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1. 发明授权

US06249694B1 Method for peripheral MR angiography 失效
标题翻译：外周血管造影的方法
公开(公告)号：US06249694B1
公开(公告)日：2001-06-19
申请号：US09118411
申请日：1998-07-17
申请人： Thomas K. F. Foo , Vincent B. Ho , Matthew A. Bernstein
发明人： Thomas K. F. Foo , Vincent B. Ho , Matthew A. Bernstein
IPC分类号： A61B5055
CPC分类号： G01R33/5635 , G01R33/5601 , G01R33/56572
摘要： A method of peripheral MR angiography is provided for imaging an artery or other vessel, wherein the vessel is of such length that MR data must be acquired at each of a plurality of scan stations spaced along the vessel. In accordance with the method, a contrast agent is intravenously injected, in order to provide a bolus which successively flows to each of the scan stations. After acquiring an initial subset of the MR data associated with a given scan station, the bolus is tracked to determine whether it has arrived at the next-following scan station. If so, at least some of the MR data associated with the next scan station are then acquired. However, if it is found that the bolus has not yet arrived at the next scan station, acquisition of further data at the given scan station is continued.
摘要翻译：提供了一种用于对动脉或其他血管进行成像的外周MR血管造影术的方法，其中所述血管具有这样的长度，使得必须在沿着血管间隔开的多个扫描站中的每一个处获取MR数据。根据该方法，静脉内注射造影剂，以提供连续流向每个扫描站的推注。在获取与给定扫描站相关联的MR数据的初始子集之后，跟踪该推注以确定其是否到达下一个扫描站。如果是，则随后获取与下一个扫描站相关联的至少一些MR数据。然而，如果发现大剂量尚未到达下一个扫描站，则继续在给定扫描站获取进一步的数据。

2. 发明授权

US6135954A Method for peripheral MR angiography 失效
公开(公告)号：US6135954A
公开(公告)日：2000-10-24
申请号：US118411
申请日：1998-07-17
申请人： Thomas K. F. Foo , Vincent B. Ho , Matthew A. Bernstein
发明人： Thomas K. F. Foo , Vincent B. Ho , Matthew A. Bernstein
摘要： A method of peripheral MR angiography is provided for imaging an artery or other vessel, wherein the vessel is of such length that MR data must be acquired at each of a plurality of scan stations spaced along the vessel. In accordance with the method, a contrast agent is intravenously injected, in order to provide a bolus which successively flows to each of the scan stations. After acquiring an initial subset of the MR data associated with a given scan station, the bolus is tracked to determine whether it has arrived at the next-following scan station. If so, at least some of the MR data associated with the next scan station are then acquired. However, if it is found that the bolus has not yet arrived at the next scan station, acquisition of further data at the given scan station is continued.

3. 发明授权

US6166545A MRI reconstruction using partial echo and partial NEX data acquisitions 失效
标题翻译：使用部分回波和部分NEX数据采集进行MRI重建
公开(公告)号：US6166545A
公开(公告)日：2000-12-26
申请号：US219129
申请日：1998-12-22
申请人： Jason A. Polzin , Matthew A. Bernstein , Thomas K. F. Foo
发明人： Jason A. Polzin , Matthew A. Bernstein , Thomas K. F. Foo
IPC分类号： G01R33/561 , G01V3/00
CPC分类号： G01R33/561
摘要： A system and method is disclosed to combine both a fractional echo (k.sub.x) and a fractional NEX (k.sub.y) to reduce acquisition times and echo times in MR imaging. The method uses both zero-filling and homodyne reconstruction to construct concurrent fractional NEX and fractional echo data in a single image while minimizing any blurring effects. The system includes acquiring partial MRI data in the k.sub.x direction and acquiring partial MRI data in the k.sub.y direction. Once a partial echo and a partial NEX are acquired, the missing data is first zero-filled in the k.sub.x direction and Fourier transformed to acquire a full x direction data set. Next, the data is synthesized in the k.sub.y direction using a homodyne reconstruction technique to acquire a full data set in the k.sub.y direction. The full x,y data set can then be used to reconstruct an MR image with reduced acquisition and echo times. In order to minimize the effects of blurring in the resulting MR image, it is preferable to acquire at least an 80% fractional echo and a 60% fractional NEX. The system can be extended to any number of desirable dimensions.
摘要翻译：公开了将分数回波（kx）和分数NEX（ky）组合以减少MR成像中的采集时间和回波时间的系统和方法。该方法使用零填充和零差重建来构建单个图像中的并发分数NEX和分数回波数据，同时最小化任何模糊效果。该系统包括以kx方向获取部分MRI数据并且获取ky方向上的部分MRI数据。一旦获得了部分回波和部分NEX，则丢失的数据首先在kx方向上零填充，并进行傅里叶变换以获取全x方向数据集。接下来，使用零差重建技术以ky方向合成数据，以获取ky方向上的完整数据集。然后可以使用完整的x，y数据集来重建具有减少的采集和回波时间的MR图像。为了最小化所得MR图像中模糊的影响，优选获得至少80％的分数回波和60％的分数NEX。该系统可以扩展到任何数量的所需尺寸。

4. 发明授权

US06408201B1 Method and apparatus for efficient stenosis identification in peripheral arterial vasculature using MR imaging 有权
标题翻译：使用MR成像的外周动脉脉管系统有效狭窄鉴别的方法和装置
公开(公告)号：US06408201B1
公开(公告)日：2002-06-18
申请号：US09591300
申请日：2000-06-09
申请人： Thomas K. F. Foo , Vincent B. Ho
发明人： Thomas K. F. Foo , Vincent B. Ho
IPC分类号： A61B505
CPC分类号： A61B5/055
摘要： A method and apparatus is disclosed to initially screen a patient's peripheral arterial vasculature for lesions, or stenotic vessels, using MR technology, and then grading the severity of any located stenosis. The invention includes tracking the passage of a contrast agent bolus through a patient, while acquiring a series of first MR images having low resolution. This initial examination uses flow sensitive bi-polar gradient waveforms with a gradient echo imaging pulse sequence to increase the sensitivity to lesion detectability. The bi-polar gradients generate a broad distribution of velocities in a large voxel. Relevant stenoses present in a voxel will result in intra-voxel flow dephasing in voxels immediate to and distal to the stenosis. After identifying a stenosis, a second MR image, having a higher resolution than the first, is used to grade the stenosis.
摘要翻译：公开了一种方法和装置，其首先使用MR技术筛选病人的外周动脉脉管系统用于病变或狭窄血管，然后对任何位置狭窄的严重程度进行分级。本发明包括在获取一系列具有低分辨率的第一MR图像的同时跟踪造影剂推注通过患者的通过。该初步检查使用具有梯度回波成像脉冲序列的流敏双极梯度波形来增加对病变可检测性的敏感性。双极梯度在大体素中产生广泛的速度分布。存在于体素中的相关狭窄将导致体内血液流动相对于狭窄直接和远端的体素变形。在确定狭窄后，使用比第一MR分辨率高的第二MR图像对狭窄进行分级。

5. 发明授权

US06963768B2 Whole body MRI scanning with moving table and interactive control 有权
标题翻译：全身MRI扫描与移动表和交互式控制
公开(公告)号：US06963768B2
公开(公告)日：2005-11-08
申请号：US10063829
申请日：2002-05-16
申请人： Vincent B. Ho , Thomas K. F. Foo
发明人： Vincent B. Ho , Thomas K. F. Foo
IPC分类号： G01R33/28 , A61B5/055 , G01R33/563 , A61B5/05
CPC分类号： G01R33/56375 , A61B5/0555 , G06F19/00
摘要： The present invention includes a method and apparatus for high sensitivity whole body scanning using MR imaging. The invention includes acquiring MR data as the patient moves through the iso-center of the magnet while providing interactive control for the operator to change scan parameters and table motion and direction. The technique allows efficient whole body scanning for fast screening of abnormalities while allowing operator control during the screening process to interrupt table motion and redirect the speed and direction of the table while also allowing control over the acquisition plane, number of sections imaged, inter-section spacing, and the scan location.
摘要翻译：本发明包括使用MR成像进行高灵敏度全身扫描的方法和装置。本发明包括当患者移动通过磁体的等中心时获取MR数据，同时为操作者提供交互式控制以改变扫描参数和表格运动和方向。该技术允许有效的全身扫描快速筛选异常，同时允许操作者在筛选过程中控制中断台面运动并重定向表的速度和方向，同时还允许控制采集平面，成像部分数量，间隔间距和扫描位置。

6. 发明授权

US06741880B1 Method and apparatus for efficient stenosis identification and assessment using MR imaging 有权
标题翻译：使用MR成像进行有效狭窄识别和评估的方法和装置
公开(公告)号：US06741880B1
公开(公告)日：2004-05-25
申请号：US09595117
申请日：2000-06-16
申请人： Thomas K. F. Foo , Vincent B. Ho , Manojkumar Saranathan
发明人： Thomas K. F. Foo , Vincent B. Ho , Manojkumar Saranathan
IPC分类号： A61B505
CPC分类号： G01R33/54 , A61B5/0263 , G01R33/56
摘要： A method and apparatus is disclosed in which a two-tiered approach is taken to first grade a patient to identify the presence of any suspected stenosis, and then a second step is used to acquire more detailed information to grade the stenosis. The invention includes performing a screening study by acquiring a first MR image having a low resolution to scan a suspected stenosis region. After analyzing the first MR image to identify a suspected stenosis within the suspected stenosis region, a more detailed study is performed by acquiring a second MR image having a higher resolution than the first MR image to scan the identified suspected stenosis. If no lesions, or stenotic vessels, are identified after the first MR image, the second MR image need not be obtained. Since the first MR image is designed to be more sensitive to the detection of such stenosis, by increasing the conspicuity of the lesions, and using a fast acquisition sequence, this two-tiered approach increases the efficiency for accurate coronary artery stenosis detection and assessment.
摘要翻译：公开了一种方法和装置，其中采用双层方法来对患者进行一级评分，以确定是否存在任何可疑的狭窄，然后使用第二步来获得更详细的信息以对狭窄进行分级。本发明包括通过获取具有低分辨率的第一MR图像来扫描疑似狭窄区域来进行筛选研究。在分析第一MR图像以识别可疑狭窄区域中的可疑狭窄之后，通过获取具有比第一MR图像更高分辨率的第二MR图像来扫描所识别的疑似狭窄来进行更详细的研究。如果在第一MR图像之后没有识别病变或狭窄血管，则不需要获得第二MR图像。由于第一MR图像被设计为对这种狭窄的检测更敏感，通过增加病变的显着性并使用快速采集序列，这种双层方法提高了精确的冠状动脉狭窄检测和评估的效率。

7. 发明授权

US06425864B1 Method and apparatus for optimal imaging of the peripheral vasculature 有权
标题翻译：用于外周脉管系统最佳成像的方法和装置
公开(公告)号：US06425864B1
公开(公告)日：2002-07-30
申请号：US09292548
申请日：1999-04-15
申请人： Thomas K. F. Foo , Vincent B. Ho , Rebecca A. McCann
发明人： Thomas K. F. Foo , Vincent B. Ho , Rebecca A. McCann
IPC分类号： A61B5055
CPC分类号： G01R33/563 , G01R33/281
摘要： A system and method for optimally imaging the peripheral vasculature is disclosed which includes defining a given number of scan stations along a patient's peripheral vasculature and initially injecting a relatively small amount of contrast agent into the patient to pass a test bolus through the patient's peripheral vasculature, and thereafter tracking the test bolus through the patient and adjusting the patient on a moveable table within the MR imaging device from one scan station to a next station to determine a maximum travel time that the test bolus takes to travel through each of the given number of scan stations. Additional contrast agent is then injected into the patient to pass an exam bolus through the patient's peripheral vasculature, and using the test bolus travel time, MR data can be acquired from each scan station while it is known that the exam bolus is present in that station to optimize image resolution. Initially, central k-space data is acquired for each scan station, and if time permits, the higher spatial frequency k-space data can be acquired. Otherwise, once the central k-space data is acquired for each station, the patient table is adjusted to the scan stations that require additional data acquisition. Similarly, if there is time remaining after all MR data is acquired for a particular scan station, the patient table can be moved to a previous scan station to acquire additional data in that station before moving to a subsequent scan station to acquire the central k-space data when the exam bolus arrives in that particular scan station.
摘要翻译：公开了一种用于对外围脉管系统进行最佳成像的系统和方法，其包括沿着患者的外周脉管系统定义给定数量的扫描站，并且首先将相对少量的造影剂注射到患者中以使测试推注通过患者的外周脉管系统，然后通过患者跟踪测试团块并将患者调整在MR成像设备内的可移动台上，从一个扫描站到下一个站，以确定测试弹丸穿过每个给定数量的扫描站。然后将另外的造影剂注射到患者中以通过患者的外周脉管系统进行检查推注，并且使用测试推注旅行时间，可以从每个扫描站获取MR数据，同时已知该测试团存在于该站以优化图像分辨率。首先，针对每个扫描站获取中心k空间数据，并且如果时间允许，则可以获取较高的空间频率k空间数据。否则，一旦为每个站获取中心k空间数据，则将患者表调整到需要附加数据采集的扫描站。类似地，如果在针对特定扫描站获取所有MR数据之后剩余时间，则可以将患者表移动到先前的扫描站以在移动到随后的扫描站以获取中央k-位之前获取该站中的附加数据，考试团到达该特定扫描站时的空间数据。

8. 发明授权

US06317620B1 Method and apparatus for rapid assessment of stenosis severity 有权
标题翻译：快速评估狭窄严重程度的方法和装置
公开(公告)号：US06317620B1
公开(公告)日：2001-11-13
申请号：US09565978
申请日：2000-05-04
申请人： Vincent B. Ho , Thomas K. F. Foo
发明人： Vincent B. Ho , Thomas K. F. Foo
IPC分类号： A61B5055
CPC分类号： G01R33/56308 , G01R33/56316
摘要： A method and apparatus is disclosed to rapidly assess the severity of a stenosis using MR technology. The invention includes identifying a suspected stenotic vessel and applying a phase contrast pulse sequence to the stenotic vessel in which the MR operator is allowed to control the amplitude and direction of the flow encoding gradient. Peak flow velocity is determined in the suspected stenotic vessel by correlating the flow encoding gradient with the onset of flow velocity aliasing. In a preferred embodiment, the invention utilizes a 2D fast gradient echo pulse sequence having flow sensitizing bipolar gradient waveforms. The resulting flow sensitizing gradients are substantially coincident in time, thereby allowing rotation of the resultant flow sensitizing gradient direction. The amplitude of the flow encoding gradient is increased until the observance of flow related aliasing. Once flow related aliasing is observed, the velocity encoding (VENC) value is recorded and used as the indicator of peak flow velocity in the suspected stenotic vessel. The process can be repeated along the suspected stenosis vessel to isolate and assess the severity of the stenosis by comparing the peak flow velocity VENC values obtained at various locations along the suspected stenosis.
摘要翻译：公开了一种使用MR技术快速评估狭窄严重程度的方法和装置。本发明包括识别怀疑的狭窄血管并将相位对比脉冲序列应用于允许MR操作者控制流动编码梯度的幅度和方向的狭窄血管。通过将流动编码梯度与流速混叠的开始相关联，在疑似狭窄的血管中确定峰值流速。在优选实施例中，本发明利用具有流敏增强双极梯度波形的2D快速梯度回波脉冲序列。所得到的流动敏化梯度在时间上基本一致，从而允许所得到的流动增感梯度方向旋转。流编码梯度的幅度增加，直到遵循流相关混叠。一旦观察到流相关的混叠，记录速度编码（VENC）值，并将其用作疑似狭窄血管中峰值流速的指标。可以沿着疑似狭窄血管重复该过程，以通过比较沿着可疑狭窄处在不同位置处获得的峰值流速VENC值来分离和评估狭窄的严重性。

9. 发明授权

US07738944B2 Whole body MRI scanning with moving table and interactive control 有权
标题翻译：全身MRI扫描与移动表和交互式控制
公开(公告)号：US07738944B2
公开(公告)日：2010-06-15
申请号：US10907883
申请日：2005-04-19
申请人： Vincent B. Ho , Thomas K. F. Foo
发明人： Vincent B. Ho , Thomas K. F. Foo
IPC分类号： A61B5/05
CPC分类号： G01R33/56375 , A61B5/0555 , G06F19/00
摘要： The present invention includes a method and apparatus for high sensitivity whole body scanning using MR imaging. The invention includes acquiring MR data as the patient moves through the iso-center of the magnet while providing interactive control for the operator to change scan parameters and table motion and direction. The technique allows efficient whole body scanning for fast screening of abnormalities while allowing operator control during the screening process to interrupt table motion and redirect the speed and direction of the table while also allowing control over the acquisition plane, number of sections imaged, inter-section spacing, and the scan location.
摘要翻译：本发明包括使用MR成像进行高灵敏度全身扫描的方法和装置。本发明包括当患者移动通过磁体的等中心时获取MR数据，同时为操作者提供交互式控制以改变扫描参数和表格运动和方向。该技术允许有效的全身扫描快速筛选异常，同时允许操作者在筛选过程中控制中断台面运动并重定向表的速度和方向，同时还允许控制采集平面，成像部分数量，间隔间距和扫描位置。

10. 发明授权

US06580937B2 Method for optimal imaging of the peripheral vasculature emphasizing distal arterial visualization in a multi-station examination 有权
标题翻译：用于在多站检查中强调远端动脉可视化的外周脉管系统的最佳成像的方法和装置
公开(公告)号：US06580937B2
公开(公告)日：2003-06-17
申请号：US09681092
申请日：2000-12-30
申请人： Vincent B. Ho , Thomas K. F. Foo
发明人： Vincent B. Ho , Thomas K. F. Foo
IPC分类号： A61B505
CPC分类号： G01R33/56375 , G01R33/281 , G01R33/5619
摘要： A method and apparatus are disclosed for creating peripheral MR angiographic images and performing an MRA examination using an intravascular contrast agent in which MR data acquisition is optimized in the most distal stations in a multi-station acquisition. The technique includes administering a contrast agent into the blood stream of the patient, acquiring low spatial resolution MR images of the arterial vasculature, and tracking the passage of the contrast agent through the patient. The patient table is moved in response to the tracking. The technique continues to acquire low spatial resolution images at each of the proximal stations until the most distal station is reached where a high spatial resolution image data set is then acquired of preferentially arterial vascular structures. Higher spatial resolution images are then acquired in the proximal stations.
摘要翻译：公开了一种用于创建外周MR血管造影图像并使用血管内造影剂进行MRA检查的方法和装置，其中在多站采集中在多数远端站中优化MR数据采集。该技术包括将造影剂施用到患者的血液流中，获取动脉脉管系统的低空间分辨率MR图像，以及跟踪造影剂通过患者的通过。响应于跟踪，移动患者台。该技术继续获得每个近端站处的低空间分辨率图像，直到达到最远端站点，然后获得优先动脉血管结构的高空间分辨率图像数据集。然后在近端站获得较高的空间分辨率图像。

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