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1. 发明授权

US10119131B2 Compositions and methods for producing clostridial collagenases 有权
公开(公告)号：US10119131B2
公开(公告)日：2018-11-06
申请号：US13422939
申请日：2012-03-16
申请人： Thomas L. Wegman , Bo Yu
发明人： Thomas L. Wegman , Bo Yu
IPC分类号： C12N9/52 , C12N1/20 , A61K38/48 , C12P21/06
摘要： The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum. The method utilizes an improved medium for the cultivation of Clostridium histolyticum which includes a non-meat-derived (i.e., non-mammalian) peptone or vegetable peptone. The method includes one or more of: (1) reducing glucose content in the meat-free or vegetable-derived media; and (2) increasing the salt concentration in the meat-free or vegetable-derived media. Also provided is a drug product which includes collagenase I and collagenase II at an optimized fixed mass ratio, and which has a purity of greater than at least 95%.

2. 发明申请

US20100233151A1 COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES 审中-公开
公开(公告)号：US20100233151A1
公开(公告)日：2010-09-16
申请号：US12759065
申请日：2010-04-13
申请人： Gregory L. SABATINO , Benjamin J. Del Tito, JR. , Phillip J. Bassett , Hazel A. Tharia , Antony G. Hitchcock , Bo Yu , Thomas L. Wegman
发明人： Gregory L. SABATINO , Benjamin J. Del Tito, JR. , Phillip J. Bassett , Hazel A. Tharia , Antony G. Hitchcock , Bo Yu , Thomas L. Wegman
IPC分类号： A61K38/46 , C12P21/04
CPC分类号： A61K38/4886 , A61K9/0019 , A61K9/19 , C12N9/52 , C12Y304/24007
摘要： A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.

3. 发明申请

US20140004094A1 COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES 审中-公开
标题翻译：用于治疗胶原介导性疾病的组合物和方法
公开(公告)号：US20140004094A1
公开(公告)日：2014-01-02
申请号：US13713019
申请日：2012-12-13
申请人： Gregory L. Sabatino , Benjamin J. Del Tito, JR. , Phillip J. Bassett , Hazel A. Tharia , Antony G. Hitchcock , Bo Yu , Thomas L. Wegman
发明人： Gregory L. Sabatino , Benjamin J. Del Tito, JR. , Phillip J. Bassett , Hazel A. Tharia , Antony G. Hitchcock , Bo Yu , Thomas L. Wegman
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A61K9/0019 , A61K9/19 , C12N9/52 , C12Y304/24007
摘要： A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
摘要翻译：公开了一种药物产品，其包含来自溶组织梭菌的高度纯化的胶原酶I和胶原酶II的组合。药物产品包括约1比1的胶原酶I和胶原酶II，纯度大于至少95％。本发明还公开了用于制备所述药物产品的改进的发酵和纯化方法。

4. 发明申请

US20100330065A1 COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES 审中-公开
标题翻译：用于治疗胶原介导性疾病的组合物和方法
公开(公告)号：US20100330065A1
公开(公告)日：2010-12-30
申请号：US12837933
申请日：2010-07-16
申请人： Gregory L. SABATINO , Benjamin J. Del Tito, JR. , Phillip J. Bassett , Hazel A. Tharia , Antony G. Hitchcock , Bo Yu , Thomas L. Wegman
发明人： Gregory L. SABATINO , Benjamin J. Del Tito, JR. , Phillip J. Bassett , Hazel A. Tharia , Antony G. Hitchcock , Bo Yu , Thomas L. Wegman
IPC分类号： A61K38/48 , A61P19/04 , A61P17/02
CPC分类号： A61K38/4886 , A61K9/0019 , A61K9/19 , C12N9/52 , C12Y304/24007
摘要： A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
摘要翻译：公开了包含高纯度胶原酶I和来自溶组织梭菌的胶原酶II的组合的药物产品。药物产品包括约1比1的胶原酶I和胶原酶II，纯度大于至少95％。本发明还公开了用于制备所述药物产品的改进的发酵和纯化方法。

5. 发明申请

US20140051456A1 METHOD AND APPARATUS FOR ENABLING VEHICLE APPLICATIONS USING HETEROGENEOUS WIRELESS DATA PIPES 有权
标题翻译：使用异质无线数据管道实现车辆应用的方法和装置
公开(公告)号：US20140051456A1
公开(公告)日：2014-02-20
申请号：US13585676
申请日：2012-08-14
申请人： Fan Bai , Donald K. Grimm , Massimo Osella , Bo Yu , David P. Pop , John J. Correia
发明人： Fan Bai , Donald K. Grimm , Massimo Osella , Bo Yu , David P. Pop , John J. Correia
IPC分类号： H04W72/08
CPC分类号： H04W48/18
摘要： A method for determining which of a plurality of data connectivity pipes will be used to transmit data for one or more applications operating on a vehicle. The method identifies which of the applications are active at a particular point in time and identifies a number of available configurations based on the number of applications that are active and the number of the data pipes that are available to transmit the data for the application. The method identifies a plurality of performance metrics for each configuration and determines an optimal performance value for each performance metric from all of the configurations. The method then determines an overall utility function for each configuration that is based on its performance metrics and the optimal performance value and selects a data pipe for each application that is active based on a maximum overall utility function from each application's available overall utility functions.
摘要翻译：一种用于确定多个数据连接管道中的哪一个将用于传输在车辆上操作的一个或多个应用的数据的方法。该方法识别哪些应用程序在特定时间点处于活动状态，并且基于活动的应用程序的数量和可用于传送应用程序的数据的数据管道的数量来识别可用配置的数量。该方法识别每个配置的多个性能度量，并且从所有配置确定针对每个性能度量的最佳性能值。该方法然后根据其性能指标和最佳性能值确定每个配置的整体效用函数，并根据每个应用程序的可用整体效用函数的最大整体效用函数为每个应用程序选择一个数据管道。

6. 发明授权

US08173753B2 Method for producing aliphatic polyester resin, and an aliphatic polyester resin composition 有权
标题翻译：脂肪族聚酯树脂的制造方法和脂肪族聚酯树脂组合物
公开(公告)号：US08173753B2
公开(公告)日：2012-05-08
申请号：US12991715
申请日：2009-05-19
申请人： Tatsuya Nagano , Tomoko Nasuno , Hiroyuki Ome , Yong He , Bo Yu , Kexin Zhu , Xiao Guo , Pujing Zuo
发明人： Tatsuya Nagano , Tomoko Nasuno , Hiroyuki Ome , Yong He , Bo Yu , Kexin Zhu , Xiao Guo , Pujing Zuo
IPC分类号： C08G63/91
CPC分类号： C08G63/80 , C08G63/06 , C08G63/08 , C08G63/823 , C08G63/87
摘要： A method for producing an aliphatic polyester resin including a melt polymerization step and a subsequent solid phase polymerization step, using a sulfonic acid group-containing compound as a catalyst, wherein the addition amount of the sulfonic acid group-containing compound during melt polymerization is 300 to 3000 ppm with respect to a raw material monomer calculated as sulfur atoms, the content of the sulfonic acid group-containing compound during melt polymerization is 300 to 3000 ppm with respect to a produced polymer calculated as sulfer atoms, and a residual rate of the sulfonic acid group-containing compound after solid phase at polymerization is more than 50.
摘要翻译：一种包含熔融聚合步骤和随后的固相聚合步骤的脂族聚酯树脂的制备方法，其中使用含磺酸基化合物作为催化剂，其中在熔融聚合期间含磺酸基的化合物的加入量为300 相对于作为硫原子计算的原料单体，为3000ppm，熔融聚合时的含磺酸基的化合物的含量相对于作为硫原子计算出的聚合度为300〜3000ppm，残留率为含有磺酸基团的化合物在聚合后固相超过50。

7. 发明申请

US20120049761A1 LIGHT EMITTING ELEMENT DRIVING CIRCUIT 有权
标题翻译：发光元件驱动电路
公开(公告)号：US20120049761A1
公开(公告)日：2012-03-01
申请号：US13177420
申请日：2011-07-06
申请人： Bo Yu , Yuancheng Ren , Lei Du , Naixing Kuang , Zhijiang Yang
发明人： Bo Yu , Yuancheng Ren , Lei Du , Naixing Kuang , Zhijiang Yang
IPC分类号： H05B37/02
CPC分类号： H05B33/0827 , G09G3/3406 , G09G2330/08 , Y02B20/341
摘要： The present disclosure discloses a light emitting element driving circuit. In one embodiment the light emitting element driving circuit may comprise a power conversion circuit and a current balancing circuit. In other embodiment the light emitting element driving circuit may further comprise other modules integrated and interacting with the power conversion circuit and the current balancing circuit, such as fault detection and protection circuits, status indication circuits and phase-shift PWM dimming circuits. In other embodiment, the present disclosure further discloses a current balancing circuit. In other embodiment, the present disclosure further discloses a fault detection and protection circuit. In still other embodiment, the present disclosure further discloses a phase-shift PWM dimming circuit.
摘要翻译：本公开公开了一种发光元件驱动电路。在一个实施例中，发光元件驱动电路可以包括功率转换电路和电流平衡电路。在另一个实施例中，发光元件驱动电路还可以包括与功率转换电路和电流平衡电路集成并相互作用的其他模块，例如故障检测和保护电路，状态指示电路和相移PWM调光电路。在另一实施例中，本公开还公开了一种电流平衡电路。在其他实施例中，本公开还公开了一种故障检测和保护电路。在另外的实施例中，本公开还公开了一种相移PWM调光电路。

8. 发明授权

US08054872B2 Method and apparatus for signal carrier-to-noise power density ratio calculation 有权
标题翻译：信号载波噪声功率密度比计算方法和装置
公开(公告)号：US08054872B2
公开(公告)日：2011-11-08
申请号：US12151668
申请日：2008-05-08
申请人： Jianhui Hou , Bo Yu , Xiaoguang Yu , Haiquan Huang
发明人： Jianhui Hou , Bo Yu , Xiaoguang Yu , Haiquan Huang
IPC分类号： H04B3/46 , H04B17/00 , H04Q1/20
CPC分类号： H04B1/7085 , G01S19/21 , H04B1/7075
摘要： There is provided an apparatus for determining a carrier-to-noise power density ratio (CN0) of a spread spectrum signal. The apparatus includes a signal power calculation unit and a conversion unit. The signal power calculation unit determines a signal power indicator indicative of a signal to noise ratio of the spread spectrum signal. The conversion unit is coupled to the signal power calculation unit and stores a lookup table representing a relationship between the signal power indicator and the carrier-to-noise power density ratio. The conversion unit is operable for converting the signal power indicator to the carrier-to-noise power density ratio according to the lookup table.
摘要翻译：提供了一种用于确定扩频信号的载波噪声功率密度比（CN0）的装置。该装置包括信号功率计算单元和转换单元。信号功率计算单元确定表示扩频信号的信噪比的信号功率指示符。转换单元耦合到信号功率计算单元，并存储表示信号功率指示符与载波噪声功率密度比之间的关系的查找表。转换单元可用于根据查找表将信号功率指示符转换为载波噪声功率密度比。

9. 发明授权

US07613258B2 Apparatus and method for determining GPS tracking loop parameter based on SNR estimation 有权
标题翻译：基于SNR估计确定GPS跟踪环路参数的装置和方法
公开(公告)号：US07613258B2
公开(公告)日：2009-11-03
申请号：US11364768
申请日：2006-02-28
申请人： Bo Yu , Jianhui Hou , ShiJie Li , MingQiang Cheng
发明人： Bo Yu , Jianhui Hou , ShiJie Li , MingQiang Cheng
IPC分类号： H03D1/04
CPC分类号： H04B1/7097
摘要： A method for estimating signal quality of a spread spectrum signal is provided. The method includes squaring a plurality of in-phase correlation results and a plurality of quadrature correlation results, summing each squared in-phase correlation result and the corresponding correlation result to obtain a plurality of sum-of-square values, detecting a peak value among the plurality of sum-of-square results, calculating an average of non-peak values among the plurality of sum-of-square results. The peak value is regarded as a signal power value, while the averaged non-peak values are regarded as an average noise power value. A signal-to-noise ratio is then calculated based on the signal power value and the average noise power value. A method for determining the parameters for the tracking loop is also provided. The method includes estimating the signal-to-noise ratio of the spread spectrum signal, and determining the tracking loop parameters based on the signal-to-noise ratio.
摘要翻译：提供了一种用于估计扩频信号的信号质量的方法。该方法包括对多个同相相关结果和多个正交相关结果进行平方，对每个平方的同相相关结果和相应的相关结果相加以获得多个平方和值，检测其中的峰值所述多个平方和结果，计算所述多个平方和结果中的非峰值的平均值。将峰值视为信号功率值，而将平均非峰值视为平均噪声功率值。然后基于信号功率值和平均噪声功率值来计算信噪比。还提供了用于确定跟踪环路的参数的方法。该方法包括估计扩频信号的信噪比，以及基于信噪比确定跟踪环路参数。

10. 发明申请

US20070072623A1 GPS application using network assistance 有权
标题翻译： GPS应用使用网络协助
公开(公告)号：US20070072623A1
公开(公告)日：2007-03-29
申请号：US11506499
申请日：2006-08-18
申请人： You-Yuh Shyr , Mingqiang Cheng , Bo Yu
发明人： You-Yuh Shyr , Mingqiang Cheng , Bo Yu
IPC分类号： H04Q7/20
CPC分类号： G01S19/09 , G01S19/05 , H04W64/00 , H04W84/06 , H04W88/08
摘要： A Global Positioning System (GPS) system comprises a user end, a mobile terminal, a positioning server, a GPS application server, and a base station network. The mobile terminal has a GPS receiver to receive GPS information from a plurality of GPS satellites. The positioning server is coupled to the user end through the network. The GPS application server is coupled to the network for communicating with the positioning server, and has a GPS receiver to receive GPS information from GPS satellites so as to calculate a position of the GPS application server. The geographic position of the GPS application server is known, and GPS assistant information is determined based on the calculated position and the geographic position of the GPS application server. The base station network communicates with the mobile terminal to obtain the GPS information of the mobile terminal and locate the mobile terminal based on the GPS information of the mobile terminal and the GPS assistant information.
摘要翻译：全球定位系统（GPS）系统包括用户端，移动终端，定位服务器，GPS应用服务器和基站网络。移动终端具有从多个GPS卫星接收GPS信息的GPS接收机。定位服务器通过网络耦合到用户端。 GPS应用服务器耦合到网络以与定位服务器进行通信，并具有GPS接收机，用于从GPS卫星接收GPS信息，以计算GPS应用服务器的位置。 GPS应用服务器的地理位置是已知的，并且基于计算出的GPS应用服务器的位置和地理位置来确定GPS辅助信息。基站网络与移动终端通信，获取移动终端的GPS信息，并根据移动终端的GPS信息和GPS辅助信息定位移动终端。

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