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1. 发明授权

US08895291B2 Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions 有权
标题翻译：在具有控制条件的中空纤维生物反应器系统中生长和收获细胞的方法和系统
公开(公告)号：US08895291B2
公开(公告)日：2014-11-25
申请号：US13269512
申请日：2011-10-07
申请人： Thomas G. Dilorenzo , Edward Allan Stanton, IV , Glen Delbert Antwiler , Michael E. Kinzie , Brian J. Nankervis , Monique Givens , Casey V. Medina , Jon A. Dodd
发明人： Thomas G. Dilorenzo , Edward Allan Stanton, IV , Glen Delbert Antwiler , Michael E. Kinzie , Brian J. Nankervis , Monique Givens , Casey V. Medina , Jon A. Dodd
IPC分类号： C12M1/36 , C12M1/38 , C12M3/00 , C12M1/00 , C12M1/12 , G06F9/44
CPC分类号： C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
摘要： Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
摘要翻译：本文描述的实施例一般涉及使用空气除去室作为电池膨胀系统中的工艺的控制的方法和系统。排气室可以安装在流体输送组件上以与系统一起使用。流体被泵送到空气移除室的流体容纳室中，其中流体容纳室中的流体水平可以通过使用一个或多个传感器来监测。传感器能够在空气去除室内的测量位置处检测空气，缺乏流体，流体和/或气体/流体界面，例如空气/流体界面。用于该系统的协议可以包括一个或多个停止条件。在一个实施例中，基于在空气移除室中检测空气，缺乏流体和/或气体/流体界面，自动停止过程。

2. 发明申请

US20120088224A1 Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System with Control Conditions 有权
标题翻译：在具有控制条件的中空纤维生物反应器系统中生长和收获细胞的方法和系统
公开(公告)号：US20120088224A1
公开(公告)日：2012-04-12
申请号：US13269512
申请日：2011-10-07
申请人： Thomas G. DILORENZO , Edward Allan STANTON, IV , Glen Delbert ANTWILER , Michael E. KINZIE , Brian J. Nankervis , Monique Givens , Casey V. Medina , Jon A. Dodd
发明人： Thomas G. DILORENZO , Edward Allan STANTON, IV , Glen Delbert ANTWILER , Michael E. KINZIE , Brian J. Nankervis , Monique Givens , Casey V. Medina , Jon A. Dodd
IPC分类号： C12Q3/00 , C12M1/36
CPC分类号： C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
摘要： Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
摘要翻译：本文描述的实施例一般涉及使用空气除去室作为电池膨胀系统中的工艺的控制的方法和系统。排气室可以安装在流体输送组件上以与系统一起使用。流体被泵送到空气移除室的流体容纳室中，其中流体容纳室中的流体水平可以通过使用一个或多个传感器来监测。传感器能够在空气去除室内的测量位置处检测空气，缺乏流体，流体和/或气体/流体界面，例如空气/流体界面。用于该系统的协议可以包括一个或多个停止条件。在一个实施例中，基于在空气移除室中检测空气，缺乏流体和/或气体/流体界面，自动停止过程。

3. 发明授权

US09057045B2 Method of loading and distributing cells in a bioreactor of a cell expansion system 有权
标题翻译：在细胞扩增系统的生物反应器中负载和分配细胞的方法
公开(公告)号：US09057045B2
公开(公告)日：2015-06-16
申请号：US12968483
申请日：2010-12-15
申请人： David M. Gibbons , Brian J. Nankervis
发明人： David M. Gibbons , Brian J. Nankervis
IPC分类号： C12N5/071 , C12M1/00 , C12M3/00 , C12M1/12 , C12M3/06
CPC分类号： C12M29/16 , C12M23/42 , C12M23/50 , C12M25/10 , C12M25/12 , C12M27/14
摘要： A method of distributing a plurality of cells in a bioreactor of a cell expansion system includes manipulating an orientation of the bioreactor such that a net impulse due to gravity acting on the plurality cells in the bioreactor is reduced. One method includes (a) rotating the bioreactor at an angular velocity ω about an axis of rotation and through an angular displacement θ, the bioreactor rotating from a first orientation to a second orientation; (b) holding the bioreactor still at the second orientation for a first period of time t1, wherein t1 substantially equals 2/ω; (c) rotating the bioreactor at the angular velocity ω about the axis of rotation and through the angular displacement θ; and (d) holding the bioreactor still for a second period of time t2, wherein t2 substantially equals t1.
摘要翻译：在细胞扩增系统的生物反应器中分配多个细胞的方法包括操纵生物反应器的取向，使得由于重力作用在生物反应器中的多个细胞上的净冲击减少。一种方法包括：（a）以围绕旋转轴线的角速度ω旋转生物反应器并通过角度位移旋转生物反应器;生物反应器从第一取向旋转到第二取向; （b）将所述生物反应器保持在所述第二方向上第一时间段t1，其中t1基本上等于2 /ω; （c）以关于旋转轴线和角位移的角速度ω旋转生物反应器; 和（d）将生物反应器保持第二时间段t2，其中t2基本上等于t1。

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