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1. 发明申请

US20070081987A1 Novel peptides and compositions which modulate apoptosis 失效
标题翻译：调节凋亡的新型肽和组合物
公开(公告)号：US20070081987A1
公开(公告)日：2007-04-12
申请号：US11501910
申请日：2006-08-10
申请人： Thomas Chittenden , Robert Lutz
发明人： Thomas Chittenden , Robert Lutz
IPC分类号： A61K38/48 , C12Q1/68 , C07H21/04 , A61K48/00 , C12N9/64
CPC分类号： G01N33/5008 , C07K14/4747 , C07K2319/70 , G01N33/5011 , G01N33/5017 , G01N33/68 , G01N2333/47 , G01N2500/00 , G01N2510/00
摘要： The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the “GD domain,” which is essential both to Bak's interaction with Bcl-xL, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.
摘要翻译：本发明涉及能够调节细胞凋亡的新型肽和组合物，以及使用本发明的新肽和组合物调节凋亡的方法。一方面，本发明涉及一种称为“GD结构域”的新肽，其对于Bak与Bcl-xLa的相互作用以及Bak的细胞杀伤功能是必不可少的。提供识别GD结构域功能的激动剂或拮抗剂的方法。 GD结构域负责调控重要蛋白质/蛋白质相互作用对多种细胞死亡调节分子的作用。

2. 发明申请

US20060177455A1 Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same 有权
标题翻译：抗CD33抗体及其治疗急性骨髓性白血病的方法
公开(公告)号：US20060177455A1
公开(公告)日：2006-08-10
申请号：US11400241
申请日：2006-04-10
申请人： Mary Hoffee , Daniel Tavares , Robert Lutz
发明人： Mary Hoffee , Daniel Tavares , Robert Lutz
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/30
CPC分类号： C07K16/2803 , A61K39/3955 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/92
摘要： The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of said antibodies, humanized and resurfaced versions of said antibodies, functional equivalents and improved versions of said antibodies, immunoconjugates and compositions comprising said antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding the antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing the antibodies.
摘要翻译：本发明涉及结合CD33的抗体。更具体地说，本发明涉及抗CD33抗体，所述抗体的片段和同系物，所述抗体的人源化和表面化形式，所述抗体的功能等同物和改进形式，免疫偶联物和包含所述抗体的组合物及其在诊断中的用途，研究和治疗应用。本发明还涉及编码抗体的多核苷酸，包含多核苷酸的载体，用多核苷酸转化的宿主细胞和产生抗体的方法。

3. 发明申请

US20060022212A1 Surface mounting optoelectronic component and method for producing same 有权
标题翻译：表面贴装光电元件及其制造方法
公开(公告)号：US20060022212A1
公开(公告)日：2006-02-02
申请号：US11202424
申请日：2005-08-11
申请人： Gunter Waitl , Robert Lutz , Herbert Brunner
发明人： Gunter Waitl , Robert Lutz , Herbert Brunner
IPC分类号： H01L33/00 , H01L31/0232
CPC分类号： H01L33/486 , H01L31/0203 , H01L31/02325 , H01L33/58 , H01L2224/48247 , H01L2224/48091 , H01L2924/00014
摘要： A method for producing a surface mounting optoelectronic component comprises the following steps: readying a base body with the optoelectronic transmitter and/or receiver arranged in a recess of the base body, filling the recess of the base body with a transparent, curable casting compound, and placing the optical device onto the base body, whereby the optical device comes into contact with the casting compound.
摘要翻译：一种用于制造表面安装光电子部件的方法包括以下步骤：利用布置在基体的凹部中的光电发射器和/或接收器准备基体，用透明的可固化铸塑料填充基体的凹部，并将光学装置放置在基体上，由此光学装置与铸塑料接触。

4. 发明授权

US06610563B1 Surface mounting optoelectronic component and method for producing same 有权
标题翻译：表面贴装光电元件及其制造方法
公开(公告)号：US06610563B1
公开(公告)日：2003-08-26
申请号：US09581585
申请日：2000-10-05
申请人： Günter Waitl , Robert Lutz , Herbert Brunner
发明人： Günter Waitl , Robert Lutz , Herbert Brunner
IPC分类号： H01L2120
CPC分类号： H01L33/486 , H01L31/0203 , H01L31/02325 , H01L33/58 , H01L2224/48247 , H01L2224/48091 , H01L2924/00014
摘要： A method for producing a surface mounting optoelectronic component having comprises the following steps: readying a base body with the optoelectronic transmitter and/or receiver arranged in a recess of the base body, filling the recess of the base body with a transparent, curable casting compound, and placing the optical device onto the base body, so whereby the optical device comes into contact with the casting compound.
摘要翻译：一种用于制造表面安装光电子部件的方法，包括以下步骤：用设置在基体的凹部中的光电发射器和/或接收器准备基体，用透明的可固化铸塑料填充基体的凹部并且将光学装置放置在基体上，由此光学装置与铸塑料接触。

5. 发明申请

US20080145374A1 METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA A NON-CLEAVABLE LINKER, SAID CONJUGATES AND METHODS OF MAKING SAID CONJUGATES 有权
公开(公告)号：US20080145374A1
公开(公告)日：2008-06-19
申请号：US11927314
申请日：2007-10-29
申请人： Rita STEEVES , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
发明人： Rita STEEVES , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
IPC分类号： A61K39/44 , C07K16/00
CPC分类号： C07K16/3092 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07K16/18 , C07K16/32 , C07K2317/24 , C07K2317/92
摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

6. 发明申请

US20060233814A1 Elimination of heterogeneous or mixed cell population in tumors 审中-公开
公开(公告)号：US20060233814A1
公开(公告)日：2006-10-19
申请号：US11404001
申请日：2006-04-14
申请人： Viktor Goldmakher , Robert Lutz , Ravi Chari , Yelena Kovtun , John Lambert , Rita Steeves , Hans Erickson
发明人： Viktor Goldmakher , Robert Lutz , Ravi Chari , Yelena Kovtun , John Lambert , Rita Steeves , Hans Erickson
IPC分类号： A61K39/395 , A61K31/5383 , C07K16/46 , A61K31/58 , A61K38/19
CPC分类号： C07K16/3046 , A61K31/5383 , A61K31/58 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07D498/18 , C07K2317/24
摘要： Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.

7. 发明申请

US20050118183A1 Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same 有权
标题翻译：抗CD33抗体及其治疗急性骨髓性白血病的方法
公开(公告)号：US20050118183A1
公开(公告)日：2005-06-02
申请号：US10700632
申请日：2003-11-05
申请人： Mary Hoffee , Daniel Tavares , Robert Lutz
发明人： Mary Hoffee , Daniel Tavares , Robert Lutz
IPC分类号： A61K20060101 , A61K39/395 , A61K39/40 , A61K39/42 , A61K39/44 , C07H21/04 , C07K16/28 , C07K16/46 , C12N5/06 , C12N5/16 , C12N15/00 , G01N33/574
CPC分类号： C07K16/2803 , A61K39/3955 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/92
摘要： The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of said antibodies, humanized and resurfaced versions of said antibodies, functional equivalents and improved versions of said antibodies, immunoconjugates and compositions comprising said antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding the antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing the antibodies.
摘要翻译：本发明涉及结合CD33的抗体。更具体地说，本发明涉及抗CD33抗体，所述抗体的片段和同系物，所述抗体的人源化和表面化形式，所述抗体的功能等同物和改进形式，免疫偶联物和包含所述抗体的组合物及其在诊断中的用途，研究和治疗应用。本发明还涉及编码抗体的多核苷酸，包含多核苷酸的载体，用多核苷酸转化的宿主细胞和产生抗体的方法。

8. 发明申请

US20080016478A1 PARASITIC IMPEDANCE ESTIMATION IN CIRCUIT LAYOUT 审中-公开
标题翻译：电路布局中的PARASITIC阻抗估计
公开(公告)号：US20080016478A1
公开(公告)日：2008-01-17
申请号：US11777094
申请日：2007-07-12
申请人： Robert Lutz , Joel Ficke
发明人： Robert Lutz , Joel Ficke
IPC分类号： G06F17/50
CPC分类号： G06F17/5036
摘要： The present invention in one embodiment performs estimation of parasitic impedances in a circuit. Leaf cells of circuit components are evaluated such that their parasitic impedances are estimated, and the leaf cells are placed in a physical layout. Parasitic impedances of interconnect wiring is evaluated, and the interconnect wire routing is placed. Parasitic impedance within the circuit is then estimated using a parasitic reduction process.
摘要翻译：本发明在一个实施例中执行电路中寄生阻抗的估计。对电路元件的叶细胞进行评估，以便估计其寄生阻抗，并将叶细胞置于物理布局中。评估互连布线的寄生阻抗，布置布线。然后使用寄生减少过程来估计电路内的寄生阻抗。

9. 发明申请

US20060208287A1 Lateral Programmable Polysilicon Structure Incorporating Polysilicon Blocking Diode 有权
标题翻译：结合多晶硅阻挡二极管的横向可编程多晶硅结构
公开(公告)号：US20060208287A1
公开(公告)日：2006-09-21
申请号：US11419558
申请日：2006-05-22
申请人： Robert Lutz , Thomas Wong
发明人： Robert Lutz , Thomas Wong
IPC分类号： H01L29/76
CPC分类号： H01L21/84 , G11C17/16 , H01L27/11801 , H01L27/1203 , H01L29/868 , Y10S257/91
摘要： A programmable element includes a diode and a programmable structure formed in a polysilicon layer isolated from a semiconductor substrate by a dielectric layer. The diode includes a first region and a second region of opposite conductivity types. The programmable structure includes a third region and a fourth region of opposite conductivity types. The first region of the diode and the third region of the programmable structure are electrically connected. In operation, the programmable structure is programmed to a low impedance state when a voltage exceeding a first breakdown voltage of the programmable structure is applied to reverse bias the programmable structure. The programmable element can be used to form a programmable array having very low parasitic capacitance, enabling the realization of a large and ultra fast programmable logic array.
摘要翻译：可编程元件包括形成在通过电介质层与半导体衬底隔离的多晶硅层中的二极管和可编程结构。二极管包括第一区域和相反导电类型的第二区域。可编程结构包括具有相反导电类型的第三区域和第四区域。二极管的第一区域和可编程结构的第三区域电连接。在操作中，当施加超过可编程结构的第一击穿电压的电压以将可编程结构反向偏置时，可编程结构被编程为低阻抗状态。可编程元件可用于形成具有非常低的寄生电容的可编程阵列，使得能够实现大型和超快速可编程逻辑阵列。

10. 发明申请

US20050169933A1 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates 有权
标题翻译：使用通过不可切割接头连接的细胞粘附剂美登木素生物碱结合物靶向特定细胞群的方法，所述缀合物和制备所述缀合物的方法
公开(公告)号：US20050169933A1
公开(公告)日：2005-08-04
申请号：US10960602
申请日：2004-10-08
申请人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
发明人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
IPC分类号： A61K39/395 , C07K16/46 , C07D491/04
CPC分类号： C07K16/3092 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07K16/18 , C07K16/32 , C07K2317/24 , C07K2317/92
摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
摘要翻译：本发明公开了一种将美登木素生物素靶向选定的细胞群体的方法，所述方法包括将怀疑含有所选细胞群的细胞群体或组织与细胞粘附剂美登木素生物碱缀合物接触，其中一种或多种美登木素生物碱共价连接到细胞结合剂通过不可切割的接头和细胞结合剂结合所选细胞群的细胞。

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