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1. 发明申请

US20050089487A1 Cosmetic or pharmaceutical preparations which comprise enaminotriazines as light protection agents, and novel enaminotriazines 失效
标题翻译：包含氨基三嗪作为防晒剂的化妆品或药物制剂，以及新的氨基三嗪
公开(公告)号：US20050089487A1
公开(公告)日：2005-04-28
申请号：US10984241
申请日：2004-11-10
申请人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wunsch
发明人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wunsch
IPC分类号： A61K8/00 , A61K8/49 , A61K31/53 , A61P17/16 , A61Q17/04 , A61Q19/00 , C07D251/70 , A61K7/42
CPC分类号： A61Q17/04 , A61K8/4966 , C07D251/70
摘要： The invention relates to the use of enaminotriazines of the formula I in which the radicals Y, independently of one another, are hydrogen, an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical having in each case up to 18 carbon atoms, the radicals X are identical or different, where at least one of the radicals X is the ethenyl radical of the formula II and X may also have the meanings of Y, and where in the formula II the radicals R are identical or different and are cyano, optionally esterified carboxyl, substituted carbonyl, optionally substituted aminocarbonyl, optionally esterified sulfo, substituted sulfonyl or optionally esterified phosphono, and where two adjacent radicals R may optionally form a ring and the radicals R′ are identical or different and are hydrogen, an optionally substituted aliphatic, cycloaliphatic or aromatic radical having in each case up to 18 carbon atoms, as UV filters in cosmetic or pharmaceutical preparations for protecting human skin or human hair against solar rays, alone or together with compounds which absorb in the UV region and which are known per se for cosmetic preparations.
摘要翻译：本发明涉及式I的氨基三嗪的用途，其中基团Y彼此独立地为氢，任选取代的脂族，脂环族，芳脂族或芳族基团，其中每种情况最多可达18个碳原子，基团X 相同或不同，其中基团X中的至少一个是式II的乙烯基，X也可以具有Y的含义，并且其中在式II中，基团R相同或不同并且是氰基，任选地被酯化羧基，取代的羰基，任选取代的氨基羰基，任选酯化的磺基，取代的磺酰基或任选酯化的膦酰基，并且其中两个相邻的基团R可以任选地形成环，并且基团R'相同或不同，并且是氢，任选取代的脂族，脂环族或在每种情况下最多18个碳原子的芳族基团，作为化妆品中的UV过滤剂或用于保护的药物制剂人类皮肤或人类头发抵抗太阳光线，单独或与在UV区域吸收的化合物一起，并且本身已知本身用于化妆品制剂。

2. 发明申请

US20050249681A1 Use of diketopiperazine derivatives as photostable uv-filters in cosmetic and pharmaceutical preparations 审中-公开
标题翻译：在化妆品和药物制剂中使用二酮哌嗪衍生物作为光稳定紫外线过滤器
公开(公告)号：US20050249681A1
公开(公告)日：2005-11-10
申请号：US10523794
申请日：2003-07-24
申请人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wunsch , Robert Parker
发明人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wunsch , Robert Parker
IPC分类号： A61K47/22 , A61K8/00 , A61K8/49 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q17/04 , A61K7/42 , A61K7/06
CPC分类号： A61Q17/04 , A61K8/494 , A61K2800/52
摘要： Use of diketopiperazine derivatives of the formula I, in which the variables have the meanings explained in the description, as photostable UV filters in cosmetic and pharmaceutical preparations for protecting the human skin or human hair against solar rays, alone or together with compounds which absorb in the UV region known per se for cosmetic and pharmaceutical preparations.
摘要翻译：使用式I的二酮哌嗪衍生物，其中变量具有在说明书中解释的含义，作为用于保护人皮肤或人类头发免受太阳光照射的化妆品和药物制剂中的光稳定性紫外线过滤器，单独或与吸收的化合物一起使用化妆品和药物制剂本身已知的UV区域。

3. 发明授权

US06458342B1 Use of sunscreen combinations comprising, as essential constituent, 2,2′-p-phenylenebis (3,1-benzoxazin-4-one) as photostable UV filters in cosmetic and pharmaceutical preparations 失效
标题翻译：在化妆品和药物制剂中使用包含作为必需成分的2,2'-对亚苯基双（3,1-苯并恶嗪-4-酮）作为光稳定性紫外线过滤剂的防晒组合
公开(公告)号：US06458342B1
公开(公告)日：2002-10-01
申请号：US10015561
申请日：2001-12-17
申请人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wünsch
发明人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wünsch
IPC分类号： A61K742
CPC分类号： A61K8/895 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/44 , A61K8/49 , A61K8/494 , A61K8/4966 , A61K2800/52 , A61K2800/57 , A61K2800/59 , A61Q17/04 , A61Q19/001
摘要： Sunscreen combinations which comprise A) effective amounts of a compound of formula I and B) effective amounts of one or more compounds selected from a group consisting of: zinc oxide, titanium oxide and the compounds of formulae II to XVI which are specified in the description, are suitable as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or human hair against solar rays. The combinations are optionally used together with other conventional UV absorbing ingredients which are known per se for cosmetic and pharmaceutical compositions.
摘要翻译：包含A）有效量的式I和B化合物的防晒组合有效量的一种或多种选自以下的化合物：氧化锌，氧化钛和在说明书中规定的式II至XVI的化合物是适合用作化妆品和药物组合物中的光稳定性紫外线过滤剂，用于保护人体皮肤或人体毛发抵抗太阳光线。这些组合可任选地与其它已知的用于化妆品和药物组合物的常规UV吸收成分一起使用。

4. 发明授权

US07217820B2 Cosmetic or pharmaceutical preparations which comprise enaminotriazines as light protection agents, and novel enaminotriazines 失效
标题翻译：包含氨基三嗪作为防晒剂的化妆品或药物制剂，以及新的氨基三嗪
公开(公告)号：US07217820B2
公开(公告)日：2007-05-15
申请号：US10984241
申请日：2004-11-10
申请人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wünsch
发明人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wünsch
IPC分类号： C07D251/70 , A61K7/42
CPC分类号： A61Q17/04 , A61K8/4966 , C07D251/70
摘要： The invention relates to the use of enaminotriazines of the formula I in which the radicals Y, independently of one another, are hydrogen, an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical having in each case up to 18 carbon atoms, the radicals X are identical or different, where at least one of the radicals X is the ethenyl radical of the formula II and X may also have the meanings of Y, and where in the formula II the radicals R are identical or different and are cyano, optionally esterified carboxyl, substituted carbonyl, optionally substituted aminocarbonyl, optionally esterified sulfo, substituted sulfonyl or optionally esterified phosphono, and where two adjacent radicals R may optionally form a ring and the radicals R′ are identical or different and are hydrogen, an optionally substituted aliphatic, cycloaliphatic or aromatic radical having in each case up to 18 carbon atoms, as UV filters in cosmetic or pharmaceutical preparations for protecting human skin or human hair against solar rays, alone or together with compounds which absorb in the UV region and which are known per se for cosmetic preparations.
摘要翻译：本发明涉及式I的氨基三嗪的用途，其中基团Y彼此独立地为氢，任选取代的脂族，脂环族，芳脂族或芳族基团，其中每种情况最多可达18个碳原子，基团X 相同或不同，其中基团X中的至少一个是式II的乙烯基，X也可以具有Y的含义，并且其中在式II中，基团R相同或不同并且是氰基，任选地被酯化羧基，取代的羰基，任选取代的氨基羰基，任选酯化的磺基，取代的磺酰基或任选酯化的膦酰基，并且其中两个相邻的基团R可以任选地形成环，并且基团R'相同或不同，并且是氢，任选取代的脂族，脂环族或在每种情况下最多18个碳原子的芳族基团，作为化妆品中的UV过滤剂或用于保护的药物制剂人类皮肤或人类头发抵抗太阳光线，单独或与在UV区域吸收的化合物一起，并且本身已知本身用于化妆品制剂。

5. 发明授权

US06887460B2 Cosmetic or pharmaceutical preparations which comprise enaminotriazines as light protection agents, and novel enaminotriazines 失效
公开(公告)号：US06887460B2
公开(公告)日：2005-05-03
申请号：US10142974
申请日：2002-05-13
申请人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wünsch
发明人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wünsch
IPC分类号： A61K8/00 , A61K8/49 , A61K31/53 , A61P17/16 , A61Q17/04 , A61Q19/00 , C07D251/70 , A61K7/42
CPC分类号： A61Q17/04 , A61K8/4966 , C07D251/70
摘要： The invention relates to the use of enaminotriazines of the formula I in which the radicals Y, independently of one another, are hydrogen, an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical having in each case up to 18 carbon atoms, the radicals X are identical or different, where at least one of the radicals X is the ethenyl radical of the formula II and X may also have the meanings of Y, and where in the formula II the radicals R are identical or different and are cyano, optionally esterified carboxyl, substituted carbonyl, optionally substituted aminocarbonyl, optionally esterified sulfo, substituted sulfonyl or optionally esterified phosphono, and where two adjacent radicals R may optionally form a ring and the radicals R′ are identical or different and are hydrogen, an optionally substituted aliphatic, cycloaliphatic or aromatic radical having in each case up to 18 carbon atoms, as UV filters in cosmetic or pharmaceutical preparations for protecting human skin or human hair against solar rays, alone or together with compounds which absorb in the UV region and which are known per se for cosmetic preparations.

6. 发明授权

US06488915B1 Use of sunscreen combinations which comprise, as essential constituent, 2-(4-alkoxyanilinomethylene) malonic dialkyl esters as photostable UV filters in cosmetic and pharmaceutical preparations 失效
标题翻译：使用防晒组合，其包含作为必需成分的2-（4-烷氧基苯胺基亚乙基）丙二酸二烷基酯作为化妆品和药物制剂中的光稳定性UV过滤剂
公开(公告)号：US06488915B1
公开(公告)日：2002-12-03
申请号：US10095224
申请日：2002-03-12
申请人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wünsch
发明人： Thomas Heidenfelder , Kristin Tiefensee , Thomas Wünsch
IPC分类号： A61K742
CPC分类号： A61Q17/04 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/411 , A61K8/4946 , A61K8/496 , A61K8/4966 , A61K8/585 , A61K8/89
摘要： Use of sunscreen combinations which comprise, as essential constituent, 2-(4-alkoxyanilinomethylene)malonic dialkyl esters as photostable UV filters in cosmetic and pharmaceutical preparations A) compound absorbing essentially in the UV-A region and B) further compounds absorbing in the UV-A region, in the UV-B region and over both regions, where the constituent absorbing in the UV-A region consists of A) effective amounts of at least one of the compounds of the formula I in which the substituents R1 to R3, independently of one another, are C1-C8-alkyl as photostable UV filters in cosmetic and pharmaceutical preparations for protecting human skin and human hair against solar rays.
摘要翻译：使用防晒组合，其包含作为必需成分的2-（4-烷氧基苯胺基亚甲基）丙二酸二烷基酯作为化妆品和药物制剂中的光稳定性UV过滤剂A）基本上在UV-A区域中吸收的化合物，以及B）在UV-A中吸收的其它化合物区域，UV-B区域和两个区域，其中在UV-A区域吸收的成分由A组成。A）有效量的至少一种式I化合物，其中取代基R 1至R 3独立地为一个另一种是用于保护人类皮肤和人类头发免受太阳光照射的化妆品和药物制剂中的C1-C8-烷基紫杉碱过滤器。

7. 发明申请

US20060246018A1 Mixture consisting of uv-a and uv-b filters 审中-公开
标题翻译：由uv-a和uv-b过滤器组成的混合物
公开(公告)号：US20060246018A1
公开(公告)日：2006-11-02
申请号：US10561001
申请日：2004-06-08
申请人： Valerie Andre , Thomas Wunsch , Thomas Heidenfelder
发明人： Valerie Andre , Thomas Wunsch , Thomas Heidenfelder
IPC分类号： A61K8/37
CPC分类号： A61K8/445 , A61K8/37 , A61Q17/04
摘要： The invention relates to a mixture consisting of a UV-A filter of the formula I and a UV-B filter of the formula II.
摘要翻译：本发明涉及由式I的UV-A过滤器和式II的UV-B过滤器组成的混合物。

8. 发明授权

US08785685B2 Process for preparing aminopolycarboxylates proceeding from amino acids 失效
标题翻译：由氨基酸制备氨基多羧酸盐的方法
公开(公告)号：US08785685B2
公开(公告)日：2014-07-22
申请号：US13430105
申请日：2012-03-26
申请人： Robert Baumann , Markus Christian Biel , Axel Franzke , Thomas Heidenfelder , Paul Klingelhoefer , Alfred Oftring
发明人： Robert Baumann , Markus Christian Biel , Axel Franzke , Thomas Heidenfelder , Paul Klingelhoefer , Alfred Oftring
IPC分类号： C07C227/18 , C07C227/02
CPC分类号： C07C227/18 , C07C227/02 , C07C227/12 , C07C229/16 , C07C229/12
摘要： The present invention relates to a process for preparing aminopolycarboxylates proceeding from an amino acid which, in a first process step is reacted with ethylene oxide to give an intermediate mixture comprising the corresponding dialkanolamine, and then the intermediate mixture, in a second process step is converted catalytically using a base to the corresponding aminopolycarboxylate, wherein the amino acid, before the reaction with ethylene oxide in the first process step, is supplied to a partial neutralization with 0.70 to 0.99 equivalent of base per acid group, or, in the first process step, an amino acid which has already been partly neutralized with 0.70 to 0.99 equivalent of base per acid group is used.
摘要翻译：本发明涉及从氨基酸制备氨基多羧酸盐的方法，该方法在第一工艺步骤与环氧乙烷反应得到包含相应的二链烷醇胺的中间体混合物，然后在第二工艺步骤中将中间体混合物转化催化地将碱用于相应的氨基多羧酸盐，其中在与第一工艺步骤中的环氧乙烷反应之前，将氨基酸以0.70-0.99当量的碱/酸组供应至部分中和，或者在第一工艺步骤使用已经用0.70〜0.99当量碱的每个酸基部分中和的氨基酸。

9. 发明申请

US20120264973A1 PROCESS FOR PREPARING AMINOPOLYCARBOXYLATES PROCEEDING FROM AMINO ACIDS 失效
标题翻译：用于制备从氨基酸处理的氨基羟基羧酸酯的方法
公开(公告)号：US20120264973A1
公开(公告)日：2012-10-18
申请号：US13430105
申请日：2012-03-26
申请人： Robert Baumann , Markus Christian Biel , Axel Franzke , Thomas Heidenfelder , Paul Klingelhoefer , Alfred Oftring
发明人： Robert Baumann , Markus Christian Biel , Axel Franzke , Thomas Heidenfelder , Paul Klingelhoefer , Alfred Oftring
IPC分类号： C07C227/18
CPC分类号： C07C227/18 , C07C227/02 , C07C227/12 , C07C229/16 , C07C229/12
摘要： The present invention relates to a process for preparing aminopolycarboxylates proceeding from an amino acid which, in a first process step is reacted with ethylene oxide to give an intermediate mixture comprising the corresponding dialkanolamine, and then the intermediate mixture, in a second process step is converted catalytically using a base to the corresponding aminopolycarboxylate, wherein the amino acid, before the reaction with ethylene oxide in the first process step, is supplied to a partial neutralization with 0.70 to 0.99 equivalent of base per acid group, or, in the first process step, an amino acid which has already been partly neutralized with 0.70 to 0.99 equivalent of base per acid group is used.
摘要翻译：本发明涉及从氨基酸制备氨基多羧酸盐的方法，该方法在第一工艺步骤与环氧乙烷反应得到包含相应的二链烷醇胺的中间体混合物，然后在第二工艺步骤中将中间体混合物转化催化地将碱用于相应的氨基多羧酸盐，其中在与第一工艺步骤中的环氧乙烷反应之前，将氨基酸以0.70-0.99当量的碱/酸组供应至部分中和，或者在第一工艺步骤使用已经用0.70〜0.99当量碱的每个酸基部分中和的氨基酸。

10. 发明申请

US20100187724A1 PROCESS FOR PRODUCING A FREE-FLOWING AND STORAGE-STABLE SOLID COMPRISING ESSENTIALLY ALPHA-ALANINE-N,N-DIACETIC ACID AND/OR ONE OR MORE DERIVATIVES OF ALPHA-ALANINE-N,N-DIACETIC ACID 审中-公开
标题翻译：用于生产含有ALPHA-ALANINE-N，N-二酸的碱性氨基酸，N-二乙酸和/或一种或多种衍生物的自由流动和储存稳定的固体的方法
公开(公告)号：US20100187724A1
公开(公告)日：2010-07-29
申请号：US12667051
申请日：2008-06-30
申请人： Robert Heinz , Karin Flore , Lars Kissau , Thomas Heidenfelder , Tanja Seebeck , Frank Mrzena
发明人： Robert Heinz , Karin Flore , Lars Kissau , Thomas Heidenfelder , Tanja Seebeck , Frank Mrzena
IPC分类号： B29C55/18
CPC分类号： C07C227/44 , B01J2/22 , B01J2/30 , C11D7/3245 , C11D17/0047 , C07C229/16
摘要： A process is proposed for producing a free-flowing and storage-stable solid comprising essentially α-alanine-N,N-diacetic acid and/or one or more derivatives of α-alanine-N,N-diacetic acid proceeding from a powder of α-alanine-N,N-diacetic acid and/or one or more derivatives of α-alanine-N,N-diacetic acid by a. compacting the powder of α-alanine-N,N-diacetic acid on a roller press to obtain slugs, b. crushing the slugs and c. screening the crushed slugs, which comprises performing the compaction on the roller press with addition of polyethylene glycol with a melting point greater than 35° C.
摘要翻译：提出了一种制备自由流动和储存稳定的固体的方法，其基本上包含α-丙氨酸-N，N-二乙酸和/或α-丙氨酸-N，N-二乙酸的一种或多种衍生物，其由 α-丙氨酸-N，N-二乙酸和/或α-丙氨酸-N，N-二乙酸的一种或多种衍生物。在辊压机上压制α-丙氨酸-N，N-二乙酸的粉末以获得s s，b。粉碎s子和c。筛选破碎的s lug，其中包括加入熔点大于35℃的聚乙二醇在辊压机上进行压实。

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