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1. 发明授权

US08574291B2 Linear drive and pump system, in particular an artificial heart 有权
标题翻译：线性驱动和泵系统，特别是人造心脏
公开(公告)号：US08574291B2
公开(公告)日：2013-11-05
申请号：US12670708
申请日：2008-08-18
申请人： Thomas Finocchiaro , Thomas Butschen , Marc Lessmann , Kay Hameyer , Thomas Schmitz-Rode , Ulrich Steinseifer , Paul Barteld Kwant
发明人： Thomas Finocchiaro , Thomas Butschen , Marc Lessmann , Kay Hameyer , Thomas Schmitz-Rode , Ulrich Steinseifer , Paul Barteld Kwant
IPC分类号： A61M1/10
CPC分类号： H02K41/031 , A61M1/1037 , A61M1/1046 , A61M1/1055 , A61M1/1075 , A61M1/12 , A61M1/122 , F04B15/00 , F04B17/04 , H02K1/27
摘要： The invention relates to an electrical linear drive, in particular for a pump system of an artificial heart, with a movable part and a stationary part, wherein the stationary part is formed by a permanent magnet arrangement and the movable part is formed by a coil arrangement, or vice versa, and wherein the coil arrangement and the permanent magnet arrangement can be moved to and fro relative to each other in an axial direction by means of current passed through the coil arrangement. The invention further relates to an electrical linear drive of this kind in which the permanent magnet arrangement is designed as a stack of frame-shaped, in particular ring-shaped magnets, which are magnetized alternately radially and axially in the axial direction, such that the magnetic field is strengthened on one side of the frame.
摘要翻译：本发明涉及一种电线性驱动装置，特别涉及具有可移动部件和静止部件的人造心脏泵系统，其中，静止部分由永磁体装置形成，并且可动部分由线圈装置，反之亦然，并且其中线圈装置和永磁体装置可以通过穿过线圈装置的电流在轴向方向上相对于彼此移动。本发明还涉及这种电线性驱动器，其中永磁体装置被设计成框架形，特别是环形磁体的堆叠，其在轴向方向上被径向和轴向地交替磁化，使得框架一侧的磁场强化。

2. 发明申请

US20100234941A1 LINEAR DRIVE AND PUMP SYSTEM, IN PARTICULAR AN ARTIFICIAL HEART 有权
公开(公告)号：US20100234941A1
公开(公告)日：2010-09-16
申请号：US12670708
申请日：2008-08-18
申请人： Thomas Finocchiaro , Thomas Butschen , Marc Lessmann , Kay Hameyer , Thomas Schmitz-Rode , Ulrich Steinseifer
发明人： Thomas Finocchiaro , Thomas Butschen , Marc Lessmann , Kay Hameyer , Thomas Schmitz-Rode , Ulrich Steinseifer
IPC分类号： A61M1/10
CPC分类号： H02K41/031 , A61M1/1037 , A61M1/1046 , A61M1/1055 , A61M1/1075 , A61M1/12 , A61M1/122 , F04B15/00 , F04B17/04 , H02K1/27
摘要： The invention relates to an electrical linear drive, in particular for a pump system of an artificial heart, with a movable part and a stationary part, wherein the stationary part is formed by a permanent magnet arrangement and the movable part is formed by a coil arrangement, or vice versa, and wherein the coil arrangement and the permanent magnet arrangement can be moved to and fro relative to each other in an axial direction by means of current passed through the coil arrangement, wherein the coil arrangement (1) is arranged in an axially extending air gap (5) of the permanent magnet arrangement (2) whose magnetic material is magnetized in the axial direction and which, at least at its two axial ends, has inner and outer pole shoes (6a, 6b) which lie radially opposite each other and are spaced apart by the air gap (5), as a result of which the magnetic field in the air gap (5) is concentrated in the radial direction in the area of the mutually facing pole shoes (6a, 6b), as a result of which at least one magnetic circuit is formed in which the magnetic field lines extend radially through the air gap (5) from the inside outwards and also through said air gap (5) from the outside inwards. The invention further relates to an electrical linear drive of this kind in which the permanent magnet arrangement (2) is designed as a stack of frame-shaped, in particular ring-shaped magnets (2a, 2b, 2c), which are magnetized alternately radially and axially in the axial direction, such that the magnetic field is strengthened on one side of the frame or in particular ring, in particular on the radially outer side, and is weakened on the other side of the frame or in particular ring, in particular on the radially inward side, and the coil arrangement (1) is arranged coaxially with respect to the permanent magnet arrangement (2) on the side with the strengthened magnetic field.

3. 发明授权

US08870738B2 Cardiac function change evaluating device 有权
标题翻译：心功能改变评估装置
公开(公告)号：US08870738B2
公开(公告)日：2014-10-28
申请号：US12598849
申请日：2008-05-09
申请人： Setsuo Takatani , Yoshimasa Yokoyama , Thomas Schmitz-Rode , Ulrich Steinseifer
发明人： Setsuo Takatani , Yoshimasa Yokoyama , Thomas Schmitz-Rode , Ulrich Steinseifer
IPC分类号： A61N1/362 , A61M1/10 , A61B5/0215 , A61M1/12 , A61B5/029 , A61B5/00
CPC分类号： A61B5/0215 , A61B5/029 , A61B5/6846 , A61M1/1005 , A61M1/101 , A61M1/1086 , A61M1/122 , A61M2230/04
摘要： A cardiac function variation evaluation apparatus includes: a continuous flow type auxiliary artificial heart 20 connected to a ventricle (10A); a pressure sensor 30 for detecting ventricle (10A) internal pressure; and means (a personal computer 40) for evaluating contractile variation of the ventricle, to which the auxiliary artificial heart 20 is connected, based on internal area APMp of a closed-loop of a relationship between the ventricle internal pressure detected by the pressure sensor 30 and a consumption power of the auxiliary artificial heart 20. Thus, the contractile variation of the ventricle, to which an auxiliary artificial heart is connected, can be continuously evaluated not by use of an ultrasonic echo apparatus or a conductance catheter but by use of a non-invasive method.
摘要翻译：心脏功能变化评价装置包括：与心室（10A）连接的连续流动型辅助人造心脏20; 用于检测心室（10A）内压的压力传感器30; 以及用于根据由压力传感器30检测到的心室内压之间的关系的闭环的内部区域APMp来评估辅助人造心脏20连接到的心室的收缩变化的装置（个人计算机40）和辅助人造心脏20的消耗功率。因此，辅助人造心脏连接到的心室的收缩变化可以不是通过使用超声回波装置或电导导管来连续评估，而是使用非侵入性方法。

4. 发明申请

US20140061116A1 EXCHANGER DEVICE 审中-公开
标题翻译：交换器设备
公开(公告)号：US20140061116A1
公开(公告)日：2014-03-06
申请号：US14115221
申请日：2012-05-02
申请人： Thomas Schmitz-Rode , Ulrich Steinseifer , Jutta Arens , Peter Schlanstein , Ralf Borchardt
发明人： Thomas Schmitz-Rode , Ulrich Steinseifer , Jutta Arens , Peter Schlanstein , Ralf Borchardt
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/1678 , A61M1/267
摘要： An exchanger device for transferring mass and/or energy between a first medium and a second medium includes a chamber having a first inlet and first outlet of the first medium and through which the first medium can flow. The chamber is equipped with at least one, preferably a plurality, of one mass- and/or energy-permeable exchanger hollow fibers connected at one end to a second inlet and at the other end to a second outlet of the second medium. The second medium can flow through the fiber(s) and the first medium can flow around the fiber(s). The chamber is equipped with at least one pump element for displacing the first medium in and out of the chamber in a pulsing manner. The pump element has an elastically deformable element, is connected to a third inlet of a third medium used as a driving medium, and is expandable by the third medium.
摘要翻译：用于在第一介质和第二介质之间传送质量和/或能量的交换器装置包括具有第一介质的第一入口和第一出口以及第一介质可以流经的室。腔室配备有至少一个，优选多个，一个质量和/或能量可渗透的交换器中空纤维，其一端连接到第二入口，另一端连接到第二介质的第二出口。第二介质可以流过纤维，第一介质可以在纤维周围流动。腔室配备有至少一个泵元件，用于以脉冲方式将第一介质移入和移出腔室。泵元件具有可弹性变形的元件，连接到用作驱动介质的第三介质的第三入口，并且可由第三介质膨胀。

5. 发明申请

US20150246166A1 VENTRICULAR ASSIST DEVICE AND METHOD OF CONTROLLING SAME 有权
标题翻译：静脉辅助装置及其控制方法
公开(公告)号：US20150246166A1
公开(公告)日：2015-09-03
申请号：US14429303
申请日：2012-09-21
申请人： Nicholas Greatrex , Ulrich Steinseifer
发明人： Nicholas Greatrex , Ulrich Steinseifer
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1086 , A61M1/101 , A61M1/122 , A61M2205/3303 , A61M2205/3334 , A61M2205/3344 , A61M2205/3365 , A61M2205/50 , A61M2210/125 , A61M2230/04
摘要： The invention relates to a method of controlling the speed of a ventricular assist device, in particular the rotational speed of a rotary blood pump, wherein at least temporarily the speed of the device is modulated around a mean speed and a response of the native heart to this modulation is measured to determine the ventricular function/contractile state of the heart, in particular to determine whether the aortic valve opens and closes at the instant mean speed, and the mean speed is set, in particular a new mean speed is set in dependence of the measured response. The invention furthermore relates to a device performing the method.
摘要翻译：本发明涉及一种控制心室辅助装置速度的方法，特别是旋转式血液泵的旋转速度，其中至少临时地将装置的速度围绕平均速度和天然心脏的响应调制到测量这种调制以确定心脏的心室功能/收缩状态，特别是确定主动脉瓣是否以即时平均速度打开和关闭，并且平均速度被设定，特别是依赖于新的平均速度的测量响应。本发明还涉及执行该方法的装置。

6. 发明申请

US20150141739A1 AXIAL-FLOW BLOOD PUMP 有权
标题翻译：轴流式血液泵
公开(公告)号：US20150141739A1
公开(公告)日：2015-05-21
申请号：US14395337
申请日：2013-07-17
申请人： Po-Lin Hsu , Ulrich Steinseifer , Jack Parker , Ruediger Autschbach
发明人： Po-Lin Hsu , Ulrich Steinseifer , Jack Parker , Ruediger Autschbach
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/125 , A61F2/82 , A61M1/101 , A61M1/1013 , A61M1/102 , A61M1/1024 , A61M1/1029 , A61M1/1031 , A61M1/1036 , A61M1/122 , A61M2205/04 , A61M2205/103 , A61M2210/12
摘要： The invention relates to an axial flow blood pump device comprising an integrated electromagnetic drive with a stationary stator assembly and a rotatable impeller assembly, wherein the stationary stator assembly at least comprises stator windings (3) and a bearing system (4) supporting the rotatable impeller assembly, the impeller assembly comprising at least one blade (9) and permanent magnets (10) interacting with the stator windings (3), wherein the stationary stator assembly comprises supporting elements (8) for mounting, in particular coaxially mounting the device in the interior of an anchoring system (7) being implantable into a vessel. The invention furthermore relates to a system comprising a device according to any of the preceding claims and a anchoring system (7), in particular a stent (7) surrounding the device, wherein the anchoring system (7) and the device, in particular the at least one blade (9) and the supporting members (8) of the device are in a collapsed/compressed/folded state for implanting the system into a vessel, the system being expandable/unfoldable after implantation.
摘要翻译：本发明涉及一种轴向血液泵装置，其包括具有固定定子组件和可旋转叶轮组件的集成电磁驱动器，其中固定定子组件至少包括定子绕组（3）和支撑可旋转叶轮的支承系统（4）组件，所述叶轮组件包括与所述定子绕组（3）相互作用的至少一个叶片（9）和永磁体（10），其中所述固定定子组件包括用于安装的支撑元件（8），特别是将所述装置同轴地安装在所述定子绕组锚固系统（7）的内部可植入容器中。本发明还涉及一种包括根据前述权利要求中任一项所述的装置和锚定系统（7）的系统，特别是围绕所述装置的支架（7），其中所述锚固系统（7）和所述装置，特别是装置的至少一个叶片（9）和支撑构件（8）处于折叠/压缩/折叠状态，用于将系统植入容器中，该系统在植入之后是可扩展的/可展开的。

7. 发明授权

US09370613B2 Axial-flow blood pump 有权
标题翻译：轴流血泵
公开(公告)号：US09370613B2
公开(公告)日：2016-06-21
申请号：US14395337
申请日：2013-07-17
申请人： Po-Lin Hsu , Ulrich Steinseifer , Jack Parker , Ruediger Autschbach
发明人： Po-Lin Hsu , Ulrich Steinseifer , Jack Parker , Ruediger Autschbach
IPC分类号： A61M1/12 , A61M1/10 , A61F2/82
CPC分类号： A61M1/125 , A61F2/82 , A61M1/101 , A61M1/1013 , A61M1/102 , A61M1/1024 , A61M1/1029 , A61M1/1031 , A61M1/1036 , A61M1/122 , A61M2205/04 , A61M2205/103 , A61M2210/12
摘要： An axial-flow blood pump has a rotatable impeller assembly rotatable about an axis and itself having a radially projecting blade and permanent magnets, A stationary stator assembly has stator windings interacting with the permanent magnets and a bearing system supporting the rotatable impeller assembly for rotation about the axis relative to the stator assembly. A stent implantable into a blood vessel is connected to ends of supports for coaxially mounting the stator assembly carrying the impeller assembly in the stent.
摘要翻译：轴向血液泵具有可旋转的叶轮组件，其可以围绕轴线旋转并且本身具有径向突出的叶片和永磁体。固定定子组件具有与永磁体相互作用的定子绕组和支撑可旋转叶轮组件以便围绕相对于定子组件的轴线。可植入血管的支架连接到支撑件的端部，以将承载叶轮组件的定子组件同轴地安装在支架中。

8. 发明申请

US20140114202A1 BLOOD WITHDRAWAL CANNULA OF A PUMP REPLACING OR ASSISTING ACTIVITY OF THE HEART 审中-公开
标题翻译：血液替代或辅助心脏活动的血液抽取性支气管
公开(公告)号：US20140114202A1
公开(公告)日：2014-04-24
申请号：US14123849
申请日：2012-05-25
申请人： Marc Hein , Greatex Nicholas , Roland Graefe , Ulrich Steinseifer
发明人： Marc Hein , Greatex Nicholas , Roland Graefe , Ulrich Steinseifer
IPC分类号： A61M1/10 , A61B5/00 , A61B5/027 , A61B5/02 , A61B5/0215 , A61B5/029
CPC分类号： A61B5/027 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0538 , A61B5/4836 , A61B5/6848 , A61B5/6869 , A61B5/7235 , A61M1/1008 , A61M1/101 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/3334 , A61M2205/3344 , A61M2205/3379
摘要： The invention relates to a blood withdrawal cannula (4) for connecting a pump (2) assisting or replacing activity of the heart to the inner volume of a heart ventricle (1), in particular the left ventricle. At the end thereof that is located in the ventricle the cannula has a pressure sensor (7a, 7b) for measuring the ventricle pressure and/or ventricle pressure differences and at the same end of the cannula has a volume sensor (3a, 3b, 5, 6) for measuring the volume and/or volume changes of the ventricle (1) in at least a partial region of the ventricle. The invention further relates to a measuring device for monitoring the ventricle contractions and/or the function of a pump replacing or assisting activity of the heart. The measuring device can be/is connected to the pressure sensor (7a, 7b) and to the volume sensor of a blood withdrawal cannula according to any one of the preceding claims and is designed to detect pressure changes and volume changes of a ventricle (1) as the heart is beating.
摘要翻译：本发明涉及一种用于将帮助或替代心脏活动的泵（2）连接到心室（1）的内部容积（尤其是左心室）的抽血套管（4）。在其位于心室的末端，套管具有用于测量心室压力和/或心室压力差的压力传感器（7a，7b），并且在插管的同一端具有体积传感器（3a，3b，5），6），用于测量在心室的至少部分区域中心室（1）的体积和/或体积变化。本发明还涉及一种用于监测心脏收缩和/或替换或辅助心脏活动的泵的功能的测量装置。根据前述权利要求中任一项所述的测量装置可以连接到所述压力传感器（7a，7b）和所述血液取出插管的体积传感器，并被设计成检测心室（1）的压力变化和体积变化），因为心脏正在跳动。

9. 发明申请

US20080317324A1 Method and Device for the Characterization of Cells, Clusters and/or Tissue 审中-公开
标题翻译：用于表征细胞，簇和/或组织的方法和装置
公开(公告)号：US20080317324A1
公开(公告)日：2008-12-25
申请号：US10588887
申请日：2005-02-10
申请人： Markus Eblenkamp , Ulrich Steinseifer , Erich Wintermantel
发明人： Markus Eblenkamp , Ulrich Steinseifer , Erich Wintermantel
IPC分类号： C12M1/34
CPC分类号： C12M41/46 , G01N15/147 , G01N2015/1497
摘要： This invention relates to an apparatus for characterizing cells, cell aggregates and/or tissue with an analysis unit which includes means by which morphological parameters of cells, cell aggregates or tissue are detected and which furthermore includes means by which the detected morphological parameters are evaluated for the purpose of the objective morphological characterization of the cells, cell aggregates or tissue. The invention furthermore relates to a method for objectively characterizing cells, cell aggregates and/or tissue.
摘要翻译：本发明涉及一种用分析单元表征细胞，细胞聚集体和/或组织的装置，该分析单元包括检测细胞，细胞聚集体或组织的形态学参数的装置，此外还包括评估检测到的形态学参数的方法细胞，细胞聚集体或组织的客观形态学表征的目的。本发明还涉及客观地表征细胞，细胞聚集体和/或组织的方法。

10. 发明授权

US06395024B1 Mechanical heart valve 有权
标题翻译：机械心脏瓣膜
公开(公告)号：US06395024B1
公开(公告)日：2002-05-28
申请号：US09323402
申请日：1999-06-01
申请人： Didier Lapeyre , Ulrich Steinseifer
发明人： Didier Lapeyre , Ulrich Steinseifer
IPC分类号： A61F206
CPC分类号： A61F2/2403 , A61F2250/0036
摘要： An improved trileaflet mechanical heart valve 100 can include an improved leaflet 110. The valve 100 and leaflet 110 provide improved flow characteristics, minimize blood clotting behind the leaflets, and provide more natural opening and closing times. The valve can include a valve housing 105 which contains pivot/hinge mechanism (130, 200, and 300) for allowing rotation of and retention of the leaflets 110. The valve housing 105 can also include windows or openings 125 which allows for complete washing of the pivot/hinge mechanism (130, 200, and 300) as well as the leaflets 110. The novel leaflets 110 are airfoil-like having a complex S-shaped curvature on their outer surface. This novel geometry, when combined with the location of the leaflet's pivot axis, causes a tendency for the leaflets 110 to rotate towards the closed position. Thus, the leaflets 110 begin to close much earlier than a conventional leaflet and are substantially closed before the flow reverses, similar to the function of a natural valve.
摘要翻译：改进的三叶草机械心脏瓣膜100可以包括改进的小叶片110.瓣膜100和小叶110提供改善的流动特性，使传单后面的血液凝固最小化，并提供更自然的开启和关闭时间。阀可以包括阀壳体105，阀壳体105包含枢轴/铰链机构（130,200和300），用于允许单张110的旋转和保持。阀壳体105还可以包括窗口或开口125，其允许完全清洗枢轴/铰链机构（130,200和300）以及小叶110.新颖的叶片110在其外表面上具有复杂的S形曲率的翼型。当与小叶的枢转轴线的位置组合时，这种新颖的几何形状导致小叶110朝着关闭位置旋转的倾向。因此，类似于自然阀的功能，传单110比常规小叶开始早得多，并且在流动反转之前基本上是封闭的。

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