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    • 3. 发明授权
    • Macrocyclic lactams
    • 大环内酰胺
    • US07112581B2
    • 2006-09-26
    • US10673036
    • 2003-09-25
    • Scott C. MitchellBenjamin Nicholson
    • Scott C. MitchellBenjamin Nicholson
    • A61K31/395A61K35/02A61P35/00C07D225/02
    • C07D225/02
    • Compounds represented by the following structure (I), acid-addition salts and pro-drugs are disclosed: wherein the ring structure includes no substitutions, one substitution, or more than one substitution; and wherein n is equal to an integer grater than 1, preferably 2, 3, or 4; m is equal to a positive integer, preferably 1, 2 or 3, and each separate Xn and X are each separately selected from a nucleophilic residue, preferably —H, —OH, —O—CO-alkyl, —O-alkyl, —NH2, a halogen and the like; and wherein the dashed line represents a C—C bond or a C—H bond, and the dashed and solid line represents either a carbon-carbon single bond or a carbon-carbon double bond.
    • 公开了由以下结构(I)表示的化合物,酸加成盐和前药:其中环结构不包括取代,一个取代或多于一个取代; 并且其中n等于1,优选2,3或4的整数倍; m等于正整数,优选1,2或3,并且每个单独的X n和X各自独立地选自亲核残基,优选-H,-OH,-O-CO- 烷基,-O-烷基,-NH 2,卤素等; 并且其中虚线表示C-C键或C-H键,虚线和实线表示碳 - 碳单键或碳 - 碳双键。
    • 4. 发明授权
    • Control of parasitic laser oscillations in solid-state lasers by frustrating total internal reflections
    • 通过抑制全内反射来控制固态激光器中的寄生激光振荡
    • US06587488B1
    • 2003-07-01
    • US09709060
    • 2000-11-08
    • Helmuth E. MeissnerScott C. Mitchell
    • Helmuth E. MeissnerScott C. Mitchell
    • H01S313
    • H01S3/0602H01S3/0604H01S3/061H01S3/0612H01S3/0617H01S3/0632H01S3/0941H01S3/2308H01S2301/02
    • Parasitic oscillations are eliminated in solid-state laser components by applying a pattern of grooves to the peripheral sections that do not transmit the desired laser radiation. Additionally, the invention frustrates total internal reflections at polished peripheral component walls by providing a pattern of roughened surface sections in between polished sections. The roughened surfaces may be only microns deep or may be as deep as a few centimeters for large components. The grooves should be sufficiently deep as to inhibit any total internal reflections. The invention applies to all common solid-state architectures that are designed with polished surfaces that do not serve to propagate the desired laser radiation. Examples are slabs, plates, laser rods, waveguides and disks functioning as laser oscillators or amplifiers. The invention is operational with conventional crystal or glass laser hosts or with hosts that are composites of same, similar or dissimilar crystals or glasses.
    • 在固体激光器部件中通过向不透射期望的激光辐射的周边部分施加凹槽图案来消除寄生振荡。 此外,本发明通过在抛光部分之间提供粗糙化表面部分的图案来抑制抛光周边部件壁处的全部内部反射。 粗糙表面可能只有微米深,或者对于大部件可能只有几厘米深。 凹槽应足够深以抑制任何全内反射。 本发明适用于设计有不用于传播所需激光辐射的抛光表面的所有常见固态架构。 示例是用作激光振荡器或放大器的板,板,激光棒,波导和盘。 本发明可与常规的晶体或玻璃激光器主机或具有相同,相似或不同晶体或玻璃的复合材料的主机一起使用。
    • 6. 发明申请
    • SYSTEM AND METHOD FOR THE DIRECT CALORIMETRIC MEASUREMENT OF LASER ABSORPTIVITY OF MATERIALS
    • 直接测量材料激光吸收率的系统和方法
    • US20170016839A1
    • 2017-01-19
    • US15213210
    • 2016-07-18
    • ALEXANDER RUBENCHIKllya V. GoloskerMary M. LeBlancScott C. MitchellSheldon S. Wu
    • ALEXANDER RUBENCHIKllya V. GoloskerMary M. LeBlancScott C. MitchellSheldon S. Wu
    • G01N25/20
    • G01N25/20G01K17/00G01K17/04G01N25/48G01N25/4846G01N25/4853G01N25/486
    • A method and system for calorimetrically measuring the temperature-dependent absorptivity of a homogeneous material dimensioned to be thin and flat with a predetermined uniform thickness and a predetermined porosity. The system includes a material holder adapted to support and thermally isolate the material to be measured, an irradiation source adapted to uniformly irradiate the material with a beam of electromagnetic radiation, and an irradiation source controller adapted to control the irradiation source to uniformly heat the material during a heating period, followed by a cooling period when the material is not irradiated. A thermal sensor measures temperature of the material during the heating and cooling periods, and a computing system first calculates temperature-dependent convective and radiative thermal losses of the material based on the measured temperature of the material during the cooling period when beam intensity is zero, followed by calculation of the temperature-dependent absorptivity of the material based on the temperature-dependent convective and radiative thermal losses determined from the cooling period.
    • 一种用于量热测量均匀材料的温度依赖性吸收率的方法和系统,其尺寸为具有预定均匀厚度和预定孔隙率的薄且平坦的材料。 该系统包括适于支撑和热隔离要测量的材料的材料保持器,适合于用电磁辐射束均匀照射材料的照射源,以及适于控制照射源以均匀加热材料的照射源控制器 在加热期间,随后是不照射材料的冷却期间。 热传感器在加热和冷却期间测量材料的温度,并且计算系统首先基于在光束强度为零时的冷却期间材料的测量温度来计算材料的温度依赖对流和辐射热损失, 然后根据从冷却期测定的温度依赖对流和辐射热损失计算材料的温度依赖性吸收率。