyethoxy)phosphazene], and poly[bis-(2-(2-(2-ω-undecylenyloxyethoxy)ethoxy)ethoxy)phosphazene]. The polyphosphazene may be used in a separation membrane to selectively separate individual gases from a gas mixture, such as to separate polar gases from nonpolar gases in the gas mixture.
摘要翻译：具有约-20℃或更低的玻璃化转变温度（“T”g“）的聚磷腈。聚磷腈具有至少一个与聚磷腈骨架连接的侧基，其中该侧基不具有卤素原子。此外，没有芳族基团连接到与主链的磷原子结合的氧原子上。聚磷腈可以具有约-100℃至约-20℃的范围。聚磷腈可以选自聚[双-3-苯基-1-丙氧基）磷腈]，聚[双 - （2-苯基-1-乙氧基）磷腈]，聚[双 - （十二烷氧基聚乙氧基）磷腈]和聚[双 - （2-（2-（2-ω-十一烷基氧基乙氧基）乙氧基）乙氧基）磷腈]。聚磷腈可用于分离膜中，以选择性地将气体与气体混合物分离，例如将极性气体与气体混合物中的非极性气体分开。

10. 发明申请

US20050255385A1 Safe battery solvents 有权
标题翻译：安全电池溶剂
公开(公告)号：US20050255385A1
公开(公告)日：2005-11-17
申请号：US10848480
申请日：2004-05-17
申请人： Mason Harrup , Joseph Delmastro , Frederick Stewart , Thomas Luther
发明人： Mason Harrup , Joseph Delmastro , Frederick Stewart , Thomas Luther
IPC分类号： H01M6/16 , H01M10/0565 , H01M10/0567 , H01M10/0569 , H01M10/40
CPC分类号： H01M10/4235 , H01M6/168 , H01M10/0565 , H01M10/0567 , H01M10/0569
摘要： An ion transporting solvent maintains very low vapor pressure, contains flame retarding elements, and is nontoxic. The solvent in combination with common battery electrolyte salts can be used to replace the current carbonate electrolyte solution, creating a safer battery. It can also be used in combination with polymer gels or solid polymer electrolytes to produce polymer batteries with enhanced conductivity characteristics. The solvents may comprise a class of cyclic and acyclic low molecular weight phosphazenes compounds, comprising repeating phosphorus and nitrogen units forming a core backbone and ion-carrying pendent groups bound to the phosphorus. In preferred embodiments, the cyclic phosphazene comprises at least 3 phosphorus and nitrogen units, and the pendent groups are polyethers, polythioethers, polyether/polythioethers or any combination thereof, and/or other groups preferably comprising other atoms from Group 6B of the periodic table of elements.
摘要翻译：离子输送溶剂保持非常低的蒸气压，含有阻燃元素，无毒。溶剂与普通电池电解质盐的组合可用于替代目前的碳酸盐电解质溶液，从而产生更安全的电池。它还可以与聚合物凝胶或固体聚合物电解质组合使用以产生具有增强的导电特性的聚合物电池。溶剂可以包括一类环状和非环状低分子量磷腈化合物，其包含重复形成核心主链的磷和氮单元和与磷结合的离子携带侧基。在优选的实施方案中，环状磷腈包含至少3个磷和氮单元，并且侧基是聚醚，聚硫醚，聚醚/聚硫醚或其任何组合，和/或优选包含周期表第6B族的其它原子的其它基团元素。

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